Le Tong

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Organoids

Articles

Article: SCIENCE TRANSLATIONAL MEDICINE. 2024;16(747):eadi2952
Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis
Neo SY; Tong L; Chong J; Liu Y; Jing X; Oliveira MMS; Chen Y; Chen Z; Lee K; Burduli N; Chen X; Gao J; Ma R; Lim JP; Huo J; Xu S; Alici E; Wickstrom SL; Haglund F; Hartman J; Wagner AK; Cao Y; Kiessling R; Lam KP; Westerberg LS; Lundqvist A
Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2024;43(1):107
A phenotypic screening approach to target p60AmotL2-expressing invasive cancer cells
Fonseca P; Cui W; Struyf N; Tong L; Chaurasiya A; Casagrande F; Zhao H; Fernando D; Chen X; Tobin NP; Seashore-Ludlow B; Lundqvist A; Hartman J; Gondor A; Ostling P; Holmgren L
Article: JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH. 2024;43(1):13
Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease
Neo SY; Oliveira MMS; Tong L; Chen Y; Chen Z; Cismas S; Burduli N; Malmerfelt A; Teo JKH; Lam K-P; Alici E; Girnita L; Wagner AK; Westerberg LS; Lundqvist A
Article: ONCOIMMUNOLOGY. 2023;12(1):2175517
CD25^bright NK cells display superior function and metabolic activity under regulatory T cell-mediated suppression
Chen Z; Tong L; Neo SY; Li S; Gao J; Schlisio S; Lundqvist A
Article: CELLS. 2023;12(17):2158
Deciphering the Role of p60AmotL2 in Epithelial Extrusion and Cell Detachment
Cui W; Subramani A; Fonseca P; Zhang Y; Tong L; Zhang Y; Egevad L; Lundqvist A; Holmgren L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(1):e2209856120
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Min ATH; Lovrot J; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J
Article: ADVANCED BIOLOGY. 2022;6(11):e2200092
Optimizing eRF1 to Enable the Genetic Encoding of Three Distinct Noncanonical Amino Acids in Mammalian Cells.
Shi N; Tong L; Lin H; Zheng Z; Zhang H; Dong L; Yang Y; Shen Y; Xia Q
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(40):e2203307119
Generation of mega brown adipose tissue in adults by controlling brown adipocyte differentiation in vivo
Du Q; Wu J; Fischer C; Seki T; Jing X; Gao J; He X; Hosaka K; Tong L; Yasue A; Miyake M; Sobajima M; Oyadomari S; Sun X; Yang Y; Zhou Q; Ge M; Tao W; Yao S; Cao Y
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(10):e005308
Tumor MHC class I expression alters cancer-associated myelopoiesis driven by host NK cells
Neo SY; Jing X; Tong L; Tong D; Gao J; Chen Z; De Los Santos MC; Burduli N; Ferreira SDS; Wagner AK; Alici E; Rolny C; Cao Y; Lundqvist A
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(5):e004592
A_2B adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models
Tay AHM; Prieto-Diaz R; Neo S; Tong L; Chen X; Carannante V; Onfelt B; Hartman J; Haglund F; Majellaro M; Azuaje J; Garcia-Mera X; Brea JM; Loza MI; Jespers W; Gutierrez-de-Teran H; Sotelo E; Lundqvist A
Article: NATURE BIOMEDICAL ENGINEERING. 2022;6(2):195-206
Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids.
Shi N; Yang Q; Zhang H; Lu J; Lin H; Yang X; Abulimiti A; Cheng J; Wang Y; Tong L; Wang T; Zhang X; Chen H; Xia Q
Article: EMBO REPORTS. 2021;22(3):e51329
Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25⁺/CD54⁺ NK cells
Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A
Article: SYNLETT. 2017;28(10):1187-1190
A New Process for the Total Synthesis of Sparstolonin B
Tang X; Tong L; Yao M; Liang Q; Wang X; Yu H

All other publications

Review: MED. 2024;5(11):1351-1377
Patient-derived organoids in precision cancer medicine
Tong L; Cui W; Zhang B; Fonseca P; Zhao Q; Zhang P; Xu B; Zhang Q; Li Z; Seashore-Ludlow B; Yang Y; Si L; Lundqvist A
Thesis / dissertation: 2024
NK cells in renal cell carcinoma : toward biomarker discovery and improved immunotherapeutic strategies
Tong, Le
Letter: CANCER COMMUNICATIONS. 2023;43(7):855-859
Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1
Tong L; Kremer V; Neo SY; Liu Y; Chen Y; Wagner AK; Yang Y; Chen Z; Seitz C; Tobin NP; Ligtenberg MA; Alici E; Chen X; Haglund F; Seliger B; Harmenberg U; Colon E; Plogell A-HS; Liu LL; Lundqvist A
Review: MOLECULAR CANCER. 2022;21(1):206
NK cells and solid tumors: therapeutic potential and persisting obstacles
Tong L; Jimenez-Cortegana C; Tay AHM; Wickstrom S; Galluzzi L; Lundqvist A
Meeting abstract: ANNALS OF ONCOLOGY. 2022;33(7):S1306
Breast cancer patient-derived whole-tumor cell culture model for efficient drug profiling and treatment response prediction
Chen X; Sifakis EG; Robertson S; Neo SY; Jun S-H; Tong L; Lovrot J; Tay A; Hellgren R; Margolin S; Bergh J; Foukakis T; Lagergren J; Lundqvist A; Ma R; Hartman J

Grants

VHL inactivation confers decreased infiltration and killing capacity of NK cells in clear cell renal cell carcinoma
Robert Lundberg Memorial Foundation

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