Laurène Adam

Articles

Article: PROTEIN SCIENCE. 2024;33(8):e5091
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstal H; Otzen DE; Johansson J; Abelein A
Journal article: NATURE COMMUNICATIONS. 2024;15(1):965
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain.
Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstål H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: NATURE COMMUNICATIONS. 2024;15(1):965
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain
Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
Molecular Mechanisms of Amyloid-? Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone
Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A

Preprint: BIORXIV. 2023
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS
Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstål H; Otzen DE; Johansson J; Abelein A
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S189
Inhibitory mechanism of the BRICHOS protein on asynuclein aggregation related to familial Parkinson′s disease
Klute H; Adam L; Molenkamp W; Kumar R; Johansson J; Abelein A
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S54
Structural insights into aggregation hotspots on Alzheimer's associated amyloid-β fibrils blocked by the BRICHOS chaperone
Abelein A; Kumar R; Le Marchand T; Adam L; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S168
Targeting a-synuclein amyloid aggregates with the BRICHOS domain - basis for treatment of Parkinson's disease
Adam L; Kumar R; Molenkamp W; Alkenayeh R; Biverstal H; Johansson J; Abelein A
Conference publication: EUROPEAN BIOPHYSICS JOURNAL. 2023;52(SUPPL 1):S89
Molecular mechanisms of amyloid-β self-assembly and chaperone-mediated inhibition can be translated to in vivo-derived fibril seeds
Kumar R; Garcia LEA; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A