Laura Sanz Ortega

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About me

Laura received her PhD on new nanomedicine-based therapeutic applications developed to treat cancer from Universidad Autónoma de Madrid, Spain, 2019. With her background in immune cell homing to the tumor microenvironment, her post-doctoral work focuses on understanding how tumor cells can impair NK cell homing to the bone marrow in acute myeloid leukemia (AML) and how to genetically modified NK cells to overcome this limitation, with the overall aim of optimizing adoptive NK cell infusion. Her work is supported by Cancerfonden.

Articles

Article: NPJ PRECISION ONCOLOGY. 2024;8(1):108
Redirecting NK cells to the lymph nodes to augment their lymphoma-targeting capacity
Sanz-Ortega L; Leijonhufvud C; Schoutens L; Lambert M; Levy E; Andersson A; Wahlin BE; Carlsten M
Article: LEUKEMIA. 2024;38(3):579-589
Harnessing upregulated E-selectin while enhancing SDF-1α sensing redirects infused NK cells to the AML-perturbed bone marrow
Sanz-Ortega L; Andersson A; Carlsten M
Article: JOURNAL OF IMMUNOLOGY. 2024;212(5):868-880
KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity
Leijonhufvud C; Sanz-Ortega L; Schlums H; Gaballa A; Andersson A; Eriksson C; Segerberg F; Uhlin M; Bryceson YT; Carlsten M
Journal article: ACS APPLIED MATERIALS & INTERFACES. 2021;13(7):7924-7944
Iron Oxide Nanoparticle Coatings Dictate Cell Outcomes Despite the Influence of Protein Coronas
Portilla Y; Mellid S; Paradela A; Ramos-Fernandez A; Daviu N; Sanz-Ortega L; Perez-Yague S; Morales MP; Barber DF
Journal article: PHARMACEUTICS. 2020;12(9):812
Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting
Sanz-Ortega L; Rojas JM; Barber DF
Journal article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2019;21:102063
Polyethylenimine-coated superparamagnetic iron oxide nanoparticles impair in vitro and in vivo angiogenesis
Mulens-Arias V; Manuel Rojas J; Sanz-Ortega L; Portilla Y; Perez-Yague S; Barber DF
Journal article: JOURNAL OF NANOBIOTECHNOLOGY. 2019;17(1):87
Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8⁺ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes
Sanz-Ortega L; Portilla Y; Perez-Yague S; Barber DF
Journal article: JOURNAL OF NANOBIOTECHNOLOGY. 2019;17(1):14
T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field
Sanz-Ortega L; Rojas JM; Marcos A; Portilla Y; Stein JV; Barber DF
Journal article: FRONTIERS IN IMMUNOLOGY. 2019;10:2073
Magnetic Nanoparticles Attached to the NK Cell Surface for Tumor Targeting in Adoptive Transfer Therapies Does Not Affect Cellular Effector Functions
Sanz-Ortega L; Rojas JM; Portilla Y; Perez-Yague S; Barber DF
Journal article: ACTA BIOMATERIALIA. 2017;58:181-195
Time-course assessment of the aggregation and metabolization of magnetic nanoparticles
Rojas JM; Gavilan H; del Dedo V; Lorente-Sorolla E; Sanz-Ortega L; da Silva GB; Costo R; Perez-Yague S; Talelli M; Marciello M; Puerto Morales M; Barber DF; Gutierrez L
Journal article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(6):1285-1296
PI3K p85 β regulatory subunit deficiency does not affect NK cell differentiation and increases NKG2D-mediated activation.
Rojas JM; Spada R; Sanz-Ortega L; Morillas L; Mejías R; Mulens-Arias V; Pérez-Yagüe S; Barber DF
Journal article: NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY, AND MEDICINE. 2016;12(4):1127-1138
Superparamagnetic iron oxide nanoparticle uptake alters M2 macrophage phenotype, iron metabolism, migration and invasion
Rojas JM; Sanz-Ortega L; Mulens-Arias V; Gutierrez L; Perez-Yague S; Barber DF

All other publications

Letter: HEMASPHERE. 2023;7(11):e974
Improved Leukemia Clearance After Adoptive Transfer of NK Cells Expressing the Bone Marrow Homing Receptor CXCR4^R334X
Segerberg F; Lambert M; Sanz-Ortega L; Andersson A; Childs RW; Carlsten M
Conference publication: BRITISH JOURNAL OF HAEMATOLOGY. 2023;201:114-115
Redirecting NK cells to the lymph nodes to augment their lymphoma-targeting capacity
Schoutens L; Sanz-Ortega L; Leijonhufvud C; Lambert M; Levy E; Andersson A; Wahlin B; Carlsten M

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