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About me

  • Professor of Pediatric Endocrinology, Dept of Women´s and Children´s Health, Karolinska Institutet
  • Senior Consultant, Pediatrics and Pediatric Endocrinology, Karolinska University Hospital
  • Chief R&D, Children´s and Women´s Health, Karolinska University Hospital

 

Education

M.D. (1986), Ph.D. (1989), Licenced physiscian (1991), Certified pediatrician (1997), Professor of Pediatric Endocrinology (2005)

Research description

Longitudinal bone growth takes place in the growth plate which is a layer of cartilage in each end of most bones in the body. Lars Sävendahl and his team have developed new research models and have thereby managed to show how growth regulation takes place at the cellular level. The results have led to the forthcoming introduction of new treatment principles of different growth disorders. Please refer to the links below for more detailed description of individual research projects run by members of Lars Sävendahl´s team.

Links

Publications

Animal models to explore the effects of glucocorticoids on skeletal growth and structure
Wood Cl, Soucek O, Wong Sc, Zaman F, Farquharson C, Savendahl L, et al
The Journal of endocrinology 2018;236(1):R69-R91

Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study
Swerdlow Aj, Cooke R, Beckers D, Borgström B, Butler G, Carel Jc, et al
The Journal of clinical endocrinology and metabolism 2017;102(5):1661-1672

Is safety of childhood growth hormone therapy related to dose? Data from a large observational study
Sävendahl L, Pournara E, Pedersen Bt, Blankenstein O
European journal of endocrinology 2017;176(3):X1-

Proinsulin C-peptide regulates ribosomal RNA expression
Lindahl E, Nyman U, Zaman F, Palmberg C, Cascante A, Shafqat J, et al
The Journal of biological chemistry 2017;292(10):4382-

Regulation of bone growth via ligand-specific activation of estrogen receptor alpha
Iravani M, Lagerquist M, Ohlsson C, Sävendahl L
The Journal of endocrinology 2017;232(3):403-410

Somapacitan, a once-weekly reversible albumin-binding GH derivative, in children with GH deficiency: A randomized dose-escalation trial
Nn8640-4042 Study Group, Battelino T, Rasmussen Mh, De Schepper J, Zuckerman-levin N, Gucev Z, et al
Clinical endocrinology 2017;87(4):350-358

The Physiology of Childhood Growth: Hormonal Regulation
Benyi E, Sävendahl L
Hormone research in paediatrics 2017;88(1):6-14

Bridging the gap: metabolic and endocrine care of patients during transition
Hokken-koelega A, Van Der Lely Aj, Hauffa B, Häusler G, Johannsson G, Maghnie M, et al
Endocrine connections 2016;5(6):R44-R54

GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults
Allen Db, Backeljauw P, Bidlingmaier M, Biller Bm, Boguszewski M, Burman P, et al
European journal of endocrinology 2016;174(2):P1-9

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets
Munns Cf, Shaw N, Kiely M, Specker Bl, Thacher Td, Ozono K, et al
The Journal of clinical endocrinology and metabolism 2016;101(2):394-415

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets
Munns Cf, Shaw N, Kiely M, Specker Bl, Thacher Td, Ozono K, et al
Hormone research in paediatrics 2016;85(2):83-106

Is safety of childhood growth hormone therapy related to dose? Data from a large observational study
Sävendahl L, Pournara E, Pedersen Bt, Blankenstein O
European journal of endocrinology 2016;174(5):681-91

Mortality Is Not Increased in Recombinant Human Growth Hormone-treated Patients When Adjusting for Birth Characteristics
Albertsson-wikland K, Mårtensson A, Sävendahl L, Niklasson A, Bang P, Dahlgren J, et al
The Journal of clinical endocrinology and metabolism 2016;101(5):2149-59

New Agents to Treat Chronic Lymphocytic Leukemia
Zaman F, Savendahl L
The New England journal of medicine 2016;374(22):2185-

The Evaluation and Management of Tall Stature
Hannema Se, Sävendahl L
Hormone research in paediatrics 2016;85(5):347-52

Venetoclax in cancer therapy and potential effects on bone
Zaman F, Kogner P, Sävendahl L
The Lancet. Oncology 2016;17(8):e319-e320

Venetoclax in cancer therapy and potential effects on bone
Zaman F, Kogner P, Savendahl L
LANCET ONCOLOGY 2016;17(8):E319-E320

Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone
Swerdlow Aj, Cooke R, Albertsson-wikland K, Borgström B, Butler G, Cianfarani S, et al
Hormone research in paediatrics 2015;84(3):172-83

Expression of the aryl hydrocarbon receptor in growth plate cartilage and the impact of its local modulation on longitudinal bone growth
Cedervall T, Lind Pm, Sävendahl L
International journal of molecular sciences 2015;16(4):8059-69

Short and tall stature: a new paradigm emerges
Baron J, Sävendahl L, De Luca F, Dauber A, Phillip M, Wit Jm, et al
Nature reviews. Endocrinology 2015;11(12):735-46

Short Stature in KBG Syndrome: First Responses to Growth Hormone Treatment
Reynaert N, Ockeloen Cw, Sävendahl L, Beckers D, Devriendt K, Kleefstra T, et al
Hormone research in paediatrics 2015;83(5):361-4

Bortezomib treatment causes long-term testicular dysfunction in young male mice
Hou M, Eriksson E, Svechnikov K, Jahnukainen K, Söder O, Meinhardt A, et al
Molecular cancer 2014;13():155-

Combined treatment with GH and IGF-I: additive effect on cortical bone mass but not on linear bone growth in female rats
Sundström K, Cedervall T, Ohlsson C, Camacho-hübner C, Sävendahl L
Endocrinology 2014;155(12):4798-807

Common DNA variants predict tall stature in Europeans
Liu F, Hendriks Ae, Ralf A, Boot Am, Benyi E, Sävendahl L, et al
Human genetics 2014;133(5):587-97

Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: role of pro-apoptotic Bid
Zaman F, Chrysis D, Huntjens K, Chagin A, Takigawa M, Fadeel B, et al
Toxicology letters 2014;224(2):196-200

Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis
Dasgupta D, Wee Mj, Reyes M, Li Y, Simm Pj, Sharma A, et al
Journal of the American Society of Nephrology : JASN 2014;25(10):2366-75

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures
Movérare-skrtic S, Henning P, Liu X, Nagano K, Saito H, Börjesson Ae, et al
Nature medicine 2014;20(11):1279-88

Protective role of humanin on bortezomib-induced bone growth impairment in anticancer treatment
Eriksson E, Wickström M, Perup Ls, Johnsen Ji, Eksborg S, Kogner P, et al
Journal of the National Cancer Institute 2014;106(3):djt459-

Recent research on the growth plate: Impact of inflammatory cytokines on longitudinal bone growth
Sederquist B, Fernandez-vojvodich P, Zaman F, Sävendahl L
Journal of molecular endocrinology 2014;53(1):T35-44

Risks of malignant and non-malignant tumours in tall women treated with high-dose oestrogen during adolescence
Benyi E, Kieler H, Linder M, Ritzén M, Carlstedt-duke J, Tuvemo T, et al
Hormone research in paediatrics 2014;82(2):89-96

Bortezomib and bone health in adults: can we extend these findings to children?
Eriksson E, Sävendahl L, Zaman F
European journal of haematology 2013;90(6):533-4

Identification of a clonally expanding haematopoietic compartment in bone marrow
Wang L, Benedito R, Bixel Mg, Zeuschner D, Stehling M, Sävendahl L, et al
The EMBO journal 2013;32(2):219-30

Interleukin-6 acts locally on the growth plate to impair bone growth
Fernandez-vojvodich P, Zaman F, Sävendahl L
Annals of the rheumatic diseases 2013;72(10):e24-

Resveratrol treatment delays growth plate fusion and improves bone growth in female rabbits
Karimian E, Tamm C, Chagin As, Samuelsson K, Kjartansdóttir Kr, Ohlsson C, et al
PloS one 2013;8(6):e67859-

The NordiNet® International Outcome Study and NovoNet® ANSWER Program®: rationale, design, and methodology of two international pharmacoepidemiological registry-based studies monitoring long-term clinical and safety outcomes of growth hormone therapy (Norditropin®)
Höybye C, Sävendahl L, Christesen Ht, Lee P, Pedersen Bt, Schlumpf M, et al
Clinical epidemiology 2013;5():119-27

Vitamin D levels in children born to vitamin D-deficient mothers
Bergström I, Blanck A, Sävendahl L
Hormone research in paediatrics 2013;80(1):6-10

Ablation of the Pro-Apoptotic Protein Bax Protects Mice from Glucocorticoid-Induced Bone Growth Impairment
Zaman F, Chrysis D, Huntjens K, Fadeel B, Savendahl L
PLOS ONE 2012;7(3):e33168-

Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice
Eriksson E, Zaman F, Chrysis D, Wehtje H, Heino Tj, Sävendahl L
PloS one 2012;7(11):e50523-

Comparison of response to 2-years' growth hormone treatment in children with isolated growth hormone deficiency, born small for gestational age, idiopathic short stature, or multiple pituitary hormone deficiency: combined results from two large observational studies
Lee Pa, Sävendahl L, Oliver I, Tauber M, Blankenstein O, Ross J, et al
International journal of pediatric endocrinology 2012;2012(1):22-

Gender Influences Short-Term Growth Hormone Treatment Response in Children
Savendahl L, Blankenstein O, Oliver I, Christesen Ht, Lee P, Pedersen Bt, et al
HORMONE RESEARCH IN PAEDIATRICS 2012;77(3):188-94

Long-Term Mortality and Causes of Death in Isolated GHD, ISS, and SGA Patients Treated with Recombinant Growth Hormone during Childhood in Belgium, The Netherlands, and Sweden: Preliminary Report of 3 Countries Participating in the EU SAGhE Study
Savendahl L, Maes M, Albertsson-wikland K, Borgstrom B, Carel Jc, Henrard S, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2012;97(2):E213-7

Pro-Inflammatory Cytokines Produced by Growth Plate Chondrocytes May Act Locally to Modulate Longitudinal Bone Growth
Fernandez-vojvodich P, Palmblad K, Karimian E, Andersson U, Savendahl L
HORMONE RESEARCH IN PAEDIATRICS 2012;77(3):180-7

The effect of acute and chronic stress on growth
Sävendahl L
Science signaling 2012;5(247):pt9-

The role of estrogen receptor-alpha and its activation function-1 for growth plate closure in female mice
Borjesson Ae, Windahl Sh, Karimian E, Eriksson Ee, Lagerquist Mk, Engdahl C, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2012;302(11):E1381-9

Estrogen signaling in growth plate cartilage
Karimian E, Sävendahl L
Endocrine development 2011;21():42-51

Genetic regulation of the growth plate
Karimian E, Chagin As, Sävendahl L
Frontiers in endocrinology 2011;2():113-

Growth hormone and treatment outcomes: expert review of current clinical practice
Cassorla F, Cianfarani S, Haverkamp F, Labarta Ji, Loche S, Luo X, et al
Pediatric endocrinology reviews : PER 2011;9(2):554-65

Insulin-like growth factor-1 restores dexamethasone-induced heart growth arrest in rats: the role of the ubiquitin pathway
Chrysis D, Chagin As, Savendahl L
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM 2011;10(1):46-56

Intravenous Pamidronate Treatment Improves Growth in Prepubertal Osteogenesis Imperfecta Patients
Heino Tj, Astrom E, Laurencikas E, Savendahl L, Soderhall S
HORMONE RESEARCH IN PAEDIATRICS 2011;75(5):354-61

Mechanisms of Growth Plate Maturation and Epiphyseal Fusion
Emons J, Chagin As, Savendahl L, Karperien M, Wit Jm
HORMONE RESEARCH IN PAEDIATRICS 2011;75(6):383-91

The Biologics Anakinra and Etanercept Prevent Cytokine-Induced Growth Retardation in Cultured Fetal Rat Metatarsal Bones
Fernandez-vojvodich P, Karimian E, Savendahl L
HORMONE RESEARCH IN PAEDIATRICS 2011;76(4):278-85

The Use of Bone Age in Clinical Practice - Part 1
Martin Dd, Wit Jm, Hochberg Z, Savendahl L, Van Rijn Rr, Fricke O, et al
HORMONE RESEARCH IN PAEDIATRICS 2011;76(1):1-9

Vitamin D deficiency during pregnancy-potential threat to the child
Savendahl L
ACTA PAEDIATRICA 2011;100(4):484-5

Catch-up growth after dexamethasone withdrawal occurs in cultured postnatal rat metatarsal bones
Chagin As, Karimian E, Sundstrom K, Eriksson E, Savendahl L
JOURNAL OF ENDOCRINOLOGY 2010;204(1):21-9

Efficacy and Safety of Percutaneous Epiphysiodesis Operation around the Knee to Reduce Adult Height in Extremely Tall Adolescent Girls and Boys
Benyi E, Berner M, Bjernekull I, Boman A, Chrysis D, Nilsson O, et al
International journal of pediatric endocrinology 2010;2010():740629-

Expression of vascular endothelial growth factor in the growth plate is stimulated by estradiol and increases during pubertal development
Emons J, Chagin As, Malmlof T, Lekman M, Tivesten A, Ohlsson C, et al
JOURNAL OF ENDOCRINOLOGY 2010;205(1):61-8

Highlights from the Second European Workshop on Growth Plate Research 2010
Späth Ss, Sävendahl L, Camacho-hübner C, Nilsson O
Pediatric endocrinology reviews : PER 2010;8(2):123-5

Hormones and Genes of Importance in Bone Physiology and Their Influence on Bone Mineralization and Growth in Turner Syndrome
Andrade Ac, Baron J, Manolagas Sc, Shaw Nj, Rappold Ga, Donaldson Mdc, et al
HORMONE RESEARCH IN PAEDIATRICS 2010;73(3):161-5

Proinsulin C-peptide Regulates Ribosomal RNA Expression
Lindahl E, Nyman U, Zaman F, Palmberg C, Cascante A, Shafqat J, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2010;285(5):3462-9

The Role of Estrogen Receptor alpha in Growth Plate Cartilage for Longitudinal Bone Growth
Borjesson Ae, Lagerquist Mk, Liu C, Shao Rj, Windahl Sh, Karlsson C, et al
JOURNAL OF BONE AND MINERAL RESEARCH 2010;25(12):2690-700

Validation and Reference Values of Automated Bone Age Determination for Four Ethnicities
Thodberg Hh, Savendahl L
ACADEMIC RADIOLOGY 2010;17(11):1425-32

Androgen Receptor Modulation Does Not Affect Longitudinal Growth of Cultured Fetal Rat Metatarsal Bones
Chagin As, Vannesjo J, Savendahl L
HORMONE RESEARCH 2009;71(4):219-27

Epiphyseal Fusion in the Human Growth Plate Does not Involve Classical Apoptosis
Emons J, Chagin As, Hultenby K, Zhivotovsky B, Wit Jm, Karperien M, et al
PEDIATRIC RESEARCH 2009;66(6):654-9

Gender differences in growth hormone (GH) responsiveness in growth hormone deficient (GHD) children and short children born small for gestational age (SGA)
Ross J, Savendahl L, Gruters A, Oliver I, Peterkova V, Snajderova M, et al
HORMONE RESEARCH 2009;:372-372

Gender disproportion in children treated with growth hormone depends on country/region, diagnosis and severity of growth retardation
Savendahl L, Ross J, Fujieda K, Tajima T, Gruters A, Blankenstein O, et al
HORMONE RESEARCH 2009;:373-373

Genes of Importance in the Hormonal Regulation of Growth Plate Cartilage
Chagin As, Savendahl L
HORMONE RESEARCH 2009;:41-7

Genome wide screening and morphological analysis of the human growth plate during pubertal development
Emons Jam, Leijten J, Van Zwet E, Goeman J, Decker E, Chagin A, et al
HORMONE RESEARCH 2009;:275-276

Improved growth during the first year of monthly intravenous pamidronate therapy in prepubertal patients with osteogenesis imperfecta
Heino Tj, Astrom E, Savendahl L, Soderhall S
HORMONE RESEARCH 2009;:223-223

Predictors of growth response after one year of Norditropin (R) treatment in Turner syndrome patients from the ANSWER program (R) and the NordiNet (R)
Ross J, Savendahl L, Karwe V, Germak J, Rakov V
HORMONE RESEARCH 2009;:372-373

Predictors of growth response after one year of Norditropin treatment in growth hormone deficient (GHD) patients from the ANSWER program (R) and NordiNet (R)
Ross J, Savendahl L, Karwe V, Rakov V, Germak J
HORMONE RESEARCH 2009;:372-372

Promoting Growth in Chronic Inflammatory Disease: Lessons from Studies of the Growth Plate
Ahmed Sf, Savendahl L
HORMONE RESEARCH 2009;:42-7

Resveratrol modulates longitudinal bone growth of cultured fetal rat metatarsal bones in a biphasic manner
Karimian E, Savendahl L
HORMONE RESEARCH 2009;:277-278

The proteasome inhibitor, bortezomib induces growth retardation and delays tumor growth in young mice
Eriksson E, Johnsen Ji, Kogner P, Savendahl L
HORMONE RESEARCH 2009;:276-276

The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice
Windahl Sh, Andersson N, Chagin As, Martensson Uea, Carlsten H, Olde B, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2009;296(3):E490-6

Dexamethasone Triggers Mitochondrial Apoptosis Through Bax in Proliferative Growth Plate Chondrocytes Causing Growth Retardation
Zaman F, Chrysis D, Huntjens K, Takigawa M, Fadeel B, Savendahl L
JOURNAL OF BONE AND MINERAL RESEARCH 2008;:S53-S53

Effects of alendronate and pamidronate on cultured rat metatarsal bones: Failure to prevent dexamethasone-induced growth retardation
Heino Tj, Chagin As, Takigawa M, Savendahl L
BONE 2008;42(4):702-9

Efficacy and safety of bilateral epiphysiodesis performed in extremely tall girls and boys
Berner M, Wehtje H, Savendahl L
HORMONE RESEARCH 2008;:113-113

Epiphyseal fusion in the human growth plate does not involve classical apoptosis
Emons J, Chagin As, Hultenby K, Zhivotovsky B, Wit Jm, Karperien M, et al
HORMONE RESEARCH 2008;:37-37

GPR30 estrogen receptor expression in bone cells during pubertal development
Heino Tj, Chagin As, Savendahl L
CALCIFIED TISSUE INTERNATIONAL 2008;:S155-S155

Hypercalcemia in children
Benjamin Rw, Moats-staats Bm, Calikoglu's A, Savendahl L, Chrysis D
Pediatric endocrinology reviews : PER 2008;5(3):778-84

Molecular regulation of the growth plate: Genome-wide expression analysis of human growth plate chondrocytes. An ESPE-RU update
Karperien M, Emons J, Van Gool S, Chagin A, Savendahl L, Rappold G, et al
HORMONE RESEARCH 2008;:9-9

Proteasome inhibition causes permanent growth retardation in young mice
Eriksson E, Zaman F, Ysis Dc, Savendahl L
HORMONE RESEARCH 2008;:37-38

Proteasome inhibition therapies in childhood cancer
Zaman F, Fadeel B, Savendahl L
LEUKEMIA 2008;22(4):883-4

Tamoxifen impairs both longitudinal and cortical bone growth in young male rats
Karimian E, Chagin As, Gjerde J, Heino T, Lien Ea, Ohllsson C, et al
JOURNAL OF BONE AND MINERAL RESEARCH 2008;23(8):1267-77

The 7th ESPE Growth Plate Working Group symposium--EUROGROP, June 27th 2007, Helsinki, Finland
Miclea Rl, Phillip M, Sävendahl L, Wit Jm
Journal of pediatric endocrinology & metabolism : JPEM 2008;21(3):287-94

The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone
Heino Tj, Chagin As, Savendahl L
JOURNAL OF ENDOCRINOLOGY 2008;197(2):R1-6

The Role of the G Protein-coupled Receptor GPR30 in Effects of Estrogen in Ovariectomized Mice.
Windahl Sh, Andersson N, Chagin A, Martensson Ue, Carlsten H, Olde B, et al
JOURNAL OF BONE AND MINERAL RESEARCH 2008;:S284-S284

Time-dependent growth responsiveness to rhIGF-I in cultured rat metatarsal bones
Sundstrom K, Chagin As, Camacho-hubner C, Savendahl L
HORMONE RESEARCH 2008;:19-19

Validation of authomated bone age determination in healthy American children of four ethnicities
Thodberg Hh, Savendahl L
HORMONE RESEARCH 2008;:88-88

Bisphosphonates stimulate linear growth of fetal rat metatarsal bones and protect chondrocytes from dexamethasone-induced apoptosis
Heino Tj, Chagin As, Savendahl L
CALCIFIED TISSUE INTERNATIONAL 2007;:S130-S130

Estrogens and growth: review
Chagin As, Sävendahl L
Pediatric endocrinology reviews : PER 2007;4(4):329-34

Etanercept treatment improves longitudinal growth in prepubertal children with juvenile idiopathic arthritis
Vojvodich Pf, Hansen Jb, Andersson U, Savendahl L, Hagelberg S
JOURNAL OF RHEUMATOLOGY 2007;34(12):2481-5

GPR30 estrogen receptor expression in the growth plate declines as puberty progresses
Chagin As, Savendahl L
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2007;92(12):4873-7

Meeting Report:The 7th ESPE Growth Plate Working Group Symposium - EUROGROP June 27th 2007, Helsinki, Finland
Miclea Rl, Phillip M, Sävendahl L, Wit Jm
Pediatric endocrinology reviews : PER 2007;5(2):680-5

Oestrogen receptors and linear bone growth
Chagin As, Savendahl L
ACTA PAEDIATRICA 2007;96(9):1275-9

Proteasome inhibition up-regulates p53 and apoptosis-inducing factor in chondrocytes causing severe growth retardation in mice
Zaman F, Menendez-benito V, Eriksson E, Chagin As, Takigawa M, Fadeel B, et al
CANCER RESEARCH 2007;67(20):10078-86

Tamoxifen induces permanent growth arrest through selective induction of apoptosis in growth plate chondrocytes in cultured rat metatarsal bones
Chagin As, Karimian E, Zaman F, Takigawa M, Chrysis D, Savendahl L
BONE 2007;40(5):1415-24

Accuracy of a new automatic method to determine Greulich-Pyle bone age
Thodberg Hh, Savendahl L
HORMONE RESEARCH 2006;:21-21

Biologic response modifiers completely rescue cytokine-induced growth retardation in fetal rat metatarsal bones
Karimian E, Vojvodich Pf, Savendahl L
HORMONE RESEARCH 2006;:28-28

Cytokines and their effect on growth plate chondrocytes
Savendahl L
HORMONE RESEARCH 2006;:7-8

Estrogen induced VEGF-expression in the rat growth plate
Malmlof T, Chagin A, Tivesten A, Savendahl L
HORMONE RESEARCH 2006;:27-28

Locally produced estrogen promotes fetal rat metatarsal bone growth; an effect mediated through increased chondrocyte proliferation and decreased apoptosis
Chagin As, Chrysis D, Takigawa M, Ritzen Em, Savendahl L
JOURNAL OF ENDOCRINOLOGY 2006;188(2):193-203

Metacarpophalangeal pattern profile analysis: Useful diagnostic tool for differentiating between dyschondrosteosis, Turner syndrome, and hypochondroplasia
Laurencikas E, Savendahl L, Jorulf H
ACTA RADIOLOGICA 2006;47(5):518-24

Proteasome inhibitors induce growth retardation in mice and apoptosis in growth plate chondrocytes
Eriksson E, Zaman F, Chrysis D, Savendahl L
HORMONE RESEARCH 2006;:20-20

Remaining estrogenic activity in the man with mutated estrogen receptor alpha [ER alpha)
Chagin A, Nilsson M, Wright Kd, Savendahl L
HORMONE RESEARCH 2006;:28-28

The Fifth European Growth Plate Working Group Symposium - 21st September 2005, Lyon, France - Abstracts
Kalirai H, Phillip M, Savendahl L, Wit Jm
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 2006;19(2):183-90

The Sixth ESPE Growth Plate Working Group Symposium (EUROGROP), June 30th, Rotterdam, the Netherlands, "a multidisciplinary approach to growth plate biology"
Emons J, Phillip M, Wit Jm, Sävendahl L
Pediatric endocrinology reviews : PER 2006;4(2):153-9

Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3 '-kinase signaling pathway
Chrysis D, Zaman F, Chagin As, Takigawa M, Savendahl L
ENDOCRINOLOGY 2005;146(3):1391-7

Glucocorticoid eye drops inhibit growth in the newborn rabbit
Kugelberg M, Shafiei K, Ohlsson C, Savendahl L, Zetterstrom C
ACTA PAEDIATRICA 2005;94(8):1096-101

Hormonal regulation of growth plate cartilage
Savendahl L
HORMONE RESEARCH 2005;:94-7

Metacarpophalangeal pattern profile analysis as a tool for early diagnosis of Turner syndrome
Laurencikas E, Soderman E, Davenport M, Jorulf H, Savendahl L
ACTA RADIOLOGICA 2005;46(4):424-30

Reduced bone mineral density and radial bone growth in young rabbits treated with dexamethasone eye drops
Kugelberg M, Ohlsson C, Savendahl L
HORMONE RESEARCH 2005;63(4):165-70

The 4th European Growth Plate Working Group Symposium (EUROGROP). 10th September 2004, Basel, Switzerland
Chagin A, Phillip M, Wit Jm, Sävendahl L
Journal of pediatric endocrinology & metabolism : JPEM 2005;18(8):823-7

Additive protective effects of estrogen and androgen treatment on trabecular bone in ovariectomized rats
Tivesten A, Moverare-skrtic S, Chagin A, Venken K, Salmon P, Vanderschueren D, et al
JOURNAL OF BONE AND MINERAL RESEARCH 2004;19(11):1833-9

Additive stimulatory effects of estrogen and androgen receptor activation on trabecular bone in ovariectomized rats.
Moverare S, Tivesten A, Chagin A, Venken K, Salmon P, Vanderschueren D, et al
JOURNAL OF BONE AND MINERAL RESEARCH 2004;:S170-S170

Estrogen receptor-beta inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice
Chagin As, Lindberg Mk, Andersson N, Moverare S, Gustafsson Ja, Savendahl L, et al
JOURNAL OF BONE AND MINERAL RESEARCH 2004;19(1):72-7

Interleukin-1 beta and TNF-alpha act in synergy to inhibit longitudinal growth in fetal rat metatarsal bones
Martensson K, Chrysis D, Savendahl L
JOURNAL OF BONE AND MINERAL RESEARCH 2004;19(11):1805-12

The Third European Growth Plate Working Group Symposium. 17th September 2003, Ljubljana, Slovenia
Robson H, Savendahl L, Phillip M, Wit Jm
Journal of pediatric endocrinology & metabolism : JPEM 2004;17(4):685-94

Growth retardation induced by dexamethasone is associated with increased apoptosis of the growth plate chondrocytes
Chrysis D, Ritzen Em, Savendahl L
JOURNAL OF ENDOCRINOLOGY 2003;176(3):331-7

Localization of estrogen receptors-alpha and -beta and androgen receptor in the human growth plate at different pubertal stages
Nilsson O, Chrysis D, Pajulo I, Boman A, Holst M, Rubinstein J, et al
JOURNAL OF ENDOCRINOLOGY 2003;177(2):319-26

Raloxifene acts as an estrogen agonist on the rabbit growth plate
Nilsson O, Falk J, Ritzen Me, Baron J, Savendahl L
PEDIATRIC RESEARCH 2003;53(4):151A-152A

Raloxifene acts as an estrogen agonist on the rabbit growth plate
Nilsson O, Falk J, Ritzen Em, Baron J, Savendahl L
ENDOCRINOLOGY 2003;144(4):1481-5

Apoptosis is developmentally regulated in rat growth plate
Chrysis D, Nilsson O, Ritzen Em, Savendahl L
ENDOCRINE 2002;18(3):271-8

Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate
Nilsson O, Abad V, Chrysis D, Ritzen Em, Savendahl L, Baron J
JOURNAL OF ENDOCRINOLOGY 2002;173(3):407-14

Expression and localization of Indian hedgehog (Ihh) and parathyroid hormone related protein (PTHrP) in the human growth plate during pubertal development
Kindblom Jm, Nilsson O, Hurme T, Ohlsson C, Savendahl L
JOURNAL OF ENDOCRINOLOGY 2002;174(2):R1-6

Growth failure in early life: An important manifestation of Turner syndrome
Davenport Ml, Punyasavatsut N, Stewart Pw, Gunther Df, Savendahl L, Sybert Vp
HORMONE RESEARCH 2002;57(5-6):157-64

Screening for Turner's syndrome by chromosome analysis of all girls with short stature - Reply
Davenport Ml, Savendahl L
JOURNAL OF PEDIATRICS 2002;140(1):140-141

Body fat content can be predicted in vivo in mice using a modified dual-energy X-ray absorptiometry technique
Sjogren K, Hellberg N, Bohlooly-y M, Savendahl L, Johansson Ms, Berglindh T, et al
JOURNAL OF NUTRITION 2001;131(11):2963-6

Delayed diagnoses of Turner's syndrome: Proposed guidelines for change
Savendahl L, Davenport Ml
JOURNAL OF PEDIATRICS 2000;137(4):455-9

Estrogens and human growth
Ritzen Em, Nilsson O, Grigelioniene G, Holst M, Savendahl L, Wroblewski J
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 2000;74(5):383-6

Demonstration of estrogen receptor-beta immunoreactivity in human growth plate cartilage
Nilsson Lo, Boman A, Savendahl L, Grigelioniene G, Ohlsson C, Ritzen Em, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 1999;84(1):370-3

Disproportional body growth in female estrogen receptor-alpha-inactivated mice
Vidal O, Lindberg M, Savendahl L, Lubahn Db, Ritzen Em, Gustafsson Ja, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1999;265(2):569-71

Expression of estrogen receptor-beta in rabbit growth plate cartilage.
Nilsson O, Abad V, Savendahl Lsg, Baron J
JOURNAL OF BONE AND MINERAL RESEARCH 1999;:S452-S452

Fasting increases serum total cholesterol, LDL cholesterol and apolipoprotein B in healthy, nonobese humans
Savendahl L, Underwood Le
JOURNAL OF NUTRITION 1999;129(11):2005-8

Turner syndrome: a pattern of early growth failure
Davenport Ml, Punyasavatsut N, Gunther D, Savendahl L, Stewart Pw
ACTA PAEDIATRICA 1999;:118-21

Decreased interleukin-2 production from cultured peripheral blood mononuclear cells in human acute starvation
Savendahl L, Underwood Le
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 1997;82(4):1177-80

Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid
Savendahl L, Underwood Le, Haldeman Km, Ulshen Mh, Lund Pk
ENDOCRINOLOGY 1997;138(2):734-40

Prolonged fasting in humans results in diminished plasma choline concentrations but does not cause liver dysfunction
Savendahl L, Mar Mh, Underwood Le, Zeisel Sh
AMERICAN JOURNAL OF CLINICAL NUTRITION 1997;66(3):622-5

Enrichment of type I and type II rat somatotrophs: Characterization of growth hormone secretion in vitro
Lindstrom P, Savendahl L
ENDOCRINOLOGY 1996;137(10):4174-80

CELL-VOLUME AND SHAPE OSCILLATIONS IN RAT TYPE-II SOMATOTROPHS AT HYPOTONIC CONDITIONS
Engstrom Kg, Savendahl L
CYTOMETRY 1995;20(1):7-13

GROWTH-HORMONE DEFICIENCY IMPAIRS BLOOD-CLOTTING AND REDUCES FACTOR-VII COAGULANT ACTIVITY IN RAT
Savendahl Lsg, Grankvist K, Engstrom Kg
THROMBOSIS AND HAEMOSTASIS 1995;73(4):626-9

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