Lars Ottosson

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CV
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Articles

Journal article: JOURNAL OF NEUROSURGERY: PEDIATRICS. 2024;34(5):470-478
Management and outcomes of foramen magnum stenosis in children with achondroplasia at a single center over 15 years.
Sandvik U; Ringvall E; Klangemo K; Hallgrimsdottir S; Gkourogianni A; Ottosson L; Svoboda J; Nilsson O
Journal article: 2023
The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation
M C; Z D; M B; EB L; A B; M K; A G; K B; L O; O N
Journal article: 2023
Bone, Growth Plate and Mineral Metabolism
Padidela R; Bendre A; Ottosson L; Nilsson O
Article: BIOMOLECULES. 2023;13(4):630
Anti-Citrullinated Protein Antibody Reactivity towards Neutrophil-Derived Antigens: Clonal Diversity and Inter-Individual Variation
Circiumaru A; Afonso MG; Wahamaa H; Krishnamurthy A; Hansson M; Mathsson-Alm L; Keszei M; Stalesen R; Ottosson L; de Vries C; Shelef MA; Malmstrom V; Klareskog L; Catrina AI; Gronwall C; Hensvold A; Rethi B
Article: NPJ REGENERATIVE MEDICINE. 2022;7(1):51
The synovial microenvironment suppresses chondrocyte hypertrophy and promotes articular chondrocyte differentiation
Chau M; Dou Z; Baroncelli M; Landman EB; Bendre A; Kanekiyo M; Gkourogianni A; Barnes K; Ottosson L; Nilsson O
Article: BONE. 2021;151:116035
Rat perichondrium transplanted to articular cartilage defects forms articular-like, hyaline cartilage
Dou Z; Muder D; Baroncelli M; Bendre A; Gkourogianni A; Ottosson L; Vedung T; Nilsson O
Article: MOLECULAR MEDICINE. 2021;27(1):58
Redox modifications of cysteine residues regulate the cytokine activity of HMGB1
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ
Journal article: BONE REPORTS. 2021;14:101026
Rat perichondrium transplanted to articular cartilage defects forms articular-like, hyaline cartilage
Dou Z; Muder D; Baroncelli M; Bendre A; Gkourogianni A; Ottosson L; Vedung T; Nilsson O
Journal article: BONE REPORTS. 2020;13:100665
Synovial cells secrete a temperature-stable protein that inhibits hypertrophic differentiation and induces articular cartilage differentiation of chondrocytes in vitro
Baroncelli M; Dou Z; Landman E; Chau M; Ottosson L; Nilsson O
Journal article: BONE REPORTS. 2020;13:100410
Growth plate cartilage transplanted to the articular surface remodels into articular-like cartilage in a process promoted by the synovial joint microenvironment
Dou Z; Chau M; Baroncelli M; Bendre A; Landman E; Ottosson L; Nilsson O
Article: JOURNAL OF NEUROINFLAMMATION. 2019;16(1):45
Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1^G93A mouse model of amyotrophic lateral sclerosis
Lee JD; Liu N; Levin SC; Ottosson L; Andersson U; Harris HE; Woodruff TM
Article: JOURNAL OF INNATE IMMUNITY. 2018;10(3):215-227
Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms
Aucott H; Lundberg J; Salo H; Klevenvall L; Damberg P; Ottosson L; Andersson U; Holmin S; Harris HE
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2016;186(3):284-291
Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model
Hoxha A; Ruffatti A; Ambrosi A; Ottosson V; Hedlund M; Ottosson L; Anandapadamanaban M; Sunnerhagen M; Sonesson S-E; Wahren-Herlenius M
Article: HEPATOLOGY. 2016;64(5):1699-1710
A novel high mobility group box 1 neutralizing chimeric antibody attenuates drug-induced liver injury and postinjury inflammation in mice
Lundback P; Lea JD; Sowinska A; Ottosson L; Furst CM; Steen J; Aulin C; Clarke JI; Kipar A; Klevenvall L; Yang H; Palmblad K; Park BK; Tracey KJ; Blom AM; Andersson U; Antoine DJ; Harris HE
Article: ADIPOCYTE. 2016;5(4):384-388
TLR4-dependant pro-inflammatory effects of HMGB1 on human adipocyte
Gunasekaran MK; Virama-Latchoumy A-L; Girard A-C; Planesse C; Guerin-Dubourg A; Ottosson L; Andersson U; Cesari M; Roche R; Hoareau L
Article: ARTHRITIS RESEARCH & THERAPY. 2015;17:338
Antibodies against High Mobility Group Box protein-1 (HMGB1) versus other anti-nuclear antibody fine-specificities and disease activity in systemic lupus erythematosus
Wirestam L; Schierbeck H; Skogh T; Gunnarsson I; Ottosson L; Erlandsson-Harris H; Wettero J; Sjowall C
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;71(Suppl 3):678
AB0693 Autoantibodies to the functionally active ring-domain of RO52/SSA associate with clinical activity in a subset of patients with lupus
Kvarnström M; Dzikaite V; Ottosson L; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(Suppl 3):a78-A79
OP0084 Cardiopathogenic Role of Human RO/SSA and LA/SSA Antibodies Demonstrated in a Novel Animal Model of Congenital Heart Block
Hoxha A; Ruffatti A; Ottosson V; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Article: LUPUS. 2013;22(5):477-485
Autoantibodies to the functionally active RING-domain of Ro52/SSA are associated with disease activity in patients with lupus
Kvarnstrom M; Dzikaite-Ottosson V; Ottosson L; Gustafsson JT; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Journal article: MOLECULAR MEDICINE. 2012;18(2):250-259
Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1) (Publication with Expression of Concern. See vol. 26, 2020) (Retracted article. See vol. 26, 2020)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Journal article: MOLECULAR MEDICINE. 2012;18(3):545
Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1) (vol 18, pg 250, 2012)
Yang H; Lundbaeck P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Article: MOLECULAR MEDICINE. 2011;17(9-10):1039-1044
Monoclonal Anti-HMGB1 (High Mobility Group Box Chromosomal Protein 1) Antibody Protection in Two Experimental Arthritis Models
Schierbeck H; Lundback P; Palmblad K; Klevenvall L; Erlandsson-Harris H; Andersson U; Ottosson L
Article: JOURNAL OF IMMUNOLOGY. 2010;185(6):3574-3582
Maternal MHC Regulates Generation of Pathogenic Antibodies and Fetal MHC-Encoded Genes Determine Susceptibility in Congenital Heart Block
Strandberg LS; Ambrosi A; Jagodic M; Dzikaite V; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2009;86(3):655-662
The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation
Hreggvidsdottir HS; Ostberg T; Wahamaa H; Schierbeck H; Aveberger A-C; Klevenvall L; Palmblad K; Ottosson L; Andersson U; Harris HE
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2008;28(3):220-231
Interferon-α induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies
Strandberg L; Arnbrosi A; Espinosa A; Ottosson L; Eloranta M-L; Zhou W; Elfving A; Greenfield E; Kuchroo VK; Wahren-Herlenius M
Article: JOURNAL OF LIPID RESEARCH. 2006;47(7):1378-1385
The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein
Ledmyr H; Ottosson L; Sunnerhagen M; Ehrenborg E
Article: MOLECULAR IMMUNOLOGY. 2006;43(6):588-598
Structural, functional and immunologic characterization of folded subdomains in the Ro52, protein targeted in Sjogren's syndrome
Ottosson L; Hennig J; Espinosa A; Brauner S; Wahren-Herlenius M; Sunnerhagen M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(39):33250-33261
Structural organization and Zn²⁺-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52
Hennig J; Ottosson L; Andrésen C; Horvath L; Kuchroo VK; Broo K; Wahren-Herlenius M; Sunnerhagen M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;61(2):109-118
Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein
Ottosson L; Salomonsson S; Hennig J; Sonesson SE; Dörner T; Raats J; Kuchroo VK; Sunnerhagen M; Wahren-Herlenius M
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2005;201(1):11-17
Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block
Salomonsson S; Sonesson SE; Ottosson L; Muhallab S; Olsson T; Sunnerhagen M; Kuchroo VK; Thorén P; Herlenius E; Wahren-Herlenius M
Article: JOURNAL OF AUTOIMMUNITY. 2004;23(2):95-102
A pH-induced modification of CII increases its arthritogenic properties
Lundberg K; Ottosson L; Westman E; Sunnerhagen M; Hultenby K; Harris HE
Article: JOURNAL OF AUTOIMMUNITY. 2004;22(2):167-177
Cloning and characterization of two human Ro52-specific monoclonal autoantibodies directed towards a domain associated with congenital heart block
Salomonsson S; Ottosson L; Säfsten P; Hof D; Brauner H; Sunnerhagen M; Raats J; Wahren-Herlenius M
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All other publications

Other: MOLECULAR MEDICINE. 2020;26(1):133
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1) (Retraction of Vol 18, Pg 250, 2012)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Other: MOLECULAR MEDICINE. 2020;26(1):18
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1) (Expression of Concern of Vol 18, Pg 250, 2012)
Yang H; Lundback P; Ottosson L; Erlandsson-Harris H; Venereau E; Bianchi ME; Al-Abed Y; Andersson U; Tracey KJ; Antoine DJ
Meeting abstract: TOXICOLOGY LETTERS. 2014;229:S69-S70
Humanized anti-HMGB1 antibody therapy attenuates in vivo acetaminophen-induced liver injury
Lea J; Lundback P; Ottosson L; Sharkey J; Sowinska A; Palmblad K; Clarke J; Park BK; Andersson U; Harris H; Antoine D
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a79-A80
ANTI HMGB1 TREATMENT REDUCES INFLAMMATION IN MODELS OF EXPERIMENTAL AUTOIMMUNITY
Lundback P; Klevenvall L; Ottosson L; Schierbeck H; Palmblad K; Andersson U; Harris HE
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a81-A82
THE PRO-INFLAMMATORY EFFECT OF HMGB1, A MEDIATOR OF INFLAMMATION IN ARTHRITIS, IS DEPENDENT ON THE REDOX STATUS OF THE PROTEIN
Ottosson L; Lundback P; Hreggvidsdottir H; Yang H; Tracey KJ; Antoine DJ; Erlandsson-Harris H; Andersson U
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S25
Anti-Ro52 antibodies inducing heart block cross-react with alpha-enolase
Ambrosi A; Strandberg L; Dzikaite V; Ottosson L; Kampe K; Wahren-Hertenius M
Thesis / dissertation: 2005
Molecular characterization of the Ro52 autoantigen and its disease related epitopes
Ottosson, Lars

Employments

Research Specialist, Department of Women's and Children's Health, Karolinska Institutet, 2021-

Degrees and Education

Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2005

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