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Publications

Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model
Levander S, Holmström F, Frelin L, Ahlén G, Rupp D, Long G, et al
Gut 2018;67(8):1525-1535

Neonatal Exposure to Hepatitis C Virus Antigens in Uninfected Children Born to Infected Mothers
Psaros Einberg A, Brenndörfer Ed, Frelin L, Hallberg L, Sällberg M, Fischler B
Journal of pediatric gastroenterology and nutrition 2018;66(1):106-111

Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties
Balasiddaiah A, Davanian H, Aleman S, Pasetto A, Frelin L, Sällberg M, et al
Journal of virology 2017;91(9):-

Lack of Association Between Interleukin 28B Polymorphism and Vertical Transmission of Hepatitis C
Psaros Einberg A, Duberg As, Filipovich O, Nyström J, Zhirkov A, Brenndörfer Ed, et al
Journal of pediatric gastroenterology and nutrition 2017;65(6):608-612

A non-human hepadnaviral adjuvant for hepatitis C virus-based genetic vaccines
Levander S, Sällberg M, Ahlén G, Frelin L
Vaccine 2016;34(25):2821-33

A targeted controlled force injection of genetic material in vivo
Ahlén G, Frelin L, Holmström F, Smetham G, Augustyn S, Sällberg M
Molecular therapy. Methods & clinical development 2016;5():16016-

Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses
Holmström F, Chen M, Balasiddaiah A, Sällberg M, Ahlén G, Frelin L
Scientific reports 2016;6():24991-

Methods to Evaluate Novel Hepatitis C Virus Vaccines
Ahlén G, Frelin L
Methods in molecular biology (Clifton, N.J.) 2016;1403():221-44

Prospects and progress of DNA vaccines for treating hepatitis B
Chen M, Jagya N, Bansal R, Frelin L, Sällberg M
Expert review of vaccines 2016;15(5):629-40

Electroporation for therapeutic DNA vaccination in patients
Sällberg M, Frelin L, Ahlén G, Sällberg-chen M
Medical microbiology and immunology 2015;204(1):131-5

Functional aspects of intrahepatic hepatitis B virus-specific T cells induced by therapeutic DNA vaccination
Brass A, Frelin L, Milich Dr, Sällberg M, Ahlén G
Molecular therapy : the journal of the American Society of Gene Therapy 2015;23(3):578-90

Hepatitis C Virus Nonstructural 3/4A Protein Dampens Inflammation and Contributes to Slow Fibrosis Progression during Chronic Fibrosis In Vivo
Bansal R, Frelin L, Brenndörfer Ed, Storm G, Prakash J, Sällberg M
PloS one 2015;10(6):e0128466-

Long-term functional duration of immune responses to HCV NS3/4A induced by DNA vaccination
Ahlén G, Holmström F, Gibbs A, Alheim M, Frelin L
Gene therapy 2014;21(8):739-50

A Heterologous Prime/Boost Vaccination Strategy Enhances the Immunogenicity of Therapeutic Vaccines for Hepatitis C Virus
Fournillier A, Frelin L, Jacquier E, Ahlen G, Brass A, Gerossier E, et al
JOURNAL OF INFECTIOUS DISEASES 2013;208(6):1008-19

A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice
Holmström F, Pasetto A, Nähr V, Brass A, Kriegs M, Hildt E, et al
Journal of immunology (Baltimore, Md. : 1950) 2013;190(3):1113-24

Containing "The Great Houdini" of viruses: combining direct acting antivirals with the host immune response for the treatment of chronic hepatitis C
Ahlén G, Frelin L, Brenndörfer Ed, Brass A, Weiland O, Chen M, et al
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2013;16(3-5):60-7

Methods for monitoring gene gun-induced HBV- and HCV-specific immune responses in mouse models
Ahlén G, Sällberg M, Frelin L
Methods in molecular biology (Clifton, N.J.) 2013;940():239-67

Non-structural 3 protein expression is associated with T cell protein tyrosine phosphatase and viral RNA levels in chronic hepatitis C patients
Rahbin N, Frelin L, Aleman S, Hultcrantz R, Sällberg M, Brenndörfer Ed
Biochemical and biophysical research communications 2013;433(1):31-5

Therapeutic DNA vaccination using in vivo electroporation followed by standard of care therapy in patients with genotype 1 chronic hepatitis C
Weiland O, Ahlén G, Diepolder H, Jung Mc, Levander S, Fons M, et al
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(9):1796-805

A bi-functional hepatitis B virus core antigen (HBcAg) chimera activates HBcAg-specific T cells and preS1-specific antibodies
Malik Ir, Chen A, Brass A, Ahlen G, Rahman M, Sallberg M, et al
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES 2012;44(1):55-9

Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3
Pasetto A, Frelin L, Brass A, Yasmeen A, Koh S, Lohmann V, et al
JOURNAL OF GENERAL VIROLOGY 2012;:247-58

Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-gamma production
Brenndorfer Ed, Brass A, Soderholm J, Frelin L, Aleman S, Bode Jg, et al
GUT 2012;61(4):589-96

Limited effect on NS3-NS4A protein cleavage after alanine substitutions within the immunodominant HLA-A2-restricted epitope of the hepatitis C virus genotype 3a non-structural 3/4A protease
Ahlén G, Chen A, Roe B, Falkeborn T, Frelin L, Hall Ww, et al
The Journal of general virology 2012;93(Pt 8):1680-6

TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity
Pasetto A, Frelin L, Aleman S, Holmström F, Brass A, Ahlén G, et al
Journal of immunology (Baltimore, Md. : 1950) 2012;189(9):4510-9

Heterologous T Cells Can Help Restore Function in Dysfunctional Hepatitis C Virus Nonstructural 3/4A-Specific T Cells during Therapeutic Vaccination
Chen A, Ahlen G, Brenndorfer Ed, Brass A, Holmstrom F, Chen M, et al
JOURNAL OF IMMUNOLOGY 2011;186(9):5107-18

Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis
Soderberg C, Marmur J, Eckes K, Glaumann H, Sallberg M, Frelin L, et al
APMIS 2011;119(7):412-20

Anti-Tumor Necrosis Factor alpha Treatment Promotes Apoptosis and Prevents Liver Regeneration in a Transgenic Mouse Model of Chronic Hepatitis C
Brenndorfer Ed, Weiland M, Frelin L, Derk E, Ahlen G, Jiao Ja, et al
HEPATOLOGY 2010;52(5):1553-63

ELECTROPORATION: A PROMISING METHOD FOR THE NONVIRAL DELIVERY OF DNA VACCINES IN HUMANS?
Frelin L, Brass A, Ahlen G, Brenndorfer Ed, Chen M, Sallberg M
DRUG NEWS & PERSPECTIVES 2010;23(10):647-53

HCV NS3/4A INTERFERES WITH INTRAHEPATIC IMMUNITY AND TNFA-INDUCED LIVER DAMAGE BY MODULATING CCL17 AND CXCL9 SECRETION IN VIVO
Brenndorfer Ed, Frelin L, Soderholm J, Bode Jg, Sallberg M
JOURNAL OF HEPATOLOGY 2010;:S265-S265

HCV NS3/4A-MEDIATED CCL2 AND TNFA SECRETION INCREASE HEPATOCYTE SURVIVAL AND LIVER REGENERATION IN VIVO
Brenndorfer Ed, Weiland M, Frelin L, Derk E, Ahlen G, Bode Jg, et al
JOURNAL OF HEPATOLOGY 2010;:S265-S265

Improving on the Ability of Endogenous Hepatitis B Core Antigen to Prime Cytotoxic T Lymphocytes
Nystrom J, Chen A, Frelin L, Ahlen G, Koh S, Brass A, et al
JOURNAL OF INFECTIOUS DISEASES 2010;201(12):1867-79

IMPROVING ON THE ABILITY OF ENDOGENOUS HEPATITIS B CORE ANTIGEN TO PRIME CYTOTOXIC T LYMPHOCYTES
Chen A, Nystrom J, Frelin L, Ahlen G, Koh S, Peterson Dl, et al
JOURNAL OF HEPATOLOGY 2010;:S239-S239

Activation of T Cell Responses and Reductions in the Viral Load Following Therapeutic Vaccination Using Naked DNA Delivered by In Vivo Electroporation in Patients with Chronic Hepatitis C
Sallberg M, Frelin L, Diepolder Hm, Jung Mc, Mathiesen I, Kjeken R, et al
MOLECULAR THERAPY 2009;:S15-S15

A FIRST CLINICAL TRIAL OF THERAPEUTIC VACCINATION USING NAKED DNA DELIVERED BY IN VIVO ELECTROPORATION SHOWS ANTIVIRAL EFFECTS IN PATIENTS WITH CHRONIC HEPATITIS C
Sallberg Mm, Frelin L, Diepolder H, Jung Mc, Mathiesen I, Fons M, et al
JOURNAL OF HEPATOLOGY 2009;:S18-S19

A small step closer to the Holy Grail of DNA vaccines: undisputed clinical benefit in humans
Frelin L, Sällberg M
Genome medicine 2009;1(1):15-

Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes
Ahlen G, Derk E, Weiland M, Jiao J, Rahbin N, Aleman S, et al
GUT 2009;58(4):560-9

COMBINATION THERAPY WITH THERAPEUTIC VACCINATION AND INHIBITION OF PD-L1 IMPROVES T CELL FUNCTION IN HCV-TRANSGENIC MICE
Frelin L, Brenndorfer Ed, Ahlen G, Chen A, Tjelle T, Kjeken R, et al
JOURNAL OF HEPATOLOGY 2009;:S47-S47

DNA vaccine therapy for chronic hepatitis C virus (HCV) infection: immune control of a moving target
Sallberg M, Frelin L, Weiland O
EXPERT OPINION ON BIOLOGICAL THERAPY 2009;9(7):805-15

Interaction of the Hepatitis B Core Antigen and the Innate Immune System
Lee Bo, Tucker A, Frelin L, Sallberg M, Jones J, Peters C, et al
JOURNAL OF IMMUNOLOGY 2009;182(11):6670-81

THE HEPATITIS C VIRUS ENHANCES ACTIVATION OF THE EGF-RECEPTOR AND AKT-ACTIVITY BY NS3/4A-MEDIATED CLEAVAGE OF THE T-CELL PROTEIN TYROSINE PHOSPHATASE
Brenndorfer E, Karthe J, Frelin L, Cebula P, Erhardt A, Hengel H, et al
JOURNAL OF HEPATOLOGY 2009;:S124-S124

The Hepatitis C Virus Non-structural NS5A Protein Impairs Both the Innate and Adaptive Hepatic Immune Response in Vivo
Kriegs M, Burckstummer T, Himmelsbach K, Bruns M, Frelin L, Ahlen G, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2009;284(41):28343-51

Therapeutic Vaccination Combined with Inhibition of PD-L1 Improves T Cell Function in Hepatitis C Virus-Transgenic Mice
Frelin L, Brenndorfer E, Ahlen G, Chen A, Tjelle T, Kjeken R, et al
MOLECULAR THERAPY 2009;:S368-S369

In vivo electroporation enhances the immunogenicity of hepatitis C virus nonstructural 3/4A DNA by increased local DNA uptake, protein expression, inflammation, and infiltration of CD3(+) T cells
Ahlen G, Soderholm J, Tjelle T, Kjeken R, Frelin L, Hoglund U, et al
JOURNAL OF IMMUNOLOGY 2007;179(7):4741-53

Relation between viral fitness and immune escape within the hepatitis C virus protease
Soderholm J, Ahlen G, Kaul A, Frelin L, Alheim M, Barnfield C, et al
GUT 2006;55(2):266-74

The hepatitis C virus and immune evasion: nonstructural 3/4A transgenic mice are resistant to lethal tumour necrosis factor alpha mediated liver disease
Frelin L, Brenndorfer Ed, Ahlen G, Weiland M, Hultgren C, Alheim M, et al
GUT 2006;55(10):1475-83

In vivo clearance of hepatitis C virus nonstructural 3/4A-expressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes
Ahlen G, Nystrom J, Pult I, Frelin L, Hultgren C, Salberg M
JOURNAL OF INFECTIOUS DISEASES 2005;192(12):2112-6

Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene
Frelin L, Ahlen G, Alheim M, Weiland O, Barnfield C, Liljestrom P, et al
GENE THERAPY 2004;11(6):522-33

Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo
Frelin L, Alheim M, Chen A, Soderholm J, Rozell B, Barnfield C, et al
GENE THERAPY 2003;10(8):686-99

Humoral and CD4(+) T helper (Th) cell responses to the hepatitis C virus non-structural 3 (NS3) protein: NS3 primes Th 1-like responses more effectively as a DNA-based immunogen than as a recombinant protein
Lazdina U, Hultgren C, Frelin L, Chen M, Lodin K, Weiland O, et al
JOURNAL OF GENERAL VIROLOGY 2001;:1299-308

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