Lakshmikanth Tadepally

About me
Publications
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About me

2022 Feb to date: Senior Research Specialist and Team lead at Brodinlab
2021 April to date: Head of Unit, Cellular Immunomonitoring Facility -
Stockholm
2017 to 2021 March: Lab Manager and Head of Facility - Mass Cytometry,
Scilifelab, Stockholm, Sweden
2014 to date: Lab Manager and Research Coordinator - National Mass Cytometry
facility, Scilifelab, Stockholm, Sweden
2012 - 2014: Senior Scientific writer II - Oncology Scientific
Communications, GMA, Novartis, Hyderabad, India
2010 - 2012: Senior Research Fellow - Type I Diabetes, Malin Flodstrom
Tullberg's lab, CIM, Karolinska University Hospital Huddinge, Sweden
2008 - 2012: Postdoctoral researcher - NK cell biology, Klas Karre/Petter
Hoglund's labs, MTC, Karolinska Institutet, Stockholm, Sweden
2004 - 2008: PhD in Tumor Immunology, University of Catanzaro 'Magna
Graecia', Catanzaro, Italy & Karolinska Institutet, Stockholm, Sweden

Research

Immunology, Mass Cytometry

Articles

Journal article: JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2023;159:104065

Immune system adaptation during gender-affirming testosterone treatment

Consiglio C; Tadepally L; Sardh F; Forlin R; Wang J; Tan Z; Barcenilla H; Rodriguez L; Sugrue J; Noori P; Paez LP; Gonzalez L; Mugabo CH; Johnsson A; Hallgren A; Pou C; Chen Y; Mikes J; James A; Dahlqvist P; Wahlberg J; Hagelin A; Holmberg M; Degerblad M; Isaksson M; Duffy D; Kampe O; Landegren N; Brodin P
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(16_suppl):3110

First-in-human (FIH) phase I dose escalation study (part A) of the first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) roginolisib in patients with advanced cancer and dose confirmation in uveal melanoma (part B).

Di Giacomo AM; Santangelo F; Amato G; Simonetti E; Graham J; Lahn MMF; Di Conza G; Hammett T; Zorrilla R; Durini M; Tan Z; Tadepally L; Brodin P; Occhipinti M; Simonelli M; Carlo-Stella C; Santoro A; Spiliopoulou P; Evans TRJ; Maio M
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):233.07

Immune system perturbations in patients with severe long COVID

Rodriguez L; Tan Z; Lakshmikanth T; Wang J; Barcenilla H; Gonzalez L; Mugabo C; Johnsson A; Chen Y; Mikes J; Landegren N; Runold M; Bruchfeld J; Brodin P
Article: OXFORD OPEN IMMUNOLOGY. 2023;4(1):iqad003

Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance.

Rodriguez L; Pou C; Lakshmikanth T; Zhang J; Mugabo CH; Wang J; Mikes J; Olin A; Chen Y; Rorbach J; Juto J-E; Li TQ; Julin P; Brodin P
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2023;43(1):136-150

Three Adult Cases of STAT1 Gain-of-Function with Chronic Mucocutaneous Candidiasis Treated with JAK Inhibitors.

Borgström EW; Edvinsson M; Pérez LP; Norlin AC; Enoksson SL; Hansen S; Fasth A; Friman V; Kämpe O; Månsson R; Estupiñán HY; Wang Q; Ziyang T; Lakshmikanth T; Smith CIE; Brodin P; Bergman P
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16_suppl):3107

First-in-human (FIH) phase I study of the highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ) inhibitor IOA-244 in patients with advanced cancer: Safety, activity, pharmacokinetic (PK), and pharmacodynamic (PD) results.

Di Giacomo AM; Santangelo F; Amato G; Simonetti E; Graham J; Lahn MMF; van der Veen LA; Johnson Z; Pickering CA; Durini M; Tan Z; Tadepally L; Brodin P; Occhipinti M; Simonelli M; Carlo-Stella C; Santoro A; Spiliopoulou P; Evans TRJ; Maio M
Article: ALLERGY. 2022;77(5):1583-1595

Longitudinal analyses of development of the immune system during the first five years of life in relation to lifestyle.

Olin A; Acevedo N; Lakshmikanth T; Chen Y; Johansson C; Alm J; Scheynius A; Brodin P
Article: CELL. 2021;184(15):3884-3898.e11

Bifidobacteria-mediated immune system imprinting early in life.

Henrick BM; Rodriguez L; Lakshmikanth T; Pou C; Henckel E; Arzoomand A; Olin A; Wang J; Mikes J; Tan Z; Chen Y; Ehrlich AM; Bernhardsson AK; Mugabo CH; Ambrosiani Y; Gustafsson A; Chew S; Brown HK; Prambs J; Bohlin K; Mitchell RD; Underwood MA; Smilowitz JT; German JB; Frese SA; Brodin P
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:727300

High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids.

Silva CS; Sundling C; Folkesson E; Fröberg G; Nobrega C; Canto-Gomes J; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Correia-Neves M; Källenius G
Article: SCIENTIFIC REPORTS. 2020;10(1):20425

High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood.

Petkov S; Bekele Y; Lakshmikanth T; Hejdeman B; Zazzi M; Brodin P; Chiodi F
Article: CELL. 2020;183(4):968-981.e7

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.

Consiglio CR; Cotugno N; Sardh F; Pou C; Amodio D; Rodriguez L; Tan Z; Zicari S; Ruggiero A; Pascucci GR; Santilli V; Campbell T; Bryceson Y; Eriksson D; Wang J; Marchesi A; Lakshmikanth T; Campana A; Villani A; Rossi P; CACTUS Study Team; Landegren N; Palma P; Brodin P
Article: NATURE COMMUNICATIONS. 2020;11(1):4487

Integration of molecular profiles in a longitudinal wellness profiling cohort.

Tebani A; Gummesson A; Zhong W; Koistinen IS; Lakshmikanth T; Olsson LM; Boulund F; Neiman M; Stenlund H; Hellström C; Karlsson MJ; Arif M; Dodig-Crnković T; Mardinoglu A; Lee S; Zhang C; Chen Y; Olin A; Mikes J; Danielsson H; von Feilitzen K; Jansson P-A; Angerås O; Huss M; Kjellqvist S; Odeberg J; Edfors F; Tremaroli V; Forsström B; Schwenk JM; Nilsson P; Moritz T; Bäckhed F; Engstrand L; Brodin P; Bergström G; Uhlen M; Fagerberg L
Article: CELL REPORTS MEDICINE. 2020;1(5):100078

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.

Rodriguez L; Pekkarinen PT; Lakshmikanth T; Tan Z; Consiglio CR; Pou C; Chen Y; Mugabo CH; Nguyen NA; Nowlan K; Strandin T; Levanov L; Mikes J; Wang J; Kantele A; Hepojoki J; Vapalahti O; Heinonen S; Kekäläinen E; Brodin P
Article: CELL REPORTS. 2020;32(3):107923

Human Immune System Variation during 1 Year.

Lakshmikanth T; Muhammad SA; Olin A; Chen Y; Mikes J; Fagerberg L; Gummesson A; Bergström G; Uhlen M; Brodin P
Article: SCIENCE. 2019;366(6472):eaax9198

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.

Uhlen M; Karlsson MJ; Zhong W; Tebani A; Pou C; Mikes J; Lakshmikanth T; Forsström B; Edfors F; Odeberg J; Mardinoglu A; Zhang C; von Feilitzen K; Mulder J; Sjöstedt E; Hober A; Oksvold P; Zwahlen M; Ponten F; Lindskog C; Sivertsson Å; Fagerberg L; Brodin P
Article: JCI INSIGHT. 2019;5(9):126492

B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets.

Sundling C; Rönnberg C; Yman V; Asghar M; Jahnmatz P; Lakshmikanth T; Chen Y; Mikes J; Forsell MN; Sondén K; Achour A; Brodin P; Persson KE; Färnert A
Article: NATURE MEDICINE. 2019;25(4):591-596

The repertoire of maternal anti-viral antibodies in human newborns.

Pou C; Nkulikiyimfura D; Henckel E; Olin A; Lakshmikanth T; Mikes J; Wang J; Chen Y; Bernhardsson AK; Gustafsson A; Bohlin K; Brodin P
Article: JCI INSIGHT. 2019;4(3):e125442

Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation.

Bekele Y; Lakshmikanth T; Chen Y; Mikes J; Nasi A; Petkov S; Hejdeman B; Brodin P; Chiodi F
Article: EBIOMEDICINE. 2019;40:517-527

B cell alterations during BAFF inhibition with belimumab in SLE.

Ramsköld D; Parodis I; Lakshmikanth T; Sippl N; Khademi M; Chen Y; Zickert A; Mikeš J; Achour A; Amara K; Piehl F; Brodin P; Gunnarsson I; Malmström V
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1913:33-48

Systems-Level Immune Monitoring by Mass Cytometry.

Lakshmikanth T; Brodin P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(1):e12732

Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.

Tang Q; Ramsköld D; Krystufkova O; Mann HF; Wick C; Dastmalchi M; Lakshmikanth T; Chen Y; Mikes J; Alexanderson H; Achour A; Brodin P; Vencovsky J; Lundberg IE; Malmström V
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1989:111-123

Automated Cell Processing for Mass Cytometry Experiments.

Mikes J; Olin A; Lakshmikanth T; Chen Y; Brodin P
Article: CELL. 2018;174(5):1277-1292.e14

Stereotypic Immune System Development in Newborn Children.

Olin A; Henckel E; Chen Y; Lakshmikanth T; Pou C; Mikes J; Gustafsson A; Bernhardsson AK; Zhang C; Bohlin K; Brodin P
Article: CELL METABOLISM. 2018;27(2):378-392.e5

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martínez-Redondo V; Ueland PM; Midttun Ø; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2018;5:81

Continuous Immune Cell Differentiation Inferred From Single-Cell Measurements Following Allogeneic Stem Cell Transplantation.

Chen Y; Lakshmikanth T; Olin A; Mikes J; Remberger M; Brodin P
Article: CELL REPORTS. 2017;20(9):2238-2250

Mass Cytometry and Topological Data Analysis Reveal Immune Parameters Associated with Complications after Allogeneic Stem Cell Transplantation.

Lakshmikanth T; Olin A; Chen Y; Mikes J; Fredlund E; Remberger M; Omazic B; Brodin P
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:717

Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease.

Stikvoort A; Chen Y; Rådestad E; Törlén J; Lakshmikanth T; Björklund A; Mikes J; Achour A; Gertow J; Sundberg B; Remberger M; Sundin M; Mattsson J; Brodin P; Uhlin M
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1130

Mass Cytometry Identifies Distinct Lung CD4+ T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis.

Kaiser Y; Lakshmikanth T; Chen Y; Mikes J; Eklund A; Brodin P; Achour A; Grunewald J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(7):1758-1769

In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation.

Lakshmikanth T; Heuts F; Muvva SSVJR; Wallin RPA; Persson A-K; Fauriat C; Applequist SE; Ljunggren H-G; Höglund P; Kärre K; Svensson M; Juarez JG
Article: CANCER IMMUNOLOGY RESEARCH. 2016;4(2):113-123

Retuning of Mouse NK Cells after Interference with MHC Class I Sensing Adjusts Self-Tolerance but Preserves Anticancer Response.

Wagner AK; Wickström SL; Tallerico R; Salam S; Lakshmikanth T; Brauner H; Höglund P; Carbone E; Johansson MH; Kärre K
Article: DIABETOLOGIA. 2015;58(2):346-354

A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models.

Larsson PG; Lakshmikanth T; Laitinen OH; Utorova R; Jacobson S; Oikarinen M; Domsgen E; Koivunen MRL; Chaux P; Devard N; Lecouturier V; Almond J; Knip M; Hyöty H; Flodström-Tullberg M
Article: PLOS ONE. 2014;9(12):e111758

Mechanical stress downregulates MHC class I expression on human cancer cell membrane.

La Rocca R; Tallerico R; Talib Hassan A; Das G; Lakshmikanth T; Matteucci M; Liberale C; Mesuraca M; Scumaci D; Gentile F; Cojoc G; Perozziello G; Ammendolia A; Gallo A; Kärre K; Cuda G; Candeloro P; Di Fabrizio E; Carbone E
Article: DIABETOLOGIA. 2013;56(4):867-874

Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.

Larsson PG; Lakshmikanth T; Svedin E; King C; Flodström-Tullberg M
Article: JOURNAL OF IMMUNOLOGY. 2012;188(5):2218-2226

Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.

Brodin P; Lakshmikanth T; Kärre K; Höglund P
Article: CELL CYCLE. 2011;10(19):3346-3358

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.

Li H; Lakshmikanth T; Garofalo C; Enge M; Spinnler C; Anichini A; Szekely L; Kärre K; Carbone E; Selivanova G
Article: PLOS ONE. 2010;5(10):e13174

Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.

Brodin P; Lakshmikanth T; Mehr R; Johansson MH; Duru AD; Achour A; Salmon-Divon M; Kärre K; Höglund P; Johansson S
Article: JOURNAL OF BIOMEDICAL OPTICS. 2010;15(2):027007

Monitoring human leukocyte antigen class I molecules by micro-Raman spectroscopy at single-cell level.

Das G; La Rocca R; Lakshmikanth T; Gentile F; Tallerico R; Zambetti LP; Devitt J; Candeloro P; De Angelis F; Carbone E; Di Fabrizio E
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(3):813-823

In vivo tumor cell rejection induced by NK cell inhibitory receptor blockade: maintained tolerance to normal cells even in the presence of IL-2.

Vahlne G; Lindholm K; Meier A; Wickström S; Lakshmikanth T; Brennan F; Wilken M; Nielsen R; Romagné F; Wagtmann NR; Kärre K; Johansson MH
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(5):1251-1263

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

Lakshmikanth T; Burke S; Ali TH; Kimpfler S; Ursini F; Ruggeri L; Capanni M; Umansky V; Paschen A; Sucker A; Pende D; Groh V; Biassoni R; Höglund P; Kato M; Shibuya K; Schadendorf D; Anichini A; Ferrone S; Velardi A; Kärre K; Shibuya A; Carbone E; Colucci F
Article: JOURNAL OF IMMUNOLOGY. 2009;182(8):4529-4537

Early hematopoietic zinc finger protein prevents tumor cell recognition by natural killer cells.

La Rocca R; Fulciniti M; Lakshmikanth T; Mesuraca M; Ali TH; Mazzei V; Amodio N; Catalano L; Rotoli B; Ouerfelli O; Grieco M; Gulletta E; Bond HM; Morrone G; Ferrone S; Carbone E
Article: BLOOD. 2009;113(11):2434-2441

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.

Brodin P; Lakshmikanth T; Johansson S; Kärre K; Höglund P
Article: JOURNAL OF IMMUNOLOGY. 2009;182(3):1460-1468

Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.

Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Höglund P; Jacobsen SEW; Sitnicka E
Article: NATIONAL ACADEMY SCIENCE LETTERS-INDIA. 2005;28(9-10):353-355

Detection of haemocyanin in native PAGE gels

Krupanidhi S; Lakshmikanth T
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All other publications

Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(16)

First-in-human (FIH) phase I dose escalation study (part A) of the first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) roginolisib in patients with advanced cancer and dose confirmation in uveal melanoma (part B).

Di Giacomo AM; Santangelo F; Amato G; Simonetti E; Graham J; Lahn MMF; Di Conza G; Hammett T; Zorrilla R; Durini M; Tan Z; Tadepally L; Brodin P; Occhipinti M; Simonelli M; Carlo-Stella C; Santoro A; Spiliopoulou P; Evans TRJ; Maio M
Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2022;40(16)

First-in-human (FIH) phase I study of the highly selective phosphoinositide 3-kinase inhibitor delta (PI3Kδ) inhibitor IOA-244 in patients with advanced cancer: Safety, activity, pharmacokinetic (PK), and pharmacodynamic (PD) results.

Di Giacomo AM; Santangelo F; Amato G; Simonetti E; Graham J; Lahn MMF; Van der Veen LA; Johnson Z; Pickering CA; Durini M; Tan Z; Tadepally L; Brodin P; Occhipinti M; Simonelli M; Carlo-Stella C; Santoro A; Spiliopoulou P; Evans TRJ; Maio M
Preprint: 2021;bioRxiv

Stimulation with mycobacterial glycolipids and PPD reveals different innate immune response profiles in active and latent TB

Silva C; Sundling C; Folkeson E; Fröberg G; Nobrega C; Canto-Gomes J; Chambers B; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Correia-Neves M; Källenius G
Preprint: 2020;bioRxiv

Bifidobacteria-mediated immune system imprinting early in life

Henrick B; Rodriguez L; Lakshmikanth T; Pou C; Henckel E; Olin A; Wang J; Mikes J; Tan Z; Chen Y; Ehrlich A; Bernhardsson AK; Mugabo CH; Ambrosiani Y; Gustafsson A; Chew S; Brown H; Prambs J; Bohlin K; Mitchell R; Underwood M; Smilowitz J; German B; Frese S; Brodin P
Preprint: 2020;bioRxiv

Single-cell classification using learned cell phenotypes

Chen Y; Lakshmikanth T; Mikes J; Brodin P
Editorial comment: ONCOIMMUNOLOGY. 2012;1(4):541-543

A novel facet of tumor suppression by p53: Induction of tumor immunogenicity.

Li H; Lakshmikanth T; Carbone E; Selivanova G
Review: TRENDS IN IMMUNOLOGY. 2010;31(9):339-345

New views on natural killer cell-based immunotherapy for melanoma treatment.

Burke S; Lakshmikanth T; Colucci F; Carbone E
Published paper: MICROELECTRONIC ENGINEERING. 2007;84(5-8):1729-1732

Preliminary study of micromechanical stress delivery for cell biology studies

Matteucci M; Lakshmikanth T; Shibu K; De Angelis F; Schadendorf D; Venuta S; Carbone E; Di Fabrizio E

Grants

Identifying a transcriptional signature of missing self rejection by NK cells in vivo

Swedish Research Council

1 July 2009 - 31 July 2010

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