Konstantin Svechnikov

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Articles

Article: ENDOCRINOLOGY. 2021;162(4):bqab017

Diabetes Type 1 Negatively Influences Leydig Cell Function in Rats, Which is Partially Reversible By Insulin Treatment.

Wagner IV; Klöting N; Savchuk I; Eifler L; Kulle A; Kralisch-Jäcklein S; Dötsch J; Hiort O; Svechnikov K; Söder O
Article: STEROIDS. 2019;149:108417

Steroidogenic potential of human fetal kidney at early gestational age.

Savchuk I; Morvan ML; Antignac JP; Kurek M; Le Bizec B; Söder O; Svechnikov K
Article: REPRODUCTION FERTILITY AND DEVELOPMENT. 2019;31(8):1395-1400

Adipocytokines may delay pubertal maturation of human Sertoli cells.

Wagner IV; Yango P; Svechnikov K; Tran ND; Söder O
Article: PLOS BIOLOGY. 2019;17(2):e3000002

Alternative (backdoor) androgen production and masculinization in the human fetus.

O'Shaughnessy PJ; Antignac JP; Le Bizec B; Morvan M-L; Svechnikov K; Söder O; Savchuk I; Monteiro A; Soffientini U; Johnston ZC; Bellingham M; Hough D; Walker N; Filis P; Fowler PA
Article: STEROIDS. 2019;141:96-103

Ontogenesis of human fetal testicular steroidogenesis at early gestational age.

Savchuk I; Morvan ML; Antignac JP; Kurek M; Le Bizec B; Söder O; Svechnikov K
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2018;477:148-155

The human genital tubercle is steroidogenic organ at early pregnancy.

Savchuk I; Morvan ML; Antignac JP; Gemzell-Danielsson K; Le Bizec B; Söder O; Svechnikov K
Article: OBESITY. 2018;26(7):1161-1167

Adipose Tissue is a Potential Source of Hyperandrogenism in Obese Female Rats.

Wagner IV; Sahlin L; Savchuk I; Klöting N; Svechnikov K; Söder O
Article: ENDOCRINE CONNECTIONS. 2017;6(6):348-359

Androgenic potential of human fetal adrenals at the end of the first trimester.

Savchuk I; Morvan ML; Antignac JP; Gemzell-Danielsson K; Le Bizec B; Söder O; Svechnikov K
Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2017;61(2)

Resveratrol inhibits steroidogenesis in human fetal adrenocortical cells at the end of first trimester.

Savchuk I; Morvan M-L; Søeborg T; Antignac J-P; Gemzell-Danielsson K; Le Bizec B; Söder O; Svechnikov K
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2016;437:154-162

Prepubertal onset of obesity negatively impacts on testicular steroidogenesis in rats.

Wagner IV; Klöting N; Atanassova N; Savchuk I; Spröte C; Kiess W; Söder O; Svechnikov K
Article: HORMONE AND METABOLIC RESEARCH. 2016;48(9):589-594

Insulin-Like Peptide 5 Interacts with Sex Hormones and Metabolic Parameters in a Gender and Adiposity Dependent Manner in Humans.

Wagner IV; Flehmig G; Scheuermann K; Löffler D; Körner A; Kiess W; Stumvoll M; Dietrich A; Blüher M; Klöting N; Söder O; Svechnikov K
Article: ENDOCRINOLOGY. 2016;157(6):2461-2468

Leptin Within the Subphysiological to Physiological Range Dose Dependently Improves Male Reproductive Function in an Obesity Mouse Model.

Hoffmann A; Manjowk G-M; Wagner IV; Klöting N; Ebert T; Jessnitzer B; Lössner U; Stukenborg J-B; Blüher M; Stumvoll M; Söder O; Svechnikov K; Fasshauer M; Kralisch S
Article: FASEB JOURNAL. 2015;29(8):3274-3286

Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice.

Shabalina IG; Landreh L; Edgar D; Hou M; Gibanova N; Atanassova N; Petrovic N; Hultenby K; Söder O; Nedergaard J; Svechnikov K
Article: TOXICOLOGICAL SCIENCES. 2015;145(1):149-156

Mono-2-ethylhexyl phthalate stimulates androgen production but suppresses mitochondrial function in mouse leydig cells with different steroidogenic potential.

Savchuk I; Söder O; Svechnikov K
Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2014;99(7):E1227-E1235

Human testicular peritubular cells host putative stem Leydig cells with steroidogenic capacity.

Landreh L; Spinnler K; Schubert K; Häkkinen MR; Auriola S; Poutanen M; Söder O; Svechnikov K; Mayerhofer A
Article: MOLECULAR CANCER. 2014;13:155

Bortezomib treatment causes long-term testicular dysfunction in young male mice.

Hou M; Eriksson E; Svechnikov K; Jahnukainen K; Söder O; Meinhardt A; Sävendahl L
Article: FRONTIERS IN ENDOCRINOLOGY. 2014;5:21

In vitro Spermatogenesis - Optimal Culture Conditions for Testicular Cell Survival, Germ Cell Differentiation, and Steroidogenesis in Rats.

Reda A; Hou M; Landreh L; Kjartansdóttir KR; Svechnikov K; Söder O; Stukenborg J-B
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2013;372(1-2):96-104

Phenotype and steroidogenic potential of PDGFRα-positive rat neonatal peritubular cells.

Landreh L; Stukenborg J-B; Söder O; Svechnikov K
Article: PLOS ONE. 2013;8(8):e71722

Mouse leydig cells with different androgen production potential are resistant to estrogenic stimuli but responsive to bisphenol a which attenuates testosterone metabolism.

Savchuk I; Söder O; Svechnikov K
Article: JOURNAL OF APPLIED TOXICOLOGY. 2011;31(6):589-594

The prenylflavonoid phytoestrogens 8-prenylnaringenin and isoxanthohumol diferentially suppress steroidogenesis in rat Leydig cells in ontogenesis.

Izzo G; Söder O; Svechnikov K
Article: REPRODUCTION. 2011;142(2):319-331

Excessive ovarian production of nerve growth factor elicits granulosa cell apoptosis by setting in motion a tumor necrosis factor α/stathmin-mediated death signaling pathway.

Garcia-Rudaz C; Dorfman M; Nagalla S; Svechnikov K; Söder O; Ojeda SR; Dissen GA
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2011;341(1-2):18-24

Steroidogenesis and steroidogenic gene expression in postnatal fetal rat Leydig cells.

Weisser J; Landreh L; Söder O; Svechnikov K
Article: JOURNAL OF APPLIED TOXICOLOGY. 2009;29(8):673-680

Effects of resveratrol analogs on steroidogenesis and mitochondrial function in rat Leydig cells in vitro.

Svechnikov K; Spatafora C; Svechnikova I; Tringali C; Söder O
Article: REPRODUCTIVE TOXICOLOGY. 2008;25(4):485-490

Inhibitory effects of mono-ethylhexyl phthalate on steroidogenesis in immature and adult rat Leydig cells in vitro.

Svechnikov K; Svechnikova I; Söder O
Article: ENDOCRINOLOGY. 2008;149(6):2917-2922

Estrogen receptor beta selective ligand 5alpha-Androstane-3beta, 17beta-diol stimulates spermatogonial deoxyribonucleic acid synthesis in rat seminiferous epithelium in vitro.

Wahlgren A; Svechnikov K; Strand M-L; Jahnukainen K; Parvinen M; Gustafsson J-A; Söder O
Article: BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM. 2008;22(1):95-106

Ontogeny of gonadal sex steroids.

Svechnikov K; Söder O
Article: JOURNAL OF ENDOCRINOLOGY. 2007;194(3):603-609

The influence of di-(2-ethylhexyl) phthalate on steroidogenesis by the ovarian granulosa cells of immature female rats.

Svechnikova I; Svechnikov K; Söder O
Article: ENDOCRINOLOGY. 2007;148(1):128-139

Insulin-like growth factor-I is an important antiapoptotic factor for rat leydig cells during postnatal development.

Colón E; Zaman F; Axelson M; Larsson O; Carlsson-Skwirut C; Svechnikov KV; Söder O
Article: JOURNAL OF ENDOCRINOLOGY. 2007;192(1):33-39

Stimulation of the pituitary-adrenal axis and of adrenocortical steroidogenesis ex vivo by administration of di-2-ethylhexyl phthalate to prepubertal male rats.

Supornsilchai V; Söder O; Svechnikov K
Article: REPRODUCTIVE TOXICOLOGY. 2006;22(4):631-635

Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein.

Supornsilchai V; Söder O; Svechnikov K
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2006;208(2):373-385

Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis.

Colón E; Strand M-L; Carlsson-Skwirut C; Wahlgren A; Svechnikov KV; Cohen P; Söder O
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2006;36(2):327-336

Induction of steroidogenesis in immature rat Leydig cells by interleukin-1alpha is dependent on extracellular signal-regulated kinases.

Renlund N; Jo Y; Svechnikova I; Holst M; Stocco DM; Söder O; Svechnikov K
Article: CYTOKINE. 2005;32(1):51-59

The p38 MAPK pathway mediates interleukin-1-induced Sertoli cell proliferation.

Petersen C; Svechnikov K; Fröysa B; Söder O
Article: JOURNAL OF ENDOCRINOLOGY. 2005;187(1):117-124

Influence of long-term dietary administration of procymidone, a fungicide with anti-androgenic effects, or the phytoestrogen genistein to rats on the pituitary-gonadal axis and Leydig cell steroidogenesis.

Svechnikov K; Supornsilchai V; Strand M-L; Wahlgren A; Seidlova-Wuttke D; Wuttke W; Söder O
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2005;240(1-2):64-73

Interleukin-18 is expressed in rat testis and may promote germ cell growth.

Strand M-L; Wahlgren A; Svechnikov K; Zetterström C; Setchell BP; Söder O
Article: PEDIATRIC RESEARCH. 2005;57(6):896-901

Single subcutaneous administration of chorionic gonadotropin to rats induces a rapid and transient increase in testicular expression of pro-inflammatory cytokines.

Assmus M; Svechnikov K; von Euler M; Setchell B; Sultana T; Zetterström C; Holst M; Kiess W; Söder O
Article: ENDOCRINOLOGY. 2005;146(6):2519-2530

The liver X receptor-{beta} is essential for maintaining cholesterol homeostasis in the testis.

Robertson KM; Schuster GU; Steffensen KR; Hovatta O; Meaney S; Hultenby K; Johansson LC; Svechnikov K; Söder O; Gustafsson J-A
Article: ENDOCRINOLOGY. 2005;146(1):221-230

Stimulation of steroidogenesis in immature rat Leydig cells evoked by interleukin-1alpha is potentiated by growth hormone and insulin-like growth factors.

Colón E; Svechnikov KV; Carlsson-Skwirut C; Bang P; Soder O
Article: HORMONE RESEARCH IN PAEDIATRICS. 2005;64(6):280-286

Phytoestrogen resveratrol suppresses steroidogenesis by rat adrenocortical cells by inhibiting cytochrome P450 c21-hydroxylase.

Supornsilchai V; Svechnikov K; Seidlova-Wuttke D; Wuttke W; Söder O
Article: ENDOCRINOLOGY. 2004;145(10):4629-4634

Extracellular signal-regulated kinases are involved in the acute activation of steroidogenesis in immature rat Leydig cells by human chorionic gonadotropin.

Martinelle N; Holst M; Söder O; Svechnikov K
Article: CANCER RESEARCH. 2001;61(17):6423-6427

Amifostine protects against early but not late toxic effects of doxorubicin in infant rats.

Jahnukainen K; Jahnukainen T; Salmi TT; Svechnikov K; Eksborg S; Söder O
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2001;182(2):193-201

Age-dependent stimulation of Leydig cell steroidogenesis by interleukin-1 isoforms.

Svechnikov KV; Sultana T; Söder O
Article: CYTOKINE. 2001;14(5):283-288

Endotoxin-induced interleukin 1 expression in testicular macrophages is accompanied by downregulation of the constitutive expression in Sertoli cells.

Jonsson CK; Setchell BP; Martinelle N; Svechnikov K; Söder O
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2000;75(4-5):329-333

Androgen and estrogen stimulation of ornithine decarboxylase activity in mouse kidney.

Svechnikov K; Ritzén EM; Holst M
Article: ENDOCRINOLOGY. 2000;141(12):4413-4418

Molecular cloning and expression of a functionally different alternative splice variant of prointerleukin-1alpha from the rat testis.

Sultana T; Svechnikov K; Weber G; Söder O
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Preprint: BIORXIV. 2018

Alternative (backdoor) androgen production and masculinization in the human fetus

O’Shaughnessy PJ; Antignac JP; Le Bizec B; Morvan M-L; Svechnikov K; Söder O; Savchuk I; Monteiro A; Soffientini U; Johnston ZC; Bellingham M; Hough D; Bhattacharya S; Walker N; Filis P; Fowler PA
Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2018;90:570

The Human Genital Tubercle Is Steroidogenic Organ at Earlypregnancy

Savchuk I; Morvan M-L; Antignac JP; Gemzell-Danielsson K; Le Bizec B; Soder O; Svechnikov K
Review: HORMONE RESEARCH IN PAEDIATRICS. 2016;86(4):253-263

Phthalates Exert Multiple Effects on Leydig Cell Steroidogenesis.

Svechnikov K; Savchuk I; Morvan M-L; Antignac J-P; Le Bizec B; Söder O
Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2016;86:82

Adipose Tissue - A Source of Hyperandrogenism in Obese Females?

Wagner IV; Sahlin L; Savchuk I; Svechnikov K; Soeder O
Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2016;86:80

Adipocytokines Delay Pubertal Maturation of Human Sertoli Cells

Wagner IV; Yango P; Svechnikov K; Tran ND; Soder O
Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2016;86:29

Steroidogenesis in the Human Fetal Adrenals at the End of the First Trimester

Savchuk I; Morvan ML; Soeborg T; Antignac JP; Danielsson KG; Le Bizec B; Soder O; Svechnikov K
Conference publication: DIABETOLOGIA. 2015;58:S572

Insulin-like factor 5: a novel orexigenic hormone in humans is dys-regulated in obesity

Wagner IV; Flehmig G; Scheuermann K; Loeffler D; Koerner A; Kiess W; Stumvoll M; Dietrich A; Blueher M; Kloeting N; Soeder O; Svechnikov K
Conference publication: DIABETOLOGIA. 2015;58:S308

Dose-dependent stimulatory effect of leptin on Leydig cell steroidogenesis in leptin-deficient obese mice

Kralisch-Jaecklein S; Wagner IV; Manjowk GM; Hoffmann A; Kloeting N; Ebert T; Jessnitzer B; Loessner U; Burkhardt R; Stumvoll M; Soeder O; Svechnikov K; Fasshauer M
Review: ASIAN JOURNAL OF ANDROLOGY. 2014;16(1):50-59

Similar causes of various reproductive disorders in early life.

Svechnikov K; Stukenborg J-B; Savchuck I; Söder O
Book chapter: HORMONE-DISRUPTIVE CHEMICAL CONTAMINANTS IN FOOD. 2011;p. 26-43

Chapter 3

Svechnikov K; Söder O
Review: HORMONE RESEARCH IN PAEDIATRICS. 2010;73(2):93-101

Origin, development and regulation of human Leydig cells.

Svechnikov K; Landreh L; Weisser J; Izzo G; Colón E; Svechnikova I; Söder O
Review: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY. 2010;2010:684504-10

Endocrine disruptors and Leydig cell function.

Svechnikov K; Izzo G; Landreh L; Weisser J; Söder O
Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2009;72:449

The protein kinase A pathway is involved in early Leydig cell differentiation

Landreh L; Svechnikov K; Soeder O
Conference publication: REPRODUCTIVE SCIENCES. 2009;16(3):72A

Effect of Mono-(2-Ethylhexyl) Phthalate on Progesterone and Estradiol Production by Rat Ovarian Granulosa Cells In Vitro.

Svechnikova I; Svechnikov K; Seder O
Review: ASIAN JOURNAL OF ANDROLOGY. 2004;6(2):149-153

Molecular identity, expression and functional analysis of interleukin-1alpha and its isoforms in rat testis.

Sultana T; Svechnikov KV; Gustafsson K; Wahlgren A; Tham E; Weber G; Soder O
Review: CURRENT DRUG TARGETS: IMMUNE, ENDOCRINE AND METABOLIC DISORDERS. 2004;4(1):67-74

The paracrine role played by interleukin-1 alpha in the testis.

Svechnikov K; Petersen C; Sultana T; Wahlgren A; Zetterström C; Colón E; Bornestaf C; Söder O
Published conference paper: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2003;30(1):59-67

Interleukin-1alpha stimulates steroidogenic acute regulatory protein expression via p38 MAP kinase in immature rat Leydig cells.

Svechnikov K; Stocco DM; Söder O

Employments

Affiliated to Research, Department of Women's and Children's Health, Karolinska Institutet, 2024-2025
Research Specialist, Department of Women's and Children's Health, Karolinska Institutet, 2022-2023

Degrees and Education

Docent, Karolinska Institutet, 2008

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