Klas Kärre

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2017;8:15627

Expression of CD226 is associated to but not required for NK cell education.

Wagner AK; Kadri N; Snäll J; Brodin P; Gilfillan S; Colonna M; Bernhardt G; Höglund P; Kärre K; Chambers BJ
Article: SEXUALLY TRANSMITTED INFECTIONS. 2017;93(3):169-174

Herpes simplex virus specific T cell response in a cohort with primary genital infection correlates inversely with frequency of subsequent recurrences.

Franzen-Röhl E; Schepis D; Atterfelt F; Franck K; Wikström A; Liljeqvist J-Å; Bergström T; Aurelius E; Kärre K; Berg L; Gaines H
Article: ONCOIMMUNOLOGY. 2017;6(3):e1284718

NK cells control breast cancer and related cancer stem cell hematological spread.

Tallerico R; Conti L; Lanzardo S; Sottile R; Garofalo C; Wagner AK; Johansson MH; Cristiani CM; Kärre K; Carbone E; Cavallo F
Article: ONCOIMMUNOLOGY. 2017;6(2):e1261242

IL-15, TIM-3 and NK cells subsets predict responsiveness to anti-CTLA-4 treatment in melanoma patients.

Tallerico R; Cristiani CM; Staaf E; Garofalo C; Sottile R; Capone M; Pico de Coaña Y; Madonna G; Palella E; Wolodarski M; Carannante V; Mallardo D; Simeone E; Grimaldi AM; Johansson S; Frumento P; Gulletta E; Anichini A; Colucci F; Ciliberto G; Kiessling R; Kärre K; Ascierto PA; Carbone E
Article: SCIENTIFIC REPORTS. 2016;6:37996

Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.

Luu TT; Ganesan S; Wagner AK; Sarhan D; Meinke S; Garbi N; Hämmerling G; Alici E; Kärre K; Chambers BJ; Höglund P; Kadri N
Article: SCIENTIFIC REPORTS. 2016;6:30636

IL-2 in the tumor microenvironment is necessary for Wiskott-Aldrich syndrome protein deficient NK cells to respond to tumors in vivo.

Kritikou JS; Dahlberg CIM; Baptista MAP; Wagner AK; Banerjee PP; Gwalani LA; Poli C; Panda SK; Kärre K; Kaech SM; Wermeling F; Andersson J; Orange JS; Brauner H; Westerberg LS
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(7):1758-1769

In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation.

Lakshmikanth T; Heuts F; Muvva SSVJR; Wallin RPA; Persson A-K; Fauriat C; Applequist SE; Ljunggren H-G; Höglund P; Kärre K; Svensson M; Juarez JG
Article: IMMUNOLOGY AND CELL BIOLOGY. 2016;94(2):177-184

Depletion of IL-2 receptor β-positive cells protects from diabetes in non-obese diabetic mice.

Brauner H; Hall HT; Flodström-Tullberg M; Kärre K; Höglund P; Johansson S
Article: CANCER IMMUNOLOGY RESEARCH. 2016;4(2):113-123

Retuning of Mouse NK Cells after Interference with MHC Class I Sensing Adjusts Self-Tolerance but Preserves Anticancer Response.

Wagner AK; Wickström SL; Tallerico R; Salam S; Lakshmikanth T; Brauner H; Höglund P; Carbone E; Johansson MH; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(2):409-419

HLA class I downregulation is associated with enhanced NK-cell killing of melanoma cells with acquired drug resistance to BRAF inhibitors.

Sottile R; Pangigadde PN; Tan T; Anichini A; Sabbatino F; Trecroci F; Favoino E; Orgiano L; Roberts J; Ferrone S; Kärre K; Colucci F; Carbone E
Article: FRONTIERS IN IMMUNOLOGY. 2016;7:119

Microchip Screening Platform for Single Cell Assessment of NK Cell Cytotoxicity.

Guldevall K; Brandt L; Forslund E; Olofsson K; Frisk TW; Olofsson PE; Gustafsson K; Manneberg O; Vanherberghen B; Brismar H; Kärre K; Uhlin M; Önfelt B
Article: NATURE COMMUNICATIONS. 2014;5:5639

Enrichment of CD56(dim)KIR + CD57 + highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients.

Ali TH; Pisanti S; Ciaglia E; Mortarini R; Anichini A; Garofalo C; Tallerico R; Santinami M; Gulletta E; Ietto C; Galgani M; Matarese G; Bifulco M; Ferrone S; Colucci F; Moretta A; Kärre K; Carbone E
Article: JOURNAL OF IMMUNOLOGY. 2014;192(4):1577-1586

A genetic defect in mice that impairs missing self recognition despite evidence for normal maturation and MHC class I-dependent education of NK cells.

Wickström SL; Öberg L; Kärre K; Johansson MH
Article: PLOS ONE. 2014;9(12):e111758

Mechanical stress downregulates MHC class I expression on human cancer cell membrane.

La Rocca R; Tallerico R; Talib Hassan A; Das G; Lakshmikanth T; Matteucci M; Liberale C; Mesuraca M; Scumaci D; Gentile F; Cojoc G; Perozziello G; Ammendolia A; Gallo A; Kärre K; Cuda G; Candeloro P; Di Fabrizio E; Carbone E
Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2381-2390

Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules.

Tallerico R; Todaro M; Di Franco S; Maccalli C; Garofalo C; Sottile R; Palmieri C; Tirinato L; Pangigadde PN; La Rocca R; Mandelboim O; Stassi G; Di Fabrizio E; Parmiani G; Moretta A; Dieli F; Kärre K; Carbone E
Article: FRONTIERS IN IMMUNOLOGY. 2013;4:65

Natural killer cell inhibitory receptor expression in humans and mice: a closer look.

Sternberg-Simon M; Brodin P; Pickman Y; Onfelt B; Kärre K; Malmberg K-J; Höglund P; Mehr R
Article: CARCINOGENESIS. 2012;33(6):1231-1238

Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APCMin/+ mice.

Li Y; Kundu P; Seow SW; de Matos CT; Aronsson L; Chin KC; Kärre K; Pettersson S; Greicius G
Article: CLINICAL IMMUNOLOGY. 2012;143(2):134-144

Expansion of T-cells from the cord blood graft as a predictive tool for complications and outcome of cord blood transplantation.

Gertow J; Berglund S; Okas M; Kärre K; Remberger M; Mattsson J; Uhlin M
Article: JOURNAL OF IMMUNOLOGY. 2012;188(5):2218-2226

Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.

Brodin P; Lakshmikanth T; Kärre K; Höglund P
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(1):129-141

Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules.

Dabrazhynetskaya A; Ma J; Guerreiro-Cacais AO; Arany Z; Rudd E; Henter J-I; Karre K; Levitskaya J; Levitsky V
Article: VIRAL IMMUNOLOGY. 2011;24(5):359-368

NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients.

Johansson SE; Rollman E; Chung AW; Center RJ; Hejdeman B; Stratov I; Hinkula J; Wahren B; Kärre K; Kent SJ; Berg L
Article: CELL CYCLE. 2011;10(19):3346-3358

Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2.

Li H; Lakshmikanth T; Garofalo C; Enge M; Spinnler C; Anichini A; Szekely L; Kärre K; Carbone E; Selivanova G
Article: CLINICAL AND VACCINE IMMUNOLOGY. 2011;18(4):655-660

Increased cell-mediated immune responses in patients with recurrent herpes simplex virus type 2 meningitis.

Franzen-Röhl E; Schepis D; Lagrelius M; Franck K; Jones P; Liljeqvist J-Å; Bergström T; Aurelius E; Kärre K; Berg L; Gaines H
Article: PLOS ONE. 2010;5(10):e13174

Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.

Brodin P; Lakshmikanth T; Mehr R; Johansson MH; Duru AD; Achour A; Salmon-Divon M; Kärre K; Höglund P; Johansson S
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2010;162(1):146-155

Characterization of long-term mixed donor-donor chimerism after double cord blood transplantation.

Gertow J; Berglund S; Okas M; Uzunel M; Berg L; Kärre K; Mattsson J; Uhlin M
Article: JOURNAL OF IMMUNOLOGY. 2010;184(5):2272-2280

Distinct phenotype and function of NK cells in the pancreas of nonobese diabetic mice.

Brauner H; Elemans M; Lemos S; Broberger C; Holmberg D; Flodström-Tullberg M; Kärre K; Höglund P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(3):813-823

In vivo tumor cell rejection induced by NK cell inhibitory receptor blockade: maintained tolerance to normal cells even in the presence of IL-2.

Vahlne G; Lindholm K; Meier A; Wickström S; Lakshmikanth T; Brennan F; Wilken M; Nielsen R; Romagné F; Wagtmann NR; Kärre K; Johansson MH
Article: CLINICAL IMMUNOLOGY. 2010;134(2):158-168

NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients.

Johansson SE; Hejdeman B; Hinkula J; Johansson MH; Romagné F; Wahren B; Wagtmann NR; Kärre K; Berg L
Article: JOURNAL OF IMMUNOTHERAPY. 2010;33(1):96-105

Clinical expansion of cord blood-derived T cells for use as donor lymphocyte infusion after cord blood transplantation.

Okas M; Gertow J; Uzunel M; Karlsson H; Westgren M; Kärre K; Ringden O; Mattsson J; Uhlin M
Article: JOURNAL OF NEUROSCIENCE. 2009;29(43):13503-13515

Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction.

Thams S; Brodin P; Plantman S; Saxelin R; Kärre K; Cullheim S
Article: PLOS ONE. 2009;4(6):e6046

Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice.

Johansson S; Salmon-Divon M; Johansson MH; Pickman Y; Brodin P; Kärre K; Mehr R; Höglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2009;69(5):429-436

Herpes simplex virus infection downmodulates NKG2D ligand expression.

Schepis D; D'Amato M; Studahl M; Bergström T; Kärre K; Berg L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(5):1251-1263

NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

Lakshmikanth T; Burke S; Ali TH; Kimpfler S; Ursini F; Ruggeri L; Capanni M; Umansky V; Paschen A; Sucker A; Pende D; Groh V; Biassoni R; Höglund P; Kato M; Shibuya K; Schadendorf D; Anichini A; Ferrone S; Velardi A; Kärre K; Shibuya A; Carbone E; Colucci F
Article: BLOOD. 2009;113(11):2434-2441

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.

Brodin P; Lakshmikanth T; Johansson S; Kärre K; Höglund P
Article: TRANSPLANTATION. 2009;87(4):467-472

Increased frequency and responsiveness of PSA-specific T cells after allogeneic hematopoetic stem-cell transplantation.

Uhlin M; Okas M; Karlsson H; Gertow J; Henningsohn L; Ringdén O; Kärre K; Levitsky V; Mattsson J
Article: IMMUNOLOGY. 2009;126(1):140-146

Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus.

Schepis D; Gunnarsson I; Eloranta M-L; Lampa J; Jacobson SH; Kärre K; Berg L
Article: IMMUNOLOGY. 2008;123(2):164-170

Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection.

Titanji K; Sammicheli S; De Milito A; Mantegani P; Fortis C; Berg L; Kärre K; Travi G; Tassandin C; Lopalco L; Rethi B; Tambussi G; Chiodi F
Article: IMMUNOLOGY. 2007;122(2):291-301

Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion.

de Matos CT; Berg L; Michaëlsson J; Felländer-Tsai L; Kärre K; Söderström K
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2007;66(2-3):335-344

The expression of human natural killer cell receptors in early life.

Sundström Y; Nilsson C; Lilja G; Kärre K; Troye-Blomberg M; Berg L
Article: JOURNAL OF IMMUNOLOGY. 2007;178(6):3536-3543

Increased expression of leukocyte Ig-like receptor-1 and activating role of UL18 in the response to cytomegalovirus infection.

Wagner CS; Riise GC; Bergström T; Kärre K; Carbone E; Berg L
Article: JOURNAL OF IMMUNOLOGY. 2006;177(8):4981-4990

DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.

French AR; Sjölin H; Kim S; Koka R; Yang L; Young DA; Cerboni C; Tomasello E; Ma A; Vivier E; Kärre K; Yokoyama WM
Article: JOURNAL OF IMMUNOLOGY. 2006;177(5):2908-2916

DAP12 signaling regulates plasmacytoid dendritic cell homeostasis and down-modulates their function during viral infection.

Sjölin H; Robbins SH; Bessou G; Hidmark A; Tomasello E; Johansson M; Hall H; Charifi F; Karlsson Hedestam GB; Biron CA; Kärre K; Höglund P; Vivier E; Dalod M
Article: NATURE MEDICINE. 2006;12(4):417-424

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants.

van Hall T; Wolpert EZ; van Veelen P; Laban S; van der Veer M; Roseboom M; Bres S; Grufman P; de Ru A; Meiring H; de Jong A; Franken K; Teixeira A; Valentijn R; Drijfhout JW; Koning F; Camps M; Ossendorp F; Kärre K; Ljunggren H-G; Melief CJM; Offringa R
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2006;36(3):732-741

Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR-1/ILT2/CD85j.

Cerboni C; Achour A; Wärnmark A; Mousavi-Jazi M; Sandalova T; Hsu M-L; Cosman D; Kärre K; Carbone E
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396

Structural basis of the differential stability and receptor specificity of H-2Db in complex with murine versus human beta2-microglobulin.

Achour A; Michaëlsson J; Harris RA; Ljunggren H-G; Kärre K; Schneider G; Sandalova T
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093

Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin.

Sandalova T; Michaëlsson J; Harris RA; Ljunggren H-G; Kärre K; Schneider G; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075

A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.

Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärre K; Achour A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(7):1145-1155

Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules.

Johansson S; Johansson M; Rosmaraki E; Vahlne G; Mehr R; Salmon-Divon M; Lemonnier F; Kärre K; Höglund P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(51):17843-17848

A role for MHC class I molecules in synaptic plasticity and regeneration of neurons after axotomy.

Oliveira ALR; Thams S; Lidman O; Piehl F; Hökfelt T; Kärre K; Lindå H; Cullheim S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(6):1646-1653

Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways.

Oberg L; Johansson S; Michaëlsson J; Tomasello E; Vivier E; Kärre K; Höglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(2):159-167

Proliferative and cytotoxic response of human natural killer cells exposed to transporter associated with antigen-processing-deficient cells.

Cerboni C; Oberg L; Terrazzano G; Zappacosta S; Carbone E; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2003;171(2):902-908

Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.

Rölle A; Mousavi-Jazi M; Eriksson M; Odeberg J; Söderberg-Nauclér C; Cosman D; Kärre K; Cerboni C
Article: CANCER IMMUNITY. 2003;3:6

The uterine cervix--a new member of the family of immunologically exceptional sites?

Höglund P; Kärre K; Klein G
Article: LANCET. 2003;361(9363):1099-1101

LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients.

Berg L; Riise GC; Cosman D; Bergström T; Olofsson S; Kärre K; Carbone E
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2002;196(11):1403-1414

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.

Michaëlsson J; Teixeira de Matos C; Achour A; Lanier LL; Kärre K; Söderström K
Article: IMMUNITY. 2002;17(6):757-768

A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.

Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2002;195(7):825-834

Pivotal role of KARAP/DAP12 adaptor molecule in the natural killer cell-mediated resistance to murine cytomegalovirus infection.

Sjölin H; Tomasello E; Mousavi-Jazi M; Bartolazzi A; Kärre K; Vivier E; Cerboni C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):149-161

Human cytomegalovirus (HCMV)-infected endothelial cells and macrophages are less susceptible to natural killer lysis independent of the downregulation of classical HLA class I molecules or expression of the HCMV class I homologue, UL18.

Odeberg J; Cerboni C; Browne H; Kärre K; Möller E; Carbone E; Söderberg-Nauclér C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):129-139

The role of an exposed loop in the alpha2 domain in the mouse MHC class I H-2Dd molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A.

Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):793-800

NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding.

Sundbäck J; Achour A; Michaëlsson J; Lindström H; Kärre K
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2001;194(10):1519-1530

Acquisition of external major histocompatibility complex class I molecules by natural killer cells expressing inhibitory Ly49 receptors.

Sjöström A; Eriksson M; Cerboni C; Johansson MH; Sentman CL; Kärre K; Höglund P
Article: JOURNAL OF IMMUNOLOGY. 2001;166(12):7327-7334

MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the beta 2-microglobulin subunit.

Michaëlsson J; Achour A; Rölle A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.

Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: VIROLOGY. 2000;273(1):112-119

Human immunodeficiency virus type 1 Nef epitopes recognized in HLA-A2 transgenic mice in response to DNA and peptide immunization.

Sandberg JK; Leandersson AC; Devito C; Kohleisen B; Erfle V; Achour A; Levi M; Schwartz S; Kärre K; Wahren B; Hinkula J
Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33

T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity.

Sandberg JK; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin RP; Sherman NE; Bergman T; Jörnvall H; Hunt DF; Kiessling R; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2000;164(12):6130-6137

Inhibition of human NK cell-mediated killing by CD1 molecules.

Carbone E; Terrazzano G; Melián A; Zanzi D; Moretta L; Porcelli S; Kärre K; Zappacosta S
Article: NATURE. 2000;405(6786):527-528

Immunology. The footprint of a killer.

Kärre K; Schneider G
Article: JOURNAL OF IMMUNOLOGY. 2000;164(9):4775-4782

Human cytomegalovirus strain-dependent changes in NK cell recognition of infected fibroblasts.

Cerboni C; Mousavi-Jazi M; Linde A; Söderström K; Brytting M; Wahren B; Kärre K; Carbone E
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(4):1088-1093

Innate and adaptive immunity to tumors: IL-12 is required for optimal responses.

Grufman P; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(2):525-533

Differential effects on T cell and NK cell development by tissue-specific expression of H-2D(d) transgene.

Johansson MH; Bieberich C; Kâse-Sjöström A; Yoshioka T; Höglund E; Christy BA; Scangos G; Kärre K; Jay G; Höglund P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2000;191(1):129-138

Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses.

Glas R; Franksson L; Une C; Eloranta ML; Ohlén C; Orn A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307

Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers.

Michaëlsson J; Achour A; Salcedo M; Kâse-Sjöström A; Sundbäck J; Harris RA; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(12):4022-4029

Recognition of autologous dendritic cells by human NK cells.

Carbone E; Terrazzano G; Ruggiero G; Zanzi D; Ottaiano A; Manzo C; Kärre K; Zappacosta S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(9):2748-2758

Peptide dependency and selectivity of the NK cell inhibitory receptor Ly-49C.

Franksson L; Sundbäck J; Achour A; Bernlind J; Glas R; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(7):2197-2204

T cell competition for the antigen-presenting cell as a model for immunodominance in the cytotoxic T lymphocyte response against minor histocompatibility antigens.

Grufman P; Wolpert EZ; Sandberg JK; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1999;162(12):7010-7014

The MHC class I molecule H-2Dp inhibits murine NK cells via the inhibitory receptor Ly49A.

Olsson-Alheim MY; Sundbäck J; Kärre K; Sentman CL
Article: JOURNAL OF IMMUNOLOGY. 1999;162(10):5910-5916

Triggering of murine NK cells by CD40 and CD86 (B7-2).

Martín-Fontecha A; Assarsson E; Carbone E; Kärre K; Ljunggren HG
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1999;189(6):883-894

Recognition of the major histocompatibility complex restriction element modulates CD8(+) T cell specificity and compensates for loss of T cell receptor contacts with the specific peptide.

Sandberg JK; Kärre K; Glas R
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 1999;55(Pt 1):260-262

Murine class I major histocompatibility complex H-2Dd: expression, refolding and crystallization.

Achour A; Harris RA; Persson K; Sundbäck J; Sentman CL; Schneider G; Lindqvist Y; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;161(9):4499-4505

Immunodominance in the CTL response against minor histocompatibility antigens: interference between responding T cells, rather than with presentation of epitopes.

Wolpert EZ; Grufman P; Sandberg JK; Tegnesjö A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(9):2872-2881

Impaired MHC class I (H-2Dd)-mediated protection against Ly-49A+ NK cells after amino acid substitutions in the antigen binding cleft.

Waldenström M; Sundbäck J; Olsson-Alheim MY; Achour A; Kärre K
Article: IMMUNITY. 1998;9(2):199-208

The crystal structure of H-2Dd MHC class I complexed with the HIV-1-derived peptide P18-I10 at 2.4 A resolution: implications for T cell and NK cell recognition.

Achour A; Persson K; Harris RA; Sundbäck J; Sentman CL; Lindqvist Y; Schneider G; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;160(12):5971-5978

The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A.

Sundbäck J; Nakamura MC; Waldenström M; Niemi EC; Seaman WE; Ryan JC; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 1998;160(7):3163-3169

Superdominance among immunodominant H-2Kb-restricted epitopes and reversal by dendritic cell-mediated antigen delivery.

Sandberg JK; Grufman P; Wolpert EZ; Franksson L; Chambers BJ; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1998;28(1):370-378

Beta2-microglobulin-deficient NK cells show increased sensitivity to MHC class I-mediated inhibition, but self tolerance does not depend upon target cell expression of H-2Kb and Db heavy chains.

Höglund P; Glas R; Ménard C; Kåse A; Johansson MH; Franksson L; Lemmonier F; Kärre K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(21):11496-11501

Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells.

Wolpert EZ; Petersson M; Chambers BJ; Sandberg JK; Kiessling R; Ljunggren HG; Kärre K
Article: CANCER RESEARCH. 1997;57(19):4348-4355

Synthetic peptides derived from the melanocyte-stimulating hormone receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes that recognize naturally processed peptides on human melanoma cells.

Salazar-Onfray F; Nakazawa T; Chhajlani V; Petersson M; Kärre K; Masucci G; Celis E; Sette A; Southwood S; Appella E; Kiessling R
Article: JOURNAL OF IMMUNOLOGY. 1997;159(7):3189-3194

NK cell receptor calibration: effects of MHC class I induction on killing by Ly49Ahigh and Ly49Alow NK cells.

Olsson-Alheim MY; Salcedo M; Ljunggren HG; Kärre K; Sentman CL
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1997;186(3):353-364

Natural killer cell tolerance in mice with mosaic expression of major histocompatibility complex class I transgene.

Johansson MH; Bieberich C; Jay G; Kärre K; Höglund P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1997;185(12):2053-2060

A new mechanism of NK cell cytotoxicity activation: the CD40-CD40 ligand interaction.

Carbone E; Ruggiero G; Terrazzano G; Palomba C; Manzo C; Fontana S; Spits H; Kärre K; Zappacosta S
Article: JOURNAL OF IMMUNOLOGY. 1997;158(7):3174-3180

Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice.

Salcedo M; Diehl AD; Olsson-Alheim MY; Sundbäck J; Van Kaer L; Kärre K; Ljunggren HG
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1997;27(1):342-345

Lack of F1 anti-parental resistance in H-2b/d F1 hybrids devoid of beta2-microglobulin.

Höglund P; Olsson-Alheim MY; Johansson M; Kärre K; Sentman CL
Article: UGESKRIFT FOR LAEGER. 1996;158(51):7379-7383

[Nobel Prize for discovery of the cell-mediated immune defence].

Klareskog L; Kärre K; Möller E; Wigzell H
Article: JOURNAL OF IMMUNOLOGY. 1996;157(9):3936-3942

Cloning of minimally divergent allelic forms of the natural killer (NK) receptor Ly-49C, differentially controlled by host genes in the MHC and NK gene complexes.

Sundbäck J; Kärre K; Sentman CL
Article: LAKARTIDNINGEN. 1996;93(42):3714-3717

[The Nobel Prize for discovery of the cell-mediated immune defense. Significance for clinical medicine].

Klareskog L; Kärre K; Möller E; Wigzell H
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(9):2127-2132

Influence of glycosylphosphatidylinositol-linked H-2Dd molecules on target cell protection and natural killer cell specificity in transgenic mice.

Sentman CL; Olsson-Alheim MY; Lendahl U; Kärre K
Article: INTERNATIONAL JOURNAL OF CANCER. 1996;67(3):365-371

Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression.

Yamasaki T; Akiyama Y; Fukuda M; Kimura Y; Moritake K; Kikuchi H; Ljunggren HG; Kärre K; Klein G
Article: JOURNAL OF IMMUNOLOGY. 1996;156(7):2423-2429

H-2Dp transgene alters natural killer cell specificity at the target and effector cell levels. Comparison with an H-2Dd transgene.

Sentman CL; Olsson-Alheim MY; Lendahl U; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(3):683-689

Natural killer clones recognize specific soluble HLA class I molecules.

Carbone E; Terrazzano G; Colonna M; Tuosto L; Piccolella E; Franksson L; Palazzolo G; Pérez-Villar JJ; Fontana S; Kärre K; Zappacosta S
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):288-293

TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity.

Sandberg JK; Chambers BJ; Van Kaer L; Kärre K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 1995;154(12):6291-6298

IL-10 converts mouse lymphoma cells to a CTL-resistant, NK-sensitive phenotype with low but peptide-inducible MHC class I expression.

Salazar-Onfray F; Petersson M; Franksson L; Matsuda M; Blankenstein T; Kärre K; Kiessling R
Article: INTERNATIONAL IMMUNOLOGY. 1995;7(6):919-928

Dominant and cryptic antigens in the MHC class I restricted T cell response across a complex minor histocompatibility barrier: analysis and mapping by elution of cellular peptides.

Wolpert E; Franksson L; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1995;25(5):1286-1291

Inhibition of natural killer cell-mediated bone marrow graft rejection by allogeneic major histocompatibility complex class I, but not class II molecules.

Ohlén C; Höglund P; Sentman CL; Carbone E; Ljunggren HG; Koller B; Kärre K
Article: CANCER RESEARCH. 1995;55(9):1911-1916

Rejection of tumors in mice with severe combined immunodeficiency syndrome determined by the major histocompatibility complex. Class I expression on the graft.

Glas R; Waldenström M; Höglund P; Klein G; Kärre K; Ljunggren HG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(5):1649-1653

Altered phenotype and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand.

Olsson MY; Kärre K; Sentman CL
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Other: NATURE. 2017;542(7641):296

George Klein (1925-2016).

Ernberg I; Kärre K; Wigzell H
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2016;395:95-114

Dynamic Regulation of NK Cell Responsiveness.

Kadri N; Wagner AK; Ganesan S; Kärre K; Wickström S; Johansson MH; Höglund P
Review: ONCOTARGET. 2014;5(24):12472-12508

Classification of current anticancer immunotherapies.

Galluzzi L; Vacchelli E; Bravo-San Pedro J-M; Buqué A; Senovilla L; Baracco EE; Bloy N; Castoldi F; Abastado J-P; Agostinis P; Apte RN; Aranda F; Ayyoub M; Beckhove P; Blay J-Y; Bracci L; Caignard A; Castelli C; Cavallo F; Celis E; Cerundolo V; Clayton A; Colombo MP; Coussens L; Dhodapkar MV; Eggermont AM; Fearon DT; Fridman WH; Fučíková J; Gabrilovich DI; Galon J; Garg A; Ghiringhelli F; Giaccone G; Gilboa E; Gnjatic S; Hoos A; Hosmalin A; Jäger D; Kalinski P; Kärre K; Kepp O; Kiessling R; Kirkwood JM; Klein E; Knuth A; Lewis CE; Liblau R; Lotze MT; Lugli E; Mach J-P; Mattei F; Mavilio D; Melero I; Melief CJ; Mittendorf EA; Moretta L; Odunsi A; Okada H; Palucka AK; Peter ME; Pienta KJ; Porgador A; Prendergast GC; Rabinovich GA; Restifo NP; Rizvi N; Sautès-Fridman C; Schreiber H; Seliger B; Shiku H; Silva-Santos B; Smyth MJ; Speiser DE; Spisek R; Srivastava PK; Talmadge JE; Tartour E; Van Der Burg SH; Van Den Eynde BJ; Vile R; Wagner H; Weber JS; Whiteside TL; Wolchok JD; Zitvogel L; Zou W; Kroemer G
Other: CANCER IMMUNOLOGY IMMUNOTHERAPY. 2012;61(4):587-591

First International Meeting of the Thematic Centre for Immune Modulatory Therapies for Autoimmunity and Cancer (IMTAC) 13-14 June 2011, Ljusterö, Sweden.

Choudhury A; Höglund P; Kiessling R; Kärre K; Lundqvist A; Malmberg K; Mellstedt H; Scheynius A; Winqvist O; Osterborg A
Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2012;18(2):S267

EXPANSION OF T-CELLS FROM THE CORD BLOOD GRAFT AS A PREDICTIVE TOOL FOR COMPLICATIONS AND OUTCOME OF CORD BLOOD TRANSPLANTATION

Gertow J; Berglund S; Okas M; Karre K; Remberger M; Mattsson J; Uhlin M
Review: TRENDS IN IMMUNOLOGY. 2009;30(4):143-149

NK cell education: not an on-off switch but a tunable rheostat.

Brodin P; Kärre K; Höglund P
Editorial comment: NATURE IMMUNOLOGY. 2008;9(5):477-480

Natural killer cell recognition of missing self.

Kärre K
Other: JOURNAL OF IMMUNOLOGY. 2007;179(7):4301-4306

Pillars article: Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature 1989. 340: 443-448.

Townsend A; Ohlén C; Bastin J; Ljunggren H-G; Foster L; Kärre K
Other: JOURNAL OF IMMUNOLOGY. 2005;174(11):6566-6569

Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy. 1986.

Kärre K; Ljunggren HG; Piontek G; Kiessling R
Editorial comment: NATURE IMMUNOLOGY. 2002;3(6):505-506

Clever, cleverer, cleverest.

Kärre K
Editorial comment: SCIENCE. 2002;295(5562):2029-2031

Immunology. A perfect mismatch.

Kärre K
Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(3):221-228

NK cells, MHC class I molecules and the missing self.

Kärre K
Published conference paper: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(10):2926-2935

Synergistic effect of IFN-gamma and human cytomegalovirus protein UL40 in the HLA-E-dependent protection from NK cell-mediated cytotoxicity.

Cerboni C; Mousavi-Jazi M; Wakiguchi H; Carbone E; Kärre K; Söderström K
Published conference paper: JOURNAL OF LEUKOCYTE BIOLOGY. 1999;66(2):268-271

Immunization with dendritic cells breaks immunodominance in CTL responses against minor histocompatibility and synthetic peptide antigens.

Grufman P; Sandberg JK; Wolpert EZ; Kärre K
Review: LAKARTIDNINGEN. 1997;94(17):1595-1600

[A scientist's day-dream or future reality? Specific immunotherapy against cancer].

Kiessling R; Kärre K
Editorial comment: NATURE. 1997;386(6624):446-447

Viral decoy vetoes killer cell.

Kärre K; Welsh RM
Review: IMMUNOLOGICAL REVIEWS. 1997;155:11-28

Host MHC class I gene control of NK-cell specificity in the mouse.

Höglund P; Sundbäck J; Olsson-Alheim MY; Johansson M; Salcedo M; Ohlén C; Ljunggren HG; Sentman CL; Kärre K
Review: IMMUNOLOGICAL REVIEWS. 1997;155:5-9

How to recognize a foreign submarine.

Kärre K
Review: IMMUNOLOGICAL REVIEWS. 1996;151:123-148

Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway.

Ljunggren HG; Glas R; Sandberg JK; Kärre K
Review: SEMINARS IN IMMUNOLOGY. 1995;7(2):109-119

Missing self recognition by natural killer cells in MHC class I transgenic mice. A 'receptor calibration' model for how effector cells adapt to self.

Sentman CL; Olsson MY; Kärre K
Editorial comment: SCIENCE. 1995;267(5200):978-979

Express yourself or die: peptides, MHC molecules, and NK cells.

Kärre K
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