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About me

I am visiting professor of Pediatric Oncology at the Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden. I am a founding member of NORDFERTIL (www.nordfertil.org) and an associated partner of EU-ITN consortium “GROWSPERM” (www.growsperm.eu). I am working also as a senior consultant in pediatric hematology and oncology in Children’s Hospital, Helsinki University Central Hospital.

Education

COURSES AND DEGREES

M.D.,University of Turku, 1992

Specialist in Pediatrics, University of Turku, 2002

Specialist in Pediatrics in Sweden, 2003

Specialist in Medical Leadership, University of Turku, 2005

Specialist in Pediatric Hematology and Oncology, Helsinki University, 2006

 

DOCTORAL DEGREE

PhD, University of Turku, 1995

 

POSTDOC APPOINTMENTS

Post-doctoral scientist, Professor Stefan Schlatt´s lab, Centre for Research in Reproductive Physiology, University of Pittsburgh, USA, 7/2005- 6/2006

Post-doctoral scientist, Professor Olle Söder´s lab, Department of Women´s and Children´s Health, Karolinska Institutet , 8/1998-12/1999

 

DOCENT-LEVEL COMPETENCE

Docent in Clinical Pediatric Hematology and Oncology, Helsinki University, 2012

Docent in Experimental Pediatric Hematology and Oncology, Helsinki University, 2008

Docent in Pediatrics, Karolinska Institutet, 2002

Research description

We focus on late adverse effects among adult survivors of childhood cancer, and pediatric hematopoietic stem cell transplantation.

We have shown that survivors after pediatric hematopoietic stem cell transplantation are at risk of early gonadal, skeletal and vascular aging and frailty. Our research group is exploring methods to predict and prevent gonadal late effects.

The clinical aim is to establish clinical quality testing of cryopreserved immature ovarian and testicular tissue collected for fertility preservation.

Teaching portfolio

Ongoing supervision of a PhD candidate:

•             M.D. Mari Wilhelmsson, (Late adverse effects after allogeneic hematopoietic stem cell transplantation in childhood AML), Department of Women´s and Children´s Health, Pediatric Endocrinology Unit, Karolinska Institutet, Sweden, registration 10/2011. Main supervisor.

•             M.D. Valentina Pampanini (Biomarkers indicating residual ovarian pool and their impact to determine fertility preservation methods in childhood cancer patients) in Department of Women´s and Children´s Health, Pediatric Endocrinology Unit, Karolinska Institutet, Sweden, registration 2/2015. Main supervisor.

•             M.D. Melanie Poganitsch, (Male fertility, late morbidity and agining after childhood cancer) Children’s Hospital, Helsinki University, Helsinki University Central Hospital, registration 12/2011. Main supervisor.

 

PhD candidates supervised up to the defence of the candidate’s doctoral thesis:

As main supervisor

•             Mi Hou (Novel strategies and putative risks for preservation of male fertility in acute leukemia) in Department of Women´s and Children´s Health, Pediatric Endocrinology Unit, Karolinska Institutet, Sweden, dissertation 26.10.2007.

•             Mirja Nurmio (Models to study cancer therapy related toxicity in immature testis) in Department of Anatomy, University of Turku, Finland, dissertation 6.6.2009.

•             M.D. Anu Vatanen, (Late adverse effects after autologous hematopoietic stem cell transplantation in childhood) Children’s Hospital, Helsinki University, Helsinki University Central Hospital, dissertation 10.6.2016.

•             McS Babak Asadi Azarbaijani (Novel methods to preserve fertility in young female cancer patients) in Department for Women & Children’s Health, Oslo University Central Hospital, dissertation 2.3.2017.

As co-supervisor

•             Mona-Lisa Strand (Antimicrobial and xenobiotic defence in the mammalian testis) in Department of Women´s and Children´s Health, Pediatric Endocrinology Unit, Karolinska Institutet, Sweden, dissertation 15.6.2012.

•             McS Ahmed Reda (Artificial testis to study early gonadal development and germ cell differentiation) in Department of Women´s and Children´s Health, Pediatric Endocrinology Unit, Karolinska Institutet, Sweden, dissertation, 30.9.2016.

Links

Publications

Acute myeloid leukemia (AML) with t(7;12)(q36;p13) is associated with infancy and trisomy 19: Data from Nordic Society for Pediatric Hematology and Oncology (NOPHO-AML) and review of the literature
Espersen Adl, Noren-nyström U, Abrahamsson J, Ha Sy, Pronk Cj, Jahnukainen K, et al
Genes, chromosomes & cancer 2018;57(7):359-365

Cancer treatment in childhood and testicular function: the importance of the somatic environment
Stukenborg Jb, Jahnukainen K, Hutka M, Mitchell Rt
Endocrine connections 2018;7(2):R69-R87

Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study
Endén K, Tainio J, Jalanko H, Jahnukainen K, Jahnukainen T
Transplant international : official journal of the European Society for Organ Transplantation 2018;31(2):157-164

Clinical and biological markers of premature aging after autologous SCT in childhood cancer
Vatanen A, Hou M, Huang T, Söder O, Jahnukainen T, Kurimo M, et al
Bone marrow transplantation 2017;52(4):600-605

Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents
Poganitsch-korhonen M, Masliukaite I, Nurmio M, Lähteenmäki P, Van Wely M, Van Pelt Amm, et al
Leukemia 2017;31(6):1460-1463

Developmental effects of imatinib mesylate on follicle assembly and early activation of primordial follicle pool in postnatal rat ovary
Asadi-azarbaijani B, Santos Rr, Jahnukainen K, Braber S, Van Duursen Mbm, Toppari J, et al
Reproductive biology 2017;17(1):25-33

Extramedullary leukemia in children with acute myeloid leukemia: A population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO)
Stove Hk, Sandahl Jd, Abrahamsson J, Asdahl Ph, Forestier E, Ha Sy, et al
PEDIATRIC BLOOD & CANCER 2017;64(12):-

Fertility preservation issues in pediatric hematopoietic stem cell transplantation: practical approaches from the consensus of the Pediatric Diseases Working Party of the EBMT and the International BFM Study Group
Int Bfm Study Grp, Pediat Dis Working Party European, Balduzzi A, Dalle Jh, Jahnukainen K, Von Wolff M, et al
BONE MARROW TRANSPLANTATION 2017;52(10):1406-1415

Hyperleucocytosis in paediatric acute myeloid leukaemia - the challenge of white blood cell counts above 200 x 10(9)/l. The NOPHO experience 1984-2014
Nopho Aml Working Grp, Zeller B, Glosli H, Forestier E, Ha Sy, Jahnukainen K, et al
BRITISH JOURNAL OF HAEMATOLOGY 2017;178(3):448-456

Outcome after intensive reinduction therapy and allogeneic stem cell transplant in paediatric relapsed acute myeloid leukaemia
Karlsson L, Forestier E, Hasle H, Jahnukainen K, Jonsson Og, Lausen B, et al
BRITISH JOURNAL OF HAEMATOLOGY 2017;178(4):592-602

Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement
Nordic Society Of Pediatric Haematology And Oncology (nopho), Ranta S, Palomäki M, Levinsen M, Taskinen M, Abrahamsson J, et al
Pediatric blood & cancer 2017;64(12):-

Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium
Skinner R, Mulder Rl, Kremer Lc, Hudson Mm, Constine Ls, Bardi E, et al
LANCET ONCOLOGY 2017;18(2):E75-E90

Recommendations for gonadotoxicity surveillance in male childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group in collaboration with the PanCareSurFup Consortium
Skinner R, Mulder Rl, Kremer Lc, Hudson Mm, Constine Ls, Bardi E, et al
The Lancet. Oncology 2017;18(2):e75-e90

Skeletal outcome in long-term survivors of childhood high-risk neuroblastoma treated with high-dose therapy and autologous stem cell rescue
Utriainen P, Vatanen A, Toiviainen-salo S, Saarinen-pihkala U, Mäkitie O, Jahnukainen K
Bone marrow transplantation 2017;52(5):711-716

State-of-the-art fertility preservation in children and adolescents undergoing haematopoietic stem cell transplantation: a report on the expert meeting of the Paediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT) in Baden, Austria, 29-30 September 2015
Dalle Jh, Lucchini G, Balduzzi A, Ifversen M, Jahnukainen K, Macklon Kt, et al
Bone marrow transplantation 2017;52(7):1029-1035

Acute Myeloid Leukemia in Adolescents and Young Adults Treated in Pediatric and Adult Departments in the Nordic Countries
Swedish Acute Myeloid Leukemia Group, Danish Acute Leukemia Group, Nordic Society Of Paediatric Haematology And Oncology (nopho), Wennström L, Edslev Pw, Abrahamsson J, et al
Pediatric blood & cancer 2016;63(1):83-92

Cardiac function in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study
Nordic Society Of Pediatric Hematology And Oncology (nopho), Jarfelt M, Andersen Nh, Glosli H, Jahnukainen K, Jónmundsson Gk, et al
European journal of haematology 2016;97(1):55-62

Establishing reference values for age-related spermatogonial quantity in prepubertal human testes: a systematic review and meta-analysis
Masliukaite I, Hagen Jm, Jahnukainen K, Stukenborg Jb, Repping S, Van Der Veen F, et al
Fertility and sterility 2016;106(7):1652-1657.e2

Left ventricular mass and ambulatory blood pressure are increased in long-term survivors of childhood cancer after autologous SCT
Vatanen A, Ojala Th, Sarkola T, Turanlahti M, Jahnukainen T, Saarinen-pihkala Um, et al
Bone marrow transplantation 2016;51(6):853-5

Minimal residual disease of leukemia and the quality of cryopreserved human ovarian tissue in vitro
Asadi-azarbaijani B, Sheikhi M, Nurmio M, Tinkanen H, Juvonen V, Dunkel L, et al
Leukemia & lymphoma 2016;57(3):700-7

Residual disease detected by flow cytometry is an independent predictor of survival in childhood acute myeloid leukaemia; results of the NOPHO-AML 2004 study
Tierens A, Bjørklund E, Siitonen S, Marquart Hv, Wulff-juergensen G, Pelliniemi Tt, et al
British journal of haematology 2016;174(4):600-9

Sexual function in male long-term survivors of childhood acute lymphoblastic leukemia
Haavisto A, Henriksson M, Heikkinen R, Puukko-viertomies Lr, Jahnukainen K
Cancer 2016;122(14):2268-76

Trisomy 8 in pediatric acute myeloid leukemia: A NOPHO-AML study
Laursen Acl, Sandahl Jd, Kjeldsen E, Abrahamsson J, Asdahl P, Ha Sy, et al
GENES CHROMOSOMES & CANCER 2016;55(9):719-26

A detailed protocol for a rapid analysis of testicular cell populations using flow cytometry
Rotgers E, Cisneros-montalvo S, Jahnukainen K, Sandholm J, Toppari J, Nurmio M
Andrology 2015;3(5):947-55

Adverse health events and late mortality after pediatric allogeneic hematopoietic SCT-two decades of longitudinal follow-up
Wilhelmsson M, Vatanen A, Borgström B, Gustafsson B, Taskinen M, Saarinen-pihkala Um, et al
Bone marrow transplantation 2015;50(6):850-7

A European perspective on testicular tissue cryopreservation for fertility preservation in prepubertal and adolescent boys
Eshre Task Force On Fertility Preservation In Severe Diseases, Picton Hm, Wyns C, Anderson Ra, Goossens E, Jahnukainen K, et al
Human reproduction (Oxford, England) 2015;30(11):2463-75

Effect of Previous Chemotherapy on the Quality of Cryopreserved Human Ovarian Tissue In Vitro
Asadi Azarbaijani B, Sheikhi M, Oskam Ic, Nurmio M, Laine T, Tinkanen H, et al
PloS one 2015;10(7):e0133985-

High-dose Thiotepa as Consolidation Therapy With Autologous Hematopoietic Stem Cell Transplantation for High-risk Ewing Family Tumors: Single-institution Experience
Jahnukainen K, Kallio P, Koivusalo A, Saarinen-pihkala Um
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 2015;37(7):536-42

Increased Body Adiposity and Serum Leptin Concentrations in Very Long-Term Adult Male Survivors of Childhood Acute Lymphoblastic Leukemia
Jahnukainen K, Heikkinen R, Henriksson M, Andersson S, Ivaska Kk, Puukko-viertomies Lr, et al
Hormone research in paediatrics 2015;84(2):108-15

Radiotherapy-related arterial intima thickening and plaque formation in childhood cancer survivors detected with very-high resolution ultrasound during young adulthood
Vatanen A, Sarkola T, Ojala Th, Turanlahti M, Jahnukainen T, Saarinen-pihkala Um, et al
Pediatric blood & cancer 2015;62(11):2000-6

Repeatability and Agreement of Real Time Three-dimensional Echocardiography Measurements of Left Ventricular Mass and Synchrony in Young Patients
Ojala T, Mathur S, Vatanen A, Sinha Md, Jahnukainen K, Simpson J
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES 2015;32(3):522-7

Testicular function and fertility preservation after treatment for haematological cancer
Jahnukainen K, Mitchell Rt, Stukenborg Jb
Current opinion in endocrinology, diabetes, and obesity 2015;22(3):217-23

The applicability of the WHO classification in paediatric AML. A NOPHO-AML study
Sandahl Jd, Kjeldsen E, Abrahamsson J, Ha Sy, Heldrup J, Jahnukainen K, et al
British journal of haematology 2015;169(6):859-67

Adult testicular volume predicts spermatogenetic recovery after allogeneic HSCT in childhood and adolescence
Wilhelmsson M, Vatanen A, Borgström B, Gustafsson B, Taskinen M, Saarinen-pihkala Um, et al
Pediatric blood & cancer 2014;61(6):1094-100

Assessment of Renal Function During High-Dose Methotrexate Treatment in Children With Acute Lymphoblastic Leukemia
Ylinen E, Jahnukainen K, Saarinen-pihkala Um, Jahnukainen T
PEDIATRIC BLOOD & CANCER 2014;61(12):2199-202

Bortezomib treatment causes long-term testicular dysfunction in young male mice
Hou M, Eriksson E, Svechnikov K, Jahnukainen K, Söder O, Meinhardt A, et al
Molecular cancer 2014;13():155-

Ovarian function after allogeneic hematopoietic stem cell transplantation in childhood and adolescence
Vatanen A, Wilhelmsson M, Borgström B, Gustafsson B, Taskinen M, Saarinen-pihkala Um, et al
European journal of endocrinology 2014;170(2):211-8

Ploidy and clinical characteristics of childhood acute myeloid leukemia: A NOPHO-AML study
Sandahl Jd, Kjeldsen E, Abrahamsson J, Ha Sy, Heldrup J, Jahnukainen K, et al
Genes, chromosomes & cancer 2014;53(8):667-75

Renal, gastrointestinal, and hepatic late effects in survivors of childhood acute myeloid leukemia treated with chemotherapy only--a NOPHO-AML study
Nordic Society Of Pediatric Hematology And Oncology, Skou As, Glosli H, Jahnukainen K, Jarfelt M, Jónmundsson Gk, et al
Pediatric blood & cancer 2014;61(9):1638-43

[Solid tumors in children]
Lohi O, Jahnukainen K, Huttunen P, Taskinen M, Taskinen S, Pakarinen M, et al
Duodecim; laaketieteellinen aikakauskirja 2014;130(20):2050-9

Testicular Function, Semen Quality, and Fertility in Young Men After Renal Transplantation During Childhood or Adolescence
Tainio J, Jahnukainen K, Nurmio M, Pakarinen M, Jalanko H, Jahnukainen T
TRANSPLANTATION 2014;98(9):987-93

Antithrombin deficiency after prolonged asparaginase treatment in children with acute lymphoblastic leukemia
Ranta S, Heyman Mm, Jahnukainen K, Taskinen M, Saarinen-pihkala Um, Frisk T, et al
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2013;24(7):749-56

BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: Treatment response and evidence for nosocomial transmission
Koskenvuo M, Dumoulin A, Lautenschlager I, Auvinen E, Mannonen L, Anttila Vj, et al
JOURNAL OF CLINICAL VIROLOGY 2013;56(1):77-81

Bone marrow remission status predicts leukemia contamination in ovarian biopsies collected for fertility preservation
Jahnukainen K, Tinkanen H, Wikström A, Dunkel L, Saarinen-pihkala Um, Mäkinen S, et al
Leukemia 2013;27(5):1183-5

[Childhood leukemia]
Lohi O, Kanerva J, Taskinen M, Harila-saari A, Rounioja S, Jahnukainen K, et al
Duodecim; laaketieteellinen aikakauskirja 2013;129(9):939-46

Long-term skeletal consequences of childhood acute lymphoblastic leukemia in adult males: a cohort study
Mäkitie O, Heikkinen R, Toiviainen-salo S, Henriksson M, Puukko-viertomies Lr, Jahnukainen K
European journal of endocrinology 2013;168(2):281-8

Outcome of poor response paediatric AML using early SCT
Wareham Ne, Heilmann C, Abrahamsson J, Forestier E, Gustafsson B, Ha Sy, et al
European journal of haematology 2013;90(3):187-94

Potential gonadotoxicity of treatment in relation to quality of life and mental well-being of male survivors of childhood acute lymphoblastic leukemia
Gunn Me, Lähteenmäki Pm, Puukko-viertomies Lr, Henriksson M, Heikkinen R, Jahnukainen K
Journal of cancer survivorship : research and practice 2013;7(3):404-12

Pubertal development and fertility in survivors of childhood acute myeloid leukemia treated with chemotherapy only: a NOPHO-AML study
Nordic Society Of Pediatric Hematology And Oncology, Molgaard-hansen L, Skou As, Juul A, Glosli H, Jahnukainen K, et al
Pediatric blood & cancer 2013;60(12):1988-95

Ultrahigh-risk Group Within the High-risk Neuroblastoma Category
Saarinen-pihkala Um, Jahnukainen K, Wikstrom S, Koivusalo A, Karikoski R, Sariola H, et al
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 2013;35(6):e254-9

Autologous ectopic grafting of cryopreserved testicular tissue preserves the fertility of prepubescent monkeys that receive sterilizing cytotoxic therapy
Jahnukainen K, Ehmcke J, Nurmio M, Schlatt S
Cancer research 2012;72(20):5174-8

Clinical review: Present and future prospects of male fertility preservation for children and adolescents
Jahnukainen K, Stukenborg Jb
The Journal of clinical endocrinology and metabolism 2012;97(12):4341-51

[Effects of cancer treatments on gonads]
Jahnukainen K
Duodecim; laaketieteellinen aikakauskirja 2012;128(8):858-65

Gemtuzumab ozogamicin as postconsolidation therapy does not prevent relapse in children with AML: results from NOPHO-AML 2004
Nordic Society Of Paediatric Haematology And Oncology (nopho), Hasle H, Abrahamsson J, Forestier E, Ha Sy, Heldrup J, et al
Blood 2012;120(5):978-84

High ERG gene expression is an unfavorable prognostic marker in pediatric acute myeloid leukemia Response
Staffas A, Kanduri M, Hovland R, Rosenquist R, Ommen Hb, Abrahamsson J, et al
BLOOD 2012;119(4):1087-1088

Peritubular myoid cells have a role in postnatal testicular growth
Nurmio M, Kallio J, Adam M, Mayerhofer A, Toppari J, Jahnukainen K
Spermatogenesis 2012;2(2):79-87

Thiotepa and melphalan based single, tandem, and triple high dose therapy and autologous stem cell transplantation for high risk neuroblastoma
Saarinen-pihkala Um, Hovi L, Koivusalo A, Jahnukainen K, Karikoski R, Sariola H, et al
PEDIATRIC BLOOD & CANCER 2012;59(7):1190-7

Hedgehog signalling promotes germ cell survival in the rat testis
Makela Ja, Saario V, Bourguiba-hachemi S, Nurmio M, Jahnukainen K, Parvinen M, et al
REPRODUCTION 2011;142(5):711-21

Ontogenesis of Ap-2 gamma Expression in Rat Testes
Hou M, Stukenborg Jb, Nurmio M, Andersson M, Toppari J, Soder O, et al
SEXUAL DEVELOPMENT 2011;5(4):188-96

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia
Nordic Soc Pediat Hematology Oncol, Staffas A, Kanduri M, Hovland R, Rosenquist R, Ommen Hb, et al
BLOOD 2011;118(22):5905-13

Pubertal Development is Normal in Adolescents After Renal Transplantation in Childhood
Tainio J, Qvist E, Vehmas R, Jahnukainen K, Holtta T, Valta H, et al
TRANSPLANTATION 2011;92(4):404-9

Quality of Health in Survivors of Childhood Acute Myeloid Leukemia Treated With Chemotherapy Only: A NOPHO-AML Study
Nordic Soc Pediat Hematology Oncol, Molgaard-hansen L, Glosli H, Jahnukainen K, Jarfelt M, Jonmundsson Gk, et al
PEDIATRIC BLOOD & CANCER 2011;57(7):1222-9

Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats
Nurmio M, Joki H, Kallio J, Maatta Ja, Vaananen Hk, Toppari J, et al
TOXICOLOGY AND APPLIED PHARMACOLOGY 2011;254(3):267-79

Response-Guided Induction Therapy in Pediatric Acute Myeloid Leukemia With Excellent Remission Rate
Abrahamsson J, Forestier E, Heldrup J, Jahnukainen K, Jonsson Og, Lausen B, et al
JOURNAL OF CLINICAL ONCOLOGY 2011;29(3):310-5

Semen quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia
Jahnukainen K, Heikkinen R, Henriksson M, Cooper Tg, Puukko-viertomies Lr, Makitie O
FERTILITY AND STERILITY 2011;96(4):837-42

Testicular function and fertility preservation in male cancer patients
Jahnukainen K, Ehmcke J, Hou M, Schlatt S
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM 2011;25(2):287-302

Testicular recovery after irradiation differs in prepubertal and pubertal non-human primates, and can be enhanced by autologous germ cell transplantation
Jahnukainen K, Ehmcke J, Quader Ma, Huq Ms, Epperly Mw, Hergenrother S, et al
HUMAN REPRODUCTION 2011;26(8):1945-54

Tyrosine kinase inhibition by imatinib mesylate interferes with bone growth and remodellation in rats
Joki H, Nurmio M, Kallio J, Maatta J, Vaananen K, Toppari J, et al
BONE 2011;:S255-S256

Effect of Childhood Acute Lymphoblastic Leukemia Therapy on Spermatogonia Populations and Future Fertility
Nurmio M, Keros V, Lahteenmaki P, Salmi T, Kallajoki M, Jahnukainen K
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2009;94(6):2119-22

Functional in vitro model to examine cancer therapy cytotoxicity in maturing rat testis
Nurmio M, Toppari J, Kallio J, Hou M, Soder O, Jahnukainen K
REPRODUCTIVE TOXICOLOGY 2009;27(1):28-34

Imatinib-treatment disturbs postnatal skeletal development in rats
Nurmio M, Joki H, Kallio J, Maatta J, Toppari J, Jahnukainen K, et al
BONE 2009;44(2):S448-S448

Immunomagnetic separation of normal rat testicular cells from Roser's T-cell leukaemia cells is ineffective
Hou M, Andersson M, Zheng C, Sundblad A, Soder O, Jahnukainen K
INTERNATIONAL JOURNAL OF ANDROLOGY 2009;32(1):66-73

Severe congenital neutropenia and pegfilgrastim
Lahteenmaki Pm, Jahnukainen K, Pelliniemi Tt, Kainulainen L, Salmi Tt
EUROPEAN JOURNAL OF HAEMATOLOGY 2009;82(1):75-6

Testicular Stem Cells for Fertility Preservation: Preclinical Studies on Male Germ Cell Transplantation and Testicular Grafting
Schlatt S, Ehmcke J, Jahnukainen K
PEDIATRIC BLOOD & CANCER 2009;53(2):274-80

Adult reproductive functions after early postnatal inhibition by imatinib of the two receptor tyrosine kinases, c-kit and PDGFR, in the rat testis
Nurmio M, Kallio J, Toppari J, Jahnukainen K
REPRODUCTIVE TOXICOLOGY 2008;25(4):442-6

Age and Prognosis in Pediatric AML
Edslev Pw, Abrahamsson J, Clausen N, Forestier E, Gustafsson G, Heldrup J, et al
BLOOD 2008;112(11):1027-1028

Estrogen receptor beta selective ligand 5 alpha-androstane-3 beta, 17 beta-diol stimulates spermatogonial deoxyribonucleic acid synthesis in rat seminiferous epithelium in vitro
Wahlgren A, Svechnikov K, Strand Ml, Jahnukainen K, Parvinen M, Gustafsson Ja, et al
ENDOCRINOLOGY 2008;149(6):2917-22

Decontamination of leukemic cells and enrichment of germ cells from testicular samples from rats with Roser's T-cell leukemia by flow cytometric sorting
Hou M, Andersson M, Zheng C, Sundblad A, Soeder O, Jahnukainen K
REPRODUCTION 2007;134(6):767-79

Effect of cold storage and cryopreservation of immature non-human primate testicular tissue on spermatogonial stem cell potential in xenografts
Jahnukainen K, Ehmcke J, Hergenrother Sd, Schlatt S
HUMAN REPRODUCTION 2007;22(4):1060-7

Fertility treatment in male cancer survivors - Panel discussion
Haugen Tb, Schmidt Kt, Kvist U, Skakkebaek Ne, Jahnukainen K, Krausz C, et al
INTERNATIONAL JOURNAL OF ANDROLOGY 2007;30(4):418-419

Gemtuzumab ozagamicin is well tolerated as post-consolidation therapy in childhood AML
Hasle H, Abrahamsson J, Clausen N, Forestier E, Gustafsson G, Heldrup J, et al
BLOOD 2007;110(11):160B-160B

Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib mesylate interferes with postnatal testicular development in the rat
Nurmio M, Toppari J, Zaman F, Andersson Am, Paranko J, Soeder O, et al
INTERNATIONAL JOURNAL OF ANDROLOGY 2007;30(4):366-76

Irradiation causes acute and long-term spermatogonial depletion in cultured and xenotransplanted testicular tissue from juvenile nonhuman primates
Jahnukainen K, Ehmcke J, Nurmio M, Schlatt S
ENDOCRINOLOGY 2007;148(11):5541-8

Methods of cryopreservation of testicular tissue with viable spermatogonia in pre-pubertal boys undergoing gonadotoxic cancer treatment
Keros V, Hultenby K, Borgstrom B, Fridstrom M, Jahnukainen K, Hovattal O
HUMAN REPRODUCTION 2007;22(5):1384-95

Xenotransplantation of testicular tissue into nude mice can be used for detecting leukemic cell contamination
Hou M, Andersson M, Eksborg S, Soder O, Jahnukainen K
HUMAN REPRODUCTION 2007;22(7):1899-906

Clinical potential and putative risks of fertility preservation in children utilizing gonadal tissue or germline stem cells
Jahnukainen K, Ehmcke J, Soder O, Schlatt S
PEDIATRIC RESEARCH 2006;59(4):40R-7R

Testicular xenografts: A novel approach to study cytotoxic damage in juvenile primate testis
Jahnukainen K, Ehmcke J, Schlatt S
CANCER RESEARCH 2006;66(7):3813-8

Doxorubicin induces apoptosis in germ line stem cells in the immature rat testis and amifostine cannot protect against this cytotoxicity
Hou M, Chrysis D, Nurmio M, Parvinen M, Eksborg S, Soder O, et al
CANCER RESEARCH 2005;65(21):9999-10005

Increased apoptosis occurring during the first wave of spermatogenesis is stage-specific and primarily affects midpachytene spermatocytes in the rat testis
Jahnukainen K, Chrysis D, Hou M, Parvinen M, Eksborg S, Soder O
BIOLOGY OF REPRODUCTION 2004;70(2):290-6

EGF stimulates rat spermatogonial DNA synthesis in seminiferous tubule segments in vitro
Wahab-wahlgren A, Martinelle N, Holst M, Jahnukainen K, Parvinen M, Soder O
MOLECULAR AND CELLULAR ENDOCRINOLOGY 2003;201(1-2):39-46

Testicular function after cancer treatment in childhood
Jahnukainen K, Söder O
Endocrine development 2003;5():124-35

Induced leukemia and antineoplastic agent carmustine cause permanent changes in craniofacial growth of immature rats
Karsila-tenovuo S, Jahnukainen K, Peltomäki T, Salmi Tt, Rönning O
Orthodontics & craniofacial research 2002;5(3):131-9

Amifostine protects against early but not late toxic effects of doxorubicin in infant rats
Jahnukainen K, Jahnukainen T, Salmi Tt, Svechnikov K, Eksborg S, Soder O
CANCER RESEARCH 2001;61(17):6423-7

Disturbances in craniofacial morphology in children treated for solid tumors
Karsila-tenovuo S, Jahnukainen K, Peltomaki T, Minn H, Kulmala J, Salmi Tt, et al
ORAL ONCOLOGY 2001;37(7):586-92

Intratesticular transplantation of testicular cells from leukemic rats causes transmission of leukemia
Jahnukainen K, Hou M, Petersen C, Setchell B, Soder O
CANCER RESEARCH 2001;61(2):706-10

Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis
Ericson Kg, Fadeel B, Nilsson-ardnor S, Soderhall C, Samuelsson A, Janka G, et al
AMERICAN JOURNAL OF HUMAN GENETICS 2001;68(3):590-7

Catch-up growth and craniofacial dimensions following administration of the antineoplastic agent vincristine to young rats
Karsila S, Jahnukainen K, Salmi Tt, Ronning O
EUROPEAN JOURNAL OF ORAL SCIENCES 2000;108(5):426-31

Stage-specific inhibition of deoxyribonucleic acid synthesis and induction of apoptosis by antracyclines in cultured rat spermatogenic cells
Jahnukainen K, Hou M, Parvinen M, Eksborg S, Soder O
BIOLOGY OF REPRODUCTION 2000;63(2):482-7

[Where did the blood cells vanish?]
Eerola A, Pietilä S, Jahnukainen K, Routi T, Salmi Tt
Duodecim; laaketieteellinen aikakauskirja 1999;115(2):131-5

The clinical indications for identical pathogenesis of isolated and non-isolated testicular relapses in acute lymphoblastic leukaemia
Jahnukainen K, Salmi Tt, Kristinsson J, Muller J, Madsen B, Gustafsson G
ACTA PAEDIATRICA 1998;87(6):638-43

Autoantigenicity of the basal compartment of seminiferous tubules in the rat
Saari T, Jahnukainen K, Pollanen P
JOURNAL OF REPRODUCTIVE IMMUNOLOGY 1996;31(1-2):65-79

ACUTE LYMPHOBLASTIC-LEUKEMIA IN RATS INDUCES PATHOMORPHOLOGICAL CHANGES IN GERM-CELLS
Yagi A, Jahnukainen K, Paranko J
ANDROLOGIA 1995;27(5):267-73

EFFECTS OF TESTICULAR CYTOKINES ON PROLIFERATION OF RAT T-LEUKEMIC LYMPHOBLASTS IN-VITRO
Jahnukainen K, Attermo P, Saari T, Salmi Tt, Voneuler M, Pollanen P, et al
JOURNAL OF REPRODUCTIVE IMMUNOLOGY 1995;28(3):263-73

Incidence of testicular mononuclear cell infiltrates in normal human males and in patients with germ cell neoplasia
Jahnukainen K, Jorgensen N, Pollanen P, Giwercman A, Skakkebaek Ne
INTERNATIONAL JOURNAL OF ANDROLOGY 1995;18(6):313-20

REACTIONS OF LEYDIG-CELLS AND BLOOD-VESSELS TO LYMPHOBLASTIC-LEUKEMIA IN THE RAT TESTIS
Jahnukainen K, Saari T, Salmi Tt, Pollanen P, Pelliniemi Lj
LEUKEMIA 1995;9(5):908-14

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