Kenneth Chien

About me
Publications
Public outreach and news

About me

Professor of Cardiovascular Research.

Articles

Article: MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT. 2024;32(2):101225
Endovascular transplantation of mRNA-enhanced mesenchymal stromal cells results in superior therapeutic protein expression in swine heart
Al-Saadi J; Walden M; Sandell M; Sohlmer J; Grankvist R; Friberger I; Andersson A; Carlsten M; Chien K; Lundberg J; Witman N; Holmin S
Article: NATURE COMMUNICATIONS. 2024;15(1):167
Derivation of human primordial germ cell-like cells in an embryonic-like culture
Esfahani SN; Zheng Y; Arabpour A; Irizarry AMR; Kobayashi N; Xue X; Shao Y; Zhao C; Agranonik NL; Sparrow M; Hunt TJ; Faith J; Lara MJ; Wu QY; Silber S; Petropoulos S; Yang R; Chien KR; Clark AT; Fu J
Article: NATURE COMMUNICATIONS. 2023;14(1):5435
Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development
Witman N; Zhou C; Haeneke T; Xiao Y; Huang X; Rohner E; Sohlmer J; Grote Beverborg N; Chien KR; Sahara M
Article: MOLECULAR THERAPY. 2023;31(3):866-874
Direct intramyocardial injection of VEGF mRNA in patients undergoing coronary artery bypass grafting
Anttila V; Saraste A; Knuuti J; Hedman M; Jaakkola P; Laugwitz K-L; Krane M; Jeppsson A; Sillanmaeki S; Rosenmeier J; Zingmark P; Rudvik A; Garkaviy P; Watson C; Pangalos MN; Chien KR; Fritsche-Danielson R; Collen A; Gan L-M
Article: MOLECULAR THERAPY. 2023;31(1):211-229
Transient secretion of VEGF protein from transplanted hiPSC-CMs enhances engraftment and improves rat heart function post MI
Ai X; Yan B; Witman N; Gong Y; Yang L; Tan Y; Chen Y; Liu M; Lu T; Luo R; Wang H; Chien KR; Wang W; Fu W
Article: CELL STEM CELL. 2022;29(9):1402-1419.e8
Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development
Zheng Y; Yan RZ; Sun S; Kobayashi M; Xiang L; Yang R; Goedel A; Kang Y; Xue X; Esfahani SN; Liu Y; Irizarry AMR; Wu W; Li Y; Ji W; Niu Y; Chien KR; Li T; Shioda T; Fu J
Article: NATURE COMMUNICATIONS. 2022;13(1):3018
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure.
De Genst E; Foo KS; Xiao Y; Rohner E; de Vries E; Sohlmér J; Witman N; Hidalgo A; Kolstad TRS; Louch WE; Pehrsson S; Park A; Ikeda Y; Li X; Mayr LM; Wickson K; Jennbacken K; Hansson K; Fritsche-Danielson R; Hunt J; Chien KR
Article: NATURE CELL BIOLOGY. 2022;24(5):645-658
Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders
Eroglu E; Yen CYT; Tsoi Y-L; Witman N; Elewa A; Araus AJ; Wang H; Szattler T; Umeano CH; Sohlmer J; Goedel A; Simon A; Chien KR
Article: NATURE CELL BIOLOGY. 2022;24(5):659-671
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors.
Poch CM; Foo KS; De Angelis MT; Jennbacken K; Santamaria G; Bähr A; Wang Q-D; Reiter F; Hornaschewitz N; Zawada D; Bozoglu T; My I; Meier A; Dorn T; Hege S; Lehtinen ML; Tsoi YL; Hovdal D; Hyllner J; Schwarz S; Sudhop S; Jurisch V; Sini M; Fellows MD; Cummings M; Clarke J; Baptista R; Eroglu E; Wolf E; Klymiuk N; Lu K; Tomasi R; Dendorfer A; Gaspari M; Parrotta E; Cuda G; Krane M; Sinnecker D; Hoppmann P; Kupatt C; Fritsche-Danielson R; Moretti A; Chien KR; Laugwitz K-L
Article: JCI INSIGHT. 2022;7(2):e152198
Sequencing of a Chinese tetralogy of Fallot cohort reveals clustering mutations in myogenic heart progenitors
Tang CSM; Mononen M; Lam W-Y; Jin SC; Zhuang X; Garcia-Barcelo M-M; Lin Q; Yang Y; Sahara M; Eroglu E; Chien KR; Hong H; Tam PKH; Gruber PJ
Article: MOLECULAR MEDICINE. 2021;27(1):102
An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation.
Rohner E; Witman N; Sohlmer J; De Genst E; Louch WE; Sahara M; Chien KR
Article: NATURE COMMUNICATIONS. 2021;12(1):5180
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy.
Grote Beverborg N; Später D; Knöll R; Hidalgo A; Yeh ST; Elbeck Z; Silljé HHW; Eijgenraam TR; Siga H; Zurek M; Palmér M; Pehrsson S; Albery T; Bomer N; Hoes MF; Boogerd CJ; Frisk M; van Rooij E; Damle S; Louch WE; Wang Q-D; Fritsche-Danielson R; Chien KR; Hansson KM; Mullick AE; de Boer RA; van der Meer P
Article: NATURE COMMUNICATIONS. 2021;12(1):5126
Amnion signals are essential for mesoderm formation in primates
Yang R; Goedel A; Kang Y; Si C; Chu C; Zheng Y; Chen Z; Gruber PJ; Xiao Y; Zhou C; Witman N; Leung C-Y; Chen Y; Fu J; Ji W; Lanner F; Niu Y; Chien K
Article: STAR PROTOCOLS. 2021;2(1):100339
Isolation of human ESC-derived cardiac derivatives and embryonic heart cells for population and single-cell RNA-seq analysis
Santoro F; Chenion KR; Sahara M
Article: COMMUNICATIONS BIOLOGY. 2021;4(1):82
BMP-2 and VEGF-A modRNAs in collagen scaffold synergistically drive bone repair through osteogenic and angiogenic pathways
Geng Y; Duan H; Xu L; Witman N; Yan B; Yu Z; Wang H; Tan Y; Lin L; Li D; Bai S; Fritsche-Danielson R; Yuan J; Chien K; Wei M; Fu W
Article: STEM CELLS. 2020;38(10):1267-1278
Trajectory mapping of human embryonic stem cell cardiogenesis reveals lineage branch points and an ISL1 progenitor-derived cardiac fibroblast lineage.
Mononen MM; Leung CY; Xu J; Chien KR
Article: CPT: PHARMACOMETRICS AND SYSTEMS PHARMACOLOGY. 2020;9(7):384-394
Model-Based Analysis Reveals a Sustained and Dose-Dependent Acceleration of Wound Healing by VEGF-A mRNA (AZD8601)
Almquist J; Rikard SM; Wagberg M; Bruce AC; Gennemark P; Fritsche-Danielson R; Chien KR; Peirce SM; Hansson K; Lundahl A
Article: STEM CELLS. 2020;38(6):741-755
Genome-wide CRISPR screen identifies ZIC2 as an essential gene that controls the cell fate of early mesodermal precursors to human heart progenitors.
Xu J; Zhou C; Foo KS; Yang R; Xiao Y; Bylund K; Sahara M; Chien KR
Article: JOURNAL OF INTERNAL MEDICINE. 2019;285(4):398-406
Superselective endovascular tissue access using trans-vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine
Grankvist R; Jensen-Urstad M; Clarke J; Lehtinen M; Little P; Lundberg J; Arnberg F; Jonsson S; Chien KR; Holmin S
Article: NATURE BIOTECHNOLOGY. 2019;37(3):232-237
Regenerating the field of cardiovascular cell therapy
Chien KR; Frisen J; Fritsche-Danielson R; Melton DA; Murry CE; Weissman IL
Article: DEVELOPMENTAL CELL. 2019;48(4):475-490.e7
Population and Single-Cell Analysis of Human Cardiogenesis Reveals Unique LGR5 Ventricular Progenitors in Embryonic Outflow Tract.
Sahara M; Santoro F; Sohlmér J; Zhou C; Witman N; Leung CY; Mononen M; Bylund K; Gruber P; Chien KR
Article: NATURE COMMUNICATIONS. 2019;10(1):871
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
Gan L-M; Lagerstrom-Fermer M; Carlsson LG; Arfvidsson C; Egnell A-C; Rudvik A; Kjaer M; Collen A; Thompson JD; Joyal J; Chialda L; Koernicke T; Fuhr R; Chien KR; Fritsche-Danielson R
Article: STEM CELLS. 2019;37(2):216-225
SMAD4 Is Essential for Human Cardiac Mesodermal Precursor Cell Formation
Xu J; Gruber PJ; Chien KR
Article: SCIENTIFIC REPORTS. 2018;8(1):17509
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing
Sun N; Ning B; Hansson KM; Bruce AC; Seaman SA; Zhang C; Rikard M; DeRosa CA; Fraser CL; Wagberg M; Fritsche-Danielson R; Wikstrom J; Chien KR; Lundahl A; Holtta M; Carlsson LG; Peirce SM; Hu S
Article: MOLECULAR THERAPY. 2018;26(7):1644-1659
Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.
Foo KS; Lehtinen ML; Leung CY; Lian X; Xu J; Keung W; Geng L; Kolstad TRS; Thams S; Wong AO-T; Wong N; Bylund K; Zhou C; He X; Jin S-B; Clarke J; Lendahl U; Li RA; Louch WE; Chien KR
Article: MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT. 2018;9:330-346
Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine
Carlsson L; Clarke JC; Yen C; Gregoire F; Albery T; Billger M; Egnell A-C; Gan L-M; Jennbacken K; Johansson E; Linhardt G; Martinsson S; Sadiq MW; Witman N; Wang Q-D; Chen C-H; Wang Y-P; Lin S; Ticho B; Hsieh PCH; Chien KR; Fritsche-Danielson R
Article: GASTROENTEROLOGY. 2018;154(4):1080-1095
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Andersson ER; Chivukula IV; Hankeova S; Sjoqvist M; Tsoi YL; Ramskold D; Masek J; Elmansuri A; Hoogendoorn A; Vazquez E; Storvall H; Netusilova J; Huch M; Fischler B; Ellis E; Contreras A; Nemeth A; Chien KC; Clevers H; Sandberg R; Bryja V; Lendahl U
Article: CIRCULATION. 2017;135(1):59-72
Insulin-Like Growth Factor 1 Receptor-Dependent Pathway Drives Epicardial Adipose Tissue Formation After Myocardial Injury
Zangi L; Oliveira MS; Ye LY; Ma Q; Sultana N; Hadas Y; Chepurko E; Spater D; Zhou B; Chew WL; Ebina W; Abrial M; Wang Q-D; Pu WT; Chien KR
Article: NATURE COMMUNICATIONS. 2016;7:10774
Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
Soh B-S; Ng S-Y; Wu H; Buac K; Park J-HC; Lian X; Xu J; Foo KS; Felldin U; He X; Nichane M; Yang H; Bu L; Li RA; Lim B; Chien KR
Article: NATURE COMMUNICATIONS. 2014;5:5629
Tolerance induction to human stem cell transplants with extension to their differentiated progeny
Lui KO; Howie D; Ng S-W; Liu S; Chien KR; Waldmann H
Article: DEVELOPMENT. 2014;141(23):4418-4431
How to make a cardiomyocyte
Spaeter D; Hansson EM; Zangi L; Chien KR
Article: CELL RESEARCH. 2014;24(12):1420-1432
N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment
Soh B-S; Buac K; Xu H; Li E; Ng S-Y; Wu H; Chmielowiec J; Jiang X; Bu L; Li RA; Cowan C; Chien KR
Article: CELL REPORTS. 2014;9(3):810-821
Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells
Drawnel FM; Boccardo S; Prummer M; Delobel F; Graff A; Weber M; Gerard R; Badi L; Kam-Thong T; Bu L; Jiang X; Hoflack J-C; Kiialainen A; Jeworutzki E; Aoyama N; Carlson C; Burcin M; Gromo G; Boehringer M; Stahlberg H; Hall BJ; Magnone MC; Kolaja K; Chien KR; Bailly J; Iacone R
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2014;5(1):a014035
Synthetic Chemically Modified mRNA (modRNA): Toward a New Technology Platform for Cardiovascular Biology and Medicine
Chien KR; Zangi L; Lui KO
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2014;4(12):a013920
Next-Generation Models of Human Cardiogenesis via Genome Editing
Lian X; Xu J; Li J; Chien KR
Article: CELL RESEARCH. 2014;24(7):820-841
Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells
Sahara M; Hansson EM; Wernet O; Lui KO; Spaeter D; Chien KR
Article: NATURE MEDICINE. 2014;20(6):616-623
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
Wang G; McCain ML; Yang L; He A; Pasqualini FS; Agarwal A; Yuan H; Jiang D; Zhang D; Zangi L; Geva J; Roberts AE; Ma Q; Ding J; Chen J; Wang D-Z; Li K; Wang J; Wanders RJA; Kulik W; Vaz FM; Laflamme MA; Murry CE; Chien KR; Kelley RI; Church GM; Parker KK; Pu WT
Article: PLOS ONE. 2014;9(4):e93638
The Muscle Ankyrin Repeat Proteins CARP, Ankrd2, and DARP Are Not Essential for Normal Cardiac Development and Function at Basal Conditions and in Response to Pressure Overload
Bang M-L; Gu Y; Dalton ND; Peterson KL; Chien KR; Chen J
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2013;3(10):a013847
Embryonic Heart Progenitors and Cardiogenesis
Brade T; Pane LS; Moretti A; Chien KR; Laugwitz K-L
Article: CELL RESEARCH. 2013;23(10):1172-1186
Driving vascular endothelial cell fate of human multipotent Isl1⁺ heart progenitors with VEGF modified mRNA
Lui KO; Zangi L; Silva EA; Bu L; Sahara M; Li RA; Mooney DJ; Chien KR
Article: NATURE BIOTECHNOLOGY. 2013;31(10):898-907
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
Zangi L; Lui KO; von Gise A; Ma Q; Ebina W; Ptaszek LM; Spater D; Xu H; Tabebordbar M; Gorbatov R; Sena B; Nahrendorf M; Briscoe DM; Li RA; Wagers AJ; Rossi DJ; Pu WT; Chien KR
Article: COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. 2013;3(9):a014050
Direct Cardiomyocyte Reprogramming: A New Direction for Cardiovascular Regenerative Medicine
Yi BA; Mummery CL; Chien KR
Article: NATURE CELL BIOLOGY. 2013;15(9):1098-1106
A HCN4+cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells
Spaeter D; Abramczuk MK; Buac K; Zangi L; Stachel MW; Clarke J; Sahara M; Ludwig A; Chien KR
Article: THE LANCET. 2012;379(9819):933-942
Towards regenerative therapy for cardiac disease.
Ptaszek LM; Mansour M; Ruskin JN; Chien KR
Article: CELL RESEARCH. 2012;22(1):142-154
Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature.
Xu H; Yi BA; Wu H; Bock C; Gu H; Lui KO; Park J-HC; Shao Y; Riley AK; Domian IJ; Hu E; Willette R; Lepore J; Meissner A; Wang Z; Chien KR
Article: CIRCULATION RESEARCH. 2011;109(7):758-769
Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart
Knoell R; Linke WA; Zou P; Miocic S; Kostin S; Buyandelger B; Ku C-H; Neef S; Bug M; Schaefer K; Knoell G; Felkin LE; Wessels J; Toischer K; Hagn F; Kessler H; Didie M; Quentin T; Maier LS; Teucher N; Unsoeld B; Schmidt A; Birks EJ; Gunkel S; Lang P; Granzier H; Zimmermann W-H; Field LJ; Faulkner G; Dobbelstein M; Barton PJR; Sattler M; Wilmanns M; Chien KR
Article: CARDIOVASCULAR RESEARCH (CVR). 2011;91(2):289-299
Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation.
Terada R; Warren S; Lu JT; Chien KR; Wessels A; Kasahara H
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2011;50(2):337-345
Cardiac origin of smooth muscle cells in the inflow tract.
Nakano H; Williams E; Hoshijima M; Sasaki M; Minamisawa S; Chien KR; Nakano A
Article: NATURE BIOTECHNOLOGY. 2010;28(6):611-615
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
Rodin S; Domogatskaya A; Strom S; Hansson EM; Chien KR; Inzunza J; Hovatta O; Tryggvason K
Article: CIRCULATION RESEARCH. 2010;106(4):695-704
A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy
Knoell R; Kostin S; Klede S; Savvatis K; Klinge L; Stehle I; Gunkel S; Koetter S; Babicz K; Sohns M; Miocic S; Didie M; Knoell G; Zimmermann WH; Thelen P; Bickeboeller H; Maier LS; Schaper W; Schaper J; Kraft T; Tschoepe C; Linke WA; Chien KR
Article: SCIENCE. 2009;326(5951):426-429
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells.
Domian IJ; Chiravuri M; van der Meer P; Feinberg AW; Shi X; Shao Y; Wu SM; Parker KK; Chien KR
Article: LABORATORY INVESTIGATION. 2009;89(9):983-993
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation.
Takeda M; Briggs LE; Wakimoto H; Marks MH; Warren SA; Lu JT; Weinberg EO; Robertson KD; Chien KR; Kasahara H
Article: CELL CALCIUM. 2009;46(3):219-225
Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models.
Andersson KB; Finsen AV; Sjåland C; Winer LH; Sjaastad I; Odegaard A; Louch WE; Wang Y; Chen J; Chien KR; Sejersted OM; Christensen G
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2009;47(2):180-187
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene.
Andersson KB; Birkeland JAK; Finsen AV; Louch WE; Sjaastad I; Wang Y; Chen J; Molkentin JD; Chien KR; Sejersted OM; Christensen G
Article: NATURE. 2009;460(7251):113-117
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages.
Bu L; Jiang X; Martin-Puig S; Caron L; Zhu S; Shao Y; Roberts DJ; Huang PL; Domian IJ; Chien KR
Article: DEVELOPMENT. 2009;136(3):495-505
Prox1 maintains muscle structure and growth in the developing heart.
Risebro CA; Searles RG; Melville AAD; Ehler E; Jina N; Shah S; Pallas J; Hubank M; Dillard M; Harvey NL; Schwartz RJ; Chien KR; Oliver G; Riley PR
Article: HUMAN MOLECULAR GENETICS. 2008;17(18):2753-2765
Beyond the sarcomere: CSRP3 mutations cause hypertrophic cardiomyopathy.
Geier C; Gehmlich K; Ehler E; Hassfeld S; Perrot A; Hayess K; Cardim N; Wenzel K; Erdmann B; Krackhardt F; Posch MG; Osterziel KJ; Bublak A; Nägele H; Scheffold T; Dietz R; Chien KR; Spuler S; Fürst DO; Nürnberg P; Ozcelik C
Article: CIRCULATION RESEARCH. 2008;103(6):580-590
Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects.
Briggs LE; Takeda M; Cuadra AE; Wakimoto H; Marks MH; Walker AJ; Seki T; Oh SP; Lu JT; Sumners C; Raizada MK; Horikoshi N; Weinberg EO; Yasui K; Ikeda Y; Chien KR; Kasahara H
Article: NATURE. 2008;454(7200):109-113
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart.
Zhou B; Ma Q; Rajagopal S; Wu SM; Domian I; Rivera-Feliciano J; Jiang D; von Gise A; Ikeda S; Chien KR; Pu WT
Article: CIRCULATION RESEARCH. 2008;102(5):571-580
Identification of cardiac-specific myosin light chain kinase.
Chan JY; Takeda M; Briggs LE; Graham ML; Lu JT; Horikoshi N; Weinberg EO; Aoki H; Sato N; Chien KR; Kasahara H
Article: NATURE BIOTECHNOLOGY. 2008;26(3):313-315
Marked differences in differentiation propensity among human embryonic stem cell lines.
Osafune K; Caron L; Borowiak M; Martinez RJ; Fitz-Gerald CS; Sato Y; Cowan CA; Chien KR; Melton DA
Article: CELL. 2008;132(4):537-543
Origins and fates of cardiovascular progenitor cells.
Wu SM; Chien KR; Mummery C
Article: CIRCULATION JOURNAL. 2007;71(12):1958-1964
Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice.
Yamamoto R; Akazawa H; Ito K; Toko H; Sano M; Yasuda N; Qin Y; Kudo Y; Sugaya T; Chien KR; Komuro I
Article: CELL STEM CELL. 2007;1(2):165-179
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway.
Qyang Y; Martin-Puig S; Chiravuri M; Chen S; Xu H; Bu L; Jiang X; Lin L; Granger A; Moretti A; Caron L; Wu X; Clarke J; Taketo MM; Laugwitz K-L; Moon RT; Gruber P; Evans SM; Ding S; Chien KR
Article: CIRCULATION. 2007;116(5):515-525
Laminin-α4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells
Knoell R; Postel R; Wang J; Kraetzner R; Hennecke G; Vacaru AM; Vakeel P; Schubert C; Murthy K; Rana BK; Kube D; Knoell G; Schaefer K; Hayashi T; Holm T; Kimura A; Schork N; Toliat MR; Nuernberg P; Schultheiss H-P; Schaper W; Schaper J; Bos E; Den Hertog J; van Eeden FJM; Peters PJ; Hasenfuss G; Chien KR; Bakkers J
Article: EMBO JOURNAL. 2007;26(14):3283-3295
Latent TGF-beta-binding protein 2 binds to DANCE/fibulin-5 and regulates elastic fiber assembly.
Hirai M; Horiguchi M; Ohbayashi T; Kita T; Chien KR; Nakamura T
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2007;50(3):253-260
Percutaneous cardiac recirculation-mediated gene transfer of an inhibitory phospholamban peptide reverses advanced heart failure in large animals.
Kaye DM; Preovolos A; Marshall T; Byrne M; Hoshijima M; Hajjar R; Mariani JA; Pepe S; Chien KR; Power JM
Article: MOLECULAR BIOLOGY OF THE CELL. 2007;18(5):1723-1733
The cytoskeleton-associated PDZ-LIM protein, ALP, acts on serum response factor activity to regulate muscle differentiation.
Pomiès P; Pashmforoush M; Vegezzi C; Chien KR; Auffray C; Beckerle MC
Article: JOURNAL OF CELL BIOLOGY. 2007;176(7):1061-1071
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo.
Hirai M; Ohbayashi T; Horiguchi M; Okawa K; Hagiwara A; Chien KR; Kita T; Nakamura T
Article: CELL. 2007;128(5):947-959
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.
Prall OWJ; Menon MK; Solloway MJ; Watanabe Y; Zaffran S; Bajolle F; Biben C; McBride JJ; Robertson BR; Chaulet H; Stennard FA; Wise N; Schaft D; Wolstein O; Furtado MB; Shiratori H; Chien KR; Hamada H; Black BL; Saga Y; Robertson EJ; Buckingham ME; Harvey RP
Article: CARDIOVASCULAR RESEARCH (CVR). 2007;73(4):739-749
Spatial distributions of Kv4 channels and KChip2 isoforms in the murine heart based on laser capture microdissection.
Teutsch C; Kondo RP; Dederko DA; Chrast J; Chien KR; Giles WR
Article: NATURE. 2007;445(7124):177-182
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.
Smart N; Risebro CA; Melville AAD; Moses K; Schwartz RJ; Chien KR; Riley PR
Article: CELL. 2006;127(6):1151-1165
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification.
Moretti A; Caron L; Nakano A; Lam JT; Bernshausen A; Chen Y; Qyang Y; Bu L; Sasaki M; Martin-Puig S; Sun Y; Evans SM; Laugwitz K-L; Chien KR
Article: CIRCULATION. 2006;114(22):2364-2373
Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling.
Yajima T; Yasukawa H; Jeon E-S; Xiong D; Dorner A; Iwatate M; Nara M; Zhou H; Summers-Torres D; Hoshijima M; Chien KR; Yoshimura A; Knowlton KU
Article: CIRCULATION RESEARCH. 2006;99(7):749-757
Reduced cardiac L-type Ca2+ current in Ca(V)beta2-/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation.
Weissgerber P; Held B; Bloch W; Kaestner L; Chien KR; Fleischmann BK; Lipp P; Flockerzi V; Freichel M
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2006;80(4):850-861
Normal hematopoiesis after conditional targeting of RXRalpha in murine hematopoietic stem/progenitor cells.
Ricote M; Snyder CS; Leung H-Y; Chen J; Chien KR; Glass CK
Article: DEVELOPMENTAL BIOLOGY. 2006;291(2):208-217
Distinct roles of HF-1b/Sp4 in ventricular and neural crest cells lineages affect cardiac conduction system development.
St Amand TR; Lu JT; Zamora M; Gu Y; Stricker J; Hoshijima M; Epstein JA; Ross JJ; Ruiz-Lozano P; Chien KR
Article: JOURNAL OF PHYSIOLOGY. 2006;571(Pt 1):131-146
Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform.
Kondo RP; Dederko DA; Teutsch C; Chrast J; Catalucci D; Chien KR; Giles WR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(1):213-220
Cardiomyopathy associated with microcirculation dysfunction in laminin α 4 chain-deficient mice
Wang JM; Hoshijima M; Lam J; Zhou ZJ; Jokiel A; Dalton ND; Hultenby K; Ruiz-Lozano P; Ross J; Tryggvason K; Chien KR
Article: SCIENTIST. 2006;20(8):34-39
Making a play at regrowing hearts
Chien K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(51):18455-18460
Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation.
Merki E; Zamora M; Raya A; Kawakami Y; Wang J; Zhang X; Burch J; Kubalak SW; Kaliman P; Izpisua Belmonte JC; Chien KR; Ruiz-Lozano P
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2005;39(2):241-250
Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy.
Lorenzen-Schmidt I; Stuyvers BD; ter Keurs HEDJ; Date M-O; Hoshijima M; Chien KR; McCulloch AD; Omens JH
Article: MOLECULAR PSYCHIATRY. 2005;10(4):393-406
Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization.
Zhou X; Long JM; Geyer MA; Masliah E; Kelsoe JR; Wynshaw-Boris A; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(9):8016-8021
Myotonic dystrophy protein kinase phosphorylates phospholamban and regulates calcium uptake in cardiomyocyte sarcoplasmic reticulum.
Kaliman P; Catalucci D; Lam JT; Kondo R; Gutiérrez JCP; Reddy S; Palacín M; Zorzano A; Chien KR; Ruiz-Lozano P
Article: NATURE. 2005;433(7026):647-653
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages.
Laugwitz K-L; Moretti A; Lam J; Gruber P; Chen Y; Woodard S; Lin L-Z; Cai C-L; Lu MM; Reth M; Platoshyn O; Yuan JX-J; Evans S; Chien KR
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;325(3):852-856
Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies.
Minamisawa S; Oshikawa J; Takeshima H; Hoshijima M; Wang Y; Chien KR; Ishikawa Y; Matsuoka R
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2004;44(11):2192-2201
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy
Hayashi T; Arimura T; Itoh-Satoh M; Ueda K; Hohda S; Inagaki N; Takahashi M; Hori H; Yasunami M; Nishi H; Koga Y; Nakamura H; Matsuzaki M; Choi BY; Bae SW; You CW; Han KH; Park JE; Knöll R; Hoshijima M; Chien KR; Kimura A
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(24):10611-10620
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.
Nishida K; Yamaguchi O; Hirotani S; Hikoso S; Higuchi Y; Watanabe T; Takeda T; Osuka S; Morita T; Kondoh G; Uno Y; Kashiwase K; Taniike M; Nakai A; Matsumura Y; Miyazaki J-I; Sudo T; Hongo K; Kusakari Y; Kurihara S; Chien KR; Takeda J; Hori M; Otsu K
Article: EMBO JOURNAL. 2004;23(22):4517-4525
Small proline-rich protein 1A is a gp130 pathway- and stress-inducible cardioprotective protein.
Pradervand S; Yasukawa H; Muller OG; Kjekshus H; Nakamura T; St Amand TR; Yajima T; Matsumura K; Duplain H; Iwatate M; Woodard S; Pedrazzini T; Ross J; Firsov D; Rossier BC; Hoshijima M; Chien KR
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(21):9414-9423
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function.
Conrad M; Jakupoglu C; Moreno SG; Lippl S; Banjac A; Schneider M; Beck H; Hatzopoulos AK; Just U; Sinowatz F; Schmahl W; Chien KR; Wurst W; Bornkamm GW; Brielmeier M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(7):937-943
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
Yamaguchi O; Watanabe T; Nishida K; Kashiwase K; Higuchi Y; Takeda T; Hikoso S; Hirotani S; Asahi M; Taniike M; Nakai A; Tsujimoto I; Matsumura Y; Miyazaki J-I; Chien KR; Matsuzawa A; Sadamitsu C; Ichijo H; Baccarini M; Hori M; Otsu K
Article: CARDIOVASCULAR RESEARCH (CVR). 2004;63(4):611-616
Genetic depletion of cardiac myocyte STAT-3 abolishes classical preconditioning.
Smith RM; Suleman N; Lacerda L; Opie LH; Akira S; Chien KR; Sack MN
Article: CARDIOVASCULAR RESEARCH (CVR). 2004;63(2):293-304
Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice
Carrier L; Knöll R; Vignier N; Keller DI; Bausero P; Prudhon B; Isnard R; Ambroisine ML; Fiszman M; Ross J; Schwartz K; Chien KR
Article: NATURE MEDICINE. 2004;10(7):739-743
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.
Mori H; Hanada R; Hanada T; Aki D; Mashima R; Nishinakamura H; Torisu T; Chien KR; Yasukawa H; Yoshimura A
Article: DEVELOPMENT. 2004;131(9):2219-2231
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis.
Chen H; Shi S; Acosta L; Li W; Lu J; Bao S; Chen Z; Yang Z; Schneider MD; Chien KR; Conway SJ; Yoder MC; Haneline LS; Franco D; Shou W
Article: CELL. 2004;117(3):373-386
Nkx2-5 pathways and congenital heart disease; loss of ventricular myocyte lineage specification leads to progressive cardiomyopathy and complete heart block.
Pashmforoush M; Lu JT; Chen H; Amand TS; Kondo R; Pradervand S; Evans SM; Clark B; Feramisco JR; Giles W; Ho SY; Benson DW; Silberbach M; Shou W; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(10):3697-3702
The cardiovascular physiologic actions of urocortin II: acute effects in murine heart failure.
Bale TL; Hoshijima M; Gu Y; Dalton N; Anderson KR; Lee K-F; Rivier J; Chien KR; Vale WW; Peterson KL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(8):6905-6910
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.
Kimura A; Kinjyo I; Matsumura Y; Mori H; Mashima R; Harada M; Chien KR; Yasukawa H; Yoshimura A
Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2004;286(1):H424-H433
Sarcoplasmic reticulum calcium defect in Ras-induced hypertrophic cardiomyopathy heart.
Zheng M; Dilly K; Dos Santos Cruz J; Li M; Gu Y; Ursitti JA; Chen J; Ross J; Chien KR; Lederer JW; Wang Y
Article: GENE THERAPY. 2003;10(21):1814-1820
In vivo high-efficiency transcoronary gene delivery and Cre-LoxP gene switching in the adult mouse heart.
Iwatate M; Gu Y; Dieterle T; Iwanaga Y; Peterson KL; Hoshijima M; Chien KR; Ross J
Article: NATURE IMMUNOLOGY. 2003;4(6):551-556
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.
Yasukawa H; Ohishi M; Mori H; Murakami M; Chinen T; Aki D; Hanada T; Takeda K; Akira S; Hoshijima M; Hirano T; Chien KR; Yoshimura A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(11):9570-9575
Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling.
Minamisawa S; Wang Y; Chen J; Ishikawa Y; Chien KR; Matsuoka R
Article: BIOTECHNOLOGY AND BIOENGINEERING. 2003;81(5):578-587
Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers.
Gopalan SM; Flaim C; Bhatia SN; Hoshijima M; Knoell R; Chien KR; Omens JH; McCulloch AD
Article: JOURNAL OF CLINICAL INVESTIGATION. 2003;111(4):469-478
The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury.
Yasukawa H; Yajima T; Duplain H; Iwatate M; Kido M; Hoshijima M; Weitzman MD; Nakamura T; Woodard S; Xiong D; Yoshimura A; Chien KR; Knowlton KU
Article: EMBO JOURNAL. 2003;22(2):216-224
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2.
Ludwig A; Budde T; Stieber J; Moosmang S; Wahl C; Holthoff K; Langebartels A; Wotjak C; Munsch T; Zong X; Feil S; Feil R; Lancel M; Chien KR; Konnerth A; Pape H-C; Biel M; Hofmann F
Article: METHODS IN MOLECULAR BIOLOGY. 2003;219:169-178
Embryonic and neonatal cardiac gene transfer in vivo.
Christensen G; Gruber PJ; Wang Y; Chien KR
Article: CELL. 2002;111(7):943-955
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
Knöll R; Hoshijima M; Hoffman HM; Person V; Lorenzen-Schmidt I; Bang ML; Hayashi T; Shiga N; Yasukawa H; Schaper W; McKenna W; Yokoyama M; Schork NJ; Omens JH; McCulloch AD; Kimura A; Gregorio CC; Poller W; Schaper J; Schultheiss HP; Chien KR
Article: DEVELOPMENT. 2002;129(24):5827-5838
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.
Hamblet NS; Lijam N; Ruiz-Lozano P; Wang J; Yang Y; Luo Z; Mei L; Chien KR; Sussman DJ; Wynshaw-Boris A
Article: MECHANISMS OF DEVELOPMENT. 2002;117(1-2):115-122
Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos.
Jiang X; Choudhary B; Merki E; Chien KR; Maxson RE; Sucov HM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(17):11375-11380
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice.
Zhao Y-Y; Liu Y; Stan R-V; Fan L; Gu Y; Dalton N; Chu P-H; Peterson K; Ross J; Chien KR
Article: NATURE MEDICINE. 2002;8(8):864-871
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery.
Hoshijima M; Ikeda Y; Iwanaga Y; Minamisawa S; Date M-O; Gu Y; Iwatate M; Li M; Wang L; Wilson JM; Wang Y; Ross J; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8880-8885
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy.
Ozcelik C; Erdmann B; Pilz B; Wettschureck N; Britsch S; Hübner N; Chien KR; Birchmeier C; Garratt AN
Article: DEVELOPMENTAL DYNAMICS. 2002;224(2):154-167
Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development.
Ferrer-Martínez A; Ruiz-Lozano P; Chien KR
Article: NATURE MEDICINE. 2002;8(5):459-465
ErbB2 is essential in the prevention of dilated cardiomyopathy.
Crone SA; Zhao Y-Y; Fan L; Gu Y; Minamisawa S; Liu Y; Peterson KL; Chen J; Kahn R; Condorelli G; Ross J; Chien KR; Lee K-F
Article: CIRCULATION. 2002;105(4):502-508
Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer.
Ikeda Y; Gu Y; Iwanaga Y; Hoshijima M; Oh SS; Giordano FJ; Chen J; Nigro V; Peterson KL; Chien KR; Ross J
Article: NATURE. 2002;415(6868):171-175
Fibulin-5/DANCE is essential for elastogenesis in vivo.
Nakamura T; Lozano PR; Ikeda Y; Iwanaga Y; Hinek A; Minamisawa S; Cheng C-F; Kobuke K; Dalton N; Takada Y; Tashiro K; Ross J; Honjo T; Chien KR
Article: CELL. 2001;107(6):801-813
A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.
Kuo HC; Cheng CF; Clark RB; Lin JJ; Lin JL; Hoshijima M; Nguyêñ-Trân VT; Gu Y; Ikeda Y; Chu PH; Ross J; Giles WR; Chien KR
Article: REVISTA ESPANOLA DE CARDIOLOGIA. 2001;54(12):1439-1445
[Developmental genes and heart disease].
Ruiz-Lozano P; Nakamura T; Chien KR
Article: JOURNAL OF CLINICAL INVESTIGATION. 2001;108(10):1459-1467
Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways.
Yasukawa H; Hoshijima M; Gu Y; Nakamura T; Pradervand S; Hanada T; Hanakawa Y; Yoshimura A; Ross J; Chien KR
Article: NATURE MEDICINE. 2001;7(11):1236-1240
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes.
Wettschureck N; Rütten H; Zywietz A; Gehring D; Wilkie TM; Chen J; Chien KR; Offermanns S
Article: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2001;280(6):H2665-H2673
Effects of deletion of muscle LIM protein on myocyte function.
Su Z; Yao A; Zubair I; Sugishita K; Ritter M; Li F; Hunter JJ; Chien KR; Barry WH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(10):5780-5785
A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function.
Giordano FJ; Gerber HP; Williams SP; VanBruggen N; Bunting S; Ruiz-Lozano P; Gu Y; Nath AK; Huang Y; Hickey R; Dalton N; Peterson KL; Ross J; Chien KR; Ferrara N
Article: NATURE MEDICINE. 2001;7(5):591-597
Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy.
Pashmforoush M; Pomiès P; Peterson KL; Kubalak S; Ross J; Hefti A; Aebi U; Beckerle MC; Chien KR
Article: CIRCULATION RESEARCH. 2001;88(3):333-339
Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43.
Gutstein DE; Morley GE; Tamaddon H; Vaidya D; Schneider MD; Chen J; Chien KR; Stuhlmann H; Fishman GI
Article: NATURE. 2000;407(6801):227-232
Genomic circuits and the integrative biology of cardiac diseases.
Chien KR
Article: CELL. 2000;102(5):671-682
A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages.
Nguyên-Trân VT; Kubalak SW; Minamisawa S; Fiset C; Wollert KC; Brown AB; Ruiz-Lozano P; Barrere-Lemaire S; Kondo R; Norman LW; Gourdie RG; Rahme MM; Feld GK; Clark RB; Giles WR; Chien KR
Article: MOLECULAR AND CELLULAR BIOLOGY. 2000;20(12):4436-4444
Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
Wan YJ; An D; Cai Y; Repa JJ; Hung-Po Chen T; Flores M; Postic C; Magnuson MA; Chen J; Chien KR; French S; Mangelsdorf DJ; Sucov HM
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2000;32(5):839-851
Differentiation of cardiomyocytes in floating embryoid bodies is comparable to fetal cardiomyocytes.
Doevendans PA; Kubalak SW; An RH; Becker DK; Chien KR; Kass RS
Article: CIRCULATION. 2000;101(2):178-184
High-efficiency, long-term cardiac expression of foreign genes in living mouse embryos and neonates.
Christensen G; Minamisawa S; Gruber PJ; Wang Y; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(52):37362-37369
Synergistic roles of neuregulin-1 and insulin-like growth factor-I in activation of the phosphatidylinositol 3-kinase pathway and cardiac chamber morphogenesis.
Hertig CM; Kubalak SW; Wang Y; Chien KR
Article: HUMAN MOLECULAR GENETICS. 1999;8(12):2229-2237
Deletion of 150 kb in the minimal DiGeorge/velocardiofacial syndrome critical region in mouse.
Kimber WL; Hsieh P; Hirotsune S; Yuva-Paylor L; Sutherland HF; Chen A; Ruiz-Lozano P; Hoogstraten-Miller SL; Chien KR; Paylor R; Scambler PJ; Wynshaw-Boris A
Article: MOLECULAR PHARMACOLOGY. 1999;56(5):886-894
Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation.
Luo ZD; Wang Y; Werlen G; Camp S; Chien KR; Taylor P
Article: CELL. 1999;99(3):313-322
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
Minamisawa S; Hoshijima M; Chu G; Ward CA; Frank K; Gu Y; Martone ME; Wang Y; Ross J; Kranias EG; Giles WR; Chien KR
Article: DEVELOPMENT. 1999;126(19):4223-4234
Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis.
Kuo H; Chen J; Ruiz-Lozano P; Zou Y; Nemer M; Chien KR
Article: MOLECULAR CELL. 1999;4(4):585-595
PPAR gamma is required for placental, cardiac, and adipose tissue development.
Barak Y; Nelson MC; Ong ES; Jones YZ; Ruiz-Lozano P; Chien KR; Koder A; Evans RM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(32):22476-22483
DANCE, a novel secreted RGD protein expressed in developing, atherosclerotic, and balloon-injured arteries.
Nakamura T; Ruiz-Lozano P; Lindner V; Yabe D; Taniwaki M; Furukawa Y; Kobuke K; Tashiro K; Lu Z; Andon NL; Schaub R; Matsumori A; Sasayama S; Chien KR; Honjo T
Article: JOURNAL OF CLINICAL INVESTIGATION. 1999;103(12):1627-1634
Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure.
Sah VP; Minamisawa S; Tam SP; Wu TH; Dorn GW; Ross J; Chien KR; Brown JH
Article: MOLECULAR CANCER RESEARCH. 1999;10(5):295-306
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.
Ruiz-Lozano P; Hixon ML; Wagner MW; Flores AI; Ikawa S; Baldwin AS; Chien KR; Gualberto A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(9):5043-5048
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.
Marszalek JR; Ruiz-Lozano P; Roberts E; Chien KR; Goldstein LS
Article: CELL. 1999;97(2):189-198
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress.
Hirota H; Chen J; Betz UA; Rajewsky K; Gu Y; Ross J; Müller W; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(15):10066-10070
A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiac growth or hypertrophy.
Minamisawa S; Gu Y; Ross J; Chien KR; Chen J
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 1998;30(11):2269-2280
Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy.
Schoenfeld JR; Vasser M; Jhurani P; Ng P; Hunter JJ; Ross J; Chien KR; Lowe DG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(22):13024-13029
Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail.
Liu X; Hwang H; Cao L; Buckland M; Cunningham A; Chen J; Chien KR; Graham RM; Zhou M
Article: JOURNAL OF CARDIAC FAILURE. 1998;4(3):213-224
Angiotensin II blockade followed by growth hormone as adjunctive therapy after experimental myocardial infarction.
Hongo M; Sentianin EM; Tanaka N; Mao L; McKirnan MD; Clark RG; Won W; Chien KR; Ross J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(17):10140-10145
Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.
Adams JW; Sakata Y; Davis MG; Sah VP; Wang Y; Liggett SB; Chien KR; Brown JH; Dorn GW
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(33):21077-21083
A novel putative protein-tyrosine phosphatase contains a BRO1-like domain and suppresses Ha-ras-mediated transformation.
Cao L; Zhang L; Ruiz-Lozano P; Yang Q; Chien KR; Graham RM; Zhou M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1998;95(12):7000-7005
Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice.
Rockman HA; Chien KR; Choi DJ; Iaccarino G; Hunter JJ; Ross J; Lefkowitz RJ; Koch WJ
Article: DEVELOPMENT. 1998;125(10):1943-1949
Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis.
Chen J; Kubalak SW; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(13):7725-7730
The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase.
Hoshijima M; Sah VP; Wang Y; Chien KR; Brown JH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(10):5423-5426
Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells.
Wang Y; Su B; Sah VP; Brown JH; Han J; Chien KR
Article: DEVELOPMENT. 1998;125(3):533-544
Energy deprivation and a deficiency in downstream metabolic target genes during the onset of embryonic heart failure in RXRalpha-/- embryos.
Ruiz-Lozano P; Smith SM; Perkins G; Kubalak SW; Boss GR; Sucov HM; Evans RM; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(4):2161-2168
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family.
Wang Y; Huang S; Sah VP; Ross J; Brown JH; Han J; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(2):1252-1256
Selective requirement of myosin light chain 2v in embryonic heart function.
Chen J; Kubalak SW; Minamisawa S; Price RL; Becker KD; Hickey R; Ross J; Chien KR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;273(3 Pt 2):H1368-H1376
Left ventricular volumes and function in the embryonic mouse heart.
Tanaka N; Mao L; DeLano FA; Sentianin EM; Chien KR; Schmid-Schönbein GW; Ross J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(22):14057-14061
The MEKK-JNK pathway is stimulated by alpha1-adrenergic receptor and ras activation and is associated with in vitro and in vivo cardiac hypertrophy.
Ramirez MT; Sah VP; Zhao XL; Hunter JJ; Chien KR; Brown JH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(9):4710-4715
Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice.
Gottshall KR; Hunter JJ; Tanaka N; Dalton N; Becker KD; Ross J; Chien KR
Article: JOURNAL OF CELL BIOLOGY. 1997;137(1):131-140
Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly.
Becker KD; Gottshall KR; Hickey R; Perriard JC; Chien KR
Article: DEVELOPMENTAL DYNAMICS. 1997;208(4):482-490
Developmental expression of the murine spliceosome-associated protein mSAP49.
Ruiz-Lozano P; Doevendans P; Brown A; Gruber PJ; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(9):5783-5791
Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophy.
Sheng Z; Knowlton K; Chen J; Hoshijima M; Brown JH; Chien KR
Article: DEVELOPMENT. 1997;124(4):793-804
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
Zou Y; Evans S; Chen J; Kuo HC; Harvey RP; Chien KR
Article: CELL. 1997;88(3):393-403
MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure.
Arber S; Hunter JJ; Ross J; Hongo M; Sansig G; Borg J; Perriard JC; Chien KR; Caroni P
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 1997;29(2):515-525
A novel A/T-rich element mediates ANF gene expression during cardiac myocyte hypertrophy.
Harris AN; Ruiz-Lozano P; Chen YF; Sionit P; Yu YT; Lilly B; Olson EN; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(49):31185-31190
Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways.
Sah VP; Hoshijima M; Chien KR; Brown JH
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;98(11):2648-2655
Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency.
Lembo G; Rockman HA; Hunter JJ; Steinmetz H; Koch WJ; Ma L; Prinz MP; Ross J; Chien KR; Powell-Braxton L
Article: JOURNAL OF CLINICAL INVESTIGATION. 1996;98(6):1332-1343
RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice.
Gruber PJ; Kubalak SW; Pexieder T; Sucov HM; Evans RM; Chien KR
Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 1996;28(9):1833-1844
Neurofilament M mRNA is expressed in conduction system myocytes of the developing and adult rabbit heart.
Vitadello M; Vettore S; Lamar E; Chien KR; Gorza L
Article: CIRCULATION. 1996;94(5):1109-1117
Transthoracic echocardiography in models of cardiac disease in the mouse.
Tanaka N; Dalton N; Mao L; Rockman HA; Peterson KL; Gottshall KR; Hunter JJ; Chien KR; Ross J
Article: CIRCULATION. 1996;93(12):2188-2196
Cardiovascular effects of insulin-like growth factor-1 and growth hormone in chronic left ventricular failure in the rat.
Duerr RL; McKirnan MD; Gim RD; Clark RG; Chien KR; Ross J
Article: DEVELOPMENT. 1996;122(6):1799-1809
An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression.
Ross RS; Navankasattusas S; Harvey RP; Chien KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(16):9535-9545
Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways.
Wollert KC; Taga T; Saito M; Narazaki M; Kishimoto T; Glembotski CC; Vernallis AB; Heath JK; Pennica D; Wood WI; Chien KR
Article: CIRCULATION RESEARCH. 1996;78(3):371-378
Developmental changes in beta-adrenergic modulation of L-type Ca2+ channels in embryonic mouse heart.
An RH; Davies MP; Doevendans PA; Kubalak SW; Bangalore R; Chien KR; Kass RS
Article: DEVELOPMENT. 1996;122(2):419-428
Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival.
Sheng Z; Pennica D; Wood WI; Chien KR
Article: CIRCULATION RESEARCH. 1996;78(1):15-25
Developmental changes in ionic channel activity in the embryonic murine heart.
Davies MP; An RH; Doevendans P; Kubalak S; Chien KR; Kass RS
Article: MOLECULAR BIOLOGY OF THE CELL. 1995;6(11):1479-1490
Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase.
Thorburn J; Carlson M; Mansour SJ; Chien KR; Ahn NG; Thorburn A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1995;270(39):23173-23178
Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice.
Hunter JJ; Tanaka N; Rockman HA; Ross J; Chien KR
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1995;269(3 Pt 2):H755-H766
Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology.
Chien KR
Article: JOURNAL OF CLINICAL INVESTIGATION. 1995;96(3):1311-1318
Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.
Knowlton KU; Rockman HA; Itani M; Vovan A; Seidman CE; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(16):7391-7395
Retinoid-dependent pathways suppress myocardial cell hypertrophy.
Zhou MD; Sucov HM; Evans RM; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(16):7386-7390
Atrial-like phenotype is associated with embryonic ventricular failure in retinoid X receptor alpha -/- mice.
Dyson E; Sucov HM; Kubalak SW; Schmid-Schönbein GW; DeLano FA; Evans RM; Ross J; Chien KR
Article: MOLECULAR AND CELLULAR BIOLOGY. 1995;15(6):2972-2982
EFIA/YB-1 is a component of cardiac HF-1A binding activity and positively regulates transcription of the myosin light-chain 2v gene.
Zou Y; Chien KR
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(4):1142-1146
Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.
Pennica D; King KL; Shaw KJ; Luis E; Rullamas J; Luoh SM; Darbonne WC; Knutzon DS; Yen R; Chien KR
Article: JOURNAL OF CLINICAL INVESTIGATION. 1995;95(2):619-627
Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure.
Duerr RL; Huang S; Miraliakbar HR; Clark R; Chien KR; Ross J
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Corrigendum: NATURE COMMUNICATIONS. 2024;15(1):283
Placental growth factor exerts a dual function for cardiomyogenesis and vasculogenesis during heart development (vol 14, 5435, 2023)
Witman N; Zhou C; Haeneke T; Xiao Y; Huang X; Rohner E; Sohlmer J; Beverborg NG; Lehtinen ML; Chien KR; Sahara M
Editorial comment: NATURE CELL BIOLOGY. 2023;25(2):203-206
Progress and challenges in stem cell biology.
Apostolou E; Blau H; Chien K; Lancaster MA; Tata PR; Trompouki E; Watt FM; Zeng YA; Zernicka-Goetz M
Review: NATURE BIOTECHNOLOGY. 2022;40(11):1586-1600
Unlocking the promise of mRNA therapeutics
Rohner E; Yang R; Foo KS; Goedel A; Chien KR
Letter: NATURE REVIEWS DRUG DISCOVERY. 2022;21(1):79-80
VEGFA mRNA for regenerative treatment of heart failure
Collen A; Bergenhem N; Carlsson L; Chien KR; Hoge S; Gan L-M; Fritsche-Danielson R
Editorial comment: NATURE CELL BIOLOGY. 2021;23(5):440-442
PHF7 directs cardiac reprogramming
Eroglu E; Schell JP; Chien KR
Corrigendum: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;109:151
Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration (vol 100, pg 29, 2020)
Witman N; Zhou C; Beverborg NG; Sahara M; Chien KR
Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;100:29-51
Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration.
Witman N; Zhou C; Grote Beverborg N; Sahara M; Chien KR
Editorial comment: EMBO MOLECULAR MEDICINE. 2019;11(12):e11502
In search of the next super models
Goedel A; Grote Beverborg N; Sahara M; Chien KR
Published conference paper: JOURNAL OF CONTROLLED RELEASE. 2019;310:103-114
Cell-mediated delivery of VEGF modified mRNA enhances blood vessel regeneration and ameliorates murine critical limb ischemia
Yu Z; Witman N; Wang W; Li D; Yan B; Deng M; Wang X; Wang H; Zhou G; Liu W; Sahara M; Cao Y; Fritsche-Danielson R; Zhang W; Fu W; Chien KR
Editorial comment: CELL STEM CELL. 2018;22(6):787-789
Lnc'ed in to Cardiogenesis
Sahara M; Eroglu E; Chien KR
Editorial comment: DEVELOPMENTAL CELL. 2017;42(1):7-8
Heart Regeneration 4.0: Matrix Medicine
Eroglu E; Chien KR
Corrigendum: NATURE COMMUNICATIONS. 2016;7:12118
Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells (vol 7, 10774, 2016)
Soh B-S; Ng S-Y; Wu H; Buac K; Park J-HC; Lian X; Xu J; Foo KS; Felldin U; He X; Nichane M; Yang H; Bu L; Li RA; Lim B; Chien KR
Editorial comment: EMBO REPORTS. 2015;16(10):1246-1249
Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances
Ljunggren H-G; Chien KR
Review: EMBO JOURNAL. 2015;34(6):710-738
Programming and reprogramming a human heart cell
Sahara M; Santoro F; Chien KR
Corrigendum: CELL RESEARCH. 2015;25(1):148
Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells (vol 24, pg 820, 2014)
Sahara M; Hansson EM; Wernet O; Lui KO; Spaeter D; Chien KR
Review: STEM CELL RESEARCH. 2014;13(3):693-704
Cardiovascular regenerative therapeutics via synthetic paracrine factor modified mRNA
Lui KO; Zangi L; Chien KR
Editorial comment: CELL RESEARCH. 2013;23(10):1161-1162
The Years of the Monkey
Lian X; Chien KR
Editorial comment: EMBO REPORTS. 2013;14(9):755-758
Body, heal thyself. An interview with Kenneth Chien, Professor of Cardiovascular Research at the Department of Cell & Molecular Biology, and the Department of Medicine at Karolinska Institutet in Sweden. Interview by Holger Breithaupt.
Chien K
Editorial comment: NATURE. 2013;498(7455):439-440
REGENERATIVE BIOLOGY Heartbroken embryos heal
Chien KR
Editorial comment: NATURE BIOTECHNOLOGY. 2013;31(3):209-211
Cardiac regenerative medicine 2.0
Soh B-S; Wu H; Chien KR
Editorial comment: CELL RESEARCH. 2012;22(11):1521-1523
In vivo reprogramming for heart disease.
Xu H; Yi BA; Chien KR
Editorial comment: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2012;53(3):311-313
Cardiomyocyte reprogramming and the new age of cellular alchemy.
Chien KR; Yi BA; Xu H; Mummery CL
Editorial comment: CELL STEM CELL. 2012;11(1):3-4
Reprogramming a broken heart.
Hansson EM; Chien KR
Editorial comment: MOLECULAR THERAPY. 2011;19(9):1576-1578
A GPS for heart progenitor cell lineages.
Chmielowiec J; Chang Y-S; Chien KR
Review: ANNUAL REVIEW OF BIOMEDICAL ENGINEERING. 2011;13:245-267
Bioengineering heart muscle: a paradigm for regenerative medicine.
Vunjak-Novakovic G; Lui KO; Tandon N; Chien KR
Editorial comment: NATURE CELL BIOLOGY. 2011;13(3):191-193
Shortcuts to making cardiomyocytes.
Xu H; Yi BA; Chien KR
Review: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 2010;26:667-687
Stem cell models of cardiac development and disease.
Musunuru K; Domian IJ; Chien KR
Letter: CELL RESEARCH. 2010;20(3):379-382
Targeted conditional gene knockout in human embryonic stem cells.
Bu L; Gao X; Jiang X; Chien KR; Wang Z
Review: JOURNAL OF CLINICAL INVESTIGATION. 2010;120(1):20-28
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration.
Yi BA; Wernet O; Chien KR
Review: CELL STEM CELL. 2009;5(4):364-377
Regeneration next: toward heart stem cell therapeutics.
Hansson EM; Lindsay ME; Chien KR
Review: SCIENCE. 2008;322(5907):1494-1497
Cardiogenesis and the complex biology of regenerative cardiovascular medicine.
Chien KR; Domian IJ; Parker KK
Editorial comment: NATURE. 2008;453(7193):302-305
Regenerative medicine and human models of human disease.
Chien KR
Review: CELL STEM CELL. 2008;2(4):320-331
Lives of a heart cell: tracing the origins of cardiac progenitors.
Martin-Puig S; Wang Z; Chien KR
Review: PHYSIOLOGY. 2008;23:6-16
Toward biologically targeted therapy of calcium cycling defects in heart failure.
Ikeda Y; Hoshijima M; Chien KR
Review: ANNUAL REVIEW OF MEDICINE. 2008;59:13-28
Reversing advanced heart failure by targeting Ca2+ cycling.
Kaye DM; Hoshijima M; Chien KR
Review: DEVELOPMENT. 2008;135(2):193-205
Islet1 cardiovascular progenitors: a single source for heart lineages?
Laugwitz K-L; Moretti A; Caron L; Nakano A; Chien KR
Review: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2008;73:297-306
Multipotent islet-1 cardiovascular progenitors in development and disease.
Nakano A; Nakano H; Chien KR
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2007;1112:171-188
Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium.
Smart N; Risebro CA; Melville AAD; Moses K; Schwartz RJ; Chien KR; Riley PR
Editorial comment: NATURE. 2007;447(7143):389-390
Molecular medicine: microRNAs and the tell-tale heart.
Chien KR
Published conference paper: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2006;48(9):A15-A23
Reversal of calcium cycling defects in advanced heart failure -: Toward molecular therapy
Hoshijima M; Knoll R; Pashmforoush M; Chien KR
Review: NOVARTIS FOUNDATION SYMPOSIUM. 2006;274:244-276
Beyond small molecule drugs for heart failure: prospects for gene therapy.
Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2006;116(7):1838-1840
Lost and found: cardiac stem cell therapy revisited.
Chien KR
Editorial comment: NEW ENGLAND JOURNAL OF MEDICINE. 2006;354(8):789-790
Herceptin and the heart--a molecular modifier of cardiac failure.
Chien KR
Editorial comment: PLOS BIOLOGY. 2005;3(4):e131
Alchemy and the new age of cardiac muscle cell biology.
Chien KR
Review: CELL. 2005;120(4):533-544
Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone.
Chien KR; Karsenty G
Editorial comment: SCIENCE. 2004;306(5694):239-240
Development. ES cells to the rescue.
Chien KR; Moretti A; Laugwitz K-L
Editorial comment: NATURE CELL BIOLOGY. 2004;6(9):807-808
Unravelling Ras signals in cardiovascular disease.
Chien KR; Hoshijima M
Editorial comment: NATURE. 2004;428(6983):607-608
Stem cells: lost in translation.
Chien KR
Review: NOVARTIS FOUNDATION SYMPOSIUM. 2003;250:260-279
Defects in cardiac conduction system lineages and malignant arrhythmias: developmental pathways and disease.
St Amand TR; Lu JT; Chien KR
Editorial comment: NATURE MEDICINE. 2003;9(5):508-509
Calcium and heart failure: the cycle game.
Chien KR; Ross J; Hoshijima M
Corrigendum: JOURNAL OF CLINICAL INVESTIGATION. 2003;111(9):1433
Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies (vol 111, pg 175, 2003)
Chien KR
Review: TRENDS IN MOLECULAR MEDICINE. 2003;9(2):59-66
Genetic modifiers of cardiac arrhythmias.
Cheng C-F; Kuo H-C; Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2003;111(2):175-178
Genotype, phenotype: upstairs, downstairs in the family of cardiomyopathies.
Chien KR
Editorial comment: NATURE GENETICS. 2003;33(1):8-9
Cre-constructing the heart.
Ruiz-Lozano P; Chien KR
Review: CELL. 2002;110(2):153-162
Converging pathways and principles in heart development and disease: CV@CSH.
Chien KR; Olson EN
Review: JOURNAL OF CLINICAL INVESTIGATION. 2002;109(7):849-855
Mixed signals in heart failure: cancer rules.
Hoshijima M; Chien KR
Editorial comment: TRENDS IN CARDIOVASCULAR MEDICINE. 2002;12(1):1-2
Something old, something new, something borrowed, something blue: notes on TCM ten years after.
Chien KR
Published conference paper: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2002;67:399-408
The MLP family of cytoskeletal Z disc proteins and dilated cardiomyopathy:: A stress pathway model for heart failure progression
Hoshijima M; Pashmforoush M; Knöll R; Chien KR
Published conference paper: JOURNAL OF MAGNETIC RESONANCE IMAGING. 2001;14(4):374-382
Dobutamine stress cine-MRI of cardiac function in the hearts of adult cardiomyocyte-specific VEGF knockout mice.
Williams SP; Gerber HP; Giordano FJ; Peale FV; Bernstein LJ; Bunting S; Chien KR; Ferrara N; van Bruggen N
Editorial comment: CIRCULATION RESEARCH. 2001;88(6):546-549
To Cre or not to Cre: the next generation of mouse models of human cardiac diseases.
Chien KR
Review: SEMINARS IN ONCOLOGY. 2000;27(6 Suppl 11):9-14
Myocyte survival pathways and cardiomyopathy: implications for trastuzumab cardiotoxicity.
Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 2000;105(10):1339-1342
Meeting Koch's postulates for calcium signaling in cardiac hypertrophy.
Chien KR
Editorial comment: CIRCULATION. 2000;101(13):1616-1618
Mentors for the new millennium : advice to a young cardiologist.
Chien KR
Review: NEW ENGLAND JOURNAL OF MEDICINE. 1999;341(17):1276-1283
Signaling pathways for cardiac hypertrophy and failure.
Hunter JJ; Chien KR
Editorial comment: NATURE MEDICINE. 1999;5(10):1122-1123
Inflammatory pathways and cardiac repair: the affliction of infarction.
Knowlton KU; Chien KR
Review: CELL. 1999;98(5):555-558
Stress pathways and heart failure.
Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1999;103(11):1483-1485
Complexity in simplicity: monogenic disorders and complex cardiomyopathies.
Chen J; Chien KR
Editorial comment: CIRCULATION. 1999;99(1):6-7
Good fences make good neighbors : cardiovascular science and medicine at the end of the millenium.
Chien KR
Editorial comment: CIRCULATION. 1997;96(12):4126-4130
Tangled up in blue: molecular cardiology in the postmolecular era.
Pashmforoush M; Chien KR
Review: JOURNAL OF MOLECULAR MEDICINE. 1997;75(7):492-501
Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development.
Wollert KC; Chien KR
Review: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;272(6 Pt 2):H2513-H2524
Physiological assessment of complex cardiac phenotypes in genetically engineered mice.
Christensen G; Wang Y; Chien KR
Review: DEVELOPMENT. 1997;124(11):2099-2117
Fashioning the vertebrate heart: earliest embryonic decisions.
Fishman MC; Chien KR
Editorial comment: CIRCULATION. 1997;95(4):766-770
Report of the National Heart, Lung, and Blood Institute Special Emphasis Panel on Heart Failure Research.
Cohn JN; Bristow MR; Chien KR; Colucci WS; Frazier OH; Leinwand LA; Lorell BH; Moss AJ; Sonnenblick EH; Walsh RA; Mockrin SC; Reinlib L
Review: CIRCULATION JOURNAL. 1997;61(2):91-118
Toward molecular strategies for heart disease--past, present, future.
Chien KR; Shimizu M; Hoshijima M; Minamisawa S; Grace AA
Review: JOURNAL OF CARDIAC FAILURE. 1996;2(4 Suppl):S28-S34
A genetic based model of cardiac hypertrophy in MLC-ras mice.
Gottshall KR; Becker KD; Hunter JJ; Chien KR
Review: CYTOKINE AND GROWTH FACTOR REVIEWS. 1996;7(1):81-91
Cardiotrophin-1: a multifunctional cytokine that signals via LIF receptor-gp 130 dependent pathways.
Pennica D; Wood WI; Chien KR
Published conference paper: MOLECULAR AND CELLULAR BIOCHEMISTRY. 1996;157(1-2):87-91
Expression of cardiac muscle markers in rat myocyte cell lines.
Engelmann GL; Worrell RA; Duff RA; Grutkoski PS; Chien KR; Harvey RP
Published conference paper: HYPERTENSION. 1996;27(3 Pt 2):495-501
Strategies for studying cardiovascular phenotypes in genetically manipulated mice.
Becker KD; Gottshall KR; Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1996;97(4):901-909
Genes and physiology: molecular physiology in genetically engineered animals.
Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1996;97(1):2
Molecular medicine in genetically engineered animals: series introduction.
Chien KR
Published conference paper: BIOCHEMICAL SOCIETY SYMPOSIUM. 1996;62:143-156
The molecular genetics of retinoic acid receptors: cardiovascular and limb development.
Sucov HM; Lou J; Gruber PJ; Kubalak SW; Dyson E; Gumeringer CL; Lee RY; Moles SA; Chien KR; Giguere V; Evans RM
Editorial comment: CIRCULATION. 1995;92(10):2786-2789
Congenital long QT syndromes. Toward molecular dissection of arrhythmia substrates.
Grace AA; Chien KR
Editorial comment: NATURE MEDICINE. 1995;1(8):749-751
Heart and lung disease in engineered mice.
Lin MC; Rockman HA; Chien KR
Editorial comment: JOURNAL OF CLINICAL INVESTIGATION. 1995;96(1):1-3
Close encounters with ET-1.
Chien KR
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1995;752:115-127
Signaling pathways for cardiac growth and hypertrophy. Recent advances and prospects for growth factor therapy.
Lembo G; Hunter JJ; Chien KR
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