Karin Sundström

Karin Sundström

Principal Researcher
Visiting address: Karolinska Universitetssjukhuset, Huddinge, F56, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLT Centrum för Cervixcancereliminering Sundström, 141 52 Huddinge

About me

  • I am a senior cancer epidemiologist and research group leader with a strong focus on molecular epidemiological studies conducted in the excellent Swedish register and biobank infrastructure.

    My main interest is in the elimination of female gynecological cancers:

    1) Human papillomavirus (HPV)-associated cancers through virological research and improved cervical screening and HPV-vaccination practices.

    2) Endometrial cancer, through research on epigenetics/methylation, and improved diagnostics of post-menopausal bleeding.

    3) Ovarian cancer, through research on risk factors and potential chemoprevention.

    As such, I am involved with several projects in clinical biobanks of cytology and histology, which are strong resources for comprehensive studies on biomarkers for female disease. I collaborate with Professor Martin Widschwendter of the University of Tirol on methylation tests for female cancers and Professor Susanne Kruger Kjaer of the Danish Cancer Society, and the large MERMAID III initiative to prevent ovarian cancer. I am also an Honorary Fellow at University College of London (UCL), where I collaborate with Professor Pam Sonnenberg.

    Apart from molecular epidemiological studies, I have worked on in silico projects within machine learning and text mining of medical records, for the improved computer-assisted prediction of screening-detectable cancer forms. 

    I have a keen interest in education at basic and advanced level and I lecture regularly at a number of programs at Karolinska Institutet, includingcourses for Residents at Karolinska University Hospital (SK). I was formerly the Study Director of the Master program for diagnostic cytology at Karolinska Institutet and was Project Manager for the development of the new Master program for biomedical laboratory science at KI.

Research

Teaching

  • Postdoctoral supervision:
    Dr. Jiangrong Wang

    Doctoral supervision, ongoing:
    Olof Grönlund (main supervisor)
    Qingyun Yao (main supervisor)

    Franziska Thimm (main supervisor)
    Rasha Polcer (co-supervisor)
    Former co-supervisor of another 7 doctoral students, who have now defended their theses.

    Other student supervision:

    2025. Kamila Abdullayeva, guest doctoral student from University College London.

    2019. Master student in Diagnostic Cytology Leila Kije Jatta's thesis
    2017. Public Health Sciences/Public Health Epidemiology student Teresa Kreusch's master thesis: “The association with cervical screening attendance — A Swedish national register-based cohort study”.

    Pedagogics/Teaching:

    2022- ongoing Lecturer in several courses at KI and KUH

    2019-2021 Study Director for the KI Magister program in Diagnostic Cytology (60 HEC)
    2016 Course in university level pedagogics, at KI, 7.5 university credits
    2015 - 2016 Member of the KI Medical program’s Teachers’ Collegium for Primary Care (Primärvårdskollegium)
    2009 - 2016 Lecturer within Scientific Development (Vetenskaplig Utveckling), a course in principles of science and evidence-based medicine for medical students.
    Active lecturer on semester 1, 6 and 10 during 2014-2015. Formally responsible for the VetU-tuition semester 6, during 2014-2015.

Articles

All other publications

Grants

  • HPV-SERVIX study: HPV among Swedish women with cancer of the cervix
    Region Stockholm
    1 January 2025 - 31 December 2025
  • HPV-SERVIX: HPV infection among Swedish women with cancer of the cervix
    Radium Hemmets Research Funds
    1 January 2024
  • HPV-SERVIX: HPV among Swedish women with cancer of the cervix
    Karolinska Institutet
    1 January 2024 - 12 December 2025
  • Task Force Cervical Cancer Research
    Karolinska Institutet
    1 January 2024 - 31 December 2025
  • European Commission
    1 January 2023 - 31 December 2024
  • Swedish Cancer Society
    1 January 2022
    The sexually transmitted virus human papillomavirus (HPV) can cause cancer of the cervix, which is the lower third of the uterus that opens into the vagina. Today, we have access to very sensitive HPV tests that can detect pre-stages of cervical cancer in time for the woman to receive effective treatment. However, around 500 women per year in Sweden are still diagnosed with invasive cervical cancer, and for these expect a demanding treatment that involves surgery and/or cytostatics and radiation. Mortality in more advanced stages of the disease is high. My research has shown that HPV testing in archived tumor material from women with cervical cancer can serve as a strong marker for survival, even when other known markers of prognosis are taken into account. However, this knowledge has not yet reached clinical everyday life, or led to any form of treatment adaptation based on HPV status in the tumor. This is because there is still a lack of a forward-looking clinical study that tests fresh material in a real clinical setting. We now have a clear opportunity to fill this gap in evidence with a translational study that will HPV test all women with cervical cancer in Sweden. My goal is to contribute to being able to better identify women with more aggressive cervical cancer, with the aim of being able to adjust the degree of treatment based on the type of HPV the patient is infected with, and to improve survival in this disease.
  • HPV16 genomic variation and risk of cervical precancer and cancer
    Swedish Society of Medicine
    1 January 2020 - 12 December 2021
  • Human papillomavirus type 16 genetics and risk of cervical cancer
    Center for Innovative Medicine Region Stockholm
    1 January 2020 - 12 December 2022

Employments

  • Principal Researcher, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 2023-

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 2013
  • University Medical Degree, Karolinska Institutet, 2009

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