Karin Hellgren

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Publications
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Public outreach and news

Research

[pubmed:20155827]
[pubmed:19439429]
[pubmed:22294058]
[pubmed:20405111]

Articles

Article: RHEUMATOLOGY. 2024;:keae168
Hydroxychloroquine in lupus or rheumatoid arthritis pregnancy and risk of major congenital malformations: a population-based cohort study
Nguyen NV; Svenungsson E; Dominicus A; Altman M; Hellgren K; Simard JF; Arkema EV
Article: RMD OPEN. 2023;9(3):e003438
Association of childhood infections and perinatal factors with ankylosing spondylitis: a Swedish nationwide case-control and sibling study
Morin M; Hellgren K; Lindstroem U; Frisell T
Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(8):1445-1455
Familial Co-Aggregation of Idiopathic Inflammatory Myopathies and Cancer: A Swedish Population-Based Study
Che WI; Baecklund F; Hellgren K; Kuja-Halkola R; Lundberg IE; Westerlind H; Holmqvist M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(7):911-919
Cancer risks with JAKi and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis or psoriatic arthritis: a national real-world cohort study
Huss V; Bower H; Hellgren K; Frisell T; Askling J; ARTIS G
Article: THE LANCET RHEUMATOLOGY. 2023;5(3):E121-E129
Temporal trends in adverse pregnancy outcomes in axial spondyloarthritis in Sweden: a cohort study.
Morin M; Frisell T; Stephansson O; Hellgren K
Article: RMD OPEN. 2023;9(1):e002924
Exposure to specific tumour necrosis factor inhibitors and risk of demyelinating and inflammatory neuropathy in cohorts of patients with inflammatory arthritis: a collaborative observational study across five Nordic rheumatology registers
Delcoigne B; Kopp TI; Arkema EV; Hellgren K; Provan SA; Relas H; Aaltonen K; Trokovic N; Gudbjornsson B; Grondal G; Klami Kristianslund E; Lindhardsen J; Dreyer L; Askling J
Article: JOURNAL OF INTERNAL MEDICINE. 2023;293(2):200-211
Familial autoimmunity in patients with idiopathic inflammatory myopathies
Che WI; Westerlind H; Lundberg IE; Hellgren K; Kuja-Halkola R; Holmqvist ME
Article: RMD OPEN. 2022;8(2):e002776
Haematological malignancies in patients with psoriatic arthritis overall and treated with TNF inhibitors: a Nordic cohort study
Cordtz RL; Askling J; Delcoigne B; Smedby KE; Baecklund E; Ballegaard C; Isomaki P; Aaltonen K; Gudbjornsson B; Love TJ; Provan SA; Michelsen B; Sexton J; Dreyer L; Hellgren K
Article: RMD OPEN. 2022;8(2):e002445
Risk of pre-eclampsia and impact of disease activity and antirheumatic treatment in women with rheumatoid arthritis, axial spondylarthritis and psoriatic arthritis: a collaborative matched cohort study from Sweden and Denmark
Secher AEP; Granath F; Glintborg B; Rom A; Hetland ML; Hellgren K
Article: RHEUMATOLOGY. 2022;61(9):3711-3722
Pregnancy outcomes in relation to disease activity and anti-rheumatic treatment strategies in women with rheumatoid arthritis: a matched cohort study from Sweden and Denmark
Hellgren K; Secher AE; Glintborg B; Rom AL; Gudbjornsson B; Michelsen B; Granath F; Hetland ML
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(3):486-495
Pregnancy Outcomes in Women With Psoriatic Arthritis In Relation To Presence and Timing of Antirheumatic Treatment
Remaeus K; Johansson K; Granath F; Stephansson O; Hellgren K
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2022;51(1):10-20
Is family history a predictor of response to tumour necrosis factor inhibitors in spondyloarthritis? A Swedish nationwide cohort study
Morin M; Hellgren K; Lindstrom U; Frisell T
Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(11):1461-1466
Familial aggregation and heritability: a nationwide family-based study of idiopathic inflammatory myopathies
Che WI; Westerlind H; Lundberg IE; Hellgren K; Kuja-Halkola R; Holmqvist M
Article: JOURNAL OF RHEUMATOLOGY. 2021;48(10):1512-1518
Effectiveness of a Second Biologic After Failure of a Non-tumor Necrosis Factor Inhibitor As First Biologic in Rheumatoid Arthritis
Chatzidionysiou K; Hetland ML; Frisell T; Di Giuseppe D; Hellgren K; Glintborg B; Nordstrom D; Peltomaa R; Aaltonen K; Trokovic N; Kristianslund EK; Kvien TK; Provan SA; Gudbjornsson B; Grondal G; Dreyer L; Kristensen LE; Jorgensen TS; Jacobsson LTH; Askling J
Article: RHEUMATOLOGY. 2021;60(8):3656-3668
Risk of solid cancers overall and by subtypes in patients with psoriatic arthritis treated with TNF inhibitors - a Nordic cohort study
Hellgren K; Ballegaard C; Delcoigne B; Cordtz R; Nordstrom D; Aaltonen K; Gudbjornsson B; Love TJ; Provan SA; Sexton J; Zobbe K; Kristensen LE; Askling J; Dreyer L
Article: RHEUMATOLOGY. 2021;60(2):809-819
Lymphoma risks in patients with rheumatoid arthritis treated with biological drugs-a Swedish cohort study of risks by time, drug and lymphoma subtype
Hellgren K; Di Giuseppe D; Smedby KE; Sundstrom C; Askling J; Baecklund E
Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2021;51(1):331-337
Overall and site-specific cancer before and after diagnosis of idiopathic inflammatory myopathies: A nationwide study 2002-2016
Dani L; Che WI; Lundberg IE; Hellgren K; Holmqvist M
Article: JOURNAL OF RHEUMATOLOGY. 2020;47(9):1392-1396
Reproductive Pattern in Women with Idiopathic Inflammatory Myopathy: A Population-based Study
Che WI; Hellgren K; Lundberg IE; Holmqvist M
Article: ALIMENTARY PHARMACOLOGY AND THERAPEUTICS. 2020;52(5):843-854
Paediatric infections in the first 3 years of life after maternal anti-TNF treatment during pregnancy
Broms G; Kieler H; Ekbom A; Gissler M; Hellgren K; Leinonen MK; Pedersen L; Schmitt-Egenolf M; Sorensen HT; Granath F
Article: RHEUMATOLOGY. 2020;59(9):2572-2580
Pregnancy outcomes in women with idiopathic inflammatory myopathy, before and after diagnosis-a population-based study
Che WI; Hellgren K; Stephansson O; Lundberg IE; Holmqvist M
Article: RHEUMATOLOGY. 2020;59(7):1695-1702
Familial aggregation and heritability of ankylosing spondylitis - a Swedish nested case-control study
Morin M; Hellgren K; Frisell T
Article: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2020;29(3):316-327
Anti-TNF treatment during pregnancy and birth outcomes: Apopulation-based study from Denmark, Finland, and Sweden
Broms G; Kieler H; Ekbom A; Gissler M; Hellgren K; Lahesmaa-Korpinen A-M; Pedersen L; Schmitt-Egenolf M; Sorensen HT; Granath F
Article: BJOG: AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY. 2019;126(10):1213-1222
Maternal and infant pregnancy outcomes in women with psoriatic arthritis: a Swedish nationwide cohort study
Remaeus K; Stephansson O; Johansson K; Granath F; Hellgren K
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(12):2025-2030
Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis: a European registries collaborative project
Mercer LK; Regierer AC; Mariette X; Dixon WG; Baecklund E; Hellgren K; Dreyer L; Hetland ML; Cordtz R; Hyrich K; Strangfeld A; Zink A; Canhao H; Victoria Hernandez M; Tubach F; Gottenberg J-E; Morel J; Zavada J; Iannone F; Askling J; Listing J
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(4):700-708
Rheumatoid Arthritis and Risk of Malignant Lymphoma
Hellgren K; Baecklund E; Backlin C; Sundstrom C; Smedby KE; Askling J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(1):105-111
Cancer risk in patients with spondyloarthritis treated with TNF inhibitors: a collaborative study from the ARTIS and DANBIO registers
Hellgren K; Dreyer L; Arkema EV; Glintborg B; Jacobsson LTH; Kristensen L-E; Feltelius N; Hetland ML; Askling J
Article: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 2016;14(2):234-41.e1-5-241.e5
Low Risk of Birth Defects for Infants Whose Mothers Are Treated With Anti-Tumor Necrosis Factor Agents During Pregnancy
Broms G; Granath F; Ekbom A; Hellgren K; Pedersen L; Sorensen HT; Stephansson O; Kieler H
Article: ANNALS OF THE RHEUMATIC DISEASES. 2016;75(1):183-189
Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden
Frisell T; Hellgren K; Alfredsson L; Raychaudhuri S; Klareskog L; Askling J
Journal article: RHEUMATOLOGY. 2015;54(suppl_1):i25
O07. First Results of a European Registries Collaborative Project to Describe the Spectrum of Lymphomas Across Different Drug Treatment Groups in Rheumatoid Arthritis
Mercer L; Mariette X; Dixon W; Baecklund E; Hellgren K; Dreyer L; Hetland M; Mellemkjær L; Hyrich K; Strangfeld A; Zink A; Canhao H; Martins F; Hernández V; Tubach F; Gottenberg J-E; Morel J; Zavada J; van Riel P; Finckh A; Iannone F; Askling J; Listing J
Article: ARTHRITIS & RHEUMATOLOGY. 2014;66(5):1282-1290
Ankylosing Spondylitis, Psoriatic Arthritis, and Risk of Malignant Lymphoma A Cohort Study Based on Nationwide Prospectively Recorded Data From Sweden
Hellgren K; Smedby KE; Backlin C; Sundstrom C; Feltelius N; Eriksson JK; Baecklund E; Askling J
Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(Suppl 3):a427
FRI0166 Does biological therapy alter the lymphoma risk or distribution of lymphoma subtypes in patients with ra?
Baecklund E; Hellgren K; Sundström C; Askling J; group AS
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2012;68(7):1033-1042
Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes
Hatta FHM; Teh LK; Hellden A; Hellgren KE; Roh H-K; Salleh MZ; Aklillu E; Bertilsson L
Article: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY. 2010;66(8):791-795
Fluconazole-induced intoxication with phenytoin in a patient with ultra-high activity of CYP2C9
Hellden A; Bergman U; Hellgren KE; Masquelier M; Remahl IN; Odar-Cederlof I; Ramsjo M; Bertilsson L
Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(5):1252-1258
Do Rheumatoid Arthritis and Lymphoma Share Risk Factors? A Comparison of Lymphoma and Cancer Risks Before and After Diagnosis of Rheumatoid Arthritis
Hellgren K; Smedby KE; Feltelius N; Baecklund E; Askling J
Article: ANNALS OF THE RHEUMATIC DISEASES. 2010;69(4):654-659
Rheumatoid arthritis, treatment with corticosteroids and risk of malignant lymphomas: results from a case-control study
Hellgren K; Iliadou A; Rosenquist R; Feltelius N; Backlin C; Enblad G; Askling J; Baecklund E
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All other publications

Review: LUPUS SCIENCE AND MEDICINE. 2024;11(1):e001106
Prevalence of coeliac disease in patients with systemic lupus erythematosus: a systematic review and meta-analysis
Sotoodeh A; Hoang MN; Hellgren K; Forss A
Conference publication: 2023;:a22.1-a2a22
LO-026 Hydroxychloroquine use in pregnant women with systemic lupus erythematosus and major congenital malformations in the offspring
Nguyen VN; Svenungsson E; Dominicus A; Hellgren K; Simard JF; Arkema E
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:231.1-23232
CHILDHOOD INFECTIONS AND PERINATAL FACTORS AS RISK FACTORS FOR ANKYLOSING SPONDYLITIS - RESULTS FROM A NATIONWIDE CASE-CONTROL STUDY
Morin M; Lindstrom U; Hellgren K; Frisell T
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:890.2-89890
HYDROXYCHLOROQUINE USE IN PREGNANT WOMEN WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND MAJOR CONGENITAL MALFORMATIONS IN THE OFFSPRING
Nguyen NV; Svenungsson E; Dominicus A; Hellgren K; Simard J; Arkema E
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:924-925
DIAGNOSTIC CHALLENGES IN A PREGNANT PATIENT WITH SLE AND SYSTEMIC SCLEROSIS OVERLAP - PREECLAMPSIA, ACTIVE LUPUS NEPHRITIS OR RENAL CRISIS?
Gheorghe K; Hellgren K; Gunnarsson K
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):415-416
FAMILIAL ASSOCIATIONS OF AUTOIMMUNE DISEASES IN PATIENTS WITH IDIOPATHIC INFLAMMATORY MYOPATHIES - A SWEDISH POPULATION-BASED STUDY
Che WI; Westerlind H; Lundberg IE; Hellgren K; Kuja-Halkola R; Holmqvist M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):435
CLUSTERING OF CANCERS IN FAMILIES OF IDIOPATHIC INFLAMMATORY MYOPATHIES: ASSOCIATIONS VARY BY CLINICAL PHENOTYPE AND SEX
Che WI; Baecklund F; Hellgren K; Kuja-Halkola R; Lundberg IE; Westerlind H; Holmqvist M
Letter: ARTHRITIS & RHEUMATOLOGY. 2022;74(10):1720-1721
Untitled Reply
Remaeus K; Johansson K; Granath F; Stephansson O; Hellgren K
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:41
EXPOSURE TO SPECIFIC TUMOR NECROSIS FACTOR INHIBITORS AND RISK OF DEMYELINATING AND INFLAMMATORY NEUROPATHY IN PATIENTS WITH INFLAMMATORY ARTHRITIS. A COLLABORATIVE OBSERVATIONAL STUDY ACROSS FIVE NORDIC RHEUMATOLOGY REGISTERS
Delcoigne B; Kopp TI; Arkema E; Hellgren K; Provan SA; Relas H; Aaltonen K; Trokovic N; Gudbjornsson B; Grondal G; Kristianslund E; Dreyer L; Askling J
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:169-170
RISK OF HAEMATOLOGICAL MALIGNANCY IN PATIENTS WITH PSORIATIC ARTHRITIS, OVERALL AND IN RELATION TO TNF INHIBITORS - A NORDIC COHORT STUDY
Cordtz R; Askling J; Delcoigne B; Smedby KE; Baecklund E; Ballegaard C; Isomaki P; Aaltonen K; Gudbjornsson B; Love T; Provan SA; Michelsen B; Sexton J; Dreyer L; Hellgren K
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:81-82
ARE WOMEN WITH SPONDYLOARTHRITIS AT INCREASED RISK OF ADVERSE MATERNAL AND INFANT OUTCOMES? - A SWEDISH COHORT STUDY
Morin M; Frisell T; Stephansson O; Hellgren K
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:1618
IMPACT OF A FAMILY HISTORY OF SPONDYLOARTHRITIS ON TNFI DRUG SURVIVAL AND TREATMENT RESPONSE IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS
Morin M; Hellgren K; Lindstrom U; Frisell T
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:866-867
TOWARDS MORE PRECISE ESTIMATES OF THE FAMILIAL AGGREGATION AND HERITABILITY OF ANKYLOSING SPONDYLITIS - A SWEDISH NESTED CASE-CONTROL STUDY
Morin M; Hellgren K; Frisell T
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:67-68
INCIDENCE OF OVERALL AND SITE-SPECIFIC CANCERS IN TNF INHIBITOR TREATED PATIENTS WITH PSORIATIC ARTHRITIS: A POPULATION-BASED COHORT STUDY FROM 4 NORDIC COUNTRIES
Ballegaard C; Hellgren K; Cordtz R; Delcoigne B; Gudbjornsson B; Love TJ; Aaltonen K; Nordstrom D; Provan SA; Askling J; Zobbe K; Kristensen LE; Dreyer L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:703-704
EFFECTIVENESS OF TNF INHIBITORS VS. NON-TNF INHIBITORS (ABATACEPT, TOCILIZUMAB AND RITUXIMAB) AFTER FAILURE OF NON-TNFI BIOLOGIC DMARD IN RHEUMATOID ARTHRITIS - COLLABORATION BETWEEN FIVE NATIONAL REGISTERS
Chatzidionysiou K; Hetland ML; Frisell T; Di Giuseppe D; Hellgren K; Glintborg B; Nordstrom D; Aaltonen K; Trokovic N; Kristianslund E; Kvien TK; Provan SA; Gudbjornsson B; Grondal G; Dreyer L; Kristensen LE; Jorgensen TS; Jacobsson LTH; Askling J
Conference publication: PHARMACOEPIDEMIOLOGY AND DRUG SAFETY. 2019;28:10
Infant Infections after Maternal Anti-TNF Treatment in Pregnancy
Broms G; Kieler H; Ekbom A; Gissler M; Hellgren K; Leinonen MK; Pedersen L; Schmitt-Egenolf M; Sorensen HT; Granath F
Review: RMD OPEN. 2018;4(1):e000655
Opportunities and challenges for real-world studies on chronic inflammatory joint diseases through data enrichment and collaboration between national registers: the Nordic example
Chatzidionysiou K; Hetland ML; Frisell T; Di Giuseppe D; Hellgren K; Glintborg B; Nordstrom D; Aaltonen K; Tormanen MRK; Kristianslund EK; Kvien TK; Provan SA; Guobjornsson B; Dreyer L; Kristensen LE; Jorgensen TS; Jacobsson L; Askling J
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67
Lymphoma in Patients with Rheumatoid Arthritis Treated with Biologic Drugs: Long-Term Follow-up of Risks and Lymphoma Subtypes
Hellgren K; Sundstrom C; Askling J; Baecklund E
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2014;73:519-520
WHAT IS THE PREDICTIVE VALUE OF A FAMILY HISTORY OF ARTHRITIS-RELATED CONDITIONS ON THE RISK OF RHEUMATOID ARTHRITIS, AND DOES IT DIFFER BETWEEN SEROPOSITIVE AND SERONEGATIVE DISEASE?
Frisell T; Hellgren K; Askling J
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2014;66:S806-S807
First Results of a European Registries Collaborative Project to Compare the Spectrum of Lymphomas Between Different Exposure Groups in Rheumatoid Arthritis
Mercer L; Mariette X; Dixon W; Baecklund E; Hellgren K; Dreyer L; Hetland ML; Mellemkjaer L; Hyrich K; Strangfeld A; Zink A; Canhao H; Martins F; Hernandez V; Tubach F; Gottenberg J-E; Morel J; Zavada J; van Riel P; Finckh A; Iannone F; Askling J; Listing J
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:16
What is the predictive value of a family history of arthritis-related conditions on the risk of rheumatoid arthritis, and does it differ between seropositive and seronegative disease?
Frisell T; Hellgren K; Askling J
Thesis / dissertation: 2013
Chronic inflammation, anti-inflammatory treatment and risk of malignant lymphomas
Hellgren, Karin
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Employments

Affiliated to Research, Department of Medicine, Karolinska Institutet, 2023-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2013
University Medical Degree, Karolinska Institutet, 1996

Research

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