Julia Niessl

Publications
Public outreach and news

Articles

Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2023;1521(1):32-45
Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report
Cable J; Balachandran S; Daley-Bauer LP; Rustagi A; Antony F; Frere JJ; Strampe J; Kedzierska K; Cannon JL; McGargill MA; Weiskopf D; Mettelman RC; Niessl J; Thomas PG; Briney B; Valkenburg SA; Bloom JD; Bjorkman PJ; Iketani S; Rappazzo CG; Crooks CM; Crofts KF; Pohlmann S; Krammer F; Sant AJ; Nabel GJ; Schultz-Cherry S
Article: ISCIENCE. 2023;26(1):105904
An extended SARS-CoV-2 mRNA vaccine prime-boost interval enhances B cell immunity with limited impact on T cells
Nicolas A; Sannier G; Dube M; Nayrac M; Tauzin A; Painter MM; Goel RR; Laporte M; Gendron-Lepage G; Medjahed H; Williams JC; Brassard N; Niessl J; Gokool L; Morrisseau C; Arlotto P; Tremblay C; Martel-Laferriere V; Finzi A; Greenplate AR; Wherry EJ; Kaufmann DE
Article: EBIOMEDICINE. 2022;84:104254
Immune checkpoint expression on HIV-specific CD4+ T cells and response to their blockade are dependent on lineage and function
Brunet-Ratnasingham E; Morou A; Dube M; Niessl J; Baxter AE; Tastet O; Brassard N; Ortega-Delgado G; Charlebois R; Freeman GJ; Tremblay C; Routy J-P; Kaufmann DE
Article: IMMUNITY. 2022;55(9):1732-1746.e5
Immunodeficiency syndromes differentially impact the functional profile of SARS-CoV-2-specific T cells elicited by mRNA vaccination
Gao Y; Cai C; Wullimann D; Niessl J; Rivera-Ballesteros O; Chen P; Lange J; Cuapio A; Blennow O; Hansson L; Mielke S; Nowak P; Vesterbacka J; Akber M; Perez-Potti A; Sekine T; Muller TR; Boulouis C; Kammann T; Parrot T; Muvva JR; Sobkowiak M; Healy K; Bogdanovic G; Muschiol S; Soderdahl G; Osterborg A; Hellgren F; Grifoni A; Weiskopf D; Sette A; Lore K; Chen MS; Ljungman P; Sandberg JK; Smith CIE; Bergman P; Ljunggren H-G; Aleman S; Buggert M
Article: CELL REPORTS. 2022;39(13):111013
Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen
Nayrac M; Dube M; Sannier G; Nicolas A; Marchitto L; Tastet O; Tauzin A; Brassard N; Lima-Barbosa R; Beaudoin-Bussieres G; Vezina D; Gong SY; Benlarbi M; Gasser R; Laumaea A; Prevost J; Bourassa C; Gendron-Lepage G; Medjahed H; Goyette G; Ortega-Delgado G-G; Belair J; Prat A; Tremblay C; MArtel-Laferriere V; Finzi A; Kaufmann DE
Article: NATURE MEDICINE. 2022;28(3):472-476
Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant
Gao Y; Cai C; Grifoni A; Muller TR; Niessl J; Olofsson A; Humbert M; Hansson L; Osterborg A; Bergman P; Chen P; Olsson A; Sandberg JK; Weiskopf D; Price DA; Ljunggren H-G; Karlsson AC; Sette A; Aleman S; Buggert M
Article: SCIENCE ADVANCES. 2021;7(48):eabj5629
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality
Brunet-Ratnasingham E; Anand SP; Gantner P; Dyachenko A; Moquin-Beaudry G; Brassard N; Beaudoin-Bussieres G; Pagliuzza A; Gasser R; Benlarbi M; Point F; Prevost J; Laumaea A; Niessl J; Nayrac M; Sannier G; Orban C; Messier-Peet M; Butler-Laporte G; Morrison DR; Zhou S; Nakanishi T; Boutin M; Descoteaux-Dinelle J; Gendron-Lepage G; Goyette G; Bourassa C; Medjahed H; Laurent L; Rebillard R-M; Richard J; Dube M; Fromentin R; Arbour N; Prat A; Larochelle C; Durand M; Richards JB; Chasse M; Tetreault M; Chomont N; Finzi A; Kaufmann DE
Article: SCIENCE IMMUNOLOGY. 2021;6(64):eabk0894
Identification of resident memory CD8⁺ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue
Niessl J; Sekine T; Lange J; Konya V; Forkel M; Maric J; Rao A; Mazzurana L; Kokkinou E; Weigel W; Llewellyn-Lacey S; Hodcroft EB; Karlsson AC; Fehrm J; Sundman J; Price DA; Mjosberg J; Friberg D; Buggert M
Article: CELL REPORTS. 2021;36(9):109643
Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity
Sannier G; Dube M; Dufour C; Richard C; Brassard N; Delgado G-G; Pagliuzza A; Baxter AE; Niessl J; Brunet-Ratnasingham E; Charlebois R; Routy B; Routy J-P; Fromentin R; Chomont N; Kaufmann DE
Article: CELL HOST AND MICROBE. 2021;29(7):1137-1150.e6
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses
Tauzin A; Nayrac M; Benlarbi M; Gong SY; Gasser R; Beaudoin-Bussieres G; Brassard N; Laumaea A; Vezina D; Prevost J; Anand SP; Bourassa C; Gendron-Lepage G; Medjahed H; Goyette G; Niessl J; Tastet O; Gokool L; Morrisseau C; Arlotto P; Stamatatos L; McGuire AT; Larochelle C; Uchil P; Lu M; Mothes W; De Serres G; Moreira S; Roger M; Richard J; Martel-Laferriere V; Duerr R; Tremblay C; Kaufmann DE; Finzi A
Article: EBIOMEDICINE. 2020;54:102727
Persistent expansion and Th1-like skewing of HIV-specific circulating T follicular helper cells during antiretroviral therapy
Niessl J; Baxtera AE; Morou A; Brunet-Ratnasingham E; Sannier G; Gendron-Lepage G; Richard J; Delgado G-G; Brassard N; Turcotte I; Fromentin R; Bernard NF; Chomont N; Routy J-P; Dube M; Finzi A; Kaufmann DE
Article: NATURE MEDICINE. 2020;26(2):222-227
Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity
Niessl J; Baxter AE; Mendoza P; Jankovic M; Cohen YZ; Butler AL; Lu C-L; Dube M; Shimeliovich I; Gruell H; Klein F; Caskey M; Nussenzweig MC; Kaufmann DE
Article: NATURE IMMUNOLOGY. 2019;20(8):1059-1070
Altered differentiation is central to HIV-specific CD4⁺ T cell dysfunction in progressive disease
Morou A; Brunet-Ratnasingham E; Dube M; Charlebois R; Mercier E; Darko S; Brassard N; Nganou-Makamdop K; Arumugam S; Gendron-Lepage G; Yang L; Niessl J; Baxter AE; Billingsley JM; Rajakumar PA; Lefebvre F; Johnson RP; Tremblay C; Routy J-P; Wyatt RT; Finzi A; Douek DC; Kaufmann DE
Article: CURRENT HIV/AIDS REPORTS. 2018;15(1):39-48
Tools for Visualizing HIV in Cure Research
Niessl J; Baxter AE; Kaufmann DE
Article: NATURE PROTOCOLS. 2017;12(10):2029-2049
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique
Baxter AE; Niessl J; Fromentin R; Richard J; Porichis F; Massanella M; Brassard N; Alsahafi N; Routy J-P; Finzi A; Chomont N; Kaufmann DE
Article: CELL HOST AND MICROBE. 2016;20(3):368-380
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals
Baxter AE; Niessl J; Fromentin R; Richard J; Porichis F; Charlebois R; Massanella M; Brassard N; Alsahafi N; Delgado G-G; Routy J-P; Walker BD; Finzi A; Chomont N; Kaufmann DE
Article: RETROVIROLOGY. 2015;12:38
Impaired Th17 polarization of phenotypically naive CD4⁺ T-cells during chronic HIV-1 infection and potential restoration with early ART
DaFonseca S; Niessl J; Pouvreau S; Wacleche VS; Gosselin A; Cleret-Buhot A; Bernard N; Tremblay C; Jenabian M-A; Routy J-P; Ancuta P

All other publications

Preprint: BIORXIV. 2021;BIORXIV
Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen.
Nayrac M; Dubé M; Sannier G; Nicolas A; Marchitto L; Tastet O; Tauzin A; Brassard N; Beaudoin-Bussières G; Vézina D; Gong SY; Benlarbi M; Gasser R; Laumaea A; Bourassa C; Gendron-Lepage G; Medjahed H; Goyette G; Ortega-Delgado G-G; Laporte M; Niessl J; Gokool L; Morrisseau C; Arlotto P; Richard J; Tremblay C; Martel-Laferrière V; Finzi A; Kaufmann DE
Review: SEMINARS IN IMMUNOLOGY. 2021;55:101505
T cell immunity to SARS-CoV-2
Niessl J; Sekine T; Buggert M
Preprint: BIORXIV. 2021;BIORXIV
A single BNT162b2 mRNA dose elicits antibodies with Fc-mediated effector functions and boost pre-existing humoral and T cell responses.
Tauzin A; Nayrac M; Benlarbi M; Gong SY; Gasser R; Beaudoin-Bussières G; Brassard N; Laumaea A; Vézina D; Prévost J; Anand SP; Bourassa C; Gendron-Lepage G; Medjahed H; Goyette G; Niessl J; Tastet O; Gokool L; Morrisseau C; Arlotto P; Stamatatos L; McGuire AT; Larochelle C; Uchil P; Lu M; Mothes W; Serres GD; Moreira S; Roger M; Richard J; Martel-Laferrière V; Duerr R; Tremblay C; Kaufmann DE; Finzi A
Review: VIRUSES. 2018;10(6):E336-336
Harnessing T Follicular Helper Cell Responses for HIV Vaccine Development
Niessl J; Kaufmann DE
Review: AIDS RESEARCH AND THERAPY. 2017;14(1):40
RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies
Baxter AE; Niessl J; Morou A; Kaufmann DE

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