Professor of Viral Immunology at the Department of Medicine, Huddinge since 2013.
Innate and adaptive immune mechanisms work together to contain viral infections including human immunodeficiency virus 1 (HIV-1) and hepatitis C virus (HCV). We investigate basic aspects of cell-mediated immunity as well as the immunopathogenesis of these infections. We do this with a basis in our solid understanding of fundamental immunology that we apply towards patient-based research and develop into translational approaches. The majority of T lymphocytes carry diverse T cell receptors (TCRs) that display classical MHC-restriction. However, the T cell compartment also includes invariant T cell subsets that recognize antigens presented by non-classical MHC-like molecules. Several of these invariant T cell subsets are evolutionarily conserved, display innate-like characteristics, and play important roles in immune control of pathogens. The group is particularly interested in the role of adaptive T cell responses mediated by CD8 T cells, and in the role that innate-like T cells such as the invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells play in host defense.
Selected recent publications:
1. Dias, J., Boulouis, C., Gorin, J. B., Van den Biggelaar, R., Lal, K. G., Gibbs, A., Loh, L., Gulam, M. Y., Sia, W. R., Bari, S., Hwang, Y. K., Nixon, D. F., Nguyen, S., Betts, M. R., Buggert, M., Eller, M. A., Broliden, K., Tjernlund, A., Sandberg J. K., and Leeansyah, E. (2018) The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool. Proc. Natl. Acad. Sci. USA. Pre-published online November 16, 2018. [pubmed: 30442667]
2. Buggert, M., Nguyen, S., Salgado-Montes de Oca, G., Bengsch, B., Darko, S., Ransier, A., Roberts, E. R., Alcazar, D. D., Bukh Brody, I., Vella, L., Beura, L., Wijeyesinghe, S., Herati, R. S., Del Rio Estrada, P. M., Ablanedo-Terrazas, Y., Kuri-Cervantes, L., Japp, A. S., Manne, S., Vartanian, S., Huffman, A., Sandberg, J. K., Gostick, E., Nadolski, G., Silvestri, G., Canaday, D. H., Price, D. A., Petrovas, C., Su, L. F., Vahedi, G., Dori, Y., Frank, I., Itkin, M. G., Wherry, E. J., Deeks, S. G., Naji, A., Reyes-Teran, G., Masopust, D., Douek, D. C. and Betts, M. R. (2018) Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue. Science Immunology. 3: eaar4526. DOI: 10.1126/sciimmunol.aar4526 [pubmed: 29858286]
3. Dias, J., Leeansyah, E., and Sandberg J. K. (2017) Multiple layers of heterogeneity and subset diversity in human MAIT cell responses to distinct microorganisms, and innate to cytokines. Proc. Natl. Acad. Sci. USA. 114: E5434-E5443. doi:10.1073/pnas.1705759114. [pubmed: 28630305]
4. Paquin-Proulx, D., Gibbs, A., Bächle, S., Checa, A., Introini, A., Leeansyah, E., Wheelock, C. E., Nixon, D. F., Broliden, K., Tjernlund, A., Moll, M., and Sandberg, J. K. (2016) Innate iNKT cell recognition of HIV-1 infected dendritic cells is an early detection mechanism targeted by viral immune evasion. J. Immunol. 197: 1843-1851. [pubmed: 27481843]
5. Leeansyah, E., Svärd, J., Dias, J., Buggert, M., Nyström, J., Quigley, M. F., Moll, M., Sönnerborg, A., Nowak, P., and Sandberg J. K. (2015) Arming of MAIT cell cytolytic antimicrobial activity is induced by IL-7 and defective in HIV-1 infection. PLoS Pathogens. 11: e1005072. [pubmed: 26295709]
6. Leeansyah, E., Loh, L., Nixon, D. F. and Sandberg, J. K. (2014) Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT cell development. Nature Communications. 5:3143. doi: 10.1038/ncomms4143. [pubmed: 24452018]