Johanna Klinge

Publications
CV
Public outreach and news

Articles

Article: BMC CANCER. 2013;13:473
Clinical instability of breast cancer markers is reflected in long-term in vitro estrogen deprivation studies
Milosevic J; Klinge J; Borg A-L; Foukakis T; Bergh J; Tobin NP
Article: ANNALS OF ONCOLOGY. 2007;18(5):845-850
Quantitative real-time PCR analysis and microarray-based RNA expression of HER2 in relation to outcome
Bergqvist J; Ohd JF; Smeds J; Klaar S; Isola J; Nordgren H; Elmberger GP; Hellborg H; Bjohle J; Borg A-L; Skoog L; Bergh J
Article: BREAST CANCER RESEARCH. 2007;9(2):R25
Inhibitory effects of estrogen receptor beta on specific hormone-responsive gene expression and association with disease outcome in primary breast cancer
Lin C-Y; Stroem A; Kong SL; Kietz S; Thomsen JS; Tee JBS; Vega VB; Miller LD; Smeds J; Bergh J; Gustafsson J-A; Liu ET
Article: GENES CHROMOSOMES AND CANCER. 2007;46(1):87-97
Gene expression in 16q is associated with survival and differs between Sorlie breast cancer subtypes
Wennmalm K; Calza S; Ploner A; Hall P; Bjoehle J; Klaar S; Smeds J; Pawitan Y; Bergh J
Article: CANCER RESEARCH. 2006;66(21):10292-10301
Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer
Ivshina AV; George J; Senko O; Mow B; Putti TC; Smeds J; Lindahl T; Pawitan Y; Hall P; Nordgren H; Wong JEL; Liu ET; Bergh J; Kuznetsov VA; Miller LD
Article: CANCER RESEARCH. 2006;66(14):7334-7340
Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome
Frasor J; Chang EC; Komm B; Lin C-Y; Vega VB; Liu ET; Miller LD; Smeds J; Bergh J; Katzenellenbogen BS
Article: BMC MEDICINE. 2006;4:16
Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis:: a cohort study
Hall P; Ploner A; Bjohle J; Huang F; Lin C-Y; Liu ET; Miller LD; Nordgren H; Pawitan Y; Shaw P; Skoog L; Smeds J; Wedren S; Ohd J; Bergh J
Article: JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2006;98(4):262-272
Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis
Sotiriou C; Wirapati P; Loi S; Harris A; Fox S; Smeds J; Nordgren H; Farmer P; Praz V; Haibe-Kains B; Desmedt C; Larsimont D; Cardoso F; Peterse H; Nuyten D; Buyse M; Van de Vijver MJ; Bergh J; Piccart MT; Delorenzi M
Article: BREAST CANCER RESEARCH. 2006;8(4):R34
Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients
Calza S; Hall P; Auer G; Bjohle J; Klaar S; Kronenwett U; T Liu E; Miller L; Ploner A; Smeds J; Bergh J; Pawitan Y
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(38):13550-13555
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival
Miller LD; Smeds J; George J; Vega VB; Vergara L; Ploner A; Pawitan Y; Hall P; Klaar S; Liu ET; Bergh J
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;115(6):930-934
Low frequency of BRAF and CDKN2A mutations in endometrial cancer
Salvesen HB; Kumar R; Stefansson I; Angelini S; MacDonald N; Smeds J; Jacobs IJ; Hemminki K; Das S; Alkslen LA
Article: BREAST CANCER RESEARCH. 2005;7(6):R953-R964
Gene expression profiling spares early breast cancer patients from adjuvant therapy:: derived and validated in two population-based cohorts
Pawitan Y; Bjöhle J; Amler L; Borg AL; Egyhazi S; Hall P; Han X; Holmberg L; Huang F; Klaar S; Liu ET; Miller L; Nordgren H; Ploner A; Sandelin K; Shaw PM; Smeds J; Skoog L; Wedrén S; Bergh J
Article: ACTA ONCOLOGICA. 2005;44(1):41-49
Ductal carcinoma in situ of the breast with different histopathological grades and corresponding new breast tumour events:: Analysis of loss of heterozygosity
Smeds J; Wärnberg F; Norberg T; Nordgren H; Holmberg L; Bergh J
Article: AMERICAN JOURNAL OF PATHOLOGY. 2002;161(1):229-237
Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase
Straume O; Smeds J; Kumar R; Hemminki K; Akslen LA
Article: CARCINOGENESIS. 2002;23(4):645-655
Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus:: the CDKN2A (p16^INK4a and p14^ARF) and p53 genes are major targets for inactivation
Smeds J; Berggren P; Ma X; Xu Z; Hemminki K; Kumar R
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;95(6):388-393
A single nucleotide polymorphism in the 3′untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare
Kumar R; Smeds J; Berggren P; Straume O; Rozell BL; Akslen LA; Hemminki K
Article: MUTAGENESIS. 2001;16(6):547-550
Polymorphic insertion of additional repeat within an area of direct 8 bp tandem repeats in the 5′-untranslated region of the p53R2 gene and cancer risk
Smeds J; Kumar R; Hemminki K
Article: HUMAN MUTATION. 2001;17(1):82
A novel polymorphism (-88 C>A) in the 5' UTR of the p53R2 gene.
Smeds J; Nava M; Kumar R; Hemminki K
Article: GENES CHROMOSOMES AND CANCER. 2000;28(4):404-414
Analysis of G₁/S checkpoint regulators in metastatic melanoma
Sauroja I; Smeds J; Vlaykova T; Kumar R; Talve L; Hahka-Kemppinen M; Punnonen K; Jansèn CT; Hemminki K; Pyrhönen S
Article: MUTAGENESIS. 2000;15(3):257-260
Increased frequency of LOH on chromosome 9 in sporadic primary melanomas is associated with increased patient age at diagnosis
Smeds J; Kumar R; Rozell BL; Hemminki K
Article: MELANOMA RESEARCH. 1999;9(2):138-147
Loss of heterozygosity at chromosome 9p21 (INK4-p14^ARF locus):: homozygous deletions and mutations in the p16 and p14^ARF genes in sporadic primary melanomas
Kumar R; Smeds J; Rozell BL; Hemminki K
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Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(49):17882
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival (vol 102, pg 13550, 2005)
Miller LD; Smeds J; George J; Vega VB; Vergara L; Ploner A; Pawitan Y; Hall P; Klaar S; Liu ET; Bergh J
Meeting abstract: BREAST CANCER RESEARCH. 2005;7:S48
Gene expression profiling in breast cancer challenges the existence of intermediate histological grade
Sotiriou C; Wirapati P; Loi S; Harris A; Bergh J; Smeds J; Praz V; Farmer P; Halbe-Kains B; Lallemand F; Buyse M; Piccart M; Delorenzi M
Published conference paper: ANNALS OF ONCOLOGY. 2005;16:ii195-ii202
Gene profile and response to treatment
Smeds J; Miller LD; Bjöhle J; Hall P; Klaar S; Liu ET; Pawitan Y; Ploner A; Bergh J
Thesis / dissertation: 2001
Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers
Smeds, Johanna

Employments

Research Engineer, Department of Oncology-Pathology, Karolinska Institutet, 2009-

Degrees and Education

Doctor Of Philosophy, Department of Biosciences and Nutrition, Karolinska Institutet, 2002

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