Johan Sandberg
About me
- Professor of Viral Immunology at the Department of Medicine, Huddinge since
2013.
Research
Innate and adaptive immune mechanisms work together to contain viral and bacterial infections. We investigate basic aspects of cell-mediated immunity as well as the immunopathogenesis of such infections. We do this with a basis in our solid understanding of fundamental immunology that we apply towards patient-based research and develop into translational approaches. The majority of T lymphocytes carry diverse T cell receptors (TCRs) that display classical MHC-restriction. However, the T cell compartment also includes invariant T cell subsets that recognize antigens presented by non-classical MHC-like molecules. Several of these invariant T cell subsets are evolutionarily conserved, display innate-like characteristics, and play important roles in immune control of pathogens. The group is particularly interested in the role of adaptive T cell responses mediated by CD8 T cells, and in the role that unconventional innate-like T cells such as the invariant natural killer T (iNKT) cells and mucosa-associated invariant T (MAIT) cells play in host defense.
Our key study on MAIT cell adaptation in human tissues, published in Science Immunology in 2024, accessible full text here:
Human MAIT cell tissue adaptation and specialization (Science Immunology, Sept 2024)
Selected publications
- Article: SCIENCE IMMUNOLOGY. 2024;9(99):eadn2362
- Journal article: NATURE MEDICINE. 2022
- Article: CELL. 2020;183(1):158-168.e14
- Article: SCIENCE IMMUNOLOGY. 2020;5(51):eabe1670
- Article: PLOS BIOLOGY. 2020;18(6):e3000644
- Article: NATURE COMMUNICATIONS. 2020;11(1):272
Articles
- Article: JOURNAL OF INFECTIOUS DISEASES. 2024;230(2):e318-e326
- Journal article: SCIENCE ADVANCES. 2024;10(24):eadn6331
- Article: JOURNAL OF IMMUNOLOGY. 2024;212(3):389-396
- Article: PLOS ONE. 2024;19(5):e0294695
- Article: SCIENCE IMMUNOLOGY. 2023;8(90):eadh0687
- Article: CELL HOST AND MICROBE. 2023;31(6):928-936.e4
- Article: RESPIRATORY RESEARCH. 2023;24(1):62
- Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440
- Article: IMMUNITY. 2022;55(9):1732-1746.e5
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2022;96(1):e13195
- Article: RESPIRATORY RESEARCH. 2022;23(1):127
- Article: MOLECULAR MEDICINE. 2022;28(1):54
- Article: HEPATOLOGY. 2022;75(5):1154-1168
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):462-471
- Article: NATURE MEDICINE. 2022;28(3):472-476
- Article: JOURNAL OF IMMUNOLOGY. 2022;208(5):1170-1179
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2022;52(3):503-510
- Article: MOLECULAR MEDICINE. 2022;28(1):20
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:985385
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(46):e2104721118
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118
- Article: JOURNAL OF INFECTIOUS DISEASES. 2021;224(4):715-725
- Article: JHEP REPORTS. 2021;3(4):100318
- Article: CELL REPORTS. 2021;35(8):109174
- Article: CELL REPORTS MEDICINE. 2021;2(3):100220
- Article: JCI INSIGHT. 2021;6(5):140074
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(6):e2018587118
- Article: CRITICAL REVIEWS IN IMMUNOLOGY. 2021;41(5):69-82
- Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1306
- Article: CELL. 2020;183(7):1946-1961.e15
- Article: ISCIENCE. 2020;23(12):101876
- Article: VIRUSES. 2020;12(12):E1426-1426
- Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
- Article: SCIENCE IMMUNOLOGY. 2020;5(49):eaba7918
- Article: JOURNAL OF IMMUNOLOGY. 2020;205(1):67-77
- Article: SCIENTIFIC REPORTS. 2020;10(1):2081
- Article: METHODS IN MOLECULAR BIOLOGY. 2020;2098:83-94
- Article: METHODS IN MOLECULAR BIOLOGY. 2020;2098:149-165
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25923-25931
- Article: JOURNAL OF IMMUNOLOGY. 2019;203(8):2210-2221
- Article: JOURNAL OF HEPATOLOGY. 2019;71(2):301-312
- Article: NATURE COMMUNICATIONS. 2019;10(1):2331
- Article: INTERNATIONAL JOURNAL OF ORAL SCIENCE. 2019;11(2):16
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1300
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(1):133-143
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(49):E11513-E11522
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(9):1456-1469
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(8):1329-1335
- Article: IMMUNOHORIZONS. 2018;2(6):172-184
- Article: SCIENCE IMMUNOLOGY. 2018;3(24):eaar4526
- Article: CHEST. 2018;153(5):e93-e96
- Article: CYTOMETRY. PART A : THE JOURNAL OF THE INTERNATIONAL SOCIETY FOR ANALYTICAL CYTOLOGY. 2018;93A(5):499-503
- Article: PLOS PATHOGENS. 2018;14(4):e1006973
- Article: AIDS. 2018;32(6):825-828
- Journal article: IMMUNOHORIZONS. 2017;1(7):142-155
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2017;189(3):359-371
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(27):E5434-E5443
- Article: PLOS BIOLOGY. 2017;15(7):e2003167
- Journal article: JOURNAL OF CYSTIC FIBROSIS. 2017;16:s86
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2017;102(1):171-184
- Article: EUROPEAN JOURNAL OF CLINICAL NUTRITION. 2017;71(2):203-205
- Article: METHODS IN MOLECULAR BIOLOGY. 2017;1514:241-256
- Article: FRONTIERS IN IMMUNOLOGY. 2017;8:525
- Article: MUCOSAL IMMUNOLOGY. 2017;10(1):35-45
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2016;73(3):258-262
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(5):1843-1851
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2016;46(9):2204-2210
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2016;100(1):233-240
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2016;72(1):15-20
- Article: PLOS ONE. 2016;11(1):e0146196
- Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272
- Article: PLOS PATHOGENS. 2015;11(8):e1005072
- Article: JOURNAL OF INFECTIOUS DISEASES. 2015;211(10):1574-1584
- Article: SCIENTIFIC REPORTS. 2015;5:9675
- Article: PLOS PATHOGENS. 2015;11(1):e1004622
- Article: MUCOSAL IMMUNOLOGY. 2014;7(5):1233-1243
- Article: JOURNAL OF INFECTIOUS DISEASES. 2014;209(9):1362-1373
- Article: AIDS. 2014;28(2):171-180
- Article: NATURE COMMUNICATIONS. 2014;5:3143
- Article: AIDS. 2013;27(16):2501-2504
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2013;63(3):289-293
- Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2150-2158
- Article: CURRENT OPINION IN HIV AND AIDS. 2013;8(2):117-124
- Article: BLOOD. 2013;121(7):1124-1135
- Article: PLOS ONE. 2013;8(10):e75199
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2012;93(3):449-455
- Article: JOURNAL OF INFECTIOUS DISEASES. 2012;206(6):969-973
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2012;61(1):9-18
- Article: JOURNAL OF IMMUNOLOGY. 2012;188(12):6216-6224
- Article: CURRENT HIV RESEARCH. 2012;10(4):327-333
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(7):1913-1923
- Article: AIDS RESEARCH AND THERAPY. 2011;8:21
- Article: JOURNAL OF VIROLOGY. 2011;85(10):4802-4811
- Article: PLOS ONE. 2011;6(4):e18779
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(2):141-146
- Article: BLOOD. 2010;116(11):1876-1884
- Article: CLINICAL AND VACCINE IMMUNOLOGY. 2010;17(6):910-918
- Article: METHODS IN MOLECULAR BIOLOGY. 2010;612:353-364
- Article: JOURNAL OF IMMUNOLOGY. 2009;183(10):6612-6618
- Article: JOURNAL OF VIROLOGY. 2009;83(21):11407-11411
- Article: AIDS. 2009;23(15):1965-1970
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(8):2293-2301
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2009;51(4):380-389
- Article: AIDS RESEARCH AND THERAPY. 2009;6:15
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2009;39(3):902-911
- Article: JOURNAL OF IMMUNOLOGY. 2008;181(6):4219-4228
- Article: CLINICAL IMMUNOLOGY. 2008;128(1):46-56
- Article: BLOOD. 2008;111(10):5037-5046
- Article: JOURNAL OF CLINICAL VIROLOGY. 2008;41(2):160-163
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2007;37(12):3352-3362
- Article: JOURNAL OF INFECTIOUS DISEASES. 2007;195(9):1361-1364
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2006;312(1-2):45-53
- Article: BLOOD. 2006;107(8):3081-3083
- Article: VIROLOGY. 2006;347(1):117-126
- Article: JOURNAL OF VIROLOGY. 2006;80(6):3083-3087
- Article: TRENDS IN IMMUNOLOGY. 2005;26(7):347-349
- Article: JOURNAL OF IMMUNOLOGY. 2004;173(1):641-648
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(18):7058-7063
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(1):109-114
- Article: JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (1999). 2003;34(5):475-481
- Article: JOURNAL OF VIROLOGY. 2003;77(10):5621-5631
- Article: JOURNAL OF IMMUNOLOGY. 2003;170(8):4403-4410
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(3):588-596
- Article: JOURNAL OF IMMUNOLOGY. 2003;170(5):2349-2355
- Journal article: AIDS. 2003;17 Suppl 4:s61-s65
- Article: IMMUNITY. 2002;17(6):757-768
- Article: JOURNAL OF IMMUNOLOGY. 2002;169(5):2788-2796
- Article: JOURNAL OF VIROLOGY. 2002;76(15):7528-7534
- Article: JOURNAL OF IMMUNOLOGY. 2001;167(1):181-187
- Article: JOURNAL OF IMMUNOLOGY. 2000;165(7):3673-3679
- Article: VIROLOGY. 2000;273(1):112-119
- Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1999;29(7):2197-2204
- Article: IMMUNOLOGY LETTERS. 1999;67(3):243-249
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1999;189(6):883-894
- Article: JOURNAL OF IMMUNOLOGY. 1998;161(12):6475-6479
- Article: JOURNAL OF IMMUNOLOGY. 1998;161(9):4499-4505
- Article: JOURNAL OF IMMUNOLOGY. 1998;160(7):3163-3169
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(21):11496-11501
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 1996;26(2):288-293
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All other publications
- Review: MUCOSAL IMMUNOLOGY. 2023;16(5):740-752
- Review: JOURNAL OF IMMUNOLOGY. 2023;211(4):511-517
- Preprint: RESEARCH SQUARE. 2023
- Review: TRENDS IN MICROBIOLOGY. 2021;29(6):504-516
- Preprint: MEDRXIV. 2020
- Preprint: BIORXIV. 2020
- Review: FRONTIERS IN IMMUNOLOGY. 2018;9:1602
- Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(4):989-990
- Corrigendum: AIDS. 2014;28(1):147
- Review: FRONTIERS IN IMMUNOLOGY. 2014;5:637
- Letter: BLOOD. 2013;121(24):4963-4964
- Review: TRENDS IN IMMUNOLOGY. 2010;31(11):401-406
- Review: CLINICAL IMMUNOLOGY. 2010;135(1):12-25
- Meeting abstract: RETROVIROLOGY. 2009;6:p143
- Editorial comment: SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES. 2009;41(11-12):881-885
- Letter: CLINICAL CANCER RESEARCH. 2007;13(14):4311
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2005;192(10):1772-1780
- Book chapter: ENCYCLOPEDIA OF LIFE SCIENCES. 2005;p.
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2003;188(6):873-882
- Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2000;182(3):766-775
- Thesis / dissertation: 1999
- Published conference paper: JOURNAL OF LEUKOCYTE BIOLOGY. 1999;66(2):268-271
- Review: IMMUNOLOGICAL REVIEWS. 1996;151:123-148
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Employments
- Professor, Department of Medicine, Huddinge, Karolinska Institutet, 2013-
Degrees and Education
- Docent, Karolinska Institutet, 2006
- Doctor Of Philosophy, Karolinska Institutet, 1999