Jil Protzmann

Jil Protzmann

Phd Student
Visiting address: Solnavägen 9, 6D, 17177 Stockholm
Postal address: C2 Medicinsk biokemi och biofysik, C2 Vaskulärbiologi Eriksson, 171 77 Stockholm
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About me

  • 2015-2018 - Molecular Bioscience (MSc) at Ruprecht-Karls University
    Heidelberg, Germany
    2012-2015 - Biomedical Science (BSc) at Philipps University Marburg, Germany

Research

  • Ischaemic stroke is associated with impaired integrity of the blood-brain
    barrier (BBB) and restoration of barrier function has emerged as a promising
    avenue for therapeutic intervention. We identified PDGF-C/PDGF receptor alpha
    (PDGFRα) signalling as a key pathway in mediating BBB opening and aim at
    understanding its involvement in the biological processes occurring in the
    neurovascular unit.
    In order to elucidate the mechanism of how PDGFRα signalling modulates BBB
    integrity, I deploy various transgenic mouse lines which are e.g. deficient
    for PDGFRα or express a fluorescent reporter in different cell types of the
    brain. In my project, I combine a photoinducible ischaemic stroke model of
    middle cerebral artery occlusion with longitudinal two-photon imaging for
    real-time assessment of stroke progression.

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