Jhon Alexander Rodriguez Buitrago

I am a highly skilled researcher specializing in structural biology, with a strong focus on elucidating the molecular mechanisms behind the aggressiveness and metastasis of prostate cancer and kidney cancer cells.

My work centers around unraveling how growth factors, specifically Transforming Growth Factor β (TGF-β), trigger these mechanisms in vitro models. My research leverages advanced techniques in structural biology, including X-ray crystallography, Cryo-Electron Microscopy (Cryo-EM), and Nuclear Magnetic Resonance (NMR) spectroscopy.I am adept at protein expression and purification, biophysical characterization, and protein-protein interaction analysis using Surface Plasmon Resonance (SPR), Bio-Layer Interferometry (BLI), and thermofluor assays.

My research aims to contribute to the development of novel cancer therapies by deciphering the structural aspects of key proteins involved in cancer progression. Moreover, I am actively engaged in the search for predictive biomarkers, which could identify patients at risk of developing aggressive forms of cancer.