Janos Fuzik

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About me

Probing neuronal connectivity, plasticity and identity is crucial to understand the architecture of neuronal circuits. We are looking at neuronal networks on the single-connection level but in large populations. We use all-optical voltage imaging and single-cell transcriptomics in combination with in vivo optogenetics and behavior to understand the neuronal networks processing threatful stimuli and governing the fight-or flight responses in the brainstem, hypothalamus and amygdala. We are particularly interested in the functional sex-differences of the investigated pathways.

Articles

Article: NATURE METHODS. 2023;20(9):1409-1416
Voltage-Seq: all-optical postsynaptic connectome-guided single-cell transcriptomics
Csillag V; Bizzozzero MH; Noble JC; Reinius B; Fuzik J
Article: NATURE NEUROSCIENCE. 2023;26(7):1245-1255
Esr1⁺ hypothalamic-habenula neurons shape aversive states
Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlen M; Meletis K
Article: JOURNAL OF NEUROSCIENCE. 2021;41(14):3120-3141
Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics.
Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Article: CELL REPORTS. 2019;29(13):4320-4333.e5
A Spatiomolecular Map of the Striatum
Martin A; Calvigioni D; Tzortzi O; Fuzik J; Warnberg E; Meletis K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(51):25958-25967
Brain-wide genetic mapping identifies the indusium griseum as a prenatal target of pharmacologically unrelated psychostimulants
Fuzik J; Rehman S; Girach F; Miklosi AG; Korchynska S; Arque G; Romanov RA; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs GG; Alpar A; Hokfelt TGM; Harkany T
Article: MOLECULAR PSYCHIATRY. 2019;24(9):1351-1368
A hypothalamus-habenula circuit controls aversion
Lazaridis I; Tzortzi O; Weglage M; Martin A; Xuan Y; Parent M; Johansson Y; Fuzik J; Furth D; Fenno LE; Ramakrishnan C; Silberberg G; Deisseroth K; Carlen M; Meletis K
Journal article: JOURNAL OF NEUROSCIENCE. 2019;39(1):125-139
Four Unique Interneuron Populations Reside in Neocortical Layer 1
Schuman B; Machold RP; Hashikawa Y; Fuzik J; Fishell GJ; Rudy B
Article: CEREBRAL CORTEX. 2017;27(4):2453-2468
Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex
Calvigioni D; Mate Z; Fuzik J; Girach F; Zhang M-D; Varro A; Beiersdorf J; Schwindling C; Yanagawa Y; Dockray GJ; McBain CJ; Hoekfelt T; Szabo G; Keimpema E; Harkany T
Article: NATURE BIOTECHNOLOGY. 2016;34(2):175-183
Integration of electrophysiological recordings with single-cell RNA-seq data identifies neuronal subtypes
Fuzik J; Zeisel A; Mate Z; Calvigioni D; Yanagawa Y; Szabo G; Linnarsson S; Harkany T
Article: SCIENTIFIC REPORTS. 2015;5:11592
Protracted brain development in a rodent model of extreme longevity
Penz OK; Fuzik J; Kurek AB; Romanov R; Larson J; Park TJ; Harkany T; Keimpema E
Article: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 2014;40(5):603-609
A simple novel technique to induce short-lasting local brain ischaemia in the rat
Knapp L; Gellert L; Heredi J; Kocsis K; Olah G; Fuzik J; Kis Z; Vecsei L; Toldi J; Farkas T
Article: NATURE COMMUNICATIONS. 2014;5:4421
Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling
Alpar A; Tortoriello G; Calvigioni D; Niphakis MJ; Milenkovic I; Bakker J; Cameron GA; Hanics J; Morris CV; Fuzik J; Kovacs GG; Cravatt BF; Parnavelas JG; Andrews WD; Hurd YL; Keimpema E; Harkany T
Article: EMBO JOURNAL. 2014;33(7):668-685
Miswiring the brain: Δ⁹-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway
Tortoriello G; Morris CV; Alpar A; Fuzik J; Shirran SL; Calvigioni D; Keimpema E; Botting CH; Reinecke K; Herdegen T; Courtney M; Hurd YL; Harkany T
Article: BIOMATERIALS. 2014;35(11):3541-3550
Long-acting beneficial effect of percutaneously intramyocardially delivered secretome of apoptotic peripheral blood cells on porcine chronic ischemic left ventricular dysfunction
Pavo N; Zimmermann M; Pils D; Mildner M; Petrasi Z; Petnehazy O; Fuzik J; Jakab A; Gabriel C; Sipos W; Maurer G; Gyoengyoesi M; Ankersmit HJ
Article: NEUROSCIENCE. 2013;228:371-381
FUNDAMENTAL INTERSTRAIN DIFFERENCES IN CORTICAL ACTIVITY BETWEEN WISTAR AND SPRAGUE-DAWLEY RATS DURING GLOBAL ISCHEMIA
Fuzik J; Gellert L; Olah G; Heredi J; Kocsis K; Knapp L; Nagy D; Kincses ZT; Kis Z; Farkas T; Toldi J
Article: DRUG DESIGN, DEVELOPMENT AND THERAPY. 2013;7:981-987
Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood-brain barrier permeability
Olah G; Heredi J; Menyhart A; Czinege Z; Nagy D; Fuzik J; Kocsis K; Knapp L; Krucso E; Gellert L; Kis Z; Farkas T; Fueloep F; Pardutz A; Tajti J; Vecsei L; Toldi J
Article: NEUROPHARMACOLOGY. 2011;61(5-6):1026-1032
Kainate postconditioning restores LTP in ischemic hippocampal CA1: Onset-dependent second pathophysiological stress
Nagy D; Kocsis K; Fuzik J; Marosi M; Kis Z; Teichberg VI; Toldi J; Farkas T
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2011;667(1-3):182-187
Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia
Gellert L; Fuzik J; Goebloes A; Sarkoezi K; Marosi M; Kis Z; Farkas T; Szatmari I; Fueloep F; Vecsei L; Toldi J
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2009;604(1-3):51-57
Oxaloacetate restores the long-term potentiation impaired in rat hippocampus CA1 region by 2-vessel occlusion
Mate M; Janos F; David N; Gabriella R; Zsolt K; Laszlo V; Jozsef T; Ruban-Matuzani A; Teichberg VI; Farkas T

All other publications

Preprint: BIORXIV. 2022
Esr1+ hypothalamic-habenula neurons shape aversive states
Calvigioni D; Fuzik J; Le Merre P; Slashcheva M; Jung F; Ortiz C; Lentini A; Csillag V; Graziano M; Nikolakopoulou I; Weglage M; Lazaridis I; Kim H; Lenzi I; Park H; Reinius B; Carlén M; Meletis K
Preprint: BIORXIV. 2022
Voltage-Seq: all-optical postsynaptic connectome-guided single-cell transcriptomics
Csillag V; Bizzozzero MH; Noble J; Reinius B; Fuzik J
Preprint: BIORXIV. 2022
Sst+ GPi output neurons provide direct feedback to key nodes of the basal ganglia and drive behavioral flexibility
Weglage M; Ährlund-Richter S; Fuzik J; Skara V; Lazaridis I; Meletis K
Preprint: BIORXIV. 2020
A critical role for trkB signaling in the adult function of parvalbumin interneurons and prefrontal network dynamics
Guyon N; Zacharias LR; van Lunteren JA; Immenschuh J; Fuzik J; Märtin A; Xuan Y; Zilberter M; Kim H; Meletis K; Lopes-Aguiar C; Carlén M
Preprint: BIORXIV. 2019
Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulants
Fuzik J; Rehman S; Girach F; Miklosi A; Korchynska S; Arque G; Romanov R; Hanics J; Wagner L; Meletis K; Yanagawa Y; Kovacs G; Alpár A; Hökfelt TGM; Harkany T
Preprint: BIORXIV. 2019
A Spatiomolecular Map of the Striatum
Märtin A; Calvigioni D; Tzortzi O; Fuzik J; Wärnberg E; Meletis K

Grants

All-optical Dissection of Hypothalamic and Periaqueductal Inhibitory Circuits of Female Panic Disorder
Swedish Research Council
1 January 2024 - 31 December 2026
Hypothalamic pathways in female anxiety
Swedish Research Council
1 January 2020 - 31 December 2023

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