Jan Voss

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About me

Researching protein interactions in the WNT-Frizzled pathways.
Researcher in G protein-coupled receptor and G protein pharacology, now
starting out as a postdoctoral researcher to track protein-protein
interactions along the WNT signaling pathway.
B. Sc. in Medial Biology (Duisburg-Essen University, Germany), M. Sc. in Drug
Research (University of Bonn, Germany), PhD in Drug Sciences (with Prof.
Christa Mueller, Pharmaceutical &
Medicinal Chemistry, University of Bonn,
Germany).

Articles

Journal article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2023;6(12):1790-1800
Recommended Tool Compounds: Application of YM-254890 and FR900359 to Interrogate Gα_q/11-Mediated Signaling Pathways
Voss JH
Article: ISCIENCE. 2023;26(4):106492
Structure-affinity and structure-residence time relationships of macrocyclic Gαq protein inhibitors.
Voss JH; Crüsemann M; Bartling CRO; Kehraus S; Inoue A; König GM; Strømgaard K; Müller CE
Article: PHARMACEUTICS. 2022;15(1):57
Imaging of Gαq Proteins in Mouse and Human Organs and Tissues.
Voss JH; Al-Hroub H; Gedschold R; Dietrich JM; Gaffal E; Toma M; Kehraus S; König GM; Brust P; Fleischmann BK; Wenzel D; Deuther-Conrad W; Müller CE
Article: MOLECULES. 2022;27(12):3792
Irreversible Antagonists for the Adenosine A2B Receptor.
Temirak A; Schlegel JG; Voss JH; Vaaßen VJ; Vielmuth C; Claff T; Müller CE
Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2022;61(22):e202115545
Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates.
Claff T; Klapschinski TA; Tiruttani Subhramanyam UK; Vaaßen VJ; Schlegel JG; Vielmuth C; Voß JH; Labahn J; Müller CE
Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2022;5(5):373-386
Agonist-Dependent Coupling of the Promiscuous Adenosine A2B Receptor to Gα Protein Subunits.
Voss JH; Mahardhika AB; Inoue A; Müller CE
Article: PHARMACOLOGICAL RESEARCH. 2021;173:105880
Unraveling binding mechanism and kinetics of macrocyclic Gαq protein inhibitors.
Voss JH; Nagel J; Rafehi M; Guixà-González R; Malfacini D; Patt J; Kehraus S; Inoue A; König GM; Kostenis E; Deupi X; Namasivayam V; Müller CE
Article: JOURNAL OF NATURAL PRODUCTS. 2021;84(7):1941-1953
Feature-Based Molecular Networking for the Targeted Identification of Gq-Inhibiting FR900359 Derivatives.
Hanke W; Patt J; Alenfelder J; Voss JH; Zdouc MM; Kehraus S; Kim JB; Grujičić GV; Namasivayam V; Reher R; Müller CE; Kostenis E; Crüsemann M; König GM
Article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2021;4(2):888-897
Macrocyclic Gq Protein Inhibitors FR900359 and/or YM-254890-Fit for Translation?
Schlegel JG; Tahoun M; Seidinger A; Voss JH; Kuschak M; Kehraus S; Schneider M; Matthey M; Fleischmann BK; König GM; Wenzel D; Müller CE
Article: NATURE COMMUNICATIONS. 2021;12(1):144
Thioesterase-mediated side chain transesterification generates potent Gq signaling inhibitor FR900359.
Hermes C; Richarz R; Wirtz DA; Patt J; Hanke W; Kehraus S; Voß JH; Küppers J; Ohbayashi T; Namasivayam V; Alenfelder J; Inoue A; Mergaert P; Gütschow M; Müller CE; Kostenis E; König GM; Crüsemann M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;296:100472
An experimental strategy to probe Gq contribution to signal transduction in living cells.
Patt J; Alenfelder J; Pfeil EM; Voss JH; Merten N; Eryilmaz F; Heycke N; Rick U; Inoue A; Kehraus S; Deupi X; Müller CE; König GM; Crüsemann M; Kostenis E
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2020;177(8):1898-1916
Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors.
Kuschak M; Namasivayam V; Rafehi M; Voss JH; Garg J; Schlegel JG; Abdelrahman A; Kehraus S; Reher R; Küppers J; Sylvester K; Hinz S; Matthey M; Wenzel D; Fleischmann BK; Pfeifer A; Inoue A; Gütschow M; König GM; Müller CE
Article: FRONTIERS IN CHEMISTRY. 2020;8:833
Sensitive LC-MS/MS Method for the Quantification of Macrocyclic Gαq Protein Inhibitors in Biological Samples.
Kuschak M; Schlegel JG; Schneider M; Kehraus S; Voss JH; Seidinger A; Matthey M; Wenzel D; Fleischmann BK; König GM; Müller CE

All other publications

Preprint: RESEARCH SQUARE. 2024
Structural Basis of Frizzled 7 Activation and Allosteric Regulation
Schulte G; Bous J; Kinsolving J; Grätz L; Scharf M; Voss J; Slecuk B; Adebali O
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2024;45(5):419-429
Frizzleds act as dynamic pharmacological entities
Schulte G; Scharf MM; Bous J; Voss JH; Gratz L; Kozielewicz P
Preprint: RESEARCH SQUARE. 2024
SAG1.3-derived Frizzled-targeting negative allosteric modulators
Schulte G; Grätz L; Turku A; Kozielewicz P; Bowin C-F; Scharf M; Voss J; Kinsolving J; Shekhani R; Oliva-Vilarnau N; Koolmeister T; Körber M; Lauschke V; Löber S; Gmeiner P
Review: CURRENT MEDICINAL CHEMISTRY. 2022;29(42):6359-6378
Heterotrimeric G Protein α-Subunits - Structures, Peptide-Derived Inhibitors, and Mechanisms.
Voss JH; Müller CE

Grants

Integration of two concepts in WNT signalling: Signalosome formation and Frizzled conformational dynamics
Deutsche Forschungsgemeinschaft
1 January 2023

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