Jan-Olov Höög

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Articles

Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 2024;390:110876
Computational analysis of human medium-chain dehydrogenases/ reductases revealing substrate- and coenzyme-binding characteristics
Ostberg LJ; Hoog J-O; Persson B
Article: BMC BIOCHEMISTRY. 2016;17(1):16
Computational studies of human class V alcohol dehydrogenase - the odd sibling
Ostberg LJ; Persson B; Hoog J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2015;234:80-84
The mammalian alcohol dehydrogenase genome shows several gene duplications and gene losses resulting in a large set of different enzymes including pseudoenzymes
Ostberg LJ; Persson B; Hoog J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2013;202(1-3):97-103
Analysis of mammalian alcohol dehydrogenase 5 (ADH5): Characterisation of rat ADH5 with comparisons to the corresponding human variant
Ostberg LJ; Stromberg P; Hedberg JJ; Persson B; Hoog J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2011;191(1-3):2-7
Mammalian alcohol dehydrogenases - A comparative investigation at gene and protein levels
Hoog J-O; Ostberg LJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(17):3005-3015
Enrichment of ligands with molecular dockings and subsequent characterization for human alcohol dehydrogenase 3
Hellgren M; Carlsson J; Ostberg LJ; Staab CA; Persson B; Hoog J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;180(1):113-118
Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3
Staab CA; Hellgren M; Grafstrom RC; Hoog J-O
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(22):3653-3663
Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes
Staab CA; Ceder R; Roberg K; Grafstrom RC; Hoog J-O
Article: BIOCHEMICAL JOURNAL. 2008;413(3):493-504
Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors
Staab CA; Alander J; Brandt M; Lengqvist J; Morgenstern R; Grafstrom RC; Hoog J-O
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2007;64(23):3129-3138
A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power
Hellgren M; Kaiser C; de Haij S; Norberg A; Hoog J-O
Article: ATLA ALTERNATIVES TO LABORATORY ANIMALS. 2007;35(6):621-639
The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals
Ceder R; Merne M; Staab CA; Nilsson JA; Hoog J-O; Dressler D; Engelhart K; Grafstrom RC
Article: JOURNAL OF PROTEOME RESEARCH. 2007;6(9):3705-3717
Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma
Staab CA; Ceder R; Jagerbrink T; Nilsson J-A; Roberg K; Jornvall H; Hoog J-O; Grafstrom RC
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2007;64(4):498-505
Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism
Hellgren M; Stromberg P; Gallego O; Martras S; Farres J; Persson B; Pares X; Hoog J-O
Article: PHARMACOGENETICS AND GENOMICS. 2004;14(11):725-732
Functionality of allelic variations in human alcohol dehydrogenase gene family:: assessment of a functional window for protection against alcoholism
Lee SL; Höög JO; Yin SJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(5):610-617
Alcohol dehydrogenase 3 transcription associates with proliferation of human oral keratinocytes
Nilsson JA; Hedberg JJ; Vondracek M; Staab CA; Hansson A; Höög JO; Grafström RC
Article: BIOCHEMISTRY. 2004;43(5):1323-1328
Enzymatic mechanism of low-activity mouse alcohol dehydrogenase 2
Strömberg P; Svensson S; Berst KB; Plapp BV; Höög JO
Article: TOXICOLOGY. 2003;184(2-3):97-112
Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes
Cheung C; Davies NG; Hoog JO; Hotchkiss SAM; Pease CKS
Article: THE FEBS JOURNAL. 2003;270(6):1249-1256
Reduction of S-nitrosoglutathione by human alcohol dehydrogenase 3 is an irreversible reaction as analysed by electrospray mass spectrometry
Hedberg JJ; Griffiths WJ; Nilsson SJF; Höög JO
Article: BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION. 2003;31(1):20-23
The S-Star trial bioinformatics course -: An on-line learning success
Lim YP; Höög JO; Gardner P; Ranganathan S; Andersson S; Subbiah S; Tan TW; Hide W; Weiss AS
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2002;54(4):423-429
Oxidation of celecoxib by polymorphic cytochrome P4502C9 and alcohol dehydrogenase
Sandberg M; Yasar Ü; Strömberg P; Höög JO; Eliasson E
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2002;59(3):552-559
Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2
Strömberg P; Svensson S; Hedberg JJ; Nordling E; Höög JO
Article: PHARMACOGENETICS AND GENOMICS. 2001;11(9):815-824
Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter
Hedberg JJ; Backlund M; Strömberg P; Lönn SS; Dahl ML; Ingelman-Sundberg M; Höög JO
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2001;58(11):1719-1726
Micro-array chip analysis of carbonyl-metabolising enzymes in normal, immortalised and malignant human oral keratinocytes
Hedberg JJ; Grafström RC; Vondracek M; Sarang Z; Wärngård L; Höög JO
Article: JOURNAL OF BIOMEDICAL SCIENCE. 2001;8(1):71-76
Mammalian alcohol dehydrogenase functional and structural implications
Höög JO; Hedberg JJ; Strömberg P; Svensson S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;278(3):544-549
Human class V alcohol dehydrogenase (ADH5):: A complex transcription unit generates C-terminal multiplicity
Strömberg P; Höög JO
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(5):1745-1755
Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa
Hedberg JJ; Höög JO; Nilsson JA; Xi Z; Elfwing Å; Grafström RC
Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;302(2):441-453
Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency
Svensson S; Höög JO; Schneider G; Sandalova T
Article: PHARMACOLOGY. 2000;61(3):184-191
Pharmacogenetics of the alcohol dehydrogenase system
Jörnvall H; Höög JO; Persson B; Parés X
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;274(3):684-688
Cyclic expression of class I alcohol dehydrogenase in male rats treated with ethanol
Badger TM; Hoog JO; Svensson S; McGehee RE; Fang C; Ronis MJJ; Ingelman-Sundberg M
Article: HEPATOLOGY. 2000;31(4):990-996
Human liver class I alcohol dehydrogenase γγ isozyme:: The sole cytosolic 3β-hydroxysteroid dehydrogenase of iso bile acids
Marschall HU; Oppermann UCT; Svensson S; Nordling E; Persson B; Höög JO; Jörnvall H
Article: BIOCHEMICAL PHARMACOLOGY. 2000;59(4):385-391
Studies on the interaction between ethanol and serotonin metabolism in rat, using deuterated ethanol and 4-methylpyrazole
Some M; Svensson S; Höög JO; Helander A
Article: MEDICAL TEACHER. 2000;22(1):30-33
Student attitudes towards laboratory exercises in medical biochemistry
Cronholm T; Höög JO; Mårtenson D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(42):29712-29719
A novel subtype of class II alcohol dehydrogenase in rodents -: Unique Pro⁴⁷ and Ser¹⁸² modulates hydride transfer in the mouse enzyme
Svensson S; Strömberg P; Höög JO
Article: BIOCHEMICAL PHARMACOLOGY. 1999;58(3):389-395
Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family
Duester G; Farrés J; Felder MR; Holmes RS; Höög JO; Parés X; Plapp BV; Yin SJ; Jörnvall H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;261(1):100-107
Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin
Cheung C; Smith CK; Hoog JO; Hotchkiss SAM
Article: THE FEBS JOURNAL. 1999;263(2):305-311
An ethanol-inducible MDR ethanol dehydrogenase/acetaldehyde reductase in Escherichia coli -: Structural and enzymatic relationships to the eukaryotic protein forms
Shafqat J; Höög JO; Hjelmqvist L; Oppermann UCT; Ibáñez C; Jörnvall H
Article: THE FEBS JOURNAL. 1999;262(2):324-329
Activities of human alcohol dehydrogenases in the metabolic pathways of ethanol and serotonin
Svensson S; Some M; Lundsjö A; Helander A; Cronholm T; Höög JO
Article: FEBS LETTERS. 1999;445(2-3):261-264
SDR and MDR:: completed genome sequences show these protein families to be large, of old origin, and of complex nature
Jörnvall H; Höög JO; Persson B
Article: FEBS LETTERS. 1998;436(1):67-70
An attempt to transform class characteristics within the alcohol dehydrogenase family
Hedberg JJ; Strömberg P; Höög JO
Article: THE FEBS JOURNAL. 1998;251(1-2):236-243
Structural and functional divergence of class II alcohol dehydrogenase -: Cloning and characterisation of rabbit liver isoforms of the enzyme
Svensson S; Hedberg JJ; Höög JO
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;273(6):C1981-C1986
Regulation of rat Na⁺-K⁺-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA
Cheng XJ; Höög JO; Nairn AC; Greengard P; Aperia A
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1997;414:303-311
Mammalian class II alcohol dehydrogenase. A highly variable enzyme.
Höög JO; Svensson S
Article: FEBS LETTERS. 1996;397(2-3):338-342
Alcohol dehydrogenase in human tissues: Localisation of transcripts coding for five classes of the enzyme
Estonius M; Svensson S; Hoog JO
Article: FEBS LETTERS. 1996;394(2):217-220
Aldehyde dismutase activity of human liver alcohol dehydrogenase
Svensson S; Lundsjo A; Cronholm T; Hoog JO
Article: FEBS LETTERS. 1995;374(3):363-366
ISOLATION, CHARACTERIZATION AND STRUCTURE OF SUBTILISIN FROM A THERMOSTABLE BACILLUS-SUBTILIS ISOLATE
KAMAL M; HOOG JO; KAISER R; SHAFQAT J; RAZZAKI T; ZAIDI ZH; JORNVALL H
Article: BIOCHEMICAL JOURNAL. 1995;311(Pt 3):861-866
HETEROLOGOUS EXPRESSION OF RAT-LIVER MICROSOMAL GLUTATHIONE TRANSFERASE IN SIMIAN COS CELLS AND ESCHERICHIA-COLI
WEINANDER R; MOSIALOU E; DEJONG J; TU CPD; DYPBUKT J; BERGMAN T; BARNES HJ; HOOG JO; MORGENSTERN R
Article: FEBS LETTERS. 1995;368(3):445-448
CLONING AND CHARACTERIZATION OF A NOVEL RAT ALCOHOL-DEHYDROGENASE OF CLASS-II TYPE
HOOG JO
Article: FEBS LETTERS. 1995;367(3):306-310
ALCOHOL-DEHYDROGENASE OF CLASS-I - KIWI LIVER-ENZYME, PARALLEL EVOLUTION IN SEPARATE VERTEBRATE LINES, AND CORRELATION WITH 12S RIBOSOMAL-RNA PATTERNS
HJELMQVIST L; METSIS M; PERSSON H; HOOG JO; MCLENNAN J; JORNVALL H
Article: GENOMICS. 1995;26(1):55-62
STRUCTURAL ORGANIZATION OF THE HUMAN SORBITOL DEHYDROGENASE GENE (SORD)
IWATA T; POPESCU NC; ZIMONJIC DB; KARLSSON C; HOOG JO; VACA G; RODRIGUEZ IR; CARPER D
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1995;372:397-406
Zinc binding of alcohol and sorbitol dehydrogenases.
Karlsson C; Jörnvall H; Höög JO
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1995;372:365-371
Crystallizations of novel forms of alcohol dehydrogenase.
el-Ahmad M; Ramaswamy S; Danielsson O; Karlsson C; Estonius M; Höög JO; Eklund H; Jörnvall H
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1995;372:355-364
Mammalian class VI alcohol dehydrogenase. Novel types of the rodent enzymes.
Höög JO; Brandt M
Article: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1995;372:327-330
Mutations of human class III alcohol dehydrogenase.
Estonius M; Höög JO; Danielsson O; Jörnvall H
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Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;178(1-3):29-35
The Janus face of alcohol dehydrogenase 3
Staab CA; Alander J; Morgenstern R; Grafstrom RC; Hoog J-O
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(24):3950-3960
Dual functions of alcohol dehydrogenase 3: implications with focus on formaldehyde dehydrogenase and S-nitrosoglutathione reductase activities
Staab CA; Hellgren M; Hoog J-O
Published conference paper: ATLA ALTERNATIVES TO LABORATORY ANIMALS. 2004;32(4):401-405
Modelling of normal and premalignant oral tissue by using the immortalised cell line, SVpgC2a:: A review of the value of the model
Staab CA; Vondracek M; Custodio H; Johansson K; Nilsson JA; Morgan P; Höög JO; Cotgreave I; Grasfström RC
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2003;143:175-181
The mammalian alcohol dehydrogenases interact in several metabolic pathways
Höög JO; Strömberg P; Hedberg JJ; Griffiths WJ
Published conference paper: ATLA ALTERNATIVES TO LABORATORY ANIMALS. 2001;29(3):325-333
Uniform expression of alcohol dehydrogenase 3 in epithelia regenerated with cultured normal, immortalised and malignant human oral keratinocytes
Hedberg JJ; Hansson A; Nilsson JA; Höög JO; Grafström RC
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130(1-3):395-404
Mammalian alcohol dehydrogenase of higher classes:: analyses of human ADH5 and rat ADH6
Höög JO; Brandt M; Hedberg JJ; Stromberg P
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130(1-3):351-358
Crystal structure of sorbitol dehydrogenase
Johansson K; El-Ahmad M; Kaiser C; Jörnvall H; Eklund H; Höög JO; Ramaswamy S
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130(1-3):339-350
Class II alcohol dehydrogenase (ADH2) -: adding the structure
Svensson S; Strömberg P; Sandalova T; Höög JO
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1999;463:331-338
Class II alcohol dehydrogenase -: A suggested function in aldehyde reduction
Höög JO; Svensson S; Strömberg P; Brandt M
Published conference paper: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 1999;463:285-293
Studies on variants of alcohol dehydrogenases and its domains
Shafqat J; Höög JO; Hjelmqvist L; Oppermann U; Ibanez C; Jörnvall H
Review: ALCOHOL AND ALCOHOLISM. 1995;30(2):153-161
NOMENCLATURE OF ALCOHOL DEHYDROGENASES
JORNVALL H; HOOG JO

Employments

Professor, Senior, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2025-2025
Affiliated to Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2024-2024
Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2001-2024

Degrees and Education

Docent, Karolinska Institutet, 1988

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