Jan-Olov Höög

Publications
CV
Public outreach and news

Articles

Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 2024;390:110876

Computational analysis of human medium-chain dehydrogenases/reductases revealing substrate- and coenzyme-binding characteristics.

Östberg LJ; Höög J-O; Persson B
Article: BMC BIOCHEMISTRY. 2016;17(1):16

Computational studies of human class V alcohol dehydrogenase - the odd sibling.

Östberg LJ; Persson B; Höög J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2015;234:80-84

The mammalian alcohol dehydrogenase genome shows several gene duplications and gene losses resulting in a large set of different enzymes including pseudoenzymes.

Östberg LJ; Persson B; Höög J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2013;202(1-3):97-103

Analysis of mammalian alcohol dehydrogenase 5 (ADH5): characterisation of rat ADH5 with comparisons to the corresponding human variant.

Ostberg LJ; Strömberg P; Hedberg JJ; Persson B; Höög J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2011;191(1-3):2-7

Mammalian alcohol dehydrogenases--a comparative investigation at gene and protein levels.

Höög J-O; Ostberg LJ
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(17):3005-3015

Enrichment of ligands with molecular dockings and subsequent characterization for human alcohol dehydrogenase 3.

Hellgren M; Carlsson J; Ostberg LJ; Staab CA; Persson B; Höög J-O
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;180(1):113-118

Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3.

Staab CA; Hellgren M; Grafström RC; Höög J-O
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(22):3653-3663

Serum-responsive expression of carbonyl-metabolizing enzymes in normal and transformed human buccal keratinocytes.

Staab CA; Ceder R; Roberg K; Grafström RC; Höög J-O
Article: BIOCHEMICAL JOURNAL. 2008;413(3):493-504

Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors.

Staab CA; Alander J; Brandt M; Lengqvist J; Morgenstern R; Grafström RC; Höög J-O
Article: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2007;35(6):621-639

The application of normal, SV40 T-antigen-immortalised and tumour-derived oral keratinocytes, under serum-free conditions, to the study of the probability of cancer progression as a result of environmental exposure to chemicals.

Ceder R; Merne M; Staab CA; Nilsson JA; Höög J-O; Dressler D; Engelhart K; Grafström RC
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2007;64(23):3129-3138

A hydrogen-bonding network in mammalian sorbitol dehydrogenase stabilizes the tetrameric state and is essential for the catalytic power.

Hellgren M; Kaiser C; de Haij S; Norberg A; Höög J-O
Article: JOURNAL OF PROTEOME RESEARCH. 2007;6(9):3705-3717

Bioinformatics processing of protein and transcript profiles of normal and transformed cell lines indicates functional impairment of transcriptional regulators in buccal carcinoma.

Staab CA; Ceder R; Jägerbrink T; Nilsson J-A; Roberg K; Jörnvall H; Höög J-O; Grafström RC
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2007;64(4):498-505

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism.

Hellgren M; Strömberg P; Gallego O; Martras S; Farrés J; Persson B; Parés X; Höög J-O
Article: PHARMACOGENETICS AND GENOMICS. 2004;14(11):725-732

Functionality of allelic variations in human alcohol dehydrogenase gene family: assessment of a functional window for protection against alcoholism.

Lee S-L; Höög J-O; Yin S-J
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(5):610-617

Alcohol dehydrogenase 3 transcription associates with proliferation of human oral keratinocytes.

Nilsson JA; Hedberg JJ; Vondracek M; Staab CA; Hansson A; Höög J-O; Grafström RC
Article: BIOCHEMISTRY. 2004;43(5):1323-1328

Enzymatic mechanism of low-activity mouse alcohol dehydrogenase 2.

Strömberg P; Svensson S; Berst KB; Plapp BV; Höög J-O
Article: TOXICOLOGY. 2003;184(2-3):97-112

Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes.

Cheung C; Davies NG; Hoog J-O; Hotchkiss SAM; Smith Pease CK
Article: FEBS JOURNAL. 2003;270(6):1249-1256

Reduction of S-nitrosoglutathione by human alcohol dehydrogenase 3 is an irreversible reaction as analysed by electrospray mass spectrometry.

Hedberg JJ; Griffiths WJ; Nilsson SJF; Höög J-O
Article: BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION. 2003;31(1):20-23

The S-Star trial bioinformatics course -: An on-line learning success

Lim YP; Höög JO; Gardner P; Ranganathan S; Andersson S; Subbiah S; Tan TW; Hide W; Weiss AS
Article: BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2002;54(4):423-429

Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase.

Sandberg M; Yasar U; Strömberg P; Höög J-O; Eliasson E
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2002;59(3):552-559

Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2.

Strömberg P; Svensson S; Hedberg JJ; Nordling E; Höög JO
Article: PHARMACOGENETICS AND GENOMICS. 2001;11(9):815-824

Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter.

Hedberg JJ; Backlund M; Strömberg P; Lönn S; Dahl ML; Ingelman-Sundberg M; Höög JO
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2001;58(11):1719-1726

Micro-array chip analysis of carbonyl-metabolising enzymes in normal, immortalised and malignant human oral keratinocytes.

Hedberg JJ; Grafström RC; Vondracek M; Sarang Z; Wärngård L; Höög JO
Article: JOURNAL OF BIOMEDICAL SCIENCE. 2001;8(1):71-76

Mammalian alcohol dehydrogenase - functional and structural implications.

Höög JO; Hedberg JJ; Strömberg P; Svensson S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;278(3):544-549

Human class V alcohol dehydrogenase (ADH5): A complex transcription unit generates C-terminal multiplicity.

Strömberg P; Höög JO
Article: AMERICAN JOURNAL OF PATHOLOGY. 2000;157(5):1745-1755

Expression of alcohol dehydrogenase 3 in tissue and cultured cells from human oral mucosa.

Hedberg JJ; Höög JO; Nilsson JA; Xi Z; Elfwing A; Grafström RC
Article: JOURNAL OF MOLECULAR BIOLOGY. 2000;302(2):441-453

Crystal structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency.

Svensson S; Höög JO; Schneider G; Sandalova T
Article: PHARMACOLOGY. 2000;61(3):184-191

Pharmacogenetics of the alcohol dehydrogenase system.

Jörnvall H; Höög JO; Persson B; Parés X
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;274(3):684-688

Cyclic expression of class I alcohol dehydrogenase in male rats treated with ethanol.

Badger TM; Hoog JO; Svensson S; McGehee RE; Fang C; Ronis MJ; Ingelman-Sundberg M
Article: HEPATOLOGY. 2000;31(4):990-996

Human liver class I alcohol dehydrogenase gammagamma isozyme: the sole cytosolic 3beta-hydroxysteroid dehydrogenase of iso bile acids.

Marschall HU; Oppermann UC; Svensson S; Nordling E; Persson B; Höög JO; Jörnvall H
Article: BIOCHEMICAL PHARMACOLOGY. 2000;59(4):385-391

Studies on the interaction between ethanol and serotonin metabolism in rat, using deuterated ethanol and 4-methylpyrazole.

Some M; Svensson S; Höög JO; Helander A
Article: MEDICAL TEACHER. 2000;22(1):30-33

Student attitudes towards laboratory exercises in medical biochemistry

Cronholm T; Höög JO; Mårtenson D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(42):29712-29719

A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse enzyme.

Svensson S; Strömberg P; Höög JO
Article: BIOCHEMICAL PHARMACOLOGY. 1999;58(3):389-395

Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family.

Duester G; Farrés J; Felder MR; Holmes RS; Höög JO; Parés X; Plapp BV; Yin SJ; Jörnvall H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;261(1):100-107

Expression and localization of human alcohol and aldehyde dehydrogenase enzymes in skin.

Cheung C; Smith CK; Hoog JO; Hotchkiss SA
Article: FEBS JOURNAL. 1999;263(2):305-311

An ethanol-inducible MDR ethanol dehydrogenase/acetaldehyde reductase in Escherichia coli: structural and enzymatic relationships to the eukaryotic protein forms.

Shafqat J; Höög JO; Hjelmqvist L; Oppermann UC; Ibáñez C; Jörnvall H
Article: FEBS JOURNAL. 1999;262(2):324-329

Activities of human alcohol dehydrogenases in the metabolic pathways of ethanol and serotonin.

Svensson S; Some M; Lundsjö A; Helander A; Cronholm T; Höög JO
Article: FEBS LETTERS. 1999;445(2-3):261-264

SDR and MDR: completed genome sequences show these protein families to be large, of old origin, and of complex nature.

Jörnvall H; Höög JO; Persson B
Article: FEBS LETTERS. 1998;436(1):67-70

An attempt to transform class characteristics within the alcohol dehydrogenase family.

Hedberg JJ; Strömberg P; Höög JO
Article: FEBS JOURNAL. 1998;251(1-2):236-243

Structural and functional divergence of class II alcohol dehydrogenase--cloning and characterisation of rabbit liver isoforms of the enzyme.

Svensson S; Hedberg JJ; Höög JO
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;273(6):c1981-c1986

Regulation of rat Na(+)-K(+)-ATPase activity by PKC is modulated by state of phosphorylation of Ser-943 by PKA.

Cheng XJ; Höög JO; Nairn AC; Greengard P; Aperia A
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;414:303-311

Mammalian class II alcohol dehydrogenase. A highly variable enzyme.

Höög JO; Svensson S
Article: FEBS LETTERS. 1996;397(2-3):338-342

Alcohol dehydrogenase in human tissues: localisation of transcripts coding for five classes of the enzyme.

Estonius M; Svensson S; Höög JO
Article: FEBS LETTERS. 1996;394(2):217-220

Aldehyde dismutase activity of human liver alcohol dehydrogenase.

Svensson S; Lundsjö A; Cronholm T; Höög JO
Article: FEBS LETTERS. 1995;374(3):363-366

Isolation, characterization and structure of subtilisin from a thermostable Bacillus subtilis isolate.

Kamal M; Höög JO; Kaiser R; Shafqat J; Razzaki T; Zaidi ZH; Jörnvall H
Article: BIOCHEMICAL JOURNAL. 1995;311 ( Pt 3)(Pt 3):861-866

Heterologous expression of rat liver microsomal glutathione transferase in simian COS cells and Escherichia coli.

Weinander R; Mosialou E; DeJong J; Tu CP; Dypbukt J; Bergman T; Barnes HJ; Höög JO; Morgenstern R
Article: FEBS LETTERS. 1995;368(3):445-448

Cloning and characterization of a novel rat alcohol dehydrogenase of class II type.

Höög JO
Article: FEBS LETTERS. 1995;367(3):306-310

Alcohol dehydrogenase of class I: kiwi liver enzyme, parallel evolution in separate vertebrate lines, and correlation with 12S rRNA patterns.

Hjelmqvist L; Metsis M; Persson H; Höög JO; McLennan J; Jörnvall H
Article: GENOMICS. 1995;26(1):55-62

Structural organization of the human sorbitol dehydrogenase gene (SORD).

Iwata T; Popescu NC; Zimonjic DB; Karlsson C; Höög JO; Vaca G; Rodriguez IR; Carper D
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1995;372:397-406

Zinc binding of alcohol and sorbitol dehydrogenases.

Karlsson C; Jörnvall H; Höög JO
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1995;372:365-371

Crystallizations of novel forms of alcohol dehydrogenase.

el-Ahmad M; Ramaswamy S; Danielsson O; Karlsson C; Estonius M; Höög JO; Eklund H; Jörnvall H
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1995;372:355-364

Mammalian class VI alcohol dehydrogenase. Novel types of the rodent enzymes.

Höög JO; Brandt M
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1995;372:327-330

Mutations of human class III alcohol dehydrogenase.

Estonius M; Höög JO; Danielsson O; Jörnvall H
Show more

All other publications

Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2009;178(1-3):29-35

The Janus face of alcohol dehydrogenase 3.

Staab CA; Alander J; Morgenstern R; Grafström RC; Höög J-O
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2008;65(24):3950-3960

Medium- and short-chain dehydrogenase/reductase gene and protein families : Dual functions of alcohol dehydrogenase 3: implications with focus on formaldehyde dehydrogenase and S-nitrosoglutathione reductase activities.

Staab CA; Hellgren M; Höög J-O
Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2004;32(4):401-405

Modelling of normal and premalignant oral tissue by using the immortalised cell line, SVpgC2a: a review of the value of the model.

Staab CA; Vondracek M; Custodio H; Johansson K; Nilsson JA; Morgan P; Höög J-O; Cotgreave I; Grafström RC
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2003;143-144:175-181

The mammalian alcohol dehydrogenases interact in several metabolic pathways.

Höög JO; Strömberg P; Hedberg JJ; Griffiths WJ
Published conference paper: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2001;29(3):325-333

Uniform expression of alcohol dehydrogenase 3 in epithelia regenerated with cultured normal, immortalised and malignant human oral keratinocytes.

Hedberg JJ; Hansson A; Nilsson JA; Höög JO; Grafström RC
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130-132(1-3):395-404

Mammalian alcohol dehydrogenase of higher classes: analyses of human ADH5 and rat ADH6.

Höög J; Brandt M; Hedberg JJ; Stromberg P
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130-132(1-3):351-358

Crystal structure of sorbitol dehydrogenase.

Johansson K; El-Ahmad M; Kaiser C; Jörnvall H; Eklund H; Höög J; Ramaswamy S
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;130-132(1-3):339-350

Class II alcohol dehydrogenase (ADH2)--adding the structure.

Svensson S; Strömberg P; Sandalova T; Höög J
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1999;463:331-338

Class II alcohol dehydrogenase. A suggested function in aldehyde reduction.

Höög JO; Svensson S; Strömberg P; Brandt M
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1999;463:285-293

Studies on variants of alcohol dehydrogenases and its domains.

Shafqat J; Höög JO; Hjelmqvist L; Oppermann U; Ibanez C; Jörnvall H
Review: ALCOHOL AND ALCOHOLISM. 1995;30(2):153-161

Nomenclature of alcohol dehydrogenases.

Jörnvall H; Höög JO

Employments

Professor, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2001-

Degrees and Education

Docent, Karolinska Institutet, 1988

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI