Jan Kehr

Publications
Public outreach and news

Articles

Article: PHARMACOLOGICAL REPORTS. 2021;73(4):1109-1121

The pivotal role of pituitary adenylate cyclase-activating polypeptide for lactate production and secretion in astrocytes during fear memory

Kambe Y; Yamauchi Y; Thanh Nguyen T; Thi Nguyen T; Ago Y; Shintani N; Hashimoto H; Yoshitake S; Yoshitake T; Kehr J; Kawamura N; Katsuura G; Kurihara T; Miyata A
Article: SCIENCE ADVANCES. 2021;7(30):eabg5733

Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging

Adori C; Daraio T; Kuiper R; Barde S; Horvathova L; Yoshitake T; Ihnatko R; Valladolid-Acebes I; Vercruysse P; Wellendorf AM; Gramignoli R; Bozoky B; Kehr J; Theodorsson E; Cancelas JA; Mravec B; Jorns C; Ellis E; Mulder J; Uhlen M; Bark C; Hokfelt T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(23):e2023750118

Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine.

Dallérac G; Li X; Lecouflet P; Morisot N; Sacchi S; Asselot R; Pham TH; Potier B; Watson DJG; Schmidt S; Levasseur G; Fossat P; Besedin A; Rivet J-M; Coyle JT; Collo G; Pollegioni L; Kehr J; Galante M; Fone KC; Gardier AM; Freret T; Contarino A; Millan MJ; Mothet J-P
Article: FRONTIERS IN PSYCHIATRY. 2021;12:801641

Preferential Effects of Cariprazine on Counteracting the Disruption of Social Interaction and Decrease in Extracellular Dopamine Levels Induced by the Dopamine D₃ Receptor Agonist, PD-128907 in Rats: Implications for the Treatment of Negative and Depressive Symptoms of Psychiatric Disorders

Kehr J; Wang F-H; Ichinose F; Yoshitake S; Farkas B; Kiss B; Adham N
Article: EXPERIMENTAL PHYSIOLOGY. 2020;105(9):1634-1647

The impact of damage-associated molecular patterns on the neurotransmitter release and gene expression in theex vivorat carotid body

Mkrtchian S; Kahlin J; Gomez-Galan M; Ebberyd A; Yoshitake T; Schmidt S; Kehr J; Hildenborg M; Fagerlund MJ; Harris HE; Eriksson LI
Article: BRAIN COMMUNICATIONS. 2020;2(2):fcaa208

Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Watanabe H; Nosova O; Sarkisyan D; Andersen MS; Zhang M; Rorick-Kehn L; Clausen F; Gawel K; Kehr J; Hallberg M; Schouenborg J; Marklund N; Bakalkin G
Article: NEUROBIOLOGY OF AGING. 2020;89:12-23

Dipeptidyl peptidase-4 inhibitors and sulfonylureas prevent the progressive impairment of the nigrostriatal dopaminergic system induced by diabetes during aging

Lietzau G; Magni G; Kehr J; Yoshitake T; Candeias E; Duarte AI; Pettersson H; Skogsberg J; Abbracchio MP; Klein T; Nystrom T; Ceruti S; Darsalia V; Patrone C
Article: PLOS ONE. 2020;15(1):e0227077

Characterization of the visceral and neuronal phenotype of 4L/PS-NA mice modeling Gaucher disease

Schiffer V; Santiago-Mujika E; Flunkert S; Schmidt S; Farcher M; Loeffler T; Schilcher I; Posch M; Neddens J; Sun Y; Kehr J; Hutter-Paier B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(11):5160-5169

Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function

Lumsden EW; Troppoli TA; Myers SJ; Zanos P; Aracava Y; Kehr J; Lovett J; Kim S; Wang F-H; Schmidt S; Jenne CE; Yuan P; Morris PJ; Thomas CJ; Zarate CAJ; Moaddel R; Traynelis SF; Pereira EFR; Thompson SM; Albuquerque EX; Gould TD
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2019;22(3):247-259

Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects

Donello JE; Banerjee P; Li Y-X; Guo Y-X; Yoshitake T; Zhang X-L; Miry O; Kehr J; Stanton PK; Gross AL; Burgdorf JS; Kroes RA; Moskal JR
Article: PSYCHOPHARMACOLOGY. 2018;235(5):1593-1607

Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor activity

Kehr J; Yoshitake T; Ichinose F; Yoshitake S; Kiss B; Gyertyan I; Adham N
Article: FRONTIERS IN PHARMACOLOGY. 2018;9:166

Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine

Zhang X; Mantas I; Alvarsson A; Yoshitake T; Shariatgorji M; Pereira M; Nilsson A; Kehr J; Andren PE; Millan MJ; Chergui K; Svenningsson P
Article: ADDICTION BIOLOGY. 2017;22(5):1232-1245

Dopamine D₄ receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

Rivera A; Gago B; Suarez-Boomgaard D; Yoshitake T; Roales-Bujan R; Valderrama-Carvajal A; Bilbao A; Medina-Luque J; Diaz-Cabiale Z; Van Craenenbroeck K; Borroto-Escuela DO; Kehr J; Rodriguez de Fonseca F; Santin L; de la Calle A; Fuxe K
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(1):349-361

Pharmacological Modulations of the Serotonergic System in a Cell-Model of Familial Alzheimer's Disease

Tajeddinn W; Persson T; Calvo-Garrido J; Ahmed MS; Maioli S; Vijayaraghavan S; Kazokoglu MS; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Hoglund K; Cedazo-Minguez A; Aarsland D
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;53(2):621-630

Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers

Tajeddinn W; Fereshtehnejad S-M; Ahmed MS; Yoshitake T; Kehr J; Shahnaz T; Milovanovic M; Behbahani H; Hoglund K; Winblad B; Cedazo-Minguez A; Jelic V; Jaremo P; Aarsland D
Article: FRONTIERS IN PHARMACOLOGY. 2016;7:492

The Synergistic Enhancing-Memory Effect of Donepezil and S 38093 (a Histamine H₃ Antagonist) Is Mediated by Increased Neural Activity in the Septo-hippocampal Circuitry in Middle-Aged Mice

Sors A; Krazem A; Kehr J; Yoshitake T; Dominguez G; Henkous N; Letondort C; Mocaer E; Beracochea DJ
Article: JOURNAL OF NEUROTRAUMA. 2015;32(16):1190-1199

Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin

Kawa L; Arborelius UP; Yoshitake T; Kehr J; Hokfelt T; Risling M; Agoston D
Article: NATURE NEUROSCIENCE. 2015;18(6):826-U404

Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease

Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gomez-Galan M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
Article: NEUROSCIENCE LETTERS. 2015;594:137-143

5-HT1B and other related serotonergic proteins are altered in APPswe mutation

Tajeddinn W; Persson T; Maioli S; Calvo-Garrido J; Parrado-Fernandez C; Yoshitake T; Kehr J; Francis P; Winblad B; Hoglund K; Cedazo-Minguez A; Aarsland D
Article: ACTA NEUROPATHOLOGICA. 2015;129(4):541-563

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease

Adori C; Glueck L; Barde S; Yoshitake T; Kovacs GG; Mulder J; Magloczky Z; Havas L; Boelcskei K; Mitsios N; Uhlen M; Szolcsanyi J; Kehr J; Ronnback A; Schwartz T; Rehfeld JF; Harkany T; Palkovits M; Schulz S; Hokfelt T
Article: CEREBRAL CORTEX. 2015;25(1):97-108

Asymmetry of the Endogenous Opioid System in the Human Anterior Cingulate: a Putative Molecular Basis for Lateralization of Emotions and Pain

Watanabe H; Fitting S; Hussain MZ; Kononenko O; Iatsyshyna A; Yoshitake T; Kehr J; Alkass K; Druid H; Wadensten H; Andren PE; Nylander I; Wedell DH; Krishtal O; Hauser KF; Nyberg F; Karpyak VM; Yakovleva T; Bakalkin G
Article: CELL REPORTS. 2014;8(4):1018-1025

Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons

Panman L; Papathanou M; Laguna A; Oosterveen T; Volakakis N; Acampora D; Kurtsdotter I; Yoshitake T; Kehr J; Joodmardi E; Muhr J; Simeone A; Ericson J; Perlmann T
Article: EXPERIMENTAL PHYSIOLOGY. 2014;99(8):1089-1098

The human carotid body releases acetylcholine, ATP and cytokines during hypoxia

Kahlin J; Mkrtchian S; Ebberyd A; Hammarstedt-Nordenvall L; Nordlander B; Yoshitake T; Kehr J; Prabhakar N; Poellinger L; Fagerlund MJ; Eriksson LI
Article: BIOLOGICAL PSYCHIATRY. 2014;75(9):701-710

Cognitive Impairment and Dentate Gyrus Synaptic Dysfunction in Experimental Parkinsonism

Bonito-Oliva A; Pignatelli M; Spigolon G; Yoshitake T; Seiler S; Longo F; Piccinin S; Kehr J; Mercuri NB; Nistico R; Fisone G
Article: SYNAPSE. 2014;68(5):179-193

Correlation Between the Effects of Local and Intracerebroventricular Infusions of Galanin on 5-HT Release Studied by Microdialysis, and Distribution of Galanin and Galanin Receptors in Prefrontal Cortex, Ventral Hippocampus, Amygdala, Hypothalamus, and Striatum of Awake Rats

Yoshitake S; Kuteeva E; Hokfelt T; Mennicken F; Theodorsson E; Yamaguchi M; Kehr J; Yoshitake T
Article: MOLECULAR PSYCHIATRY. 2013;18(10):1096-1105

Bidirectional regulation of emotional memory by 5-HT_1B receptors involves hippocampal p11

Eriksson TM; Alvarsson A; Stan TL; Zhang X; Hascup KN; Hascup ER; Kehr J; Gerhardt GA; Warner-Schmidt J; Arango-Lievano M; Kaplitt MG; Ogren SO; Greengard P; Svenningsson P
Article: EXPERIMENTAL NEUROLOGY. 2013;247:456-465

Cutaneous noradrenaline measured by microdialysis in complex regional pain syndrome during whole-body cooling and heating

Terkelsen AJ; Gierthmuehlen J; Petersen LJ; Knudsen L; Christensen NJ; Kehr J; Yoshitake T; Madsen CS; Wasner G; Baron R; Jensen TS
Article: NEUROSCIENCE LETTERS. 2013;534:58-63

Inhibition of histamine release by local and intracerebroventricular infusion of galanin in hypothalamus, hippocampus and prefrontal cortex of awake rat: A microdialysis study

Yoshitake S; Ijiri S; Kehr J; Yoshitake T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(6):2360-2365

Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons

Kadkhodaei B; Alvarsson A; Schintu N; Ramskold D; Volakakis N; Joodmardi E; Yoshitake T; Kehr J; Decressac M; Bjorklund A; Sandberg R; Svenningsson P; Perlmann T
Article: NEUROCHEMISTRY INTERNATIONAL. 2013;62(3):314-323

Concurrent modulation of extracellular levels of noradrenaline and cAMP during stress and by anxiogenic- or anxiolytic-like neuropeptides in the prefrontal cortex of awake rats

Yoshitake S; Ijiri S; Kehr J; Yoshitake T
Article: INTERNATIONAL PSYCHOGERIATRICS. 2012;24:S25-S34

Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761®

Kehr J; Yoshitake S; Ijiri S; Koch E; Noeldner M; Yoshitake T
Article: JOURNAL OF NEUROCHEMISTRY. 2012;122(3):619-627

An allosteric modulator of metabotropic glutamate receptors (mGluR2), (+)-TFMPIP, inhibits restraint stress-induced phasic glutamate release in rat prefrontal cortex

Hascup ER; Hascup KN; Pomerleau F; Huettl P; Hajos-Korcsok E; Kehr J; Gerhardt GA
Article: SYNAPSE. 2012;66(3):196-203

Increased affinity of dopamine for D2-like versus D1-like receptors. Relevance for volume transmission in interpreting PET findings

Marcellino D; Kehr J; Agnati LF; Fuxe K
Article: JIMD REPORTS. 2012;3:53-57

A twelve-year follow-up study on a case of early-onset parkinsonism preceding clinical manifestation of Gaucher disease.

Machaczka M; Arce MP; Rucinska M; Yoshitake T; Kehr J; Jurczak W; Skotnicki AB; Månsson J-E; Tylki-Szymanska A; Svenningsson P
Article: SKIN PHARMACOLOGY AND PHYSIOLOGY. 2012;25(2):65-72

Determination of Histamine in Microdialysis Samples from Guinea Pig Skin by High-Performance Liquid Chromatography with Fluorescence Detection

Yoshitake T; Ijiri S; Yoshitake S; Todoroki K; Yoshida H; Kehr J; Nohta H; Yamaguchi M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2011;164(8):1949-1958

Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats

Kehr J; Ichinose F; Yoshitake S; Goiny M; Sievertsson T; Nyberg F; Yoshitake T
Article: NEUROSCIENCE. 2011;197:172-180

GALANIN DIFFERENTIALLY REGULATES ACETYLCHOLINE RELEASE IN VENTRAL AND DORSAL HIPPOCAMPUS: A MICRODIALYSIS STUDY IN AWAKE RAT

Yoshitake T; Yoshitake S; Savage S; Elvander-Tottie E; Ogren SO; Kehr J
Article: NEUROSCIENCE. 2011;195:60-69

IMPAIRED SOCIAL INTERACTION AND ENHANCED SENSITIVITY TO PHENCYCLIDINE-INDUCED DEFICITS IN NOVEL OBJECT RECOGNITION IN RATS WITH CORTICAL CHOLINERGIC DENERVATION

Savage S; Kehr J; Olson L; Mattsson A
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2011;25(7):896-907

Cytochrome P450 and ABCB1 genetics: association with quetiapine and norquetiapine plasma and cerebrospinal fluid concentrations and with clinical response in patients suffering from schizophrenia. A pilot study

Nikisch G; Baumann P; Oneda B; Kiessling B; Weisser H; Mathe AA; Yoshitake T; Kehr J; Wiedemann G; Eap CB
Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(8):1769-1777

Resting Glutamate Levels and Rapid Glutamate Transients in the Prefrontal Cortex of the Flinders Sensitive Line Rat: A Genetic Rodent Model of Depression

Hascup KN; Hascup ER; Stephens ML; Glaser PEA; Yoshitake T; Mathe AA; Gerhardt GA; Kehr J
Article: NANOTECHNOLOGY. 2011;22(1):015103

Diffusion and clearance of superparamagnetic iron oxide nanoparticles infused into the rat striatum studied by MRI and histochemical techniques

Hwang FH; Kim DK; Yoshitake T; Johansson SM; Bjelke B; Muhammed M; Kehr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(46):20087-20092

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

Ross JM; Oberg J; Brene S; Coppotelli G; Terzioglu M; Pernold K; Goiny M; Sitnikov R; Kehr J; Trifunovic A; Larsson N-G; Hoffer BJ; Olson L
Article: DALTON TRANSACTIONS. 2010;39(37):8626-8630

ECL performance of ruthenium tris-bipyridyl complexes covalently linked with phenothiazine through different bridge

Sun S; Yang Y; Liu F; Fan J; Kehr J; Sun L; Peng X
Article: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. 2010;30(5):496-503

Quetiapine and Norquetiapine in Plasma and Cerebrospinal Fluid of Schizophrenic Patients Treated With Quetiapine Correlations to Clinical Outcome and HVA, 5-HIAA, and MHPG in CSF

Nikisch G; Baumann P; Wiedemann G; Kiessling B; Weisser H; Hertel A; Yoshitake T; Kehr J; Mathe AA
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2010;20(7):487-500

The selective 5-HT_1A receptor antagonist NAD-299 increases acetylcholine release but not extracellular glutamate levels in the frontal cortex and hippocampus of awake rat

Kehr J; Hu X-J; Yoshitake T; Wang F-H; Osborne P; Stenfors C; Ogren SO
Article: JOURNAL OF NEURAL TRANSMISSION. 2010;117(6):681-687

On the role of P2X₇ receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X₇ receptor antagonist A-438079

Marcellino D; Suarez-Boomgaard D; Dolores Sanchez-Reina M; Aguirre JA; Yoshitake T; Yoshitake S; Hagman B; Kehr J; Agnati LF; Fuxe K; Rivera A
Article: GENES BRAIN AND BEHAVIOR. 2010;9(2):173-181

MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease

Galter D; Pernold K; Yoshitake T; Lindqvist E; Hoffer B; Kehr J; Larsson N-G; Olson L
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2010;159(3):659-668

The Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex

Yoshitake T; Yoshitake S; Kehr J
Article: DALTON TRANSACTIONS. 2009;(38):7969-7974

Intra- and intermolecular interaction ECL study of novel ruthenium tris-bipyridyl complexes with different amine reductants

Sun S; Yang Y; Liu F; Fan J; Peng X; Kehr J; Sun L
Article: CHROMATOGRAPHIA. 2009;70(3-4):575-580

Determination of Histamine in Rat Plasma and Tissue Extracts by Intramolecular Excimer-Forming Derivatization and LC with Fluorescence Detection

Ichinose F; Yoshitake T; Yoshida H; Todoroki K; Kehr J; Inoue O; Nohta H; Yamaguchi M
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2007;21(8):795-804

Reciprocal effects of combined administration of serotonin, noradrenaline and dopamine reuptake inhibitors on serotonin and dopamine levels in the rat prefrontal cortex:: the role of 5-HT_1A receptors

Weikop P; Kehr J; Scheel-Kruger J
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17(10):658-671

Differential effects of adjunctive methylphenidate and citalopram on extracellular levels of serotonin, noradrenaline and dopamine in the rat brain

Weikop P; Yoshitake T; Kehr J
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17(9):580-586

Effects of the 5-HT_1B receptor antagonist NAS-181 on extracellular levels of acetylcholine, glutamate and GABA in the frontal cortex and ventral hippocampus of awake rats:: A microdialysis study

Hu XJ; Wang F-H; Stenfors C; Ogren SO; Kehr J
Article: JOURNAL OF NEURAL TRANSMISSION. 2007;114(8):1027-1031

Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulation

Kehr J; Hu X-J; Goiny M; Scheller DKA
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2007;845(1):109-113

Determination of the dopamine agonist rotigotine in microdialysates from the rat brain by microbore column liquid chromatography with electrochemical detection

Kehr J; Hu X-J; Yoshitake T; Scheller D
Article: NANOTECHNOLOGY. 2006;17(8):1911-1915

Magnetic resonance tracking of nanoparticle labelled neural stem cells in a rat's spinal cord

Wang FH; Lee IH; Holmstrom N; Yoshitake T; Kim DK; Muhammed M; Frisen J; Olson L; Spenger C; Kehr J
Article: BIOMEDICAL CHROMATOGRAPHY. 2006;20(3):267-281

Derivatization chemistries for determination of serotonin, norepinephrine and dopamine in brain microdialysis samples by liquid chromatography with fluorescence detection

Yoshitake T; Kehr J; Todoroki K; Nohta H; Yamaguchi M
Article: BRAIN RESEARCH. 2005;1033(2):216-220

Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP

Aguirre JA; Kehr J; Yoshitake T; Liu FL; Rivera A; Fernandez-Espinola S; Andbjer B; Leo G; Medhurst AD; Agnati LF; Fuxe K
Article: EXPERIMENTAL NEUROLOGY. 2004;190(2):535-543

Effects of isoflurane on prefrontal acetylcholine release and hypothalamic Fos response in young adult and aged rats

Jansson A; Olin K; Yoshitake T; Hagman B; Herrington MK; Kehr J; Permert J
Article: JOURNAL OF PSYCHOPHARMACOLOGY. 2004;18(3):395-403

The role of α₁- and α₂-adrenoreceptors on venlafaxine-induced elevation of extracellular serotonin, noradrenaline and dopamine levels in the rat prefrontal cortex and hippocampus

Weikop P; Kehr J; Scheel-Krüger J
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 2004;807(2):177-183

Determination of serotonin, noradrenaline, dopamine and their metabolites in rat brain extracts and microdialysis samples by column liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine

Yoshitake T; Kehr J; Yoshitake S; Fujino K; Nohta H; Yamaguchi M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2004;142(3):414-418

Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex

Yoshitake T; Iizuka R; Yoshitake S; Weikop P; Müller WE; Ögren SO; Kehr J
Article: LIFE SCIENCES. 2004;74(23):2865-2875

Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats

Yoshitake T; Kehr J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(1):354-359

Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test

Yoshitake T; Wang FH; Kuteeva E; Holmberg K; Yamaguchi M; Crawley JN; Steiner R; Bartfai T; Ögren SO; Hökfelt T; Kehr J
Article: NEUROSCIENCE. 2004;126(3):541-557

Intraseptal muscarinic ligands and galanin:: Influence on hippocampal acetylcholine and cognition

Elvander E; Schött PA; Sandin J; Bjelke B; Kehr J; Yoshitake T; Ögren SO
Article: BIOMEDICAL CHROMATOGRAPHY. 2003;17(8):509-516

A sensitive and selective determination method of histamine by HPLC with intramolecular excimer-forming derivatization and fluorescence detection

Yoshitake T; Ichinose F; Yoshida H; Todoroki K; Kehr J; Inoue O; Nohta H; Yamaguchi M
Article: CHEMISTRY OF MATERIALS. 2003;15(23):4343-4351

Starch-coated superparamagnetic nanoparticles as MR contrast agents

Kim DK; Mikhaylova M; Wang FH; Kehr J; Bjelke B; Zhang Y; Tsakalakos T; Muhammed M
Article: JOURNAL OF CHROMATOGRAPHY A. 2003;1012(2):169-177

Simultaneous determination of 5-hydroxyindoles and catechols by high-performance liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine

Fujino K; Yoshitake T; Kehr J; Nohta H; Yamaguchi M
Article: JOURNAL OF NEUROSCIENCE METHODS. 2003;127(1):11-17

Determination of histamine in microdialysis samples from rat brain by microbore column liquid chromatography following intramolecular excimer-forming derivatization with pyrene-labeling reagent

Yoshitake T; Yamaguchi M; Nohta H; Ichinose F; Yoshida H; Yoshitake S; Fuxe K; Kehr J
Article: JOURNAL OF NANOPARTICLE RESEARCH. 2003;5(1-2):137-146

Determination of conjugation efficiency of antibodies and proteins to the superparamagnetic iron oxide nanoparticles by capillary electrophoresis with laser-induced fluorescence detection

Wang FH; Yoshitake T; Kim DK; Muhammed M; Bjelke O; Kehr J
Article: NEUROSCIENCE LETTERS. 2003;339(3):239-242

Galanin attenuates basal and antidepressant drug-induced increase of extracellular serotonin and noradrenaline levels in the rat hippocampus

Yoshitake T; Reenilä K; Ögren SO; Hökfelt T; Kehr J
Article: NEUROPHARMACOLOGY. 2003;44(2):206-213

Activation of 5-HT_1A autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo

Yoshitake T; Yoshitake S; Yamaguchi M; Ögren SO; Kehr J
Article: ANALYTICAL BIOCHEMISTRY. 2003;312(2):125-133

Simultaneous determination of norepinephrine, serotonin, and 5-hydroxyindole-3-acetic acid in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine

Yoshitake T; Fujino K; Kehr J; Ishida J; Nohta H; Yamaguchi M
Article: NEUROPSYCHOPHARMACOLOGY. 2002;27(3):341-356

Galanin is a potent in vivo modulator of mesencephalic serotonergic neurotransmission

Kehr J; Yoshitake T; Wang FH; Razani H; Gimenez-Llort L; Jansson A; Yamaguchi M; Ögren SO
Article: JOURNAL OF NEUROCHEMISTRY. 2002;81(1):94-107

Quantitative dual-probe microdialysis:: mathematical model and analysis

Chen KC; Höistad M; Kehr J; Fuxe K; Nicholson C
Article: JOURNAL OF NEUROCHEMISTRY. 2002;81(1):80-93

Quantitative dual-probe microdialysis:: evaluation of [³H]mannitol diffusion in agar and rat striatum

Höistad M; Chen KC; Nicholson C; Fuxe K; Kehr J
Article: JOURNAL OF NEUROCHEMISTRY. 2002;81(1):108-121

Theory relating in vitro and in vivo microdialysis with one or two probes

Chen KC; Höistad M; Kehr J; Fuxe K; Nicholson C
Article: NEUROSCIENCE LETTERS. 2002;320(1-2):91-95

Increased serotonin release in mice frontal cortex and hippocampus induced by acute physiological stressors

Fujino K; Yoshitake T; Inoue O; Ibii N; Kehr J; Ishida J; Nohta H; Yamaguchi M
Article: JOURNAL OF NEUROSCIENCE METHODS. 2001;109(2):91-96

Determination of serotonin in microdialysis samples from rat brain by microbore column liquid chromatography with post-column derivatization and fluorescence detection

Yoshitake T; Iizuka R; Kehr J; Nohta H; Ishida J; Yamaguchi M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(21):11569-11574

Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons

O'Meara G; Coumis U; Ma SY; Kehr J; Mahoney S; Bacon A; Allen SJ; Holmes F; Kahl U; Wang FH; Kearns IR; Ove-Ogren S; Dawbarn D; Mufson EJ; Davies C; Dawson G; Wynick D
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12(7):2505-2514

Intracerebral infusion of ³H-dopamine and ³H-mannitol in the striatum of halothane-anaesthetized male rats.: A dual-probe microdialysis study of long-distance diffusion

Höistad M; Kehr J; Andbjer B; Jansson A; Fuxe K
Article: ANALYTICAL BIOCHEMISTRY. 1999;270(2):296-302

Determination of norepinephrine in microdialysis samples by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine

Yamaguchi M; Yoshitake T; Fujino K; Kawano K; Kehr J; Ishida J
Article: NEUROPHARMACOLOGY. 1999;38(1):129-140

Adenosine A_2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D₂ receptors in the rat striatum

Ferré S; Popoli P; Rimondini R; Reggio R; Kehr J; Fuxe K
Article: JOURNAL OF NEUROSCIENCE METHODS. 1998;83(2):143-150

Simultaneous determination of acetylcholine, choline and physostigmine in microdialysis samples from rat hippocampus by microbore liquid chromatography electrochemistry on peroxidase redox polymer coated electrodes

Kehr J; Dechent P; Kato T; Ögren SO
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 1998;708(1-2):49-54

Determination of γ-aminobutyric acid in microdialysis samples by microbore column liquid chromatography and fluorescence detection

Kehr J
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 1998;708(1-2):27-38

Determination of glutamate and aspartate in microdialysis samples by reversed-phase column liquid chromatography with fluorescence and electrochemical detection

Kehr J
Article: BRITISH JOURNAL OF PHARMACOLOGY. 1997;121(6):1180-1186

Differential effects of the neuropeptide galanin on striatal acetylcholine release in anaesthetized and awake rats

Antoniou K; Kehr J; Snitt K; Ogren SO
Article: JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. 1997;692(1):207-212

Microbore high-performance liquid chromatographic method for measuring acetylcholine in microdialysis samples: Optimizing performance of platinum electrodes

Carter AJ; Kehr J
Article: NEUROSCIENCE. 1996;75(4):1127-1140

Effects of ventral hippocampal galanin on spatial learning and on in vivo acetylcholine release in the rat

Ogren SO; Kehr J; Schott PA
Article: NEUROSCIENCE. 1996;74(3):793-804

Modulation of neurotransmitter release by cholecystokinin in the neostriatum and substantia nigra of the rat: Regional and receptor specificity

You ZB; HerreraMarschitz M; Pettersson E; Nylander I; Goiny M; Shou HZ; Kehr J; Godukhin O; Hokfelt T; Terenius L; Ungerstedt U
Article: BRAIN RESEARCH. 1996;710(1-2):241-248

Effect of morphine on dynorphin B and GABA release in the basal ganglia of rats

You ZB; HerreraMarschitz M; Nylander I; Goiny M; Kehr J; Ungerstedt U; Terenius L
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Review: FRONTIERS IN NEURAL CIRCUITS. 2018;12:106

Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness

Hokfelt T; Barde S; Xu Z-QD; Kuteeva E; Ruegg J; Le Maitre E; Risling M; Kehr J; Ihnatko R; Theodorsson E; Palkovits M; Deakin W; Bagdy G; Juhasz G; Prud'homme HJ; Mechawar N; Diaz-Heijtz R; Ogren SO
Review: FRONTIERS IN BIOSCIENCE - ELITE. 2013;5(3):947-954

Monitoring molecules in neuroscience: historical overview and current advancements.

Kehr J; Yoshitake T
Corrigendum: JOURNAL OF PSYCHIATRIC RESEARCH. 2012;46(8):1108

Relationship between dopamine D₂ receptor occupancy, clinical response, and drug and monoamine metabolites levels in plasma and cerebrospinal fluid. A pilot study in patients suffering from first-episode schizophrenia treated with quetiapine (Retraction of vol 44, pg 754, 2010)

Nikisch G; Baumann P; Kiessling B; Reinert M; Wiedemann G; Kehr J; Mathe AA; Piel M; Roesch F; Weisser H; Schneider P; Hertel A
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S41-S42

Neuropeptide Y modulation of the glutamatergic system in the Flinders Sensitive Line rat: a rat model of depression

Hascup KN; Hascup ER; Gerhardt GA; Mathe AA; Kehr J
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S40-S41

The source of resting and physiologically evoked L-glutamate levels in prefrontal cortex in awake rats

Hascup ER; Hascup KN; Pomerleau F; Huettl P; Gerhardt GA; Kehr J
Review: BEHAVIOURAL BRAIN RESEARCH. 2008;195(1):54-77

The role of 5-HT_1A receptors in learning and memory

Ogren SO; Eriksson TM; Elvander-Tottie E; D'Addario C; Ekstrom JC; Svenningsson P; Meister B; Kehr J; Stiedl O
Review: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):172-179

The neuropeptide galanin as an in vivo modulator of brain 5-HT_1A receptors:: Possible relevance for affective disorders

Ogren SO; Razani H; Elvander-Tottle E; Kehr J
Published conference paper: BRAIN RESEARCH REVIEWS. 2007;55(1):17-54

From the Golgi-Cajal mapping to the transmitter-based characterization of the neuronal networks leading to two modes of brain communication:: Wiring and volume transmission

Fuxe K; Dahlstrom A; Hoistad M; Marcellino D; Jansson A; Rivera A; Diaz-Cabiale Z; Jacobsen K; Tinner-Staines B; Hagman B; Leo G; Staines W; Guidolin D; Kehr J; Genedani S; Belluardo N; Agnati LF
Review: CNS DRUGS. 2006;20(8):633-654

Galanin receptor antagonists -: A potential novel pharmacological treatment for mood disorders

Ogren SO; Kuteeva E; Hokfelt T; Kehr J
Published conference paper: JOURNAL OF NEUROSCIENCE METHODS. 2004;140(1-2):163-168

High-sensitive liquid chromatographic method for determination of neuronal release of serotonin, noradrenaline and dopamine monitored by microdialysis in the rat prefrontal cortex

Yoshitake T; Yoshitake S; Fujino K; Nohta H; Yamaguchi M; Kehr J
Published conference paper: JOURNAL OF NEUROSCIENCE METHODS. 2004;140(1-2):59-65

Application of triple-probe microdialysis for fast pharmacokinetic/pharmacodynamic evaluation of dopamimetic activity of drug candidates in the rat brain

Weikop P; Egestad B; Kehr J
Editorial comment: JOURNAL OF NEUROSCIENCE METHODS. 2004;140(1-2):1-187

10th International Conference on In Vivo Methods: Monitoring Molecules in Neuroscience - Editorial

Kehr J
Other: JOURNAL OF NEUROSCIENCE METHODS. 2004;140(1-2):3-4

Prof. Ralph N. Adams (1924-2002) - In Memoriam

Kehr J
Published conference paper: PARKINSONISM & RELATED DISORDERS. 2004;10(5):273-280

Striatal plasticity at the network level.: Focus on adenosine A_2A and D₂ interactions in models of Parkinson's Disease

Tanganelli S; Nielsen KS; Ferraro L; Antonelli T; Kehr J; Franco R; Ferré S; Agnati LF; Fuxe K; Scheel-Krüger J
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2003;13:S396-S397

Hippocampal galanin and acetylcholine in spatial learning of the rat

Elvander E; Yoshitake T; Kehr J; Sandin J; Ögren SO
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2003;13:S137-S138

Hippocampal neuropeptides in learning and memory:: Implications for cognitive dysfunction and aging

Ögren SO; Kuzmin A; Kehr J; Terenius L; Sandin J
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2003;13:S262

The role of galanin/5-HT_1A receptors interaction on attenuation of basal and antidepressant drug-induced increase of extracellular 5-HT levels in the rat hippocampus

Kehr J; Yoshitake S; Yamaguchi M; Ögren SO; Yoshitake T
Published conference paper: JOURNAL OF NEUROSCIENCE METHODS. 2001;109(1):71-80

Microdialysis in freely moving mice:: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice

Kehr J; Yoshitake T; Wang FH; Wynick D; Holmberg H; Lendahl U; Bartfai T; Yamaguchi M; Hökfelt T; Ögren SO
Editorial comment: JOURNAL OF NEUROSCIENCE METHODS. 2001;109(1):1-2

Sensors for brain mapping - Foreword

Kehr J
Published conference paper: SCRIPTA MATERIALIA. 2001;44(8-9):1713-1717

Superparamagnetic iron oxide nanoparticles for bio-medical applications

Kim DK; Zhang Y; Voit W; Kao KV; Kehr J; Bjelke B; Muhammed M
Published conference paper: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. 2001;225(1-2):256-261

Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain

Kim DK; Zhang Y; Kehr J; Klason T; Bjelke B; Muhammed M
Published conference paper: EXPERIMENTAL NEUROLOGY. 2000;164(1):154-165

Fetal ventral mesencephalic grafts functionally reduce the dopamine D2 receptor supersensitivity in partially dopamine reinnervated host striatum

Strömberg I; Kehr J; Andbjer B; Fuxe K
Review: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 2000;125:309-315

Restoration of dopamine transmission in graft reinnervated striatum.: Evidence for regulation of dopamine D2 receptor function in regions lacking dopamine

Strömberg I; Kehr J; Fuxe K
Published conference paper: NEUROSCIENCE FOR ADDICTION MEDICINE: FROM PREVENTION TO REHABILITATION - CONSTRUCTS AND DRUGS. 2000;125:179-190

Diffusion of radiolabeled dopamine, its metabolites and mannitol in the rat striatum studied by dual-probe microdialysis

Kehr J; Höistad M; Fuxe K
Published conference paper: BRAIN RESEARCH. 1999;848(1-2):174-182

Galanin and learning

Ögren SO; Schött PA; Kehr J; Misane I; Razani H
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1998;863:342-363

Modulation of acetylcholine and serotonin transmission by galanin -: Relationship to spatial and aversive learning

Ögren SO; Schött PA; Kehr J; Yoshitake T; Misane I; Mannström P; Sandin J
Published conference paper: ANALYTICA CHIMICA ACTA. 1998;365(1-3):227-232

Serotonin monitoring in microdialysate from rat brain by microbore liquid chromatography with fluorescence detection

Ishida J; Yoshitake T; Fujino K; Kawano K; Kehr J; Yamaguchi M
Review: METHODS OF BIOCHEMICAL ANALYSIS. 1998;38:115-136

Microdialysis: An in vivo method for the analysis of body fluids

Rossomando EF; Kehr J
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