Jan-Bernd Stukenborg
Senior Lecturer | Docent
E-mail: jan-bernd.stukenborg@ki.se
Telephone: +46852482788
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Stukenborg, 171 77 Stockholm
About me
- I am working right now as senior lecturer and group leader (NORDFERTIL research lab Stockholm) at the Department of Women’s and Children’s
Health, Childhood Cancer Research Unit, Karolinska Institutet and University Hospital, Stockholm, Sweden. In addtion to my work as group leader, I am the research coordinator of NORDFERTIL (www.nordfertil.org).
*COURSES AND DEGREES*
2001 - 2005 - Study of Biology, Westphalian Wilhelms University (WWU), Münster Germany
2005 - Diploma-thesis (Master Thesis - Biology), Centre of Reproductive Medicine and Andrology (CeRA), WWU, Münster, Germany &
- University of
Pittsburgh, USA
2005 - 2009 - Ph.D.-studies (Biology), CeRA, WWU, Münster, Germany
*DOCTORAL DEGREE*
2009 - Biology (Reproductive Biology), Title: “/In vitro/ differentiation of male germ cells.” CeRA, WWU, Münster, Germany - PhD supervision: Prof.
Dr. E. Liebau - Prof. Dr. S. Schlatt
*POSTDOC APPOINTMENTS*
2009 – 2013 - Post-Doc at the Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Karolinska Institutet - supervision:
Prof. Dr. Olle Söder
*DOCENT-LEVEL COMPETENCE*
2016 - Docent in Reproductive Biology - Karolinska Institutet
Research
- *Main research areas: *
* Germ cell differentiation /in vivo/ and /in vitro./
* Fertility preservation techniques in children with gonadal dysfunctions.
* Experiments on /in vitro/ differentiation techniques include novel cell culture approaches with human and animal gonadal cells as well as human
embryonic and human induced pluripotent stem cells (hESCs and hiPSCs).
Teaching
- *Ongoing supervision of a PhD candidate:*
1) Yanhua Cui, Karolinska Institutet
Title: “Novel strategies to preserve future fertility in boys and men.”
Registration: 2018-09-11
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden),
Michael Landreh, PhD (Karolinska Institutet
2) Hajar Ali Mohammed Ba Omar, Karolinska Institutet
Title: “Effects of haematological and oncological diseases on
spermatogonial stem cell populations in boys.”
Registration: 2018-09-04
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden),
Nikolas Herold, MD (Karolinska Institutet)
3) Yifan Yang, Karolinska Institutet
Title: “Effects of medical treatments of gonadal development in boys and
men.”
Registration: 2020-01-15
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden)
Jingtao Guo, PhD (University of Utah, USA)
4) Femke Harteveld, Karolinska Institutet
Title: “Macrophages and the testicular microenvironment in humans.”
Registration: 2020-10-10
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Kirsi Jahnukainen, MD, PhD (Karolinska Institutet, Sweden)
Susana Chuva de Sousa Lopes, PhD (University of Leiden, The Netherlands)
*Ongoing supervision of a PhD candidate as co-supervisor:*
1) Ieva Masliukaite, University of Amsterdam, The Netherlands
Title: “Propagation of human SSCs”.
Registration: 2015-10-20- main supervisor: Sjoerd Repping, MD, PhD
(University of Amsterdam, The Netherlands), co-supervision: Ans M. M. van
Pelt, PhD (University of Amsterdam, The Netherlands), Jan-Bernd Stukenborg,
PhD (Karolinska Institutet, Sweden).
2) Melanie Poganitsch-Korhonen, University of Helsinki, Finland
Title: “Male fertility, late morbidity and ageing after childhood cancer”
Registration: 2014-09-24- main supervisor Kirsi Jahnukainen, MD, PhD
(University of Helsinki, Finland), co-supervision: Jan-Bernd Stukenborg, PhD
(Karolinska Institutet, Sweden)
3) Bethel Embiae, Karolinska Institutet
Title: "Functional characterization and targeting of neuroblastoma cell of
origin"
Registration: 2021-01.20 - main supervisor: Ninib Baryawno, PhD (Karolinska
Institutet) - co-supervision: John Inge Johnson, PhD (Karolinska Institutet),
Malin Wickström Näsman, PhD (Karolinska Institutet), Jan-Bernd Stukenborg,
PhD (Karolinska Institutet)
*PhD candidates supervised up to the defence of the candidate’s doctoral
thesis:*
1) Magdalena Kurek, Karolinska Institutet
Title: “Human induced pluripotent stem cells differentiation towards the
male germ cell lineage.”
Registration: 2015-01-19 - halftime seminar: 2017-05-31
- defence: 2019-10-25
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden), Sarita
Panula, PhD (Karolinska Institutet), Rod Mitchell, MD, PhD (University
Edinburgh, UK)
2) Halima Al-Balushi, Karolinska Institutet
Title: “In vitro models aiming for fertility preservation.”
Registration: 2014-04-22- halftime seminar: 2016-08-31
- defence: 2018-11-16
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden)- Outi
Hovatta, MD, PhD (Karolinska Institutet, Sweden) - Elisabet Åkesson, MD, PhD
(Karolinska Institutet, Sweden)
3) Joao Pedro Alves Lopes, Karolinska Institutet
Title: “Novel culture systems to model testicular function and
organization.” Registration: 2015-01-19 - halftime seminar: 2017-06-07
defense: 2018-08-31
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden), Ellen
Goossens, PhD (VUB, Belgium)
4) Mina Nikolova Mincheva, University of Münster, Germany
Title: “Interaction of male gonadal cell types in differentiation cell
culture” Registration: 2015-01-01- defense: 2018-03-15
main supervisor: Stefan Schlatt, PhD (University of Münster, Germany),
co-supervision: Sylvia Kaiser, PhD (University of Münster, Germany),
Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
5) Ahmed Reda, Karolinska Institutet
Title: “Artificial testis to study early gonadal development and germ cell
differentiation.”
Registration: 2012-04-24 - halftime seminar: 2014-06-03
- defence: 2016-09-30
main supervisor: Jan-Bernd Stukenborg, PhD (Karolinska Institutet, Sweden)
co-supervision: Olle Söder, MD, PhD (Karolinska Institutet, Sweden)- Kirsi
Jahnukainen, MD, PhD (Karolinska Institutet, Sweden & - University of Helsinki,
Finland
6) Sarita Panula, Karolinska Institutet
Title: “Differentiation and charaterization of human iPSC derived germ
cells and the derivation of patient specific iPSC lines for the study of
infertility.” Registration: 2009-11-12 - halftime seminar: 2012-09-18
defence: 2015-06-09- main supervisor: Outi Hovatta, MD, PhD (Karolinska
Institutet, Sweden) - co-supervision: Olle Söder, MD, PhD (Karolinska
Institutet, Sweden) - Jan-Bernd Stukenborg, PhD (Karolinska Institutet,
Sweden), Renee Reijo Pera (Stanford University, USA)
Articles
- Article: BRITISH JOURNAL OF HAEMATOLOGY. 2024;205(1):229-235
- Article: HUMAN REPRODUCTION OPEN. 2024;2024(3):hoae049
- Article: HUMAN REPRODUCTION OPEN. 2024;2024(2):hoae010
- Article: DEVELOPMENTAL CELL. 2023;58(20):2097-2111.e3
- Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
- Article: REPRODUCTION AND FERTILITY. 2023;4(2):RAF-22-0050
- Article: DEVELOPMENTAL CELL. 2022;57(9):1160-1176.e5
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2490:235-249
- Article: FRONTIERS IN TOXICOLOGY. 2022;4:825734
- Article: BMC BIOLOGY. 2021;19(1):212
- Article: FERTILITY AND STERILITY. 2021;116(3):713-720
- Article: BEST PRACTICE AND RESEARCH: CLINICAL ENDOCRINOLOGY AND METABOLISM. 2021;35(5):101567
- Article: THE FASEB JOURNAL. 2021;35(5):e21513
- Article: CELL STEM CELL. 2021;28(4):764-778.e4
- Article: CELLS. 2021;10(2):241
- Article: BMC MEDICINE. 2020;18(1):374
- Article: ANNALS OF ONCOLOGY. 2020;31(12):1664-1678
- Article: CANCERS. 2020;12(10):E2830-2830
- Article: MOLECULAR HUMAN REPRODUCTION. 2020;26(6):374-388
- Article: HUMAN REPRODUCTION OPEN. 2020;2020(3):hoaa016
- Article: JOURNAL OF CLINICAL MEDICINE. 2020;9(1):E266-266
- Article: REPRODUCTIVE TOXICOLOGY. 2019;90:68-76
- Article: DEVELOPMENTAL BIOLOGY. 2019;456(1):25-30
- Article: HUMAN REPRODUCTION. 2019;34(11):2297-2310
- Article: ENDOCRINOLOGY. 2019;160(1):133-142
- Article: HUMAN REPRODUCTION. 2018;33(9):1677-1683
- Article: HUMAN REPRODUCTION. 2018;33(4):636-645
- Article: NATURE PROTOCOLS. 2018;13(2):248-259
- Article: MOLECULAR HUMAN REPRODUCTION. 2018;24(2):55-63
- Article: STEM CELLS INTERNATIONAL. 2018;2018:7127042-9
- Article: ANNALS OF BIOMEDICAL ENGINEERING. 2017;45(7):1783-1794
- Article: BIOMATERIALS. 2017;130:76-89
- Article: JOURNAL OF ENDOCRINOLOGY. 2017;232(2):247-257
- Article: STEM CELL REPORTS. 2017;8(1):30-38
- Article: TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS. 2016;107(6):225-242
- Article: MOLECULAR HUMAN REPRODUCTION. 2016;22(9):601-612
- Article: ENDOCRINOLOGY. 2016;157(6):2461-2468
- Article: PLOS ONE. 2016;11(10):e0165268
- Article: HUMAN REPRODUCTION. 2015;30(2):256-267
- Article: REPRODUCTION. 2014;147(6):875-883
- Journal article: INTERNATIONAL JOURNAL OF CHILD HEALTH AND NUTRITION. 2014;3(2):99-107
- Article: TISSUE AND CELL. 2014;46(1):86-96
- Article: FRONTIERS IN ENDOCRINOLOGY. 2014;5:21
- Article: PLOS ONE. 2014;9(8):e103809
- Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2013;372(1-2):96-104
- Journal article: L'ENDOCRINOLOGO. 2013;14(1):45
- Article: SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE. 2012;58(6):330-338
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2012;97(12):4588-4595
- Article: THE FEBS JOURNAL. 2012;279(24):4589-4597
- Article: INTERNATIONAL JOURNAL OF ANDROLOGY. 2012;35(2):211-213
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;418(3):489-493
- Article: SEXUAL DEVELOPMENT. 2011;5(4):188-196
- Article: SEXUAL DEVELOPMENT. 2010;4(4-5):199-212
- Article: ENDOCRINOLOGY. 2010;151(6):2898-2910
- Journal article: BIOLOGY OF REPRODUCTION. 2009;81(Suppl_1):184
- Article: JOURNAL OF ANDROLOGY. 2008;29(3):312-329
- Article: ENDOCRINOLOGY. 2008;149(4):1736-1747
- Show more
All other publications
- Editorial comment: MOLECULAR HUMAN REPRODUCTION. 2024;30(2):gaae009
- Review: NPJ MICROGRAVITY. 2023;9(1):24
- Review: HORMONE RESEARCH IN PAEDIATRICS. 2023;96(2):190-206
- Letter: HAEMATOLOGICA. 2022;107(4):975-979
- Editorial comment: FRONTIERS IN ENDOCRINOLOGY. 2022;13:1027813
- Preprint: BIORXIV. 2021
- Review: ANDROLOGY. 2020;8(4):825-834
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(3):E1028-1028
- Review: ECANCERMEDICALSCIENCE. 2020;14:1016
- Review: HORMONE RESEARCH IN PAEDIATRICS. 2020;93(11-12):599-608
- Conference publication: HUMAN REPRODUCTION. 2019;34:47-48
- Review: HUMAN REPRODUCTION UPDATE. 2018;24(2):176-191
- Review: ENDOCRINE CONNECTIONS. 2018;7(2):R69-R87
- Letter: LEUKEMIA. 2017;31(6):1460-1463
- Conference publication: HUMAN REPRODUCTION. 2017;32:40-41
- Conference publication: HUMAN REPRODUCTION. 2017;32:8
- Conference publication: HUMAN REPRODUCTION. 2017;32:8-9
- Book chapter: GENETICS OF HUMAN INFERTILITY: MONOGRAPHS IN HUMAN GENETICS. 2017;p. 162-172
- Book chapter: MALE HYPOGONADISM: CONTEMPORARY ENDOCRINOLOGY. 2017;p. 235-256
- Review: FERTILITY AND STERILITY. 2016;106(7):1652-1657.e2
- Conference publication: BONE MARROW TRANSPLANTATION. 2016;51:S453
- Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2016;86:257
- Review: CURRENT OPINION IN ENDOCRINOLOGY, DIABETES AND OBESITY. 2015;22(3):217-223
- Conference publication: HUMAN REPRODUCTION. 2015;30:327
- Review: ASIAN JOURNAL OF ANDROLOGY. 2014;16(1):50-59
- Review: HORMONE RESEARCH IN PAEDIATRICS. 2014;81(1):2-12
- Review: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2012;97(12):4341-4351
- Other: ASIAN JOURNAL OF ANDROLOGY. 2012;14(5):796
- Conference publication: INTERNATIONAL JOURNAL OF ANDROLOGY. 2010;33:81
- Review: MOLECULAR HUMAN REPRODUCTION. 2009;15(9):521-529
- Conference publication: BIOLOGY OF REPRODUCTION. 2009;:89-90
- Other: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2006;257-258:1-5
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Grants
- Swedish Research Council1 January 2022 - 31 December 2024
- Swedish Research Council1 January 2019 - 31 December 2021
- Deutsche Forschungsgemeinschaft1 January 2010 - 31 December 2013
Employments
- Senior Lecturer, Department of Women's and Children's Health, Karolinska Institutet, 2021-
Degrees and Education
- Docent, Karolinska Institutet, 2016