Jakob Michaelsson

About me
Publications
CV
Public outreach and news

About me

I am the group leader of the Jakob Michaelssons research group
[1] at the at the Center for Infectious Medicine, CIM at the Department of
Medicine Huddinge.
[1] https://ki.se/en/medh/jakob-michaelsson-group

Articles

Article: RESPIRATORY RESEARCH. 2023;24(1):62

Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.

Palma Medina LM; Babačić H; Dzidic M; Parke Å; Garcia M; Maleki KT; Unge C; Lourda M; Kvedaraite E; Chen P; Muvva JR; Cornillet M; Emgård J; Moll K; Karolinska K. I./K. COVID-19 Study Group; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Gredmark-Russ S; Rooyackers O; Svensson M; Chambers BJ; Eriksson LI; Pernemalm M; Björkström NK; Aleman S; Ljunggren H-G; Klingström J; Strålin K; Norrby-Teglund A
Article: NATURE CELL BIOLOGY. 2023;25(2):351-365

A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung.

Sountoulidis A; Marco Salas S; Braun E; Avenel C; Bergenstråhle J; Theelke J; Vicari M; Czarnewski P; Liontos A; Abalo X; Andrusivová Ž; Mirzazadeh R; Asp M; Li X; Hu L; Sariyar S; Martinez Casals A; Ayoglu B; Firsova A; Michaëlsson J; Lundberg E; Wählby C; Sundström E; Linnarsson S; Lundeberg J; Nilsson M; Samakovlis C
Article: CELL REPORTS. 2022;38(10):110503

SARS-CoV-2 Nsp13 encodes for an HLA-E-stabilizing peptide that abrogates inhibition of NKG2A-expressing NK cells.

Hammer Q; Dunst J; Christ W; Picarazzi F; Wendorff M; Momayyezi P; Huhn O; Netskar HK; Maleki KT; García M; Sekine T; Sohlberg E; Azzimato V; Aouadi M; Karolinska COVID-19 Study Group; Severe COVID-19 GWAS Group; Degenhardt F; Franke A; Spallotta F; Mori M; Michaëlsson J; Björkström NK; Rückert T; Romagnani C; Horowitz A; Klingström J; Ljunggren H-G; Malmberg K-J
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:834862

Comparison of Lung-Homing Receptor Expression and Activation Profiles on NK Cell and T Cell Subsets in COVID-19 and Influenza.

Brownlie D; Rødahl I; Varnaite R; Asgeirsson H; Glans H; Falck-Jones S; Vangeti S; Buggert M; Ljunggren H-G; Michaëlsson J; Gredmark-Russ S; Smed-Sörensen A; Marquardt N
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(40):e2109123118

High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19.

Lourda M; Dzidic M; Hertwig L; Bergsten H; Palma Medina LM; Sinha I; Kvedaraite E; Chen P; Muvva JR; Gorin J-B; Cornillet M; Emgård J; Moll K; García M; Maleki KT; Klingström J; Michaëlsson J; Flodström-Tullberg M; Brighenti S; Buggert M; Mjösberg J; Malmberg K-J; Sandberg JK; Henter J-I; Folkesson E; Gredmark-Russ S; Sönnerborg A; Eriksson LI; Rooyackers O; Aleman S; Strålin K; Ljunggren H-G; Björkström NK; Svensson M; Ponzetta A; Norrby-Teglund A; Chambers BJ; Karolinska KI/K COVID-19 Study Group
Article: CELLS. 2021;10(7):1713

In Vitro Study of Human Immune Responses to Hyaluronic Acid Hydrogels, Recombinant Spidroins and Human Neural Progenitor Cells of Relevance to Spinal Cord Injury Repair.

Lin C; Ekblad-Nordberg Å; Michaëlsson J; Götherström C; Hsu C-C; Ye H; Johansson J; Rising A; Sundström E; Åkesson E
Article: SCIENCE TRANSLATIONAL MEDICINE. 2021;13(599):eabb3107

A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells.

Zimmer CL; von Seth E; Buggert M; Strauss O; Hertwig L; Nguyen S; Wong AYW; Zotter C; Berglin L; Michaëlsson J; Hansson MR; Arnelo U; Sparrelid E; Ellis ECS; Söderholm JD; Keita ÅV; Holm K; Özenci V; Hov JR; Mold JE; Cornillet M; Ponzetta A; Bergquist A; Björkström NK
Article: CELL REPORTS. 2021;35(8):109174

Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans.

Mold JE; Modolo L; Hård J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Ståhl PL; Borgström E; Picelli S; Reinius B; Sandberg R; Réu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaëlsson J; Frisén J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(11):e2016580118

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood.

Brownlie D; Scharenberg M; Mold JE; Hård J; Kekäläinen E; Buggert M; Nguyen S; Wilson JN; Al-Ameri M; Ljunggren H-G; Marquardt N; Michaëlsson J
Article: IMMUNITY. 2021;54(2):259-275.e7

Distinct developmental pathways from blood monocytes generate human lung macrophage diversity.

Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaëlsson J; Smed-Sörensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:752104

CD5 Surface Expression Marks Intravascular Human Innate Lymphoid Cells That Have a Distinct Ontogeny and Migrate to the Lung.

Alisjahbana A; Gao Y; Sleiers N; Evren E; Brownlie D; von Kries A; Jorns C; Marquardt N; Michaëlsson J; Willinger T
Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström NK; Karolinska COVID-19 Study Group
Article: PLOS BIOLOGY. 2019;17(10):e3000383

Cell generation dynamics underlying naive T-cell homeostasis in adult humans.

Mold JE; Réu P; Olin A; Bernard S; Michaëlsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisén J
Article: NATURE COMMUNICATIONS. 2019;10(1):3841

Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.

Marquardt N; Kekäläinen E; Chen P; Lourda M; Wilson JN; Scharenberg M; Bergman P; Al-Ameri M; Hård J; Mold JE; Ljunggren H-G; Michaëlsson J
Article: GENOME BIOLOGY. 2019;20(1):68

Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing.

Hård J; Al Hakim E; Kindblom M; Björklund ÅK; Sennblad B; Demirci I; Paterlini M; Reu P; Borgström E; Ståhl PL; Michaelsson J; Mold JE; Frisén J
Article: JOURNAL OF CROHNS & COLITIS. 2019;13(1):67-78

Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis.

Forkel M; van Tol S; Höög C; Michaëlsson J; Almer S; Mjösberg J
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1116

Influenza A Virus Infection Induces Hyperresponsiveness in Human Lung Tissue-Resident and Peripheral Blood NK Cells.

Scharenberg M; Vangeti S; Kekäläinen E; Bergman P; Al-Ameri M; Johansson N; Sondén K; Falck-Jones S; Färnert A; Ljunggren H-G; Michaëlsson J; Smed-Sörensen A; Marquardt N
Article: IMMUNOHORIZONS. 2018;2(6):172-184

Breadth and Dynamics of HLA-A2- and HLA-B7-Restricted CD8+ T Cell Responses against Nonstructural Viral Proteins in Acute Human Tick-Borne Encephalitis Virus Infection.

Lampen MH; Uchtenhagen H; Blom K; Varnaitė R; Pakalniene J; Dailidyte L; Wälchli S; Lindquist L; Mickiene A; Michaëlsson J; Schumacher TN; Ljunggren H-G; Sandberg JK; Achour A; Gredmark-Russ S
Article: BIOINFORMATICS. 2018;34(3):485-493

High dimensional classification with combined adaptive sparse PLS and logistic regression.

Durif G; Modolo L; Michaelsson J; Mold JE; Lambert-Lacroix S; Picard F
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2017;47(8):1280-1294

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.

Forkel M; Berglin L; Kekäläinen E; Carlsson A; Svedin E; Michaëlsson J; Nagasawa M; Erjefält JS; Mori M; Flodström-Tullberg M; Bergquist A; Ljunggren H-G; Westgren M; Lindforss U; Friberg D; Jorns C; Ellis E; Björkström NK; Mjösberg J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1321-1330.e4

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69-CD56dim cells.

Marquardt N; Kekäläinen E; Chen P; Kvedaraite E; Wilson JN; Ivarsson MA; Mjösberg J; Berglin L; Säfholm J; Manson ML; Adner M; Al-Ameri M; Bergman P; Orre A-C; Svensson M; Dahlén B; Dahlén S-E; Ljunggren H-G; Michaëlsson J
Article: IMMUNITY. 2017;46(2):287-300

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin.

Cheuk S; Schlums H; Gallais Sérézal I; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Höög C; Tjernlund A; Michaëlsson J; Folkersen L; Mjösberg J; Blomqvist L; Ehrström M; Ståhle M; Bryceson YT; Eidsmo L
Article: NATURE GENETICS. 2016;48(11):1430-1435

Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq.

Reinius B; Mold JE; Ramsköld D; Deng Q; Johnsson P; Michaëlsson J; Frisén J; Sandberg R
Article: JOURNAL OF IMMUNOLOGY. 2016;197(8):3069-3075

Fetal CD103+ IL-17-Producing Group 3 Innate Lymphoid Cells Represent the Dominant Lymphocyte Subset in Human Amniotic Fluid.

Marquardt N; Ivarsson MA; Sundström E; Åkesson E; Martini E; Eidsmo L; Mjösberg J; Friberg D; Kublickas M; Ek S; Tegerstedt G; Seiger Å; Westgren M; Michaëlsson J
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771

NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection.

Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaëlsson J; Ljunggren H-G; Gredmark-Russ S
Article: JOURNAL OF IMMUNOLOGY. 2015;195(7):3262-3272

The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.

Marquardt N; Ivarsson MA; Blom K; Gonzalez VD; Braun M; Falconer K; Gustafsson R; Fogdell-Hahn A; Sandberg JK; Michaëlsson J
Article: IMMUNITY. 2015;43(2):394-407

Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues.

Renoux VM; Zriwil A; Peitzsch C; Michaëlsson J; Friberg D; Soneji S; Sitnicka E
Article: JOURNAL OF IMMUNOLOGY. 2015;194(6):2467-2471

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.

Marquardt N; Béziat V; Nyström S; Hengst J; Ivarsson MA; Kekäläinen E; Johansson H; Mjösberg J; Westgren M; Lankisch TO; Wedemeyer H; Ellis EC; Ljunggren H-G; Michaëlsson J; Björkström NK
Article: PLOS PATHOGENS. 2015;11(1):e1004622

Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection.

Blom K; Braun M; Pakalniene J; Dailidyte L; Béziat V; Lampen MH; Klingström J; Lagerqvist N; Kjerstadius T; Michaëlsson J; Lindquist L; Ljunggren H-G; Sandberg JK; Mickiene A; Gredmark-Russ S
Article: MUCOSAL IMMUNOLOGY. 2014;7(5):1233-1243

Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine.

Loh L; Ivarsson MA; Michaëlsson J; Sandberg JK; Nixon DF
Article: PLOS PATHOGENS. 2014;10(7):e1004251

T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.

Buggert M; Tauriainen J; Yamamoto T; Frederiksen J; Ivarsson MA; Michaëlsson J; Lund O; Hejdeman B; Jansson M; Sönnerborg A; Koup RA; Betts MR; Karlsson AC
Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(9):3889-3901

Differentiation and functional regulation of human fetal NK cells.

Ivarsson MA; Loh L; Marquardt N; Kekäläinen E; Berglin L; Björkström NK; Westgren M; Nixon DF; Michaëlsson J
Article: BLOOD. 2013;121(14):2678-2688

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.

Béziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Björklund AT; Retière C; Sverremark-Ekström E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2013;190(5):2150-2158

Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response.

Blom K; Braun M; Ivarsson MA; Gonzalez VD; Falconer K; Moll M; Ljunggren H-G; Michaëlsson J; Sandberg JK
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2011;41(8):2279-2290

The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function.

Herrath J; Müller M; Amoudruz P; Janson P; Michaëlsson J; Larsson PT; Trollmo C; Raghavan S; Malmström V
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(2):141-146

NK cells and CD1d-restricted NKT cells respond in different ways with divergent kinetics to IL-2 treatment in primary HIV-1 infection.

Kuylenstierna C; Snyder-Cappione JE; Loo CP; Long BR; Gonzalez VD; Michaëlsson J; Moll M; Spotts G; Hecht FM; Nixon DF; Sandberg JK
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2011;208(1):13-21

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus.

Björkström NK; Lindgren T; Stoltz M; Fauriat C; Braun M; Evander M; Michaëlsson J; Malmberg K-J; Klingström J; Ahlm C; Ljunggren H-G
Article: SCIENCE. 2010;330(6011):1695-1699

Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans.

Mold JE; Venkatasubrahmanyam S; Burt TD; Michaëlsson J; Rivera JM; Galkina SA; Weinberg K; Stoddart CA; McCune JM
Article: BLOOD. 2010;116(19):3853-3864

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.

Björkström NK; Riese P; Heuts F; Andersson S; Fauriat C; Ivarsson MA; Björklund AT; Flodström-Tullberg M; Michaëlsson J; Rottenberg ME; Guzmán CA; Ljunggren H-G; Malmberg K-J
Article: BLOOD. 2010;115(6):1166-1174

Education of human natural killer cells by activating killer cell immunoglobulin-like receptors.

Fauriat C; Ivarsson MA; Ljunggren H-G; Malmberg K-J; Michaëlsson J
Article: BLOOD. 2009;114(23):4823-4831

Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.

Milush JM; Long BR; Snyder-Cappione JE; Cappione AJ; York VA; Ndhlovu LC; Lanier LL; Michaëlsson J; Nixon DF
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2009;25(6):603-605

HIV-1-specific T Cell-dependent natural killer (NK) cell activation: major contribution by NK cells to interferon-gamma production in response to HIV-1 antigens.

Loo CP; Long BR; Hecht FM; Nixon DF; Michaëlsson J
Article: SCIENCE. 2008;322(5907):1562-1565

Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.

Mold JE; Michaëlsson J; Burt TD; Muench MO; Beckerman KP; Busch MP; Lee T-H; Nixon DF; McCune JM
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019

Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype.

Fauriat C; Andersson S; Björklund AT; Carlsten M; Schaffer M; Björkström NK; Baumann BC; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: BMC IMMUNOLOGY. 2008;9:41

The frequency of CD127low expressing CD4+CD25high T regulatory cells is inversely correlated with human T lymphotrophic virus type-1 (HTLV-1) proviral load in HTLV-1-infection and HTLV-1-associated myelopathy/tropical spastic paraparesis.

Michaëlsson J; Barbosa HMR; Jordan KA; Chapman JM; Brunialti MKC; Neto WK; Nukui Y; Sabino EC; Chieia MA; Oliveira ASB; Nixon DF; Kallas EG
Article: CLINICAL IMMUNOLOGY. 2008;128(1):46-56

Expansion of CD56- NK cells in chronic HCV/HIV-1 co-infection: reversion by antiviral treatment with pegylated IFNalpha and ribavirin.

Gonzalez VD; Falconer K; Michaëlsson J; Moll M; Reichard O; Alaeus A; Sandberg JK
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2008;330(1-2):64-74

Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets.

Gonzalez VD; Björkström NK; Malmberg K-J; Moll M; Kuylenstierna C; Michaëlsson J; Ljunggren H-G; Sandberg JK
Article: CLINICAL AND VACCINE IMMUNOLOGY. 2008;15(1):120-130

Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus.

Long BR; Michaelsson J; Loo CP; Ballan WM; Vu B-AN; Hecht FM; Lanier LL; Chapman JM; Nixon DF
Article: JOURNAL OF INFECTIOUS DISEASES. 2008;197(1):117-125

Immune reconstitution of CD56(dim) NK cells in individuals with primary HIV-1 infection treated with interleukin-2.

Michaëlsson J; Long BR; Loo CP; Lanier LL; Spotts G; Hecht FM; Nixon DF
Article: IMMUNOLOGY. 2007;122(2):291-301

Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion.

de Matos CT; Berg L; Michaëlsson J; Felländer-Tsai L; Kärre K; Söderström K
Article: JOURNAL OF IMMUNOLOGY. 2007;179(5):3362-3370

Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity.

Ballan WM; Vu B-AN; Long BR; Loo CP; Michaëlsson J; Barbour JD; Lanier LL; Wiznia AA; Abadi J; Fennelly GJ; Rosenberg MG; Nixon DF
Article: JOURNAL OF VIROLOGY. 2007;81(11):5759-5765

Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point.

Northfield JW; Loo CP; Barbour JD; Spotts G; Hecht FM; Klenerman P; Nixon DF; Michaëlsson J
Article: JOURNAL OF IMMUNOLOGY. 2007;178(2):647-651

Cutting Edge: KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation.

Carr WH; Rosen DB; Arase H; Nixon DF; Michaelsson J; Lanier LL
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):5741-5748

Regulation of T cell responses in the developing human fetus.

Michaëlsson J; Mold JE; McCune JM; Nixon DF
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;356(2):382-396

Structural basis of the differential stability and receptor specificity of H-2Db in complex with murine versus human beta2-microglobulin.

Achour A; Michaëlsson J; Harris RA; Ljunggren H-G; Kärre K; Schneider G; Sandalova T
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 12):1090-1093

Expression, refolding and crystallization of murine MHC class I H-2Db in complex with human beta2-microglobulin.

Sandalova T; Michaëlsson J; Harris RA; Ljunggren H-G; Kärre K; Schneider G; Achour A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(29):27069-27075

A structural basis for CD8+ T cell-dependent recognition of non-homologous peptide ligands: implications for molecular mimicry in autoreactivity.

Sandalova T; Michaëlsson J; Harris RA; Odeberg J; Schneider G; Kärre K; Achour A
Article: MICROBES AND INFECTION. 2005;7(7-8):1063-1065

CD4+CD25+ regulatory T cells in HIV infection.

Nixon DF; Aandahl EM; Michaëlsson J
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2004;34(6):1646-1653

Loss or mismatch of MHC class I is sufficient to trigger NK cell-mediated rejection of resting lymphocytes in vivo - role of KARAP/DAP12-dependent and -independent pathways.

Oberg L; Johansson S; Michaëlsson J; Tomasello E; Vivier E; Kärre K; Höglund P
Article: JOURNAL OF IMMUNOLOGY. 2004;172(9):5504-5511

Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition.

Velloso LM; Michaëlsson J; Ljunggren H-G; Schneider G; Achour A
Article: JOURNAL OF VIROLOGY. 2004;78(5):2454-2459

Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens.

Aandahl EM; Michaëlsson J; Moretto WJ; Hecht FM; Nixon DF
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2003;33(10):2727-2735

Regulation of perforin-independent NK cell-mediated cytotoxicity.

Wallin RPA; Screpanti V; Michaëlsson J; Grandien A; Ljunggren H-G
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2002;196(11):1403-1414

A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.

Michaëlsson J; Teixeira de Matos C; Achour A; Lanier LL; Kärre K; Söderström K
Article: IMMUNITY. 2002;17(6):757-768

A structural basis for LCMV immune evasion: subversion of H-2D(b) and H-2K(b) presentation of gp33 revealed by comparative crystal structure.Analyses.

Achour A; Michaëlsson J; Harris RA; Odeberg J; Grufman P; Sandberg JK; Levitsky V; Kärre K; Sandalova T; Schneider G
Article: CANCER RESEARCH. 2002;62(4):1116-1122

Apoptosis-dependent subversion of the T-lymphocyte epitope hierarchy in lymphoma cells.

Castiglioni P; Martin-Fontecha A; Milan G; Tomajer V; Magni F; Michaelsson J; Rugarli C; Rosato A; Bellone M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(2):129-139

The role of an exposed loop in the alpha2 domain in the mouse MHC class I H-2Dd molecule for recognition by the monoclonal antibody 34-5-8S and the NK-cell receptor Ly49A.

Waldenström M; Achour A; Michaelsson J; Rölle A; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2002;168(2):793-800

NK cell inhibitory receptor Ly-49C residues involved in MHC class I binding.

Sundbäck J; Achour A; Michaëlsson J; Lindström H; Kärre K
Article: JOURNAL OF IMMUNOLOGY. 2001;166(12):7327-7334

MHC class I recognition by NK receptors in the Ly49 family is strongly influenced by the beta 2-microglobulin subunit.

Michaëlsson J; Achour A; Rölle A; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2001;31(3):869-875

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro.

Kambayashi T; Michaëlsson J; Fahlén L; Chambers BJ; Sentman CL; Kärre K; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(9):4964-4969

Emergence of CD8+ T cells expressing NK cell receptors in influenza A virus-infected mice.

Kambayashi T; Assarsson E; Michaëlsson J; Berglund P; Diehl AD; Chambers BJ; Ljunggren HG
Article: JOURNAL OF IMMUNOLOGY. 2000;165(1):25-33

T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity.

Sandberg JK; Franksson L; Sundbäck J; Michaelsson J; Petersson M; Achour A; Wallin RP; Sherman NE; Bergman T; Jörnvall H; Hunt DF; Kiessling R; Kärre K
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2000;30(1):300-307

Visualization of inhibitory Ly49 receptor specificity with soluble major histocompatibility complex class I tetramers.

Michaëlsson J; Achour A; Salcedo M; Kâse-Sjöström A; Sundbäck J; Harris RA; Kärre K
Show more

All other publications

Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2174

Cell-Mediated Immune Responses and Immunopathogenesis of Human Tick-Borne Encephalitis Virus-Infection.

Blom K; Cuapio A; Sandberg JT; Varnaite R; Michaëlsson J; Björkström NK; Sandberg JK; Klingström J; Lindquist L; Gredmark Russ S; Ljunggren H-G
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(1):318

Reply.

Marquardt N; Ljunggren H-G; Michaëlsson J
Review: NATURE REVIEWS IMMUNOLOGY. 2016;16(5):310-320

Emerging insights into natural killer cells in human peripheral tissues.

Björkström NK; Ljunggren H-G; Michaëlsson J
Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):2192-2196

Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation.

Béziat V; Traherne J; Malmberg J-A; Ivarsson MA; Björkström NK; Retière C; Ljunggren H-G; Michaëlsson J; Trowsdale J; Malmberg K-J
Review: FRONTIERS IN IMMUNOLOGY. 2014;5:184-9

Activating killer cell Ig-like receptors in health and disease.

Ivarsson MA; Michaëlsson J; Fauriat C
Other: IMMUNITY. 2011;35(5):653-657

Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation.

Malmberg K-J; Michaëlsson J; Parham P; Ljunggren H-G
Meeting abstract: RETROVIROLOGY. 2009;6:p23

Preserved cellular and humoral immune responses in macaques infected with SIVmac239 and subjected to early antiretroviral therapy

Makitalo B; Walther-Jallow L; Sahin GO; Michaelsson J; Spangberg M; Thorstensson R; Fenyo E; Spetz A

Employments

Principal Researcher, Department of Medicine, Huddinge, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2015
Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2002

About me

Articles

All other publications

Employments

Degrees and Education

News from KI

Events from KI