Iryna Kolosenko

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Public outreach and news

Articles

Article: BLOOD CANCER JOURNAL. 2023;13(1):139
PLK1 as a cooperating partner for BCL2-mediated antiapoptotic program in leukemia
Shah K; Nasimian A; Ahmed M; Al Ashiri L; Denison L; Sime W; Bendak K; Kolosenko I; Siino V; Levander F; Palm-Apergi C; Massoumi R; Lock RB; Kazi JU
Article: THE FASEB JOURNAL. 2021;35(7):e21741
Thermal proteome profiling identifies PIP4K2A and ZADH2 as off-targets of Polo-like kinase 1 inhibitor volasertib
Goroshchuk O; Kolosenko I; Kunold E; Vidarsdottir L; Pirmoradian M; Azimi A; Jafari R; Palm-Apergi C
Article: THE FASEB JOURNAL. 2021;35(5):e21476
RNAi prodrugs decrease elevated mRNA levels of Polo-like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients
Kolosenko I; Goroshchuk O; Vidarsdottir L; Bjorklund A-C; Dowdy SF; Palm-Apergi C
Journal article: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2020;20:s163
ALL-166: Novel RNAi Prodrugs Targeting Plk1 Induce Specific mRNA Cleavage in Pediatric Acute B-Cell Lymphoblastic Leukemia
Goroshchuk O; Vidarsdottir L; Björklund A-C; Hamil A; Kolosenko I; Dowdy S; Palm-Apergi C
Article: SCIENCE ADVANCES. 2020;6(12):eaax7945
Irreversible TrxR1 inhibitors block STAT3 activity and induce cancer cell death
Busker S; Qian W; Haraldsson M; Espinosa B; Johansson L; Attarha S; Kolosenko I; Liu J; Dagnell M; Grander D; Arner ESJ; Tamm KP; Page BDG
Article: SCIENTIFIC REPORTS. 2020;10(1):2688
Targeting Plk1 with siRNNs in primary cells from pediatric B-cell acute lymphoblastic leukemia patients
Goroshchuk O; Vidarsdottir L; Bjorklund A-C; Hamil AS; Kolosenko I; Dowdy SF; Palm-Apergi C
Article: SCIENTIFIC REPORTS. 2019;9(1):536
STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes
Edsbacker E; Serviss JT; Kolosenko I; Palm-Apergi C; De Milito A; Tamm KP
Article: METHODS IN MOLECULAR BIOLOGY. 2019;2036:53-72
Designing siRNA and Evaluating Its Effect on RNA Targets Using qPCR and Western Blot.
Vidarsdottir L; Goroshchuk O; Kolosenko I; Palm-Apergi C
Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2018;160:80-88
STAT3 differential scanning fluorimetry and differential scanning light scattering assays: Addressing a missing link in the characterization of STAT3 inhibitor interactions
Desroses M; Busker S; Astorga-Wells J; Attarha S; Kolosenko I; Zubarev RA; Helleday T; Grander D; Page BDG
Article: CANCER CELL INTERNATIONAL. 2018;18:147
A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini P; Serviss JT; Lundback T; Bancaro N; Mazurkiewicz M; Kolosenko I; Yu D; Haraldsson M; D'Arcy P; Linder S; De Milito A
Article: JOURNAL OF CONTROLLED RELEASE. 2017;261:199-206
RNAi prodrugs targeting Plk1 induce specific gene silencing in primary cells from pediatric T-acute lymphoblastic leukemia patients
Kolosenko I; Edsbacker E; Bjorklund A-C; Hamil AS; Goroshchuk O; Grander D; Dowdy SF; Palm-Apergi C
Article: PLOS ONE. 2017;12(6):e0178844
Identification of novel small molecules that inhibit STAT3-dependent transcription and function
Kolosenko I; Yu Y; Busker S; Dyczynski M; Liu J; Haraldsson M; Apergi CP; Helleday T; Tamm KP; Page BDG; Grander D
Article: INTERNATIONAL JOURNAL OF CANCER. 2015;136(4):e51-e61
Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs
Kolosenko I; Fryknas M; Forsberg S; Johnsson P; Cheon H; Holvey-Bates EG; Edsbacker E; Pellegrini P; Rassoolzadeh H; Brnjic S; Larsson R; Stark GR; Grander D; Linder S; Tamm KP; De Milito A
Article: CURRENT MEDICINAL CHEMISTRY. 2014;21(26):3042-3047
IL-6 Activated JAK/STAT3 Pathway and Sensitivity to Hsp90 Inhibitors in Multiple Myeloma
Kolosenko I; Grander D; Tamm KP
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(5):600-611
An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma
Lin H; Kolosenko I; Bjorklund A-C; Protsyuk D; Osterborg A; Grander D; Tamm KP
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;39(2):311-318
miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer
Akcakaya P; Ekelund S; Kolosenko I; Caramuta S; Ozata DM; Xie H; Lindforss U; Olivecrona H; Lui W-O
Article: EXPERIMENTAL CELL RESEARCH. 2011;317(1):9-19
Activation of STAT1 is required for interferon-alpha-mediated cell death
Arulampalam V; Kolosenko I; Hjortsbert L; Bjorklund A-C; Grander D; Tamm KP

All other publications

Editorial comment: FUTURE MEDICINAL CHEMISTRY. 2020;12(16):1457-1460
Small-molecule inhibitors for targeting polo-like kinase 1
Kolosenko I; Palm-Apergi C
Conference publication: CLINICAL LYMPHOMA, MYELOMA AND LEUKEMIA. 2020;20:S163
Novel RNAi Prodrugs Targeting Plk1 Induce Specific mRNA Cleavage in Pediatric Acute B-Cell Lymphoblastic Leukemia
Goroshchuk O; Vidarsdottir L; Bjorklund A-C; Hamil A; Kolosenko I; Dowdy S; Palm-Apergi C
Review: ONCOGENE. 2019;38(1):1-16
Polo-like kinases and acute leukemia
Goroshchuk O; Kolosenko I; Vidarsdottir L; Azimi A; Palm-Apergi C
Review: SEMINARS IN CANCER BIOLOGY. 2017;43:119-133
Therapeutic implications of tumor interstitial acidification
Kolosenko I; Avnet S; Baldini N; Viklund J; De Milito A
Thesis / dissertation: 2016
Therapeutic response in human cancers : the dual role of STAT signalling
Kolosenko, Iryna
Conference publication: CYTOKINE. 2015;76(1):105
Cell-to-cell contact triggers the expression of the interferon-stimulated genes and mediates therapy resistance in cancer cell lines through a soluble factor
Kolosenko I; Grander D; Pokrovskaja K; De Milito A
Conference publication: CYTOKINE. 2013;63(3):303
Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding
Tamm KP; Kolosenko I; Fryknas M; Johnsson P; Forsberg S; Brnjic S; Rassoolzadeh H; Pellegrini P; Grander D; Larsson R; Linder S; De Milito A
Conference publication: CYTOKINE. 2013;63(3):278
Cell crowding results in accumulation of interferon-stimulated genes independently of STAT1
Kolosenko I; Edsbacker E; Fryknas M; Johnsson P; Grander D; Tamm KP; Lindera S; De Milito A
Conference publication: CANCER RESEARCH. 2013;73(8):3999
Spontaneous time-dependent accumulation of interferon-regulatory factor 9 induces chemo-resistance in colon carcinoma cells independently of STAT1 signaling
Kolosenko I; Fryknas M; Rassoolzadeh H; Pellegrini P; Brnjic S; Johnsson P; Di Lernia G; Grander D; Larsson R; Pokrovskaja K; Linder S; De Milito ADM
Conference publication: CYTOKINE. 2011;56(1):41-42
Activated JAK-STAT3 pathway is associated with sensitivity to Hsp90 inhibitors in multiple myeloma
Tamm KP; Kolosenko I; Lin H; Grander D
Conference publication: CYTOKINE. 2011;56(1):41
Inhibition of Hsp90 induces apoptosis in multiple myeloma cell lines through downregulation of STAT3 activity
Kolosenko I; Lin H; Grander D; Tamm KP

Employments

Laboratory Manager, Department of Medicine, Karolinska Institutet, 2023-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Oncology-Pathology, Karolinska Institutet, 2016
Degree Of Master Of Medical Science 120 Credits, Karolinska Institutet, 2010

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