Hussein Rubaiy

Publications
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Articles

Article: BIOCHEMICAL JOURNAL. 2020;477(3):671-689
Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K_ATP channel complex
Brennan S; Rubaiy HN; Imanzadeh S; Reid R; Lodwick D; Norman RI; Rainbow RD
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(19):3845-3856
Mibefradil, a T-type Ca²⁺ channel blocker also blocks Orai channels by action at the extracellular surface
Li PI; Rubaiy HN; Chen G-L; Hallett T; Zaibi N; Zeng B; Saurabh R; Xu S-Z
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2018;175(16):3361-3368
Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1/4/5 channels
Rubaiy HN; Ludlow MJ; Siems K; Norman K; Foster R; Wolf D; Beutler JA; Beech DJ
Article: ONCOTARGET. 2018;9(51):29634-29643
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
Cheung SY; Henrot M; Al-Saad M; Baumann M; Muller H; Unger A; Rubaiy HN; Mathar I; Dinkel K; Nussbaumer P; Klebl B; Freichel M; Rode B; Trainor S; Clapcote SJ; Christmann M; Waldmann H; Abbas SK; Beech DJ; Vasudev NS
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2018;175(5):830-839
Identification of an (-)-englerin A analogue, which antagonizes (-)-englerin A at TRPC1/4/5 channels
Rubaiy HN; Seitz T; Hahn S; Choidas A; Habenberger P; Klebl B; Dinkel K; Nussbaumer P; Waldmann H; Christmann M; Beech DJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(20):8158-8173
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels
Rubaiy HN; Ludlow MJ; Henrot M; Gaunt HJ; Miteva K; Cheung SY; Tanahashi Y; Hamzah N; Musialowski KE; Blythe NM; Appleby HL; Bailey MA; McKeown L; Taylor R; Foster R; Waldmann H; Nussbaumer P; Christmann M; Bon RS; Muraki K; Beech DJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2017;292(2):723-731
(-)-Englerin A-evoked Cytotoxicity Is Mediated by Na⁺ Influx and Counteracted by Na⁺/K⁺-ATPase
Ludlow MJ; Gaunt HJ; Rubaiy HN; Musialowski KE; Blythe NM; Vasudev NS; Muraki K; Beech DJ
Article: JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. 2017;20:48-67
A Short Guide to Electrophysiology and Ion Channels
Rubaiy HN
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2016;173(3):562-574
Natural and synthetic flavonoid modulation of TRPC5 channels
Naylor J; Minard A; Gaunt HJ; Amer MS; Wilson LA; Migliore M; Cheung SY; Rubaiy HN; Blythe NM; Musialowski KE; Ludlow MJ; Evans WD; Green BL; Yang H; You Y; Li J; Fishwick CWG; Muraki K; Beech DJ; Bon RS
Article: JOURNAL OF PHYSIOLOGICAL SCIENCES. 2015;65(3):233-241
Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore
Rubaiy HN; Linsdell P
Article: BIOCHEMICAL JOURNAL. 2014;464(3):343-354
Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge
Lodwick D; Rainbowl RD; Rubaiy HN; Al Johi M; Vuister GW; Norman RI
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2014;466(3):477-490
Relative contribution of different transmembrane segments to the CFTR chloride channel pore
Wang W; El Hiani Y; Rubaiy HN; Linsdell P

All other publications

Review: PHARMACEUTICALS. 2023;16(2):162
ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets
Rubaiy HNN
Review: PHARMACY. 2021;9(2):70
Strategies to Inspire Students' Engagement in Pharmacology Courses
Rubaiy HN
Meeting abstract: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2020;140:26-27
T-type Ca²⁺ channel blocker mibefradil inhibits ORAI store-operated channels
Li P; Rubaiy HN; Chen G; Hallett T; Zaibi N; Zeng B; Saurabh R; Xu S
Review: BRITISH JOURNAL OF PHARMACOLOGY. 2019;176(7):832-846
Treasure troves of pharmacological tools to study transient receptor potential canonical 1/4/5 channels
Rubaiy HN
Review: CELLS. 2018;7(6):E52-52
Remarkable Progress with Small-Molecule Modulation of TRPC1/4/5 Channels: Implications for Understanding the Channels in Health and Disease
Minard A; Bauer CC; Wright DJ; Rubaiy HN; Muraki K; Beech DJ; Bon RS
Editorial comment: CHANNELS. 2017;11(5):362-364
Pico145-powerful new tool for TRPC1/4/5 channels
Rubaiy HN; Ludlow MJ; Bon RS; Beech DJ
Review: ACTA PHARMACEUTICA. 2016;66(1):23-34
The therapeutic agents that target ATP-sensitive potassium channels
Rubaiy HN
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):131A
A Cytoplasmic Inter-Subunit Salt Bridge, Kir6.1R347/SUR2AE1318, Contributes to Allosteric Information Transmission in Kir6.14/SUR2A4 Channel Complexes
Rubaiy HN; Rainbow RD; Lodwick D; Norman RI
Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):130A-131A
A Single Point Mutation in the Distal C-Terminal of the Pore Forming Kir6.1 Subunit Modifies ATP-Sensitive Potassium (K_ATP) Channel Regulation
Rubaiy HN; Rainbow RD; Lodwick D; Norman RI

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