Hui Wang

Publications
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Articles

Article: GENOME MEDICINE. 2024;16(1):42
scDrugPrio: a framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases
Schafer S; Smelik M; Sysoev O; Zhao Y; Eklund D; Lilja S; Gustafsson M; Heyn H; Julia A; Kovacs IA; Loscalzo J; Marsal S; Zhang H; Li X; Gawel D; Wang H; Benson M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2023;98(4):e13309
Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b
Xu M; Ren J; Jia W; Wang S; Liu Y; Chen X; Shi J; Wang H
Article: CELL REPORTS MEDICINE. 2023;4(3):100956
Multi-organ single-cell analysis reveals an on/off switch system with potential for personalized treatment of immunological diseases
Lilja S; Li X; Smelik M; Lee EJ; Loscalzo J; Marthanda PB; Hu L; Magnusson M; Sysoev O; Zhang H; Zhao Y; Sjowall C; Gawel D; Wang H; Benson M
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2023;97(1)
Sputum basophils from allergic asthmatic patients do not express IL-7Rα that is essential for TSLP signalling
Gao S; Shi Y; Bai R; Li H; Ren J; Chen X; Hu L; Shi Z; Zhao S; Wang H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(18):e147566
The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity.
Chen X; Hu J; Wang Y; Lee Y; Zhao X; Lu H; Zhu G; Wang H; Jiang Y; Liu F; Chen Y; Kim B-S; Zhou Q; Liu X; Wang X; Chang SH; Dong C
Article: GENOME MEDICINE. 2022;14(1):48
A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets
Li X; Lee EJ; Lilja S; Loscalzo J; Schafer S; Smelik M; Strobl MR; Sysoev O; Wang H; Zhang H; Zhao Y; Gawel DR; Bohle B; Benson M
Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2022;101(2):150-158
An efficient and cost-effective method for the purification of human basophils
He C; Gao S; Zhao X; Shi Y; Tang Y; Cao Y; Bai R; Ren J; Zhao S; Shi Z; Wang H
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:946202
Identification of novel B-1 transitional progenitors by B-1 lymphocyte fate-mapping transgenic mouse model Bhlhe41 dTomato-Cre.
Li H; Tang Y; Ren J; Bai R; Hu L; Jia W; Cao Y; Hong L; Xu M; Gao S; Shi Y; Pan S; Wang L; Zheng K; Zhao S; Wang H
Article: IMMUNOLOGY. 2021;164(2):292-304
Induction of the apoptosis, degranulation and IL-13 production of human basophils by butyrate and propionate via suppression of histone deacetylation
Shi Y; Xu M; Pan S; Gao S; Ren J; Bai R; Li H; He C; Zhao S; Shi Z; Yu F; Xiang Z; Wang H
Article: SCIENCE ADVANCES. 2021;7(36):eabh0609
Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway.
Jie Z; Ko C-J; Wang H; Xie X; Li Y; Gu M; Zhu L; Yang J-Y; Gao T; Ru W; Tang S-J; Cheng X; Sun S-C
Article: CELLULAR & MOLECULAR IMMUNOLOGY. 2021;18(9):2262-2274
TRAF2 regulates T cell immunity by maintaining a Tpl2-ERK survival signaling axis in effector and memory CD8 T cells.
Xie X; Zhu L; Jie Z; Li Y; Gu M; Zhou X; Wang H; Chang J-H; Ko C-J; Cheng X; Sun S-C
Article: CELL REPORTS. 2021;35(9):109188
Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription.
Sun L; Zhao X; Liu X; Zhong B; Tang H; Jin W; Clevers H; Wang H; Wang X; Dong C
Journal article: THERANOSTICS. 2021;11(10):4655-4671
Aurka loss in CD19+ B cells promotes megakaryocytopoiesis via IL-6/STAT3 signaling-mediated thrombopoietin production.
Chen X; Wang C; Sun N; Pan S; Li R; Li X; Zhao J; Tong H; Tang Y; Han J; Qiao J; Qiu H; Wang H; Yang J; Ikezoe T
Article: CYTOKINE. 2020;136:155268
Interleukin 3-induced GITR promotes the activation of human basophils.
Hong L; Tang Y; Pan S; Xu M; Shi Y; Gao S; Sui C; He C; Zheng K; Tang R; Shi Z; Wang Q; Wang H
Article: CYTOKINE. 2020;127:154934
Interleukin 2 regulates the activation of human basophils.
Zhao S; Tang Y; Hong L; Xu M; Pan S; Zhen K; Tang R; Zhai X; Shi Z; Wang H
Article: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2020;10:586466
iTRAQ-Based Phosphoproteomic Analysis of Toxoplasma gondii Tachyzoites Provides Insight Into the Role of Phosphorylation for its Invasion and Egress.
He C; Xu M-Z; Pan S; Wang H; Peng H-J; Liu Z-Z
Article: CELLULAR & MOLECULAR IMMUNOLOGY. 2019;16(2):165-177
Lymphatic endothelial cells regulate B-cell homing to lymph nodes via a NIK-dependent mechanism.
Yang J; Zhang S; Zhang L; Xie X; Wang H; Jie Z; Gu M; Yang J-Y; Cheng X; Sun S-C
Journal article: NATURE IMMUNOLOGY. 2018;19(11):1224-1235
NIK signaling axis regulates dendritic cell function in intestinal immunity and homeostasis.
Jie Z; Yang J-Y; Gu M; Wang H; Xie X; Li Y; Liu T; Zhu L; Shi J; Zhang L; Zhou X; Joo D; Brightbill HD; Cong Y; Lin D; Cheng X; Sun S-C
Article: NATURE COMMUNICATIONS. 2018;9(1):2812
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Zhu L; Xie X; Zhang L; Wang H; Jie Z; Zhou X; Shi J; Zhao S; Zhang B; Cheng X; Sun S-C
Article: CYTOKINE. 2017;96:234-237
GAB2 regulates type 2 T helper cell differentiation in humans.
Wang H; Nestor CE; Benson M; Zhang H
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(5):1493-1507
The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.
Xiao Y; Zou Q; Xie X; Liu T; Li HS; Jie Z; Jin J; Hu H; Manyam G; Zhang L; Cheng X; Wang H; Marie I; Levy DE; Watowich SS; Sun S-C
Article: CELL REPORTS. 2016;16(2):559-570
5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4⁺ T Cells
Nestor CE; Lentini A; Nilsson CH; Gawel DR; Gustafsson M; Mattson L; Wang H; Rundquist O; Meehan RR; Klocke B; Seifert M; Hauck SM; Laumen H; Zhang H; Benson M
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 2016;213(3):399-414
Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
Hu H; Wang H; Xiao Y; Jin J; Chang J-H; Zou Q; Xie X; Cheng X; Sun S-C
Journal article: SCIENTIFIC REPORTS. 2016;6:22115
Cell intrinsic role of NF-κB-inducing kinase in regulating T cell-mediated immune and autoimmune responses.
Li Y; Wang H; Zhou X; Xie X; Chen X; Jie Z; Zou Q; Hu H; Zhu L; Cheng X; Brightbill HD; Wu LC; Wang L; Sun S-C
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(313):313ra178
A validated gene regulatory network and GWAS identifies early regulators of T cell-associated diseases
Gustafsson M; Gawel DR; Alfredsson L; Baranzini S; Bjorkander J; Blomgran R; Hellberg S; Eklund D; Ernerudh J; Kockum I; Konstantinell A; Lahesmaa R; Lentini A; Liljenstrom HRI; Mattson L; Matussek A; Mellergard J; Mendez M; Olsson T; Pujana MA; Rasool O; Serra-Musach J; Stenmarker M; Tripathi S; Viitala M; Wang H; Zhang H; Nestor CE; Benson M
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;287(1):1-8
Roles of miRNAs in microcystin-LR-induced Sertoli cell toxicity.
Zhou Y; Wang H; Wang C; Qiu X; Benson M; Yin X; Xiang Z; Li D; Han X
Article: SCIENCE TRANSLATIONAL MEDICINE. 2014;6(218):218ra4
A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy.
Bruhn S; Fang Y; Barrenäs F; Gustafsson M; Zhang H; Konstantinell A; Krönke A; Sönnichsen B; Bresnick A; Dulyaninova N; Wang H; Zhao Y; Klingelhöfer J; Ambartsumian N; Beck MK; Nestor C; Bona E; Xiang Z; Benson M
Article: PLOS GENETICS. 2014;10(1):e1004059
DNA Methylation Changes Separate Allergic Patients from Healthy Controls and May Reflect Altered CD4⁺ T-Cell Population Structure
Nestor CE; Barrenas F; Wang H; Lentini A; Zhang H; Bruhn S; Jornsten R; Langston MA; Rogers G; Gustafsson M; Benson M
Article: RNA. 2013;19(11):1552-1562
MicroRNAs act complementarily to regulate disease-related mRNA modules in human diseases.
Chavali S; Bruhn S; Tiemann K; Saetrom P; Barrenäs F; Saito T; Kanduri K; Wang H; Benson M
Article: INFLAMMATION. 2013;36(4):821-829
Comprehensive Profiling of Peripheral Immune Cells and Subsets in Patients with Intermittent Allergic Rhinitis Compared to Healthy Controls and After Treatment with Glucocorticoids
Zhang H; Cardell LO; Bjorkander J; Benson M; Wang H
Article: PLOS ONE. 2013;8(10):e74821
Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response.
Couto Alves A; Bruhn S; Ramasamy A; Wang H; Holloway JW; Hartikainen A-L; Jarvelin M-R; Benson M; Balding DJ; Coin LJM
Article: GENOME BIOLOGY. 2012;13(6):r46
Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms.
Barrenäs F; Chavali S; Alves AC; Coin L; Jarvelin M-R; Jörnsten R; Langston MA; Ramasamy A; Rogers G; Wang H; Benson M
Article: ALLERGY. 2012;67(6):831-833
Monozygotic twins discordant for intermittent allergic rhinitis differ in mRNA and protein levels.
Sjogren A-KM; Barrenas F; Muraro A; Gustafsson M; Saetrom P; Wang H; Benson M
Article: ALLERGY. 2012;67(1):33-40
Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis.
Bruhn S; Barrenäs F; Mobini R; Andersson BA; Chavali S; Egan BS; Hovig E; Sandve GK; Langston MA; Rogers G; Wang H; Benson M
Article: PLOS ONE. 2012;7(6):e39016
Combined multivariate and pathway analyses show that allergen-induced gene expression changes in CD4+ T cells are reversed by glucocorticoids.
Zhao Y; Wang H; Gustafsson M; Muraro A; Bruhn S; Benson M
Article: ALLERGY. 2011;66(1):132-140
A pathway-based approach to find novel markers of local glucocorticoid treatment in intermittent allergic rhinitis.
Wang H; Chavali S; Mobini R; Muraro A; Barbon F; Boldrin D; Aberg N; Benson M
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2010;40(8):1194-1202
Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation.
Wang H; Mobini R; Fang Y; Barrenäs F; Zhang H; Xiang Z; Benson M
Article: CELL BIOLOGY INTERNATIONAL. 2008;32(9):1091-1098
Transdifferentiation of mesenchymal stem cells derived from human fetal lung to hepatocyte-like cells.
Ling L; Ni Y; Wang Q; Wang H; Hao S; Hu Y; Jiang W; Hou Y
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;60(2):97-102
Protein expression and purification of human Zbtb7A in Pichia pastoris via gene codon optimization and synthesis.
Wang H; Wang Q; Zhang F; Huang Y; Ji Y; Hou Y
Article: WORLD JOURNAL OF GASTROENTEROLOGY. 2008;14(12):1858-1865
Over-expressed and truncated midkines promote proliferation of BGC823 cells in vitro and tumor growth in vivo.
Wang Q-L; Wang H; Zhao S-L; Huang Y-H; Hou Y-Y
Article: JOURNAL OF BIOMEDICAL SCIENCE. 2007;14(6):783-795
siRNA targeting midkine inhibits gastric cancer cells growth and induces apoptosis involved caspase-3,8,9 activation and mitochondrial depolarization.
Wang Q; Huang Y; Ni Y; Wang H; Hou Y
Article: CELLULAR & MOLECULAR IMMUNOLOGY. 2007;4(2):135-140
The expression and location of midkine in gastric carcinomas of Chinese patients.
Huang Y; Cao G; Wang H; Wang Q; Hou Y
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Review: JOURNAL OF SICHUAN UNIVERSITY (MEDICAL SCIENCE EDITION). 2022;53(1):28-34
[Research Progress in Regulation of Allergic Diseases by Short-Chain Fatty Acids].
Shi Y-B; Gao S-J; Wang H
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2013;132(4):1005-1008
Profiling of human CD4⁺ T-cell subsets identifies the T_H2-specific noncoding RNA GATA3-AS1
Zhang H; Nestor CE; Zhao S; Lentini A; Bohle B; Benson M; Wang H
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;124(6):1360-1362
Increased IFN-gamma activity in seasonal allergic rhinitis is decreased by corticosteroid treatment.
Wang H; Barrenäs F; Bruhn S; Mobini R; Benson M

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