Hemantha Mallapura

In my current doctoral project, I have successfully developed radiosynthesis methods for radiotracers, such as [11C]flumazenil, L-[11C]deprenyl, [68Ga]DOTA-FAPI-46, [68Ga]DOTA-TOC, L-[11C]methionine, and [11C]choline, using the iMiDEV, microfluidic cassette-based automated radiosynthesizer. My work at the intersection of radiochemistry and advanced technology. It may act as an instrumental in advancing dose-on-demand radiopharmaceutical production.

With 14 years of experience in radiopharmaceuticals development and production, I've focused on radiolabeling and radiosynthesis of various tracers, including FDG, F-DOPA, F-Choline, FHBG, Clofarabine, PSMA, DOTA conjugated peptides, Ammonia, DOTA-TATE, FAPi analogs, Rituximab, methionine, mHED, and choline, using radionuclides such as 18F, 68Ga, 13N, 177Lu, 131I, and 11C.

My expertise extends to method development for quality control, data verification, and documentation, encompassing iTLC, TLC, GC, and HPLC methods. I possess in-depth knowledge of instrumentation and programming using iMiDEV, Fx C Pro, Mx tracer lab, Ora, and Perform synthesizer from PMB-Alcen, GE, Neptis, and Elixysis automated synthesizer. Documentation of routine cGMP clinical production and adherence to cGMP and GMP standards for developing new molecules, both for clinical and preclinical applications.

New radiotracer development, microfluidics in radiopharmaceutical production,  

#PET radionuclides #radiotracers #microfluidics #research #development #technology