Helene Engstrand Lilja

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About me

Helene Engstrand Lilja, MD, PhD, is Adjunct Professor of Paediatric Surgery
at the Department of Women’s and Children’s Health, Karolinska
Institutet.

Articles

Article: NEONATOLOGY. 2024;:1-6

The Incidence of Necrotizing Enterocolitis and Late-Onset Sepsis during the COVID-19 Pandemic in Sweden: A Population-Based Cohort Study.

Palleri E; Svenningsson A; Markasz L; Engstrand Lilja H
Article: ACTA PAEDIATRICA. 2024;113(3):550-556

Swedish registry study showed that 50% of paediatric operations were performed in university hospitals and mortality was low.

Pelkonen R-M; Frykholm P; Enlund G; Lilja HE
Article: BMC PEDIATRICS. 2024;24(1):6

Experiences and satisfaction of video follow up of children with paediatric gastrointestinal conditions linking tertiary centre with guardians and clinicians at the local hospital: a cross-sectional study.

Kassa A-M; Nyström N; Waldenvik K; Engstrand Lilja H
Article: JOURNAL OF PEDIATRIC SURGERY. 2023;58(11):2249-2254

Paediatric Adhesive Small Bowel Obstruction is Associated with a Substantial Economic Burden and High Frequency of Postoperative Complications.

Håkanson CA; Fredriksson F; Lilja HE
Article: JOURNAL OF PEDIATRIC SURGERY. 2023;58(10):1942-1948

Bowel Control, Bladder Function, and Quality of Life in Children with Cloacal Malformations.

Örtqvist L; Holmdahl G; Borg H; Bjornland K; Lilja H; Stenström P; Qvist N; Hagen TS; Pakarinen M; Wester T; Rintala R
Article: JOURNAL OF PEDIATRIC SURGERY. 2023;58(9):1646-1655

Prevalence of Mental Health Problems, Associated Factors, and Health-Related Quality of Life in Children with Long-Gap Esophageal Atresia in Sweden.

Dellenmark-Blom M; Ax SÖ; Lilja HE; Reilly C; Svensson JF; Kassa A-M; Jönsson L; Abrahamsson K; Gatzinsky V; Omling E; Tollne A; Stenström P; Öst E
Article: ORPHANET JOURNAL OF RARE DISEASES. 2023;18(1):233

Schooling experiences in children with long-gap esophageal atresia compared with children with esophageal atresia and primary anastomosis: a Swedish study.

Dellenmark-Blom M; Reilly C; Öst E; Örnö Ax S; Svensson JF; Kassa A-M; Jönsson L; Abrahamsson K; Gatzinsky V; Tollne AM; Omling E; Stenström P; Engstrand Lilja H
Article: ACTA PAEDIATRICA. 2023;112(8):1683-1688

Surgical management of necrotising enterocolitis in Sweden: A national cohort study.

Svenningsson A; Borg H; Hagander L; Engstrand Lilja H
Article: DISEASES OF THE ESOPHAGUS. 2023;36(7):doac097

The risk of autism spectrum disorder and intellectual disability but not attention deficit/hyperactivity disorder is increased in individuals with esophageal atresia.

Kassa A-M; Håkanson CA; Lilja HE
Article: CLINICAL NUTRITION. 2023;42(7):1095-1103

A nordic multicenter study on contemporary outcomes of pediatric short bowel syndrome in 208 patients.

Mutanen A; Engstrand Lilja H; Wester T; Norrby H; Borg H; Persson S; Bjornland K; Brun AC; Telborn L; Stenström P; Pakarinen MP
Article: EUROPEAN JOURNAL OF PEDIATRICS. 2023;182(6):2775-2784

Paneth cell proteins DEFA6 and GUCA2A as tissue markers in necrotizing enterocolitis.

Hoffsten A; Lilja HE; Mobini-Far H; Sindelar R; Markasz L
Article: PLOS ONE. 2023;18(6):e0288061

Neurodevelopmental outcomes in individuals with VACTERL association. A population-based cohort study.

Kassa A-M; Lilja HE
Article: BMC MEDICINE. 2022;20(1):492

Population-based cohort study: proton pump inhibitor use during pregnancy in Sweden and the risk of maternal and neonatal adverse events.

Breddels EM; Simin J; Fornes R; Lilja Engstrand H; Engstrand L; Bruyndonckx R; Brusselaers N
Article: GUT PATHOGENS. 2022;14(1):47

Effect of proton pump inhibitors in infants with esophageal atresia on the gut microbiome: a pilot cohort.

Brusselaers N; Pereira M; Alm J; Engstrand L; Engstrand Lilja H
Article: BMC PEDIATRICS. 2022;22(1):640

Vascular adhesion protein-1 expression is reduced in the intestines of infants with necrotizing enterocolitis: an observational research study.

Andersson B; Markasz L; Mobini-Far H; Lilja HE
Article: ORPHANET JOURNAL OF RARE DISEASES. 2022;17(1):239

Postoperative morbidity and health-related quality of life in children with delayed reconstruction of esophageal atresia: a nationwide Swedish study.

Dellenmark-Blom M; Örnö Ax S; Öst E; Svensson JF; Kassa A-M; Jönsson L; Abrahamsson K; Gatzinsky V; Stenström P; Tollne A; Omling E; Engstrand Lilja H
Article: EUROPEAN JOURNAL OF PEDIATRICS. 2022;181(6):2291-2298

Outcome and management in neonates with gastroschisis in the third millennium-a single-centre observational study.

Räsänen L; Lilja HE
Article: HUMAN GENETICS AND GENOMICS ADVANCES. 2022;3(2):100093

First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B.

Gehlen J; Giel A-S; Köllges R; Haas SL; Zhang R; Trcka J; Sungur AÖ; Renziehausen F; Bornholdt D; Jung D; Hoyer PD; Nordenskjöld A; Tibboel D; Vlot J; Spaander MCW; Smigiel R; Patkowski D; Roeleveld N; van Rooij IA; de Blaauw I; Hölscher A; Pauly M; Leutner A; Fuchs J; Niethammer J; Melissari M-T; Jenetzky E; Zwink N; Thiele H; Hilger AC; Hess T; Trautmann J; Marks M; Baumgarten M; Bläss G; Landén M; Fundin B; Bulik CM; Pennimpede T; Ludwig M; Ludwig KU; Mangold E; Heilmann-Heimbach S; Moebus S; Herrmann BG; Alsabeah K; Burgos CM; Lilja HE; Azodi S; Stenström P; Arnbjörnsson E; Frybova B; Lebensztejn DM; Debek W; Kolodziejczyk E; Kozera K; Kierkus J; Kaliciński P; Stefanowicz M; Socha-Banasiak A; Kolejwa M; Piaseczna-Piotrowska A; Czkwianianc E; Nöthen MM; Grote P; Rygl M; Reinshagen K; Spychalski N; Ludwikowski B; Hubertus J; Heydweiller A; Ure B; Muensterer OJ; Aubert O; Gosemann J-H; Lacher M; Degenhardt P; Boemers TM; Mokrowiecka A; Małecka-Panas E; Wöhr M; Knapp M; Seitz G; de Klein A; Oracz G; Brosens E; Reutter H; Schumacher J
Article: PLOS ONE. 2022;17(4):e0266995

Predictors of histopathological esophagitis in infants and adolescents with esophageal atresia within a national follow-up programme.

Donoso F; Beckman A; Malinovschi A; Engstrand Lilja H
Article: PLOS ONE. 2022;17(5):e0269163

Understanding of the transition to adult healthcare services among individuals with VACTERL association in Sweden: A qualitative study.

Kassa A-M; Engvall G; Dellenmark Blom M; Engstrand Lilja H
Article: FRONTIERS IN PEDIATRICS. 2021;9:755437

Early Postnatal Comprehensive Biomarkers Cannot Identify Extremely Preterm Infants at Risk of Developing Necrotizing Enterocolitis.

Hoffsten A; Markasz L; Lilja HE; Olsson KW; Sindelar R
Article: NEONATOLOGY. 2021;118(1):73-79

The Risk of Necrotizing Enterocolitis following the Administration of Hyperosmolar Enteral Medications to Extremely Preterm Infants.

Latheef F; Wahlgren H; Lilja HE; Diderholm B; Paulsson M
Article: JOURNAL OF PEDIATRIC SURGERY. 2020;55(11):2419-2424

Adhesive small bowel obstruction after appendectomy in children - Laparoscopic versus open approach.

Håkanson CA; Fredriksson F; Lilja HE
Article: BJS OPEN. 2020;4(5):943-953

Total colonic aganglionosis: multicentre study of surgical treatment and patient-reported outcomes up to adulthood.

Stenström P; Kyrklund K; Bräutigam M; Engstrand Lilja H; Juul Stensrud K; Löf Granström A; Qvist N; Söndergaard Johansson L; Arnbjörnsson E; Borg H; Wester T; Björnland K; Pakarinen MP
Article: BMC PEDIATRICS. 2020;20(1):400

Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair: a systematic review and meta-analysis.

Teimourian A; Donoso F; Stenström P; Arnadottir H; Arnbjörnsson E; Lilja H; Salö M
Article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 2020;71(2):223-231

Improved Outcome of Intestinal Failure in Preterm Infants.

Fredriksson F; Nyström N; Waldenvik K; Ördén H; Lindblom M; Paulsson M; Finkel Y; Lilja HE
Article: QUALITY OF LIFE RESEARCH. 2020;29(4):913-924

Children and adolescents with VACTERL association: health-related quality of life and psychological well-being in children and adolescents and their parents.

Kassa A-M; Dellenmark-Blom M; Thorsell Cederberg J; Engvall G; Engstrand Lilja H
Article: ACTA PAEDIATRICA. 2020;109(4):783-789

Attention difficulties and physical dysfunction common in children with complex congenital malformations: a study of preschool children with VACTERL association.

Kassa A-M; Dahl M; Strinnholm M; Engstrand Lilja H
Article: PEDIATRIC PULMONOLOGY. 2020;55(1):206-213

Pulmonary function in children and adolescents after esophageal atresia repair.

Donoso F; Hedenström H; Malinovschi A; E Lilja H
Article: PLOS ONE. 2020;15(10):e0240891

Attention deficit hyperactivity disorder and educational level in adolescent and adult individuals after anesthesia and abdominal surgery during infancy.

Arana Håkanson C; Fredriksson F; Engstrand Lilja H
Article: ACTA PAEDIATRICA. 2019;108(9):1603-1608

Survival rates for surgically treated necrotising enterocolitis have improved over the last four decades.

Fredriksson F; Engstrand Lilja H
Article: JOURNAL OF PEDIATRIC SURGERY. 2019;54(8):1638-1643

Functional outcome and health-related quality of life in patients with sacrococcygeal teratoma - a Swedish multicenter study.

Hambraeus M; Al-Mashhadi A; Wester T; Svensson P-J; Stenström P; Lilja HE
Article: JOURNAL OF PEDIATRIC SURGERY. 2019;54(3):423-428

Surgical repair of long-gap esophageal atresia: A retrospective study comparing the management of long-gap esophageal atresia in the Nordic countries.

Stadil T; Koivusalo A; Pakarinen M; Mikkelsen A; Emblem R; Svensson JF; Ehrén H; Jönsson L; Bäckstrand J; Lilja HE; Donoso F; Thorup JM; Sæter T; Rasmussen L; Pedersen RN; Stenström P; Arnbjörnsson E; Óskarsson K; Qvist N
Article: PLOS ONE. 2019;14(4):e0215751

From crisis to self-confidence and adaptation; Experiences of being a parent of a child with VACTERL association - A complex congenital malformation.

Kassa A-M; Engstrand Lilja H; Engvall G
Article: GASTROENTEROLOGY RESEARCH AND PRACTICE. 2018;2018:7345426-7

Diminished DEFA6 Expression in Paneth Cells Is Associated with Necrotizing Enterocolitis.

Markasz L; Wanders A; Szekely L; Lilja HE
Article: JOURNAL OF PEDIATRIC SURGERY. 2017;52(11):1853-1858

Sutures impregnated with carbazate-activated polyvinyl alcohol reduce intraperitoneal adhesions.

Fredriksson F; Sellberg F; Bowden T; Engstrand T; Berglund D; Lilja HE
Article: ACTA PAEDIATRICA. 2017;106(10):1694-1701

Young children with severe congenital malformations (VACTERL) expressed mixed feelings about their condition and worries about needles and anaesthesia.

Kassa A-M; Engvall G; Engstrand Lilja H
Article: JOURNAL OF PEDIATRIC SURGERY. 2017;52(8):1302-1307

Patient-reported Swedish nationwide outcomes of children and adolescents with total colonic aganglionosis.

Stenström P; Brautigam M; Borg H; Graneli C; Lilja HE; Wester T
Article: SURGERY. 2017;161(3):818-822

Absent ileocecal valve predicts the need for repeated step in children.

Wester T; Lilja HE; Stenström P; Pakarinen M
Article: PEDIATRIC SURGERY INTERNATIONAL. 2017;33(3):317-323

Risk factors for postoperative mortality in congenital diaphragmatic hernia: a single-centre observational study.

Kadir D; Lilja HE
Article: EUROPEAN JOURNAL OF PEDIATRIC SURGERY. 2017;27(1):50-55

Risk Factors for Anastomotic Strictures after Esophageal Atresia Repair: Prophylactic Proton Pump Inhibitors Do Not Reduce the Incidence of Strictures.

Donoso F; Lilja HE
Article: JOURNAL OF PEDIATRIC SURGERY. 2016;51(9):1421-1425

Outcome and management in infants with esophageal atresia - A single centre observational study.

Donoso F; Kassa A-M; Gustafson E; Meurling S; Lilja HE
Article: BRITISH JOURNAL OF SURGERY. 2016;103(3):284-289

Adhesive small bowel obstruction after laparotomy during infancy.

Fredriksson F; Christofferson RH; Lilja HE
Article: PEDIATRIC SURGERY INTERNATIONAL. 2015;31(11):1067-1072

Outcome of laparoscopic versus open gastrostomy in children.

Angsten G; Danielson J; Kassa A-M; Lilja HE
Article: MICROBIOME. 2015;3:18

Intestinal dysbiosis in children with short bowel syndrome is associated with impaired outcome.

Engstrand Lilja H; Wefer H; Nyström N; Finkel Y; Engstrand L
Article: JOURNAL OF PEDIATRIC SURGERY. 2014;49(10):1480-1484

Locally increased concentrations of inflammatory cytokines in an experimental intraabdominal adhesion model.

Fredriksson F; Christofferson RH; Carlsson PO; Lilja HE
Article: BRITISH JOURNAL OF SURGERY. 2014;101(10):1329-1333

Serial transverse enteroplasty to facilitate enteral autonomy in selected children with short bowel syndrome.

Wester T; Borg H; Naji H; Stenström P; Westbacke G; Lilja HE
Article: JOURNAL OF PEDIATRIC SURGERY. 2013;48(11):2308-2312

Genes regulating tight junctions and cell adhesion are altered in early experimental necrotizing enterocolitis.

Högberg N; Stenbäck A; Carlsson P-O; Wanders A; Lilja HE
Article: ACTA PAEDIATRICA. 2013;102(2):129-136

Intestinal microbial profiles in extremely preterm infants with and without necrotizing enterocolitis.

Normann E; Fahlén A; Engstrand L; Lilja HE
Article: JOURNAL OF PEDIATRIC SURGERY. 2012;47(9):1646-1651

Intraluminal intestinal microdialysis detects markers of hypoxia and cell damage in experimental necrotizing enterocolitis.

Högberg N; Carlsson P-O; Hillered L; Stenbäck A; Lilja HE
Article: JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. 2012;36(5):587-595

Improved outcome in neonatal short bowel syndrome using parenteral fish oil in combination with ω-6/9 lipid emulsions.

Angsten G; Finkel Y; Lucas S; Kassa A-M; Paulsson M; Lilja HE
Article: LAKARTIDNINGEN. 2011;108(46):2380-2381

[Does the doctor know what a child's bottom looks like? Late detection of anorectal abnormalities in children].

Naji H; Zetterlind L; Lilja HE; Gustafson E; Lindblad K; Christofferson R
Article: JOURNAL OF PEDIATRIC SURGERY. 2011;46(11):2108-2114

Predictors of postnatal outcome in neonates with gastroschisis.

Kassa A-M; Lilja HE
Article: JOURNAL OF PEDIATRIC SURGERY. 2011;46(7):1361-1367

Prevention and reversal of intestinal failure-associated liver disease in premature infants with short bowel syndrome using intravenous fish oil in combination with omega-6/9 lipid emulsions.

Lilja HE; Finkel Y; Paulsson M; Lucas S
Article: LAKARTIDNINGEN. 2008;105(24-25):1849-1851

[Serial transverse enteroplasty (STEP). A new surgical technique for treatment of short bowel syndrome].

Lilja HE; Finkel Y; Wester T
Article: PEDIATRIC SURGERY INTERNATIONAL. 2008;24(5):531-536

Outcome in neonates with esophageal atresia treated over the last 20 years.

Lilja HE; Wester T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;273(1):129-135

Inhibition of signal transducer and activator transcription factor 3 in rats with acute hepatic failure.

Kamohara Y; Sugiyama N; Mizuguchi T; Inderbitzin D; Lilja H; Middleton Y; Neuman T; Demetriou AA; Rozga J
Article: JOURNAL OF SURGICAL RESEARCH. 1999;85(2):243-250

Bioartificial liver treatment in rats with fulminant hepatic failure: effect on DNA-binding activity of liver-enriched and growth-associated transcription factors.

Suh KS; Lilja H; Kamohara Y; Eguchi S; Arkadopoulos N; Neuman T; Demetriou AA; Rozga J
Article: MOLECULAR CELL BIOLOGY RESEARCH COMMUNICATIONS. 1999;1(3):188-195

Transforming growth factor beta1 helps maintain differentiated functions in mitogen-treated primary rat hepatocyte cultures.

Lilja H; Kamohara Y; Neuman T; Demetriou AA; Rozga J
Article: HEPATOLOGY. 1998;28(5):1365-1370

Intrasplenic transplantation of allogeneic hepatocytes prolongs survival in anhepatic rats.

Arkadopoulos N; Lilja H; Suh KS; Demetriou AA; Rozga J
Article: CELL TRANSPLANTATION. 1998;7(4):357-363

Transplantation of hepatocytes for prevention of intracranial hypertension in pigs with ischemic liver failure.

Arkadopoulos N; Chen SC; Khalili TM; Detry O; Hewitt WR; Lilja H; Kamachi H; Petrovic L; Mullon CJ; Demetriou AA; Rozga J
Article: CELL TRANSPLANTATION. 1998;7(3):257-266

Response of cultured fetal and adult rat hepatocytes to growth factors and cyclosporine.

Lilja H; Blanc P; Demetriou AA; Rozga J
Article: TRANSPLANTATION. 1997;64(9):1240-1248

Fetal rat hepatocytes: isolation, characterization, and transplantation in the Nagase analbuminemic rats.

Lilja H; Arkadopoulos N; Blanc P; Eguchi S; Middleton Y; Meurling S; Demetriou AA; Rozga J
Article: JOURNAL OF SURGICAL RESEARCH. 1997;72(2):112-122

Loss and recovery of liver regeneration in rats with fulminant hepatic failure.

Eguchi S; Lilja H; Hewitt WR; Middleton Y; Demetriou AA; Rozga J
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Review: JOURNAL OF PEDIATRIC SURGERY. 2019;54(11):2242-2249

Surgical treatment and major complications Within the first year of life in newborns with long-gap esophageal atresia gross type A and B - a systematic review.

Stadil T; Koivusalo A; Svensson JF; Jönsson L; Lilja HE; Thorup JM; Sæter T; Stenström P; Qvist N
Review: MICROBIOME. 2017;5(1):31

Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis.

Pammi M; Cope J; Tarr PI; Warner BB; Morrow AL; Mai V; Gregory KE; Kroll JS; McMurtry V; Ferris MJ; Engstrand L; Lilja HE; Hollister EB; Versalovic J; Neu J
Letter: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 1998;78(3):306-307

Lethal autosomal recessive syndrome with intrauterine growth retardation, intra- and extrahepatic biliary atresia, and esophageal and duodenal atresia.

Annerén G; Meurling S; Lilja H; Wallander J; von Döbeln U

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