Hassan Gharibi

About me
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About me

I am a Postdoctoral Fellow in the Chemical Proteomics Core Facility in the Department of Medical
Biochemistry and Biophysics at Karolinska Institute, Sweden.
2018 - 2023: PhD in Medical Science, Karolinska Institutet,
Sweden
2015 - 2018: MSc in Biotechnology Engineering, Tarbiat Modares University,
Iran
2009 - 2015: BSc in Chemical Engineering, Sharif University of Technology,
Iran

Research

My project is focused on developing a high-resolution Orbitrap-based mass
spectrometry to simultaneously acquire isotopic ratio of C, H, N, and O
elements in individual amino acids alongside protein sequencing and profiling
with only a microgram amount of sample.

Teaching

Lab Teacher Assistant for General and Organic Chemistry (2021HT, 2022HT, 2023HT, 2024HT)

Articles

Journal article: NATURE COMMUNICATIONS. 2024;15(1):9638
Small molecule modulation of protein corona for deep plasma proteome profiling.
Ashkarran AA; Gharibi H; Sadeghi SA; Modaresi SM; Wang Q; Lin T-J; Yerima G; Tamadon A; Sayadi M; Jafari M; Lin Z; Ritz D; Kakhniashvili D; Guha A; Mofrad MRK; Sun L; Landry MP; Saei AA; Mahmoudi M
Journal article: ADVANCED SCIENCE. 2024;11(38):e2401502
Multifaceted Proteome Analysis at Solubility, Redox, and Expression Dimensions for Target Identification
Saei AA; Lundin A; Lyu H; Gharibi H; Luo H; Teppo J; Zhang X; Gaetani M; Vegvari A; Holmdahl R; Gygi SP; Zubarev RA
Article: BIORXIV. 2024;:2024.03.06.582595
Deep Plasma Proteome Profiling by Modulating Single Nanoparticle Protein Corona with Small Molecules.
Ashkarran AA; Gharibi H; Sadeghi SA; Modaresi SM; Wang Q; Lin T-J; Yerima G; Tamadon A; Sayadi M; Jafari M; Lin Z; Ritz D; Kakhniashvili D; Guha A; Mofrad MRK; Sun L; Landry MP; Saei AA; Mahmoudi M
Journal article: ANALYTICAL CHEMISTRY. 2024;96(33):13533-13541
Gel-Assisted Proteome Position Integral Shift Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Caspase 3 Substrates
Meng Z; Saei AA; Gharibi H; Zhang X; Lyu H; Lundstrom SL; Vegvari A; Gaetani M; Zubarev RA
Journal article: NANO LETTERS. 2024;24(32):9874-9881
Standardizing Protein Corona Characterization in Nanomedicine: A Multicenter Study to Enhance Reproducibility and Data Homogeneity
Ashkarran AA; Gharibi H; Modaresi SM; Saei AA; Mahmoudi M
Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2024;63(3):e202316488
Ultralight Ultrafast Enzymes
Zhang X; Meng Z; Beusch CM; Gharibi H; Cheng Q; Lyu H; Di Stefano L; Wang J; Saei AA; Vegvari A; Gaetani M; Zubarev RA
Journal article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2024;136(3)
Ultralight Ultrafast Enzymes**
Zhang X; Meng Z; Beusch CM; Gharibi H; Cheng Q; Lyu H; Di Stefano L; Wang J; Saei AA; Végvári Á; Gaetani M; Zubarev RA
Article: NATURE COMMUNICATIONS. 2024;15(1):342
A uniform data processing pipeline enables harmonized nanoparticle protein corona analysis across proteomics core facilities
Gharibi H; Ashkarran AA; Jafari M; Voke E; Landry MP; Saei AA; Mahmoudi M
Article: MOLECULES. 2023;28(19):6768
Massive Solubility Changes in Neuronal Proteins upon Simulated Traumatic Brain Injury Reveal the Role of Shockwaves in Irreversible Damage
Saei AA; Gharibi H; Lyu H; Nilsson B; Jafari M; Von Holst H; Zubarev RA
Article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2023;62(24):e202216610
DOPA Residues Endow Collagen with Radical Scavenging Capacity
Kurth M; Barayeu U; Gharibi H; Kuzhelev A; Riedmiller K; Zilke J; Noack K; Denysenkov V; Kappl R; Prisner TF; Zubarev RA; Dick TP; Graeter F
Journal article: ANGEWANDTE CHEMIE INTERNATIONAL EDITION. 2023;135(24)
DOPA Residues Endow Collagen with Radical Scavenging Capacity**
Kurth M; Barayeu U; Gharibi H; Kuzhelev A; Riedmiller K; Zilke J; Noack K; Denysenkov V; Kappl R; Prisner TF; Zubarev RA; Dick TP; Gräter F
Article: ACS BIO & MED CHEM AU. 2023;3(1):62-73
Sex-Specific Silica Nanoparticle Protein Corona Compositions Exposed to Male and Female BALB/c Mice Plasmas
Ashkarran AA; Gharibi H; Grunberger JW; Saei AA; Khurana N; Mohammadpour R; Ghandehari H; Mahmoudi M
Article: BIOSENSORS AND BIOELECTRONICS. 2023;220:114862
Multi-omics analysis of magnetically levitated plasma biomolecules
Ashkarran AA; Gharibi H; Abou Zeki D; Radu I; Khalighinejad F; Keyhanian K; Abrahamsson CK; Ionete C; Saei AA; Mahmoudi M
Article: NATURE COMMUNICATIONS. 2022;13(1):6610
Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities
Ashkarran AA; Gharibi H; Voke E; Landry MP; Saei AA; Mahmoudi M
Article: ANALYTICAL CHEMISTRY. 2022;94(43):15048-15056
Proteomics-Compatible Fourier Transform Isotopic Ratio Mass Spectrometry of Polypeptides
Gharibi H; Chernobrovkin AL; Saei AA; Zhang X; Gaetani M; Makarov AA; Zubarev RA
Article: ACS APPLIED BIO MATERIALS. 2022;5(6):2643-2663
Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels
Sharifi S; Saei AA; Gharibi H; Mahmoud NN; Harkins S; Dararatana N; Lisabeth EM; Serpooshan V; Vegvari A; Moore A; Mahmoudi M
Article: ELIFE. 2022;11:e74549
Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation
James J; Chen Y; Hernandez CM; Forster F; Dagnell M; Cheng Q; Saei AA; Gharibi H; Lahore GF; astrand A; Malhotra R; Malissen B; Zubarev RA; Arner ESJ; Holmdahl R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2022;144(6):2484-2487
Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass
Gharibi H; Chernobrovkin AL; Eriksson G; Saei AA; Timmons Z; Kitchener AC; Kalthoff DC; Liden K; Makarov AA; Zubarev RA
Article: NATURE COMMUNICATIONS. 2021;12(1):1296
System-wide identification and prioritization of enzyme substrates by thermal analysis
Saei AA; Beusch CM; Sabatier P; Wells JA; Gharibi H; Meng Z; Chernobrovkin A; Rodin S; Nareoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundstrom SL; Gaetani M; Vegvari A; Arner ESJ; Schuler H; Zubarev RA
Article: BIOINTERPHASES. 2021;16(1):011008
Can the biomolecular corona induce an allergic reaction?-A proof-of-concept study
Muehe A; Nejadnik H; Muehe H; Rosenberg J; Gharibi H; Saei AA; Lyu S-C; Nadeau KC; Mahmoudi M; Daldrup-Link HE

All other publications

Preprint: BIORXIV. 2024
ThermoTargetMiner as a proteome integral solubility alteration target database for prospective drugs against lung cancer
Lyu H; Gharibi H; Sokolova B; Voiland A; Nilsson B; Meng Z; Gaetani M; Saei AA; Zubarev RA
Preprint: BIORXIV. 2024
Gel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates
Meng Z; Saei AA; Zhang X; Lyu H; Gharibi H; Lundström S; Végvári Á; Gaetani M; Zubarev R
Thesis / dissertation: 2023
Novel methods of tandem mass spectrometry in life sciences
Gharibi, Mohammadhassan
Preprint: BIORXIV. 2023
Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification
Saei AA; Lundin A; Lyu H; Gharibi H; Luo H; Teppo J; Zhang X; Gaetani M; Végvári Á; Holmdahl R; Gygi S; Zubarev R
Preprint: BIORXIV. 2023
DOPA residues endow collagen with radical scavenging capacity
Kurth M; Barayeu U; Gharibi H; Kuzhelev A; Riedmiller K; Zilke J; Noack K; Denysenkov V; Kappl R; Prisner T; Zubarev R; Dick T; Gräter F
Preprint: BIORXIV. 2022
Mapping the GALNT1 substrate landscape with versatile proteomics tools
Saei AA; Lundström S; Lyu H; Gharibi H; Lu W; Fang P; Zhang X; Meng Z; Wang J; Gaetani M; Végvári Á; Gygi S; Zubarev R
Preprint: BIORXIV. 2021
Abnormal (hydroxy)prolines deuterium content redefines hydrogen chemical mass
Gharibi H; Chernobrovkin A; Eriksson G; Saei AA; Timmons Z; Kitchener A; Kalthoff D; Lidén K; Makarov A; Zubarev R

Employments

Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023

About me

Research

Teaching

Articles

All other publications

Employments

Degrees and Education

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