Hassan Gharibi

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About me

I am a Postdoctoral Fellow in the Chemical Proteomics Core Facility in the Department of Medical Biochemistry and Biophysics at Karolinska Institute, Sweden. 2018 - 2023: PhD in Medical Science, Karolinska Institutet, Sweden 2015 - 2018: MSc in Biotechnology Engineering, Tarbiat Modares University, Iran 2009 - 2015: BSc in Chemical Engineering, Sharif University of Technology, Iran

Research

My project is focused on developing a high-resolution Orbitrap-based mass spectrometry to simultaneously acquire isotopic ratio of C, H, N, and O elements in individual amino acids alongside protein sequencing and profiling with only a microgram amount of sample.

Teaching

Lab Teacher Assistant for General and Organic Chemistry (2021HT, 2022HT, 2023HT)

Articles

Journal article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024;136(3)

Ultralight Ultrafast Enzymes**

Zhang X; Meng Z; Beusch CM; Gharibi H; Cheng Q; Lyu H; Di Stefano L; Wang J; Saei AA; Végvári Á; Gaetani M; Zubarev RA
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2024;63(3):e202316488

Ultralight Ultrafast Enzymes.

Zhang X; Meng Z; Beusch CM; Gharibi H; Cheng Q; Lyu H; Di Stefano L; Wang J; Saei AA; Végvári Á; Gaetani M; Zubarev RA
Article: NATURE COMMUNICATIONS. 2024;15(1):342

A uniform data processing pipeline enables harmonized nanoparticle protein corona analysis across proteomics core facilities.

Gharibi H; Ashkarran AA; Jafari M; Voke E; Landry MP; Saei AA; Mahmoudi M
Article: MOLECULES. 2023;28(19):6768

Massive Solubility Changes in Neuronal Proteins upon Simulated Traumatic Brain Injury Reveal the Role of Shockwaves in Irreversible Damage.

Saei AA; Gharibi H; Lyu H; Nilsson B; Jafari M; Von Holst H; Zubarev RA
Article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023;62(24):e202216610

DOPA Residues Endow Collagen with Radical Scavenging Capacity.

Kurth M; Barayeu U; Gharibi H; Kuzhelev A; Riedmiller K; Zilke J; Noack K; Denysenkov V; Kappl R; Prisner TF; Zubarev RA; Dick TP; Gräter F
Journal article: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. 2023;135(24)

DOPA Residues Endow Collagen with Radical Scavenging Capacity**

Kurth M; Barayeu U; Gharibi H; Kuzhelev A; Riedmiller K; Zilke J; Noack K; Denysenkov V; Kappl R; Prisner TF; Zubarev RA; Dick TP; Gräter F
Article: ACS BIO AND MED CHEM AU. 2023;3(1):62-73

Sex-Specific Silica Nanoparticle Protein Corona Compositions Exposed to Male and Female BALB/c Mice Plasmas.

Ashkarran AA; Gharibi H; Grunberger JW; Saei AA; Khurana N; Mohammadpour R; Ghandehari H; Mahmoudi M
Article: BIOSENSORS & BIOELECTRONICS. 2023;220:114862

Multi-omics analysis of magnetically levitated plasma biomolecules.

Ashkarran AA; Gharibi H; Zeki DA; Radu I; Khalighinejad F; Keyhanian K; Abrahamsson CK; Ionete C; Saei AA; Mahmoudi M
Article: NATURE COMMUNICATIONS. 2022;13(1):6610

Measurements of heterogeneity in proteomics analysis of the nanoparticle protein corona across core facilities.

Ashkarran AA; Gharibi H; Voke E; Landry MP; Saei AA; Mahmoudi M
Article: ANALYTICAL CHEMISTRY. 2022;94(43):15048-15056

Proteomics-Compatible Fourier Transform Isotopic Ratio Mass Spectrometry of Polypeptides.

Gharibi H; Chernobrovkin AL; Saei AA; Zhang X; Gaetani M; Makarov AA; Zubarev RA
Article: ACS APPLIED BIO MATERIALS. 2022;5(6):2643-2663

Mass Spectrometry, Structural Analysis, and Anti-Inflammatory Properties of Photo-Cross-Linked Human Albumin Hydrogels.

Sharifi S; Saei AA; Gharibi H; Mahmoud NN; Harkins S; Dararatana N; Lisabeth EM; Serpooshan V; Végvári Á; Moore A; Mahmoudi M
Article: ELIFE. 2022;11:e74549

Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation.

James J; Chen Y; Hernandez CM; Forster F; Dagnell M; Cheng Q; Saei AA; Gharibi H; Lahore GF; Åstrand A; Malhotra R; Malissen B; Zubarev RA; Arnér ESJ; Holmdahl R
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2022;144(6):2484-2487

Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass.

Gharibi H; Chernobrovkin AL; Eriksson G; Saei AA; Timmons Z; Kitchener AC; Kalthoff DC; Lidén K; Makarov AA; Zubarev RA
Article: NATURE COMMUNICATIONS. 2021;12(1):1296

System-wide identification and prioritization of enzyme substrates by thermal analysis.

Saei AA; Beusch CM; Sabatier P; Wells JA; Gharibi H; Meng Z; Chernobrovkin A; Rodin S; Näreoja K; Thorsell A-G; Karlberg T; Cheng Q; Lundström SL; Gaetani M; Végvári Á; Arnér ESJ; Schüler H; Zubarev RA
Article: BIOINTERPHASES. 2021;16(1):011008

Can the biomolecular corona induce an allergic reaction?-A proof-of-concept study.

Muehe A; Nejadnik H; Muehe H; Rosenberg J; Gharibi H; Saei AA; Lyu S-C; Nadeau KC; Mahmoudi M; Daldrup-Link HE

All other publications

Preprint: 2024;bioRxiv

Gel-Assisted Proteome Position Integral Shift (GAPPIS) Assay Returns Molecular Weight to Shotgun Proteomics and Identifies Novel Caspase 3 Substrates

Meng Z; Saei AA; Zhang X; Lyu H; Gharibi H; Lundström SL; Végvári Á; Gaetani M; Zubarev RA
KI thesis / dissertation: 2023

Novel methods of tandem mass spectrometry in life sciences

Gharibi, Mohammadhassan
Preprint: 2023;bioRxiv

Multifaceted proteome analysis at solubility, redox, and expression dimensions for target identification

Saei AA; Lundin A; Lyu H; Gharibi H; Luo H; Teppo J; Zhang X; Gaetani M; Végvári Á; Holmdahl R; Gygi S; Zubarev R
Preprint: 2023;bioRxiv

DOPA residues endow collagen with radical scavenging capacity

Kurth M; Barayeu U; Gharibi H; Kuzhelev A; Riedmiller K; Zilke J; Noack K; Denysenkov V; Kappl R; Prisner T; Zubarev R; Dick T; Gräter F
Preprint: 2022;bioRxiv

Mapping the GALNT1 substrate landscape with versatile proteomics tools

Saei AA; Lundström S; Lyu H; Gharibi H; Lu W; Fang P; Zhang X; Meng Z; Wang J; Gaetani M; Végvári Á; Gygi S; Zubarev R
Preprint: 2021;bioRxiv

Abnormal (hydroxy)prolines deuterium content redefines hydrogen chemical mass

Gharibi H; Chernobrovkin A; Eriksson G; Saei AA; Timmons Z; Kitchener A; Kalthoff D; Lidén K; Makarov A; Zubarev R

Employments

Postdoctoral Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2025

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023

About me

Research

Teaching

Articles

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