Göran K Hansson

Göran K Hansson

Professor Emeritus
Visiting address: BioClinicum, Plan 8,Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Kardiov m Olofsson P, 171 77 Stockholm
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About me

  • Professor of Experimental Cardiovascular Research

    Member of the Royal Swedish Academy of Sciences

    Member of Academia Europaea

    Education
    Medical school, Gothenburg University; Med.kand. (Bachelor of Medicine) 1972; Läkarexamen (M.D.) 1977; Ph.D. 1980 in histology, Gothenburg University.

    Positions and commissions of trust:
    Docent, Histology, Gothenburg University 1981 Fogarty Postdoctoral Research Fellow, University of Washington, Seattle, 1981-2 Internship and residency, Sahlgrenska University Hospital, Gothenburg, 1983-89 Senior Scientist, Medical Research Council 1990-94 Professor of Cell Biology, Gothenburg University, 1994-95 Professor of Cardiovascular Research, Karolinska Institutet, 1995-18 Chairman, Nobel Committee for Physiology or Medicine 2004-6 Visiting Professor, Harvard Medical School, 2008 Secretary, Nobel Assembly at Karolinska Institutet 2009-15 Vice Chairman, Board of Directors, The Nobel Foundation 2010-2022 Distinguished Professor, Karolinska Institutet, 2010-18. Senior Professor, Karolinska Institutet, 2019- Secretary General, Royal Swedish Academy of Sciences, 2015-2022

    Academic honours, awards and prizes
    Erik K. Fernström Prize to young medical scientists, 1992 Visiting Professor, Università Catolica del Sacro Cuore, Rome 1996 Elected to the Nobel Assembly at Karolinska Institute, 1997 Lars Werkö Prize for Heart Research, 1999 Russell Ross Memorial Lecture, International Atherosclerosis Society, 2000 Pfizer Visiting Professor, Univ of Texas at Houston, 2001 Nikkilä Lecture, Scand Soc Atherosclerosis Research, 2002 Eijkman Medal, Utrecht University 2003 Vulnerable Plaque Lifetime Achievement Award, AEHA, Chicago 2003 Leducq Visiting Professor, Harvard Medical School, Boston 2005 Kennedy Visiting Professor, Imperial College, London 2005 David Geffen School of Medicine Visiting Professor, UCLA 2006 Anitschkow Prize, European Atherosclerosis Society 2007 Hugh Sinclair Lecture, British Atherosclerosis Society 2007 George Lyman Duff Memorial Lecture, American Heart Association 2007 Elected to the Royal Swedish Academy of Sciences 2007 Elected to Academia Europæa 2007 William Harvey Medal, European Society of Cardiology, Munich 2008 Outstanding Achievement Award, Intl Atherosclerosis Society, Boston 2009 Distinguished Service Award, American Heart Association, Orlando 2009 Federa Prize, Federation of Biomedical Scientific Societies, Leiden 2011 Middlesex Memorial Lecture, University College London 2012 Honorary Professor, Shandong University, China 2014 Anthony Cerami Prize in Translational Medicine, Feinstein Institute, New York 2014 Doctor of Medicine honoris causa, University of Eastern Finland, Kuopio 2015 Shimamoto Takio Memorial Lecture, Japan Atherosclerosis Society 2016 His Majesty the King’s Medal in Gold, 2017 Gold Medal of the European Society of Cardiology 2022

Research

  • Cardiovascular disease is the leading cause of death in the world. We have established that chronic inflammation and adaptive immune reactions play important roles in the pathogenesis of atherosclerosis. This has opened new avenues to target vascular inflammation in patients suffering from cardiovascular diseases.

    The goals of our current research project are (i) to elucidate the immunopathogenesis of atherosclerosis and (ii) to adapt this knowledge for cardiovascular medicine. The following specific aims are addressed in forthcoming years:

    1. Characterize effects of immune activation on atherosclerosis.

    2. Determine molecular epitopes of LDL particles that trigger immune reactions.

    3. Identify druggable effector mechanisms to prevent vascular inflammation and improve lipoprotein metabolism.

    We have constructed a humanized model system of LDL autoimmunity with T-cell receptor transgenic mice, which enables us to perform detailed studies of immune activation and regulation in atherosclerosis. Substantial effects are observed on atherosclerosis development and lipoprotein metabolism in the model system, but we need to fully clarify the effector mechanisms in order to find targets for development of new prevention, diagnostics and therapy against atherosclerosis. We will combine studies in mouse models with experiments in cultures of human plaque cells, and validate findings in human tissue samples derived from our carotid endarterectomy biobank.

Articles

  • Article: VASCULAR PHARMACOLOGY. 2025;159:107490
    Suur BE; Karadimou G; Willems CJJM; Bergman O; Lengquist M; Kronqvist M; Baumgartner R; Malin S; Gistera A; Hansson GK; Malarstig A; Hedin U; Ketelhuth DFJ; Matic L
  • Article: ATHEROSCLEROSIS. 2025;403:119158
    Lindberg K; Ovchinnikova O; Moor MB; Pirault J; Ketelhuth DFJ; Olauson H; Hansson GK; Larsson TE
  • Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(8):1510-1523
    Mailer RK; Konrath S; Zhan L; Thode H; Beerens M; Frye M; Ketelhuth DFJ; Renne T; Hansson GK
  • Article: CIRCULATION RESEARCH. 2022;130(12):1869-1887
    Gistera A; Ketelhuth DFJ; Malin SG; Hansson GK
  • Article: ISCIENCE. 2022;25(5):104219
    Waden K; Karlof E; Narayanan S; Lengquist M; Hansson GK; Hedin U; Roy J; Matic L
  • Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2022;42(5):659-676
    Rykaczewska U; Zhao Q; Saliba-Gustafsson P; Lengquist M; Kronqvist M; Bergman O; Huang Z; Lund K; Waden K; Pons Vila Z; Caidahl K; Skogsberg J; Vukojevic V; Lindeman JHN; Roy J; Hansson GK; Treuter E; Leeper NJ; Eriksson P; Ehrenborg E; Razuvaev A; Hedin U; Matic L
  • Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(24):e142883
    Arnardottir H; Thul S; Pawelzik S-C; Karadimou G; Artiach G; Gallina AL; Mysdotter V; Carracedo M; Tarnawski L; Caravaca AS; Baumgartner R; Ketelhuth DF; Olofsson PS; Paulsson-Berne G; Hansson GK; Back M
  • Article: JOURNAL OF INTERNAL MEDICINE. 2021;289(1):53-68
    Baumgartner R; Berg M; Matic L; Polyzos KP; Forteza MJ; Hjorth SA; Schwartz TW; Paulson-Berne G; Hansson GK; Hedin U; Ketelhuth DFJ
  • Article: CARDIOVASCULAR RESEARCH. 2020;116(12):1948-1957
    Berg M; Polyzos KA; Agardh H; Baumgartner R; Forteza MJ; Kareinen I; Gistera A; Bottcher G; Hurt-Camejo E; Hansson GK; Ketelhuth DFJ
  • Article: JOURNAL OF INTERNAL MEDICINE. 2020;288(3):321-334
    Karadimou G; Gistera A; Gallina AL; Caravaca AS; Centa M; Salagianni M; Andreakos E; Hansson GK; Malin S; Olofsson PS; Paulsson-Berne G
  • Article: CIRCULATION RESEARCH. 2020;126(9):1281-1296
    Nilsson J; Hansson GK
  • Article: CIRCULATION RESEARCH. 2020;126(5):571-585
    Rykaczewska U; Suur BE; Rohl S; Razuvaev A; Lengquist M; Sabater-Lleal M; van der Laan SW; Miller CL; Wirka RC; Kronqvist M; Diez MG; Vesterlund M; Gillgren P; Odeberg J; Lindeman JH; Veglia F; Humphries SE; de Faire U; Baldassarre D; Tremoli E; Lehtio J; Hansson GK; Paulsson-Berne G; Pasterkamp G; Quertermous T; Hamsten A; Eriksson P; Hedin U; Matic L
  • Article: ATHEROSCLEROSIS. 2020;292:215-223
    Rafnsson A; Matic LP; Lengquist M; Mahdi A; Shemyakin A; Paulsson-Berne G; Hansson GK; Gabrielsen A; Hedin U; Yang J; Pernow J
  • Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(10):1457-1973
    Cossarizza A; Chang H-D; Radbruch A; Acs A; Adam D; Adam-Klages S; Agace WW; Aghaeepour N; Akdis M; Allez M; Almeida LN; Alvisi G; Anderson G; Andrae I; Annunziato F; Anselmo A; Bacher P; Baldari CT; Bari S; Barnaba V; Barros-Martins J; Battistini L; Bauer W; Baumgart S; Baumgarth N; Baumjohann D; Baying B; Bebawy M; Becher B; Beisker W; Benes V; Beyaert R; Blanco A; Boardman DA; Bogdan C; Borger JG; Borsellino G; Boulais PE; Bradford JA; Brenner D; Brinkman RR; Brooks AES; Busch DH; Buescher M; Bushnell TP; Calzetti F; Cameron G; Cammarata I; Cao X; Cardell SL; Casola S; Cassatella MA; Cavani A; Celada A; Chatenoud L; Chattopadhyay PK; Chow S; Christakou E; Cicin-Sain L; Clerici M; Colombo FS; Cook L; Cooke A; Cooper AM; Corbett AJ; Cosma A; Cosmi L; Coulie PG; Cumano A; Cvetkovic L; Dang VD; Dang-Heine C; Davey MS; Davies D; De Biasi S; Del Zotto G; Dela Cruz GV; Delacher M; Della Bella S; Dellabona P; Deniz G; Dessing M; Di Santo JP; Diefenbach A; Dieli F; Dolf A; Doerner T; Dress RJ; Dudziak D; Dustin M; Dutertre C-A; Ebner F; Eckle SBG; Edinger M; Eede P; Ehrhardt GRA; Eich M; Engel P; Engelhardt B; Erdei A; Esser C; Everts B; Evrard M; Falk CS; Fehniger TA; Felipo-Benavent M; Ferry H; Feuerer M; Filby A; Filkor K; Fillatreau S; Follo M; Foerster I; Foster J; Foulds GA; Frehse B; Frenette PS; Frischbutter S; Fritzsche W; Galbraith DW; Gangaev A; Garbi N; Gaudilliere B; Gazzinelli RT; Geginat J; Gerner W; Gherardin NA; Ghoreschi K; Gibellini L; Ginhoux F; Goda K; Godfrey DI; Goettlinger C; Gonzalez-Navajas JM; Goodyear CS; Gori A; Grogan JL; Grummitt D; Gruetzkau A; Haftmann C; Hahn J; Hammad H; Haemmerling G; Hansmann L; Hansson G; Harpur CM; Hartmann S; Hauser A; Hauser AE; Haviland DL; Hedley D; Hernandez DC; Herrera G; Herrmann M; Hess C; Hoefer T; Hoffmann P; Hogquist K; Holland T; Hollt T; Holmdahl R; Hombrink P; Houston JP; Hoyer BF; Huang B; Huang F-P; Huber JE; Huehn J; Hundemer M; Hunter CA; Hwang WYK; Iannone A; Ingelfinger F; Ivison SM; Jaeck H-M; Jani PK; Javega B; Jonjic S; Kaiser T; Kalina T; Kamradt T; Kaufmann SHE; Keller B; Ketelaars SLC; Khalilnezhad A; Khan S; Kisielow J; Klenerman P; Knopf J; Koay H-F; Kobow K; Kolls JK; Kong WT; Kopf M; Korn T; Kriegsmann K; Kristyanto H; Kroneis T; Krueger A; Kuehne J; Kukat C; Kunkel D; Kunze-Schumacher H; Kurosaki T; Kurts C; Kvistborg P; Kwok I; Landry J; Lantz O; Lanuti P; LaRosa F; Lehuen A; LeibundGut-Landmann S; Leipold MD; Leung LYT; Levings MK; Lino AC; Liotta F; Litwin V; Liu Y; Ljunggren H-G; Lohoff M; Lombardi G; Lopez L; Lopez-Botet M; Lovett-Racke AE; Lubberts E; Luche H; Ludewig B; Lugli E; Lunemann S; Maecker HT; Maggi L; Maguire O; Mair F; Mair KH; Mantovani A; Manz RA; Marshall AJ; Martinez-Romero A; Martrus G; Marventano I; Maslinski W; Matarese G; Mattioli AV; Maueroder C; Mazzoni A; McCluskey J; McGrath M; McGuire HM; McInnes IB; Mei HE; Melchers F; Melzer S; Mielenz D; Miller SD; Mills KHG; Minderman H; Mjosberg J; Moore J; Moran B; Moretta L; Mosmann TR; Mueller S; Multhoff G; Munoz LE; Munz C; Nakayama T; Nasi M; Neumann K; Ng LG; Niedobitek A; Nourshargh S; Nunez G; O'Connor J-E; Ochel A; Oja A; Ordonez D; Orfao A; Orlowski-Oliver E; Ouyang W; Oxenius A; Palankar R; Panse I; Pattanapanyasat K; Paulsen M; Pavlinic D; Penter L; Peterson P; Peth C; Petriz J; Piancone F; Pickl WF; Piconese S; Pinti M; Pockley AG; Podolska MJ; Poon Z; Pracht K; Prinz I; Pucillo CEM; Quataert SA; Quatrini L; Quinn KM; Radbruch H; Radstake TRDJ; Rahmig S; Rahn H-P; Rajwa B; Ravichandran G; Raz Y; Rebhahn JA; Recktenwald D; Reimer D; Reis e Sousa C; Remmerswaal EBM; Richter L; Rico LG; Riddell A; Rieger AM; Robinson JP; Romagnani C; Rubartelli A; Ruland J; Saalmueller A; Saeys Y; Saito T; Sakaguchi S; Sala-de-Oyanguren F; Samstag Y; Sanderson S; Sandrock I; Santoni A; Sanz RB; Saresella M; Sautes-Fridman C; Sawitzki B; Schadt L; Scheffold A; Scherer HU; Schiemann M; Schildberg FA; Schimisky E; Schlitzer A; Schlosser J; Schmid S; Schmitt S; Schober K; Schraivogel D; Schuh W; Schueler T; Schulte R; Schulz AR; Schulz SR; Scotta C; Scott-Algara D; Sester DP; Shankey TV; Silva-Santos B; Simon AK; Sitnik KM; Sozzani S; Speiser DE; Spidlen J; Stahlberg A; Stall AM; Stanley N; Stark R; Stehle C; Steinmetz T; Stockinger H; Takahama Y; Takeda K; Tan L; Tarnok A; Tiegs G; Toldi G; Tornack J; Traggiai E; Trebak M; Tree TIM; Trotter J; Trowsdale J; Tsoumakidou M; Ulrich H; Urbanczyk S; van de Veen W; van den Broek M; van der Pol E; Van Gassen S; Van Isterdael G; van Lier RAW; Veldhoen M; Vento-Asturias S; Vieira P; Voehringer D; Volk H-D; von Borstel A; von Volkmann K; Waisman A; Walker RV; Wallace PK; Wang SA; Wang XM; Ward MD; Ward-Hartstonge KA; Warnatz K; Warnes G; Warth S; Waskow C; Watson JV; Watzl C; Wegener L; Weisenburger T; Wiedemann A; Wienands J; Wilharm A; Wilkinson RJ; Willimsky G; Wing JB; Winkelmann R; Winkler TH; Wirz OF; Wong A; Wurst P; Yang JHM; Yang J; Yazdanbakhsh M; Yu L; Yue A; Zhang H; Zhao Y; Ziegler SM; Zielinski C; Zimmermann J; Zychlinsky A
  • Article: NATURE REVIEWS DISEASE PRIMERS. 2019;5(1):57
  • Article: NATURE REVIEWS DISEASE PRIMERS. 2019;5(1):56
    Libby P; Buring JE; Badimon L; Hansson CK; Deanfield J; Bittencourt MS; Tokgozoglu L; Lewis EF
  • Article: EUROPEAN HEART JOURNAL. 2019;40(30):2495-2503
    Christersdottir T; Pirault J; Gistera A; Bergman O; Gallina AL; Baumgartner R; Lundberg AM; Eriksson P; Yan Z-Q; Paulsson-Berne G; Hansson GK; Olofsson PS; Halle M
  • Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(3):304-317
    Jiang X; Wang F; Wang Y; Gistera A; Roy J; Paulsson-Berne G; Hedin U; Lerman A; Hansson GK; Herrmann J; Yan Z-Q
  • Article: CIRCULATION. 2019;139(21):2466-2482
    Centa M; Jin H; Hofste L; Hellberg S; Busch A; Baumgartner R; Verzaal NJ; Enoksson SL; Matic LP; Boddul SV; Atzler D; Li DY; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Lutgens E; Binder CJ; Maegdesfessel L; Malin SG
  • Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(1):72-82
    Eken SM; Christersdottir T; Winski G; Sangsuwan T; Jin H; Chernogubova E; Pirault J; Sun C; Simon N; Winter H; Backlund A; Haghdoost S; Hansson GK; Halle M; Maegdefessel L
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Employments

  • Professor Emeritus, Department of Medicine, Karolinska Institutet, 2026-2029
  • Professor, Senior, Department of Medicine, Karolinska Institutet, 2025-2026
  • Professor, Department of Medicine, Karolinska Institutet, 2020-2024
  • Professor, Senior, Department of Medicine, Karolinska Institutet, 2018-2020
  • Professor, Department of Medicine, Karolinska Institutet, 1994-2018

Degrees and Education

  • Docent, Göteborgs universitet, 1981

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