Gilad Silberberg

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Research

We are interested in the functional organization of neuronal circuits in the basal ganglia underlying sensory and motor functions. We use various electrophysiological, optical, and morphological methods to study the local and long-range synaptic connectivity of these circuits.
Our lab is located at Karolinska Institutet, Stockholm, please contact us for more information.
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Articles

Journal article: ELIFE. 2024;12
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism
Boi L; Johansson Y; Tonini R; Moratalla R; Fisone G; Silberberg G
Article: ISCIENCE. 2024;27(4):109583
The single D380 amino acid substitution increases pneumolysin cytotoxicity towards neuronal cells
Serra S; Iannotti V; Ferrante M; Tofiño-Vian M; Baxendale J; Silberberg G; Kohler TP; Hammerschmidt S; Ulijasz AT; Iovino F
Article: CURRENT OPINION IN NEUROBIOLOGY. 2023;83:102781
Corticostriatal pathways for bilateral sensorimotor functions
Gomez-Ocadiz R; Silberberg G
Article: NATURE COMMUNICATIONS. 2023;14(1):1004
Ongoing movement controls sensory integration in the dorsolateral striatum
de la Torre-Martinez R; Ketzef M; Silberberg G
Article: CELL REPORTS. 2022;39(8):110842
GABAergic interneurons expressing the α2 nicotinic receptor subunit are functionally integrated in the striatal microcircuit
Tokarska A; Silberberg G
Article: ELIFE. 2022;11:e75829
A tonic nicotinic brake controls spike timing in striatal spiny projection neurons
Matityahu L; Malgady JM; Schirelman M; Johansson Y; Wilking JA; Silberberg G; Goldberg JA; Plotkin JL; Ding J
Article: FRONTIERS IN COMPUTATIONAL NEUROSCIENCE. 2022;16:806086

Data-Driven Model of Postsynaptic Currents Mediated by NMDA or AMPA Receptors in Striatal Neurons

Carannante I; Johansson Y; Silberberg G; Hellgren Kotaleski J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(33):e2104119118
Astrocyte-derived neurons provide excitatory input to the adult striatal circuitry
Dorst MC; Diaz-Moreno M; Dias DO; Guimaraes EL; Holl D; Kalkitsas J; Silberberg G; Goritz C
Article: NEURON. 2021;109(3):516-529.e4
Differential Synaptic Input to External Globus Pallidus Neuronal Subpopulations In Vivo
Ketzef M; Silberberg G
Article: NATURE COMMUNICATIONS. 2020;11(1):5113
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
Dorst MC; Tokarska A; Zhou M; Lee K; Stagkourakis S; Broberger C; Masmanidis S; Silberberg G
Article: CURRENT BIOLOGY. 2020;30(14):2777-2790.e4
Synaptic Connectivity between the Cortex and Claustrum Is Organized into Functional Modules
Chia Z; Augustine GJ; Silberberg G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(17):9554-9565
The microcircuits of striatum in silico
Hjorth JJJ; Kozlov A; Carannante I; Nylen JF; Lindroos R; Johansson Y; Tokarska A; Dorst MC; Suryanarayana SM; Silberberg G; Kotaleski JH; Grillner S
Article: CELL REPORTS. 2020;30(4):1178-1194.e3
The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities
Johansson Y; Silberberg G
Article: JOURNAL OF NEUROPHYSIOLOGY. 2019;122(6):2294-2303
Direct pathway neurons in mouse dorsolateral striatum in vivo receive stronger synaptic input than indirect pathway neurons
Filipovic M; Ketzef M; Reig R; Aertsen A; Silberberg G; Kumar A
Article: MOLECULAR PSYCHIATRY. 2019;24(9):1351-1368
A hypothalamus-habenula circuit controls aversion
Lazaridis I; Tzortzi O; Weglage M; Martin A; Xuan Y; Parent M; Johansson Y; Fuzik J; Furth D; Fenno LE; Ramakrishnan C; Silberberg G; Deisseroth K; Carlen M; Meletis K
Article: CELL REPORTS. 2019;27(11):3182-3198.e9
The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons
Ruud J; Alber J; Tokarska A; Ruud LE; Nolte H; Biglari N; Lippert R; Lautenschlager A; Ciealak PE; Szumiec L; Hess ME; Broenneke HS; Krueger M; Nissbrandt H; Korotkova T; Silberberg G; Parkitna JR; Bruening JC
Article: NATURE COMMUNICATIONS. 2018;9(1):3691
Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system
Petitpre C; Wu H; Sharma A; Tokarska A; Fontanet P; Wang Y; Helmbacher F; Yackle K; Silberberg G; Hadjab S; Lallemend F
Article: NEUROSCIENCE. 2018;381:115-123
A New Micro-holder Device for Local Drug Delivery during In Vivo Whole-cell Recordings
Saez M; Ketzef M; Alegre-Cortes J; Reig R; Silberberg G
Article: FRONTIERS IN NEURAL CIRCUITS. 2018;12:3
Basal Ganglia Neuromodulation Over Multiple Temporal and Structural Scales-Simulations of Direct Pathway MSNs Investigate the Fast Onset of Dopaminergic Effects and Predict the Role of Kv4.2
Lindroos R; Dorst MC; Du K; Filipovic M; Keller D; Ketzef M; Kozlov AK; Kumar A; Lindahl M; Nair AG; Perez-Fernandez J; Grillner S; Silberberg G; Kotaleski JH
Article: FRONTIERS IN NEURAL CIRCUITS. 2018;12:64
Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio
Papathanou M; Creed M; Dorst MC; Bimpisidis Z; Dumas S; Pettersson H; Bellone C; Silberberg G; Luscher C; Wallen-Mackenzie A
Journal article: CLAUSTRUM. 2017;2(1):1357412
Functional properties, topological organization and sexual dimorphism of claustrum neurons projecting to anterior cingulate cortex
Chia Z; Silberberg G; Augustine GJ
Article: NEURON. 2017;94(4):855-865.e5
Dopamine Depletion Impairs Bilateral Sensory Processing in the Striatum in a Pathway-Dependent Manner
Ketzef M; Spigolon G; Johansson Y; Bonito-Oliva A; Fisone G; Silberberg G
Article: CEREBRAL CORTEX. 2016;26(12):4405-4415
Distinct Corticostriatal and Intracortical Pathways Mediate Bilateral Sensory Responses in the Striatum
Reig R; Silberberg G
Journal article: BMC NEUROSCIENCE. 2016;17(Suppl 1):54
25th Annual Computational Neuroscience Meeting CNS-2016, Seogwipo City, South Korea, July 2-7, 2016 Abstracts
Article: ELIFE. 2016;5:e14170
CO₂-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture
Forsberg D; Horn Z; Tserga E; Smedler E; Silberberg G; Shvarev Y; Kaila K; Uhlen P; Herlenius E
Article: CEREBRAL CORTEX. 2016;26(1):96-105
Novel Striatal GABAergic Interneuron Populations Labeled in the 5HT3a^EGFP Mouse
Munoz-Manchado AB; Foldi C; Szydlowski S; Sjulson L; Farries M; Wilson C; Silberberg G; Hjerling-Leffler J
Article: CELL. 2015;163(2):456-492
Reconstruction and Simulation of Neocortical Microcircuitry
Markram H; Muller E; Ramaswamy S; Reimann MW; Abdellah M; Sanchez CA; Ailamaki A; Alonso-Nanclares L; Antille N; Arsever S; Kahou GAA; Berger TK; Bilgili A; Buncic N; Chalimourda A; Chindemi G; Courcol J-D; Delalondre F; Delattre V; Druckmann S; Dumusc R; Dynes J; Eilemann S; Gal E; Gevaert ME; Ghobril J-P; Gidon A; Graham JW; Gupta A; Haenel V; Hay E; Heinis T; Hernando JB; Hines M; Kanari L; Keller D; Kenyon J; Khazen G; Kim Y; King JG; Kisvarday Z; Kumbhar P; Lasserre S; Le Be J-V; Magalhaes BRC; Merchan-Perez A; Meystre J; Morrice BR; Muller J; Munoz-Cespedes A; Muralidhar S; Muthurasa K; Nachbaur D; Newton TH; Nolte M; Ovcharenko A; Palacios J; Pastor L; Perin R; Ranjan R; Riachi I; Rodriguez J-R; Riquelme JL; Roessert C; Sfyrakis K; Shi Y; Shillcock JC; Silberberg G; Silva R; Tauheed F; Telefont M; Toledo-Rodriguez M; Traenkler T; Van Geit W; Diaz JV; Walker R; Wang Y; Zaninetta SM; DeFelipe J; Hill SL; Segev I; Schuermann F
Article: FRONTIERS IN NEURAL CIRCUITS. 2015;9:60
Long-range recruitment of Martinotti cells causes surround suppression and promotes saliency in an attractor network model
Krishnamurthy P; Silberberg G; Lansner A
Article: NEURON. 2014;83(5):1200-1212
Multisensory Integration in the Mouse Striatum
Reig R; Silberberg G
Article: NEURON. 2014;83(3):663-678
A Whole-Brain Atlas of Inputs to Serotonergic Neurons of the Dorsal and Median Raphe Nuclei
Dorocic IP; Furth D; Xuan Y; Johansson Y; Pozzi L; Silberberg G; Carlen M; Meletis K
Article: JOURNAL OF NEUROSCIENCE. 2013;33(18):8045-8054
Dopamine Differentially Modulates the Excitability of Striatal Neurons of the Direct and Indirect Pathways in Lamprey
Ericsson J; Stephenson-Jones M; Perez-Fernandez J; Robertson B; Silberberg G; Grillner S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1524-E1532
Neural progenitors organize in small-world networks to promote cell proliferation
Malmersjo S; Rebellato P; Smedler E; Planert H; Kanatani S; Liste I; Nanou E; Sunner H; Abdelhady S; Zhang S; Andang M; El Manira A; Silberberg G; Arenas E; Uhlen P
Article: JOURNAL OF PHYSIOLOGY. 2013;591(4):859-874
Evolutionarily conserved differences in pallial and thalamic short-term synaptic plasticity in striatum
Ericsson J; Stephenson-Jones M; Kardamakis A; Robertson B; Silberberg G; Grillner S
Article: JOURNAL OF NEUROSCIENCE. 2013;33(4):1678-1683
Target Selectivity of Feedforward Inhibition by Striatal Fast-Spiking Interneurons
Szydlowski SN; Dorocic IP; Planert H; Carlen M; Meletis K; Silberberg G
Article: PLOS ONE. 2013;8(3):e57054
Membrane Properties of Striatal Direct and Indirect Pathway Neurons in Mouse and Rat Slices and Their Modulation by Dopamine
Planert H; Berger TK; Silberberg G
Article: PLOS ONE. 2012;7(4):e30752
A Cortical Attractor Network with Martinotti Cells Driven by Facilitating Synapses
Krishnamurthy P; Silberberg G; Lansner A
Journal article: BMC NEUROSCIENCE. 2011;12(Suppl 1):p187
A cortical attractor network with dynamic synapses
Krishnamurthy P; Silberberg G; Lansner A
Article: JOURNAL OF PHYSIOLOGY. 2011;589(12):2979-2992
Striatal cellular properties conserved from lampreys to mammals
Ericsson J; Silberberg G; Robertson B; Wikstrom MA; Grillner S
Article: FRONTIERS IN SYSTEMS NEUROSCIENCE. 2011;5:57
Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact.
Klaus A; Planert H; Hjorth JJJ; Berke JD; Silberberg G; Kotaleski JH
Article: EMBO JOURNAL. 2010;29(22):3869-3878
Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis
Norberg E; Karlsson M; Korenovska O; Szydlowski S; Silberberg G; Uhlen P; Orrenius S; Zhivotovsky B
Article: PLOS BIOLOGY. 2010;8(9):e1000473
Brief Bursts Self-Inhibit and Correlate the Pyramidal Network
Berger TK; Silberberg G; Perin R; Markram H
Article: JOURNAL OF NEUROSCIENCE. 2010;30(9):3499-3507
Dynamics of Synaptic Transmission between Fast-Spiking Interneurons and Striatal Projection Neurons of the Direct and Indirect Pathways
Planert H; Szydlowski SN; Hjorth JJJ; Grillner S; Silberberg G
Article: JOURNAL OF PHYSIOLOGY. 2009;587(22):5411-5425
Frequency-dependent disynaptic inhibition in the pyramidal network: a ubiquitous pathway in the developing rat neocortex
Berger TK; Perin R; Silberberg G; Markram H
Article: CEREBRAL CORTEX. 2009;19(10):2308-2320
Input Specificity and Dependence of Spike Timing-Dependent Plasticity on Preceding Postsynaptic Activity at Unitary Connections between Neocortical Layer 2/3 Pyramidal Cells
Zilberter M; Holmgren C; Shemer I; Silberberg G; Grillner S; Harkany T; Zilberter Y
Article: FRONTIERS IN COMPUTATIONAL NEUROSCIENCE. 2009;3:27
Multiquantal release underlies the distribution of synaptic efficacies in the neocortex
Loebel A; Silberberg G; Helbig D; Markram H; Tsodyks M; Richardson MJE
Article: JOURNAL OF COMPUTATIONAL NEUROSCIENCE. 2008;25(2):308-316
Slow oscillations in neural networks with facilitating synapses
Melamed O; Barak O; Silberberg G; Markram H; Tsodyks M
Article: CEREBRAL CORTEX. 2008;18(4):763-770
Hyperconnectivity of local neocortical microcircuitry induced by prenatal exposure to valproic acid
Rinaldi T; Silberberg G; Markram H
Article: JOURNAL OF NEUROSCIENCE. 2008;28(8):1904-1915
Locomotor deficiencies and aberrant development of subtype-specific GABAergic Interneurons caused by an unliganded thyroid hormone receptor α1
Wallis K; Sjogren M; Van Hogerlinden M; Silberberg G; Fisahn A; Nordstrom K; Larsson L; Westerblad H; De Escobar GM; Shupliakov O; Vennstrom B
Article: JOURNAL OF NEUROPHYSIOLOGY. 2008;99(2):1020-1031
Measurement and analysis of postsynaptic potentials using a novel voltage-deconvolution method
Richardson MJE; Silberberg G
Article: CEREBRAL CORTEX. 2007;17(9):2204-2213
Morphological, electrophysiological, and synaptic properties of corticocallosal pyramidal cells in the neonatal rat neocortex
Le Be J-V; Silberberg G; Wang Y; Markram H
Article: NEURON. 2007;53(5):735-746
Disynaptic inhibition between neocortical pyramidal cells mediated by martinotti cells
Silberberg G; Markram H
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(3):880-885
The neocortical microcircuit as a tabula rasa
Kalisman N; Silberberg G; Markram H
Article: JOURNAL OF PHYSIOLOGY. 2004;561(1):65-90
Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat
Wang Y; Toledo-Rodriguez M; Gupta A; Wu CZ; Silberberg G; Luo JY; Markram H
Article: JOURNAL OF PHYSIOLOGY. 2004;556(1):19-27
Synaptic dynamics control the timing of neuronal excitation in the activated neocortical microcircuit
Silberberg G; Wu CZ; Markram H
Article: JOURNAL OF NEUROPHYSIOLOGY. 2004;91(2):704-709
Dynamics of population rate codes in ensembles of neocortical neurons
Silberberg G; Bethge M; Markram H; Pawelzik K; Tsodyks M
Article: BIOLOGICAL CYBERNETICS. 2003;88(3):210-218
Deriving physical connectivity from neuronal morphology
Kalisman N; Silberberg G; Markram H
Article: TRENDS IN NEUROSCIENCES. 2002;25(5):227-230
Stereotypy in neocortical microcircuits
Silberberg G; Gupta A; Markram H
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All other publications

Preprint: ELIFE. 2024
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism
Boi L; Johansson Y; Tonini R; Moratalla R; Fisone G; Silberberg G
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism
Boi L; Johansson Y; Tonini R; Moratalla R; Fisone G; Silberberg G
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2024
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism
Boi L; Johansson Y; Tonini R; Moratalla R; Fisone G; Silberberg G
Preprint: BIORXIV. 2024
Motor cortex directly excites the output nucleus of the basal ganglia, the substantia nigra pars reticulata
Thompson WS; Grillner S; Silberberg G
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2023
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for Parkinson’s disease
Boi L; Johansson Y; Tonini R; Moratalla R; Fisone G; Silberberg G
Preprint: BIORXIV. 2023
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for parkinsonism
Boi L; Johansson Y; Tonini R; Moratalla R; Fisone G; Silberberg G
Preprint: BIORXIV. 2023
Presynaptic and Postsynaptic Determinants of the Functional Connectivity Between the Claustrum and Anterior Cingulate Cortex
de la Torre-Martínez R; Chia Z; Tokarska A; Frost-Nylén J; Augustine G; Silberberg G
Preprint: BIORXIV. 2022
Sensory responses in dorsolateral striatum are modulated by motor activity in a dopamine-dependent manner
de la Torre-Martinez R; Ketzef M; Silberberg G
Preprint: BIORXIV. 2021
A tonic nicotinic brake controls spike timing in striatal spiny projection neurons
Matityahu L; Malgady J; Schirelman M; Johansson Y; Wilking J; Silberberg G; Goldberg J; Plotkin J
Preprint: BIORXIV. 2020
Differential Synaptic Input to External Globus Pallidus Neuronal SubpopulationsIn Vivo
Ketzef M; Silberberg G
Preprint: BIORXIV. 2019
Direct Pathway Neurons in Mouse Dorsolateral Striatum In Vivo Receive Stronger Synaptic Input than Indirect Pathway Neurons
Filipović M; Ketzef M; Reig R; Aertsen A; Silberberg G; Kumar A
Book chapter: ADVANCED PATCH-CLAMP ANALYSIS FOR NEUROSCIENTISTS: NEUROMETHODS. 2016;p. 151-170
Optogenetic Dissection of the Striatal Microcircuitry
Silberberg G; Planert H
Review: CURRENT OPINION IN NEUROBIOLOGY. 2015;33:182-187
Local and afferent synaptic pathways in the striatal microcircuitry
Silberberg G; Bolam JP
Review: CURRENT OPINION IN NEUROBIOLOGY. 2008;18(3):332-337
Polysynaptic subcircuits in the neocortex: spatial and temporal diversity
Silberberg G
Review: TRENDS IN NEUROSCIENCES. 2005;28(10):541-551
Synaptic pathways in neural microcircuits
Silberberg G; Grillner S; LeBeau FEN; Maex R; Markram H
Review: TRENDS IN NEUROSCIENCES. 2005;28(10):525-533
Microcircuits in action - from CPGs to neocortex
Grillner S; Markram H; De Schutter E; Silberberg G; LeBeau FEN
Published conference paper: NEUROCOMPUTING. 2005;65:685-690
Subthreshold cross-correlations between cortical neurons: A reference model with static synapses
Melamed O; Silberberg G; Markram H; Gerstner W; Richardson MJE
Published conference paper: JOURNAL OF COMPUTATIONAL NEUROSCIENCE. 2005;18(3):323-331
Short-term synaptic plasticity orchestrates the response of pyramidal cells and interneurons to population bursts
Richardson MJE; Melamed O; Silberberg G; Gerstner W; Markram H
Review: NATURE REVIEWS NEUROSCIENCE. 2004;5(10):793-807
Interneurons of the neocortical inhibitory system
Markram H; Toledo-Rodriguez M; Wang Y; Gupta A; Silberberg G; Wu CZ

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