Gabriel Pitollat
About me
I obtained my Ph.D. in Neuroscience from the University of Bordeaux (France) in 2023.
- My Ph.D. initially focused on identifying pharmacological agents that could compensate for the respiratory deficits associated with Congenital Central Hypoventilation Syndrome, and later on determining the cellular and molecular mechanisms underlying the pathogenesis of this disease.
I subsequently joined the Herlenius group in May 2024 as a postdoctoral fellow to investigate the perinatal development of the neural networks controlling breathing.
As a neurophysiologist, I specialized in fundamental and preclinical research, combining in vitro electrophysiological, neuroanatomical, and pharmacological approaches.
Research
Breathing at birth is the most tremendous physiological challenge that a newborn faces in sustaining life and relies on the proper fetal development of the brainstem neural networks that control respiratory rhythmogenesis. Birth triggers complex neuroendocrine responses, involving crucial peptidergic regulation of cardiovascular, pulmonary, and homeostatic functions. However, the specific roles of these neuroendocrine responses in both supporting respiratory-related networks development and triggering a newborn's breathing at birth remain poorly understood.
Thus, my research mainly focuses on improving our understanding on whether and how several important peptidergic systems help the respiratory "machinery" ensure breathing at birth and facilitate the transition from intra- to extra-uterine life.
Articles
- Journal article: MOLECULAR THERAPY: NUCLEIC ACIDS. 2024;35(4):102319
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;204(10):1200-1210