Fredrik Wermeling
Principal Researcher | Docent
E-mail: fredrik.wermeling@ki.se
Visiting address: D2:01, Karolinska Universitetssjukhuset, 17177 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Wermeling F, 171 77 Stockholm
About me
- Using experimental systems and patient material we study the immune system
with a specific interest related to inflammation, autoimmune disease and
cancer.
A major part of the different projects in the lab involves using CRISPR-based
custom screens as a discovery platform to understand complex biological
processes and to identify novel drug targets.
Currently several projects in the lab relates to our interest in signaling
downstream of the IL-4 receptor (IL-4R). The basis for this interest was the
unexpected finding that the expression of the IL-4R on myeloid cells is
essential for the activity of a drug (IVIG) used to treat patients with
autoimmune disease, and that this receptor is highly regulated during
inflammation (Anthony et al, 2011, Nature and Wermeling et al, 2013, PNAS).
The Wermeling Laboratory is located at the Center for Molecular Medicine
(CMM), Karolinska University Hospital, Solna, Sweden. The group is part of
the Devision of Rheumatology, Department of Medicine, Karolinska Institutet,
Solna.
Wenner-Gren fellow, 2010
Ingvar Carlsson Award (SSF), 2013
Senior Investigator Award from Swedish Cancer Foundation, 2022
Teaching
- More than 200h teaching in several KI programs, including Medical, Optometry,
Biomedicine, and various master programs and PhD courses.
Articles
- Journal article: BLOOD ADVANCES. 2024;8(15):3941-3945Mo J; Wermeling F; Nilsson G; Dahlin JS
- Article: NATURE COMMUNICATIONS. 2024;15(1):6419Kakhki MP; Giordano A; Cucuzza CS; Badam TVS; Samudyata S; Lemee MV; Stridh P; Gkogka A; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Hillert J; Olsson T; Kockum I; Sellgren CM; Golzio C; Kular L; Jagodic M
- Article: ISCIENCE. 2024;27(6):109862Ingelshed K; Melssen MM; Kannan P; Chandramohan A; Partridge AW; Jiang L; Wermeling F; Lane DP; Nestor M; Spiegelberg D
- Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335Zaghmi A; Aybay E; Jiang L; Shang M; Steinmetz-Spah J; Wermeling F; Kogner P; Korotkova M; Ostling P; Jakobsson P-J; Seashore-Ludlow B; Larsson K
- Article: JOURNAL OF NUCLEAR MEDICINE. 2024;65(2):294-299Puuvuori E; Shen Y; Hulsart-Billstrom G; Mitran B; Zhang B; Cheung P; Wegrzyniak O; Ingvast S; Persson J; Stahl S; Korsgren O; Lofblom J; Wermeling F; Eriksson O
- Journal article: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(5):724-726Raposo B; Afonso M; Israelsson L; Waehaemaa H; Stalesen R; Wermeling F; Hensvold AH; Groenwall C; Rethi B; Klareskog L; Malmstrom V
- Article: SCIENTIFIC REPORTS. 2023;13(1):4583Lerma Clavero A; Boqvist PL; Ingelshed K; Bosdotter C; Sedimbi S; Jiang L; Wermeling F; Vojtesek B; Lane DP; Kannan P
- Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310Steinmetz-Spah J; Liu J; Singh R; Ekoff M; Boddul S; Tang X; Bergqvist F; Idborg H; Heitel P; Ronnberg E; Merk D; Wermeling F; Haeggstrom JZ; Nilsson G; Steinhilber D; Larsson K; Korotkova M; Jakobsson P-J
- Article: JOURNAL OF AUTOIMMUNITY. 2022;133:102903Sakuraba K; Krishnamurthy A; Sun J; Zheng X; Xu C; Peng B; Engstrom M; Jakobsson P-J; Wermeling F; Catrina S; Gronwall C; Catrina AI; Rethi B
- Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
- Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857Iyer VS; Boddul SV; Johnsson A-K; Raposo B; Sharma RK; Shen Y; Kasza Z; Lim KW; Chemin K; Nilsson G; Malmstrom V; Phan AT; Wermeling F
- Article: ONCOSCIENCE. 2022;9:27-29Jiang L; Wermeling F
- Article: CANCER RESEARCH. 2022;82(1):36-45Jiang L; Ingelshed K; Shen Y; Boddul SV; Iyer VS; Kasza Z; Sedimbi S; Lane DP; Wermeling F
- Article: SCIENTIFIC REPORTS. 2021;11(1):24512Sharma RK; Boddul SV; Yoosuf N; Turcinov S; Dubnovitsky A; Kozhukh G; Wermeling F; Kwok WW; Klareskog L; Malmstrom V
- Article: BIOMEDICINES. 2021;9(8):961Kumar S; Koenig J; Schneider A; Wermeling F; Boddul S; Theobald SJ; Vollmer M; Kloos D; Lachmann N; Klawonn F; Lienenklaus S; Talbot SR; Bleich A; Wenzel N; von Kaisenberg C; Keck J; Stripecke R
- Article: TRANSLATIONAL RESEARCH. 2021;229:69-82Sundstrom Y; Shang M-M; Panda SK; Gronwall C; Wermeling F; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L
- Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100087Boddul SV; Sharma RK; Dubnovitsky A; Raposo B; Gerstner C; Shen Y; Iyer VS; Kasza Z; Kwok WW; Winkler AR; Klareskog L; Malmstrom V; Bettini M; Wermeling F
- Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2021;19:5360-5370Shen Y; Jiang L; Iyer VS; Raposo B; Dubnovitsky A; Boddul SV; Kasza Z; Wermeling F
- Article: HAEMATOLOGICA. 2020;105(5):1339-1350Record J; Sendel A; Kritikou JS; Kuznetsov NV; Brauner H; He M; Nagy N; Oliveira MMS; Griseti E; Haase CB; Dahlstrom J; Boddul S; Wermeling F; Thrasher AJ; Liu C; Andersson J; Claesson H-E; Winqvist O; Burns SO; Bjorkholm M; Westerberg LS
- Journal article: CANCER IMMUNOLOGY RESEARCH. 2020;8(3_Supplement):a79Ingelshed K; Lianoudaki D; Lama D; Sohn S; Fritz N; Jiang L; Wermeling F; Karlsson M; Lane DP; Sedimbi SK
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):3103-3113Panda SK; Wigerblad G; Jiang L; Jimenez-Andrade Y; Iyer VS; Shen Y; Boddul SV; Guerreiro-Cacais AO; Raposo B; Kasza Z; Wermeling F
- Article: ACS SENSORS. 2020;5(1):217-224Xu X; Makaraviciute A; Abdurakhmanov E; Wermeling F; Li S; Danielson UH; Nyholm L; Zhang Z
- Article: CELL REPORTS. 2019;29(5):1074-1081.e5Schulz A; Jiang L; de Vor L; Ehrstrom M; Wermeling F; Eidsmo L; Melican K
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2019;216(8):1904-1924Farinotti AB; Wigerblad G; Nascimento D; Bas DB; Urbina CM; Nandakumar KS; Sandor K; Xu B; Abdelmoaty S; Hunt MA; Moller KA; Baharpoor A; Sinclair J; Jardemark K; Lanner JT; Khmaladze I; Borm LE; Zhang L; Wermeling F; Cragg MS; Lengqvist J; Chabot-Dore A-J; Diatchenko L; Belfer I; Collin M; Kultima K; Heyman B; Miguel Jimenez-Andrade J; Codeluppi S; Holmdahl R; Svensson CI
- Article: CIRCULATION. 2019;139(21):2466-2482Centa M; Jin H; Hofste L; Hellberg S; Busch A; Baumgartner R; Verzaal NJ; Enoksson SL; Matic LP; Boddul SV; Atzler D; Li DY; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Lutgens E; Binder CJ; Maegdesfessel L; Malin SG
- Article: FRONTIERS IN IMMUNOLOGY. 2019;9:3033Lloyd KA; Wigerblad G; Sahlstrom P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stalesen R; Ossipova E; Lundqvist C; Ekwall O; Ronnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
- Article: LUPUS. 2018;27(9):1470-1478Parodis I; Soder F; Faustini F; Kasza Z; Samuelsson I; Zickert A; Svenungsson E; van Vollenhoven RF; Malmstrom V; Wermeling F; Gunnarsson I
- Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1387Habir K; Aeinehband S; Wermeling F; Malin S
- Article: BIOINFORMATICS. 2017;33(7):1099-1100Panda SK; Boddul SV; Jimenez-Andrade GY; Jiang L; Kasza Z; Fernandez-Ricaud L; Wermeling F
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2618-2626Duhlin A; Chen Y; Wermeling F; Sedimbi SK; Lindh E; Shinde R; Halaby MJ; Kaiser Y; Winqvist O; McGaha TL; Karlsson MCI
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068Prokopec KE; Georgoudaki A-M; Sohn S; Wermeling F; Gronlund H; Lindh E; Carroll MC; Karlsson MCI
- Article: SCIENTIFIC REPORTS. 2016;6:30636Kritikou JS; Dahlberg CIM; Baptista MAP; Wagner AK; Banerjee PP; Gwalani LA; Poli C; Panda SK; Karre K; Kaech SM; Wermeling F; Andersson J; Orange JS; Brauner H; Westerberg LS
- Article: NATURE COMMUNICATIONS. 2016;7:11314Bosma M; Gerling M; Pasto J; Georgiadi A; Graham E; Shilkova O; Iwata Y; Almer S; Soderman J; Toftgard R; Wermeling F; Bostrom EA; Bostrom PA
- Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2014;34(1):56-70Siegmann N; Worbs D; Effinger F; Bormann T; Gebhardt M; Ulrich M; Wermeling F; Mueller-Hermelink E; Biedermann T; Tighe M; Edwards MJ; Caldwell C; Leadbetter E; Karlsson MCI; Becker KA; Gulbins E; Doering G
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13487-13491Wermeling F; Anthony RM; Brombacher F; Ravetch JV
- Article: JOURNAL OF AUTOIMMUNITY. 2013;42:1-6Lindh E; Brannstrom J; Jones P; Wermeling F; Hassler S; Betterle C; Garty BZ; Stridsberg M; Herrmann B; Karlsson MCI; Winqvist O
- Journal article: JOURNAL OF TRANSLATIONAL MEDICINE. 2012;10(Suppl 3):p58Lindh E; Brännström J; Jones P; Wermeling F; Hässler S; Betterle C; Garty BZ; Stridsberg M; Herrmann B; Karlsson MC; Winqvist O
- Journal article: JOURNAL OF CYSTIC FIBROSIS. 2012;11:s39Döring G; Siegmann N; Gebhardt M; Ulrich M; Wermeling F; Biedermann T; Høiby N; Hötzenecker K; Karlsson MCI; Gulbins E
- Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2012;1253:170-180Anthony RM; Wermeling F; Ravetch JV
- Article: NATURE. 2011;475(7354):110-113Anthony RM; Kobayashi T; Wermeling F; Ravetch JV
- Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 2010;70(4):237-243Sakthivel P; Wermeling F; Elmgren A; Hulthe J; Kakoulidou M; Lefvert AK; Lind L
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(5):943-952Wermeling F; Lind SM; Jordo ED; Cardell SL; Karlsson MCI
- Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5)Chen Y; Wermeling F; Sundqvist J; Jonsson A; Tryggvason K; Pikkarainen T; Karlsson MCI
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460Chen Y; Wermeling F; Sundqvist J; Jonsson A-B; Tryggvason K; Pikkarainen T; Karlsson MCI
- Article: AUTOIMMUNITY REVIEWS. 2009;9(1):49-52Wermeling F; Karlsson MCI; McGaha TL
- Article: ALLERGY. 2009;64(6):919-926Thunberg S; Neimert-Andersson T; Cheng Q; Wermeling F; Bergstrom U; Swedin L; Dahlen S-E; Arner E; Scheynius A; Karlsson MCI; Gafvelin G; van Hage M; Gronlund H
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19571-19578Anthony RM; Wermeling F; Karlsson MCI; Ravetch JV
- Article: BLOOD. 2008;112(10):4139-4147Westerberg LS; de la Fuente MA; Wermeling F; Ochs HD; Karlsson MCI; Snapper SB; Notarangelo LD
- Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2007;204(10):2259-2265Wermeling F; Chen Y; Pikkarainen T; Scheynius A; Winqvist O; Izui S; Ravetch JRV; Tryggvason K; Karlsson MCI
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All other publications
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:837Raposo B; Afonso MG; Israelsson L; Stalesen R; Wahamaa H; Hansson M; Hensvold A; Wermeling F; Mueller D; Rethi B; Gronwall C; Klareskog L; Malmstrom V
- Preprint: BIORXIV. 2022Clavero AL; Boqvist PL; Ingelshed K; Bosdotter C; Sedimbi S; Jiang L; Wermeling F; Vojtesek B; Lane D; Kannan P
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):226-227Kakhki MP; Cucuzza CS; Gyllenberg A; Badam TVS; Liu Y; Boddul S; James T; Wermeling F; Gustafsson M; Casaccia P; Kockum I; Hillert J; Olsson T; Kular L; Jagodic M
- Preprint: BIORXIV. 2022Raposo B; Afonso M; Israelsson L; Wähämaa H; Stålesen R; Wermeling F; Hensvold A; Grönwall C; Rethi B; Klareskog L; Malmström V
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:1193-1194Sun J; Sakuraba K; Krishnamurthy A; Zheng X; Afonso MG; Xu C; Peng B; Jakobsson P-J; Engstrom M; Wermeling F; Catrina S; Gronwall C; Catrina A; Rethi B
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3446Kumar R; Dubnovitsky A; Gerstner C; Yoosuf N; Turcinov S; Boddul S; Wermeling F; Klareskog L; Padyukov L; Malmstrom V
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022;49(SUPPL 1):S279-S280Puuvuori E; Shen Y; Zhang B; Billstrom GH; Persson J; Stahl S; Korsgren O; Lofblom J; Wermeling F; Eriksson O
- Preprint: MEDRXIV. 2022Kakhki MP; Cucuzza CS; Giordano A; Badam TV; Strid P; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Kockum I; Hillert J; Olsson T; Kular L; Jagodic M
- Conference publication: HUMAN GENE THERAPY. 2022;33(7-8):A30Iyer V; Phan AT; Wermeling F
- Preprint: RESEARCH SQUARE. 2021Sharma R; Boddul S; Yoosuf N; Turcinov S; Dubnovitsky A; Kozhukh G; Wermeling F; Kwok W; Klareskog L; Malmström V
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:397Shen Y; Jiang L; Iyer VS; Raposo B; Boddul SV; Kasza Z; Wermeling F
- Preprint: BIORXIV. 2021Jiang L; Ingelshed K; Shen Y; Boddul SV; Iyer VS; Kasza Z; Sedimbi S; Lane DP; Wermeling F
- Preprint: BIORXIV. 2021Shen Y; Jiang L; Iyer VS; Raposo B; Boddul S; Kasza Z; Wermeling F
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2020;72Kumar R; Yoosuf N; Boddul S; Gerstner C; Turcinov S; Dubnovitsky A; Wermeling F; Chemin K; Malmstrom V
- Conference publication: CANCER IMMUNOLOGY RESEARCH. 2020;8(3):71Ingelshed K; Lianoudaki D; Lama D; Sohn S; Fritz N; Jiang L; Wermeling F; Karlsson M; Lane DP; Sedimbi SK
- Preprint: BIORXIV. 2020Sundström Y; Shang M-M; Panda SK; Grönwall C; Wermeling F; Gunnarsson I; Lundberg I; Sundström M; Jakobsson P-J; Berg L
- Review: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:2237-2246Iyer VS; Jiang L; Shen Y; Boddul SV; Panda SK; Kasza Z; Schmierer B; Wermeling F
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;90(6)Panda SK; Sundstrom Y; Shang M-M; Gronwall C; Wermeling F; Gunnarsson I; Lundberg I; Sundstrom M; Jakobsson P-J; Berg L
- Preprint: ARXIV. 2019Farinotti AB; Wigerblad G; Nascimento D; Bas DB; Urbina CM; Nandakumar KS; Sandor K; Xu B; Abdelmoaty S; Hunt MA; Möller KÄ; Baharpoor A; Sinclair J; Jardemark K; Lanner JT; Khmaladze I; Borm LE; Zhang L; Wermeling F; Cragg MS; Lengqvist J; Chabot-Doré A-J; Diatchenko L; Belfer I; Collin M; Kultima K; Heyman B; Jimenez-Andrade JM; Codeluppi S; Holmdahl R; Svensson CI
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:A7-A8Wigerblad G; Lloyd KA; Sahlstrom P; Ossipova E; Chemin K; Steen J; Titcombe PJ; Zhou D; Stalesen R; Ronnelid J; Mueller DL; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70Wigerblad G; Lloyd KA; Sahlstrom P; Chemin K; Steen J; Titcombe PJ; Zhou D; Stalesen R; Marklein B; Ossipova E; Ronnelid J; Piccoli L; Lanzavecchia A; Mueller DL; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
- Conference publication: 2018;:a101.2-a1a102Parodis I; Söder F; Faustini F; Kasza Z; Wermeling F; Gunnarsson I
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):282Centa M; Jin H; Matic LP; Baumgartner R; Li Y; Boddul SV; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Binder CJ; Maegdesfessel L; Malin S
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):271-272Centa M; Jin H; Matic LP; Baumgartner R; Li Y; Boddul SV; Sun C; Hansson GK; Ketelhuth DFJ; Hedin U; Wermeling F; Binder CJ; Maegdesfessel L; Malin S
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):314Boddul S; Kaza Z; Panda S; Wermeling F
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):276Deciphering the IL-4Rα regulating factor, produced during inflammation, by customized CRISPR screensPanda SK; Kasza Z; Boddul S; Jimenez Y; Jiang L; Wigerblad G; Fernandez-Ricaud L; Wermeling F
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2017;76:864Parodis I; Soder F; Faustini F; Wermeling F; van Vollenhoven RF; Svenungsson E; Gunnarsson I
- Conference publication: JOURNAL OF IMMUNOLOGY. 2015;194:118.10Wermeling F
- Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:42.11Chen Y; Wermeling F; Petersen S; Kaiser Y; Karlsson M
- Review: MOLECULAR IMMUNOLOGY. 2011;48(11):1307-1318Jordo ED; Wermeling F; Chen Y; Karlsson MCI
- Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(9):E25Ravetch J; Anthony R; Wermeling F; Karlsson M
- Conference publication: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;154:16-17Notarangelo LD; Westerberg L; de la Fuente M; Wermeling F; Ochs HD; Karlsson M; Snapper S
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):196Wermeling F; Yunying C; Timo P; Annika S; Ola W; Shozo I; Ravetch JV; Karl T; Mikael K
- Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S64Westerberg L; De La Fuente M; Wermeling F; Ochs H; Karlsson M; Notarangelo L; Snapper S
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Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2021
- Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2010
- Master Of Medical Science, Karolinska Institutet, 2009