Fredrik Wermeling
Principal Researcher | Docent
E-mail: fredrik.wermeling@ki.se
Visiting address: D2:01, Karolinska Universitetssjukhuset, 17177 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Wermeling F, 171 77 Stockholm
About me
- Using experimental systems and patient material we study the immune system
with a specific interest related to inflammation, autoimmune disease and
cancer.
A major part of the different projects in the lab involves using CRISPR-based
custom screens as a discovery platform to understand complex biological
processes and to identify novel drug targets.
Currently several projects in the lab relates to our interest in signaling
downstream of the IL-4 receptor (IL-4R). The basis for this interest was the
unexpected finding that the expression of the IL-4R on myeloid cells is
essential for the activity of a drug (IVIG) used to treat patients with
autoimmune disease, and that this receptor is highly regulated during
inflammation (Anthony et al, 2011, Nature and Wermeling et al, 2013, PNAS).
The Wermeling Laboratory is located at the Center for Molecular Medicine
(CMM), Karolinska University Hospital, Solna, Sweden. The group is part of
the Devision of Rheumatology, Department of Medicine, Karolinska Institutet,
Solna.
Wenner-Gren fellow, 2010
Ingvar Carlsson Award (SSF), 2013
Senior Investigator Award from Swedish Cancer Foundation, 2022
Teaching
- More than 200h teaching in several KI programs, including Medical, Optometry,
Biomedicine, and various master programs and PhD courses.
Articles
- Article: JOURNAL OF NUCLEAR MEDICINE. 2024;65(2):294-299
- Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335
- Article: SCIENTIFIC REPORTS. 2023;13(1):4583
- Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310
- Article: JOURNAL OF AUTOIMMUNITY. 2022;133:102903
- Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088
- Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857
- Article: ONCOSCIENCE. 2022;9:27-29
- Article: CANCER RESEARCH. 2022;82(1):36-45
- Article: SCIENTIFIC REPORTS. 2021;11(1):24512
- Article: BIOMEDICINES. 2021;9(8):961
- Article: TRANSLATIONAL RESEARCH. 2021;229:69-82
- Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2021;19:5360-5370
- Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100087
- Article: HAEMATOLOGICA. 2020;105(5):1339-1350
- Journal article: CANCER IMMUNOLOGY RESEARCH. 2020;8(3_Supplement):a79
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):3103-3113
- Article: ACS SENSORS. 2020;5(1):217-224
- Article: CELL REPORTS. 2019;29(5):1074-1081.e5
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(8):1904-1924
- Article: CIRCULATION. 2019;139(21):2466-2482
- Article: LUPUS. 2018;27(9):1470-1478
- Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033
- Article: BIOINFORMATICS. 2017;33(7):1099-1100
- Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1387
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2618-2626
- Article: JOURNAL OF IMMUNOLOGY. 2016;197(6):2063-2068
- Article: SCIENTIFIC REPORTS. 2016;6:30636
- Article: NATURE COMMUNICATIONS. 2016;7:11314
- Article: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2014;34(1):56-70
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(33):13487-13491
- Article: JOURNAL OF AUTOIMMUNITY. 2013;42:1-6
- Journal article: JOURNAL OF TRANSLATIONAL MEDICINE. 2012;10(Suppl 3):p58
- Journal article: JOURNAL OF CYSTIC FIBROSIS. 2012;11:s39
- Article: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2012;1253:170-180
- Article: NATURE. 2011;475(7354):110-113
- Article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION. 2010;70(4):237-243
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2010;207(5):943-952
- Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5)
- Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1451-1460
- Article: AUTOIMMUNITY REVIEWS. 2009;9(1):49-52
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2009;64(6):919-926
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(50):19571-19578
- Article: BLOOD. 2008;112(10):4139-4147
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2007;204(10):2259-2265
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All other publications
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:837.2-83837
- Letter: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(5):724-726
- Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022;49(SUPPL 1):S279-S280
- Conference publication: HUMAN GENE THERAPY. 2022;33(7-8):A30
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:1193-1194
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3446
- Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):226-227
- Preprint: RESEARCH SQUARE. 2021
- Preprint: BIORXIV. 2021
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:397
- Conference publication: CANCER IMMUNOLOGY RESEARCH. 2020;8(3):71
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2020;72
- Review: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:2237-2246
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2019;78:A7-A8
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;90(6)
- Conference publication: 2018;:a101.2-a1a102
- Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2017;76:864
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):282
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):271-272
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):314
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):276
- Conference publication: JOURNAL OF IMMUNOLOGY. 2015;194:118.10
- Conference publication: JOURNAL OF IMMUNOLOGY. 2013;190:42.11
- Review: MOLECULAR IMMUNOLOGY. 2011;48(11):1307-1318
- Thesis / dissertation: 2010
- Letter: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(9):E25
- Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S64
- Conference publication: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;154:16-17
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):196
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Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2021
- Degree Of Doctor Of Philosophy, Department of Medicine, Solna, Karolinska Institutet, 2010
- Master Of Medical Science, Karolinska Institutet, 2009