Francis Ndungu

Publications
Public outreach and news

Articles

Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2020;50(8):1187-1194

Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype

Aye R; Sutton HJ; Nduati EW; Kai O; Mwacharo J; Musyoki J; Otieno E; Wambua J; Bejon P; Cockburn IA; Ndungu FM
Article: BMC MEDICINE. 2020;18(1):31

Estimating the burden of iron deficiency among African children

Muriuki JM; Mentzer AJ; Webb EL; Morovat A; Kimita W; Ndungu FM; Macharia AW; Crane RJ; Berkley JA; Lule SA; Cutland C; Sirima SB; Diarra A; Tiono AB; Bejon P; Madhi SA; Hill AVS; Prentice AM; Suchdev PS; Elliott AM; Williams TN; Atkinson SH
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:619398

Memory B-Cell Responses Against Merozoite Antigens After Acute Plasmodium falciparum Malaria, Assessed Over One Year Using a Novel Multiplexed FluoroSpot Assay

Jahnmatz P; Sundling C; Yman V; Widman L; Asghar M; Sonden K; Stenstrom C; Smedman C; Ndungu F; Ahlborg N; Farnert A
Article: SCIENCE ADVANCES. 2019;5(9):eaaw0109

The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia

Muriuki JM; Mentzer AJ; Band G; Gilchrist JJ; Carstensen T; Lule SA; Goheen MM; Joof F; Kimita W; Mogire R; Cutland CL; Diarra A; Rautanen A; Pomilla C; Gurdasani D; Rockett K; Mturi N; Ndungu FM; Scott JAG; Sirima SB; Morovat A; Prentice AM; Madhi SA; Webb EL; Elliott AM; Bejon P; Sandhu MS; Hill AVS; Kwiatkowski DP; Williams TN; Cerami C; Atkinson SH
Article: JOURNAL OF INFECTIOUS DISEASES. 2019;220(4):687-698

Longitudinal Analysis of Infant Stool Bacteria Communities Before and After Acute Febrile Malaria and Artemether-Lumefantrine Treatment

Mandal RK; Crane RJ; Berkley JA; Gumbi W; Wambua J; Ngoi JM; Ndungu FM; Schmidt NW
Article: CLINICAL INFECTIOUS DISEASES. 2019;68(11):1807-1814

Iron Status and Associated Malaria Risk Among African Children

Muriuki JM; Mentzer AJ; Kimita W; Ndungu FM; Macharia AW; Webb EL; Lule SA; Morovat A; Hill AVS; Bejon P; Elliott AM; Williams TN; Atkinson SH
Article: BMC MEDICINE. 2019;17(1):60

Repeated clinical malaria episodes are associated with modification of the immune system in children

Bediako Y; Adams R; Reid AJ; Valletta JJ; Ndungu FM; Sodenkamp J; Mwacharo J; Ngoi JM; Kimani D; Kai O; Wambua J; Nyangweso G; de Villiers EP; Sanders M; Lotkowska ME; Lin J-W; Manni S; Addy JWG; Recker M; Newbold C; Berriman M; Bejon P; Marsh K; Langhorne J
Article: JOURNAL OF INFECTIOUS DISEASES. 2019;219(4):556-561

Detectable Vesicular Stomatitis Virus (VSV)-Specific Humoral and Cellular Immune Responses Following VSV-Ebola Virus Vaccination in Humans

Poetsch JH; Dahlke C; Zinser ME; Kasonta R; Lunemann S; Rechtien A; Ly ML; Stubbe HC; Kraehling V; Biedenkopf N; Eickmann M; Fehling SK; Olearo F; Strecker T; Sharma P; Lang KS; Lohse AW; Schmiedel S; Becker S; Siegrist C-A; Huttner A; Addo MM; Bejon P; Njuguna P; Ndungu F; Kremsner PG; Brosnahan JS; Agnandji ST; Krishna S; Kieny MP; Modjarrad K; Moorthy V; Fast P; Savarese B; Lapujade O
Article: WELLCOME OPEN RESEARCH. 2019;4:42

A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01 E on blood stage immunity in young Kenyan children.

Ndungu FM; Mwacharo J; Wambua J; Njuguna P; Marsh K; Drakeley C; Bejon P
Article: LANCET INFECTIOUS DISEASES. 2018;18(7):738-748

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study

Huttner A; Agnandji ST; Combescure C; Fernandes JF; Bache EB; Kabwende L; Ndungu FM; Brosnahan J; Monath TP; Lemaitre B; Grillet S; Botto M; Engler O; Portmann J; Siegrist D; Bejon P; Silvera P; Kremsner P; Siegrist C-A
Article: NATURE. 2017;548(7669):597-601

Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

Pieper K; Tan J; Piccoli L; Foglierini M; Barbieri S; Chen Y; Silacci-Fregni C; Wolf T; Jarrossay D; Anderle M; Abdi A; Ndungu FM; Doumbo OK; Traore B; Tran TM; Jongo S; Zenklusen I; Crompton PD; Daubenberger C; Bull PC; Allusto FS; Lanzavecchia A
Article: MALARIA JOURNAL. 2017;16(1):314

The establishment of a WHO Reference Reagent for anti-malaria (Plasmodium falciparum) human serum

Bryan D; Silva N; Rigsby P; Dougall T; Corran P; Bowyer PW; Ho MM
Article: BMC MEDICINE. 2016;14(1):143

The effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum - an epidemiological "natural experiment"

Bediako Y; Ngoi JM; Nyangweso G; Wambua J; Opiyo M; Nduati EW; Bejon P; Marsh K; Ndungu FM
Article: NATURE. 2016;529(7584):105-109

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens

Tan J; Pieper K; Piccoli L; Abdi A; Foglierini M; Geiger R; Tully CM; Jarrossay D; Ndungu FM; Wambua J; Bejon P; Fregni CS; Fernandez-Rodriguez B; Barbieri S; Bianchi S; Marsh K; Thathy V; Corti D; Sallusto F; Bull P; Lanzavecchia A
Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(317):317ps24

Ebola vaccine R&D: Filling the knowledge gaps

Medaglini D; Harandi AM; Ottenhoff THM; Siegrist C-A; Agnandji ST; Ahmed R; Anderson J; Auderset F; Borgianni L; Brosnahan J; Ciabattini A; Engler O; Haks MC; Heppner G; Gerlini A; Kremsner PG; Leib S; Monath T; Ndungu F; Njuguna P; Page M; Pozzi G; Rappuoli R; Santoro F; Strasser M
Article: BMC MEDICINE. 2015;13:183

Identifying children with excess malaria episodes after adjusting for variation in exposure: identification from a longitudinal study using statistical count models

Ndungu FM; Marsh K; Fegan G; Wambua J; Nyangweso G; Ogada E; Mwangi T; Nyundo C; Macharia A; Uyoga S; Williams TN; Bejon P
Article: PLOS ONE. 2014;9(12):e115126

Avidity of Anti-Circumsporozoite Antibodies following Vaccination with RTS,S/AS01_E in Young Children

Olotu A; Clement F; Jongert E; Vekemans J; Njuguna P; Ndungu FM; Marsh K; Leroux-Roels G; Bejon P
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2013;43(11):2919-2929

Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers

Ndungu FM; Lundblom K; Rono J; Illingworth J; Eriksson S; Farnert A
Article: JOURNAL OF IMMUNOLOGY. 2013;190(3):1038-1047

Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion

Illingworth J; Butler NS; Roetynck S; Mwacharo J; Pierce SK; Bejon P; Crompton PD; Marsh K; Ndungu FM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(21):8247-8252

Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children

Ndungu FM; Olotu A; Mwacharo J; Nyonda M; Apfeld J; Mramba LK; Fegan GW; Bejon P; Marsh K
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;375(1-2):68-74

High efficiency human memory B cell assay and its application to studying Plasmodium falciparum-specific memory B cells in natural infections

Weiss GE; Ndungu FM; McKittrick N; Li S; Kimani D; Crompton PD; Marsh K; Pierce SK
Article: MALARIA JOURNAL. 2011;10:55

Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study

Muema DKM; Ndungu FM; Kinyanjui SM; Berkley JA
Article: PLOS ONE. 2010;5(11):e15007

Distinct Kinetics of Memory B-Cell and Plasma-Cell Responses in Peripheral Blood Following a Blood-Stage Plasmodium chabaudi Infection in Mice

Nduati EW; Ng DHL; Ndungu FM; Gardner P; Urban BC; Langhorne J
Article: PLOS PATHOGENS. 2009;5(12):e1000690

Functional Memory B Cells and Long-Lived Plasma Cells Are Generated after a Single Plasmodium chabaudi Infection in Mice

Ndungu FM; Cadman ET; Coulcher J; Nduati E; Couper E; MacDonald DW; Ng D; Langhorne J
Article: PARASITE IMMUNOLOGY. 2009;31(1):20-31

Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells

Stephens R; Ndungu FM; Langhorne J
Article: JOURNAL OF IMMUNOLOGY. 2006;176(9):5504-5512

CD4 T cells from malaria-nonexposed individuals respond to the CD36-binding domain of Plasmodium falciparum erythrocyte membrane protein-1 via an MHC class II-TCR-independent pathway

Ndungu FM; Sanni L; Urban B; Stephens R; Newbold CI; Marsh K; Langhorne J
Article: JOURNAL OF INFECTIOUS DISEASES. 2005;192(6):1119-1126

Plasmodium falciparum antigenic variation:: Relationships between in vivo selection, acquired antibody response, and disease severity

Bull PC; Pain A; Ndungu FM; Kinyanjui SM; Roberts DJ; Newbold CI; Marsh K
Article: JOURNAL OF INFECTIOUS DISEASES. 2005;191(10):1623-1630

B cell memory to 3 Plasmodium falciparum blood-stage antigens in a malaria-endemic area

Dorfman JR; Bejon P; Ndungu FM; Langhorne J; Kortok MM; Lowe BS; Mwangi TW; Williams TN; Marsh K
Article: JOURNAL OF INFECTIOUS DISEASES. 2002;185(6):812-819

CD4 T cell responses to a variant antigen of the malaria parasite Plasmodium falciparum, erythrocyte membrane protein-1, in individuals living in malaria-endemic areas

Allsopp CEM; Sanni LA; Reubsaet L; Ndungu F; Newbold C; Mwangi T; Marsh K; Langhorne J
Article: PARASITE IMMUNOLOGY. 2002;24(2):77-82

Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates:: evidence for association with protection for IgG1 and disease for IgG2

Ndungu FM; Bull PC; Ross A; Lowe BS; Kabiru E; Marsh K
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2001;113(2):486-491

Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria

Griffiths MJ; Ndungu F; Baird KL; Muller DPR; Marsh K; Newton CRJC
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Review: IMMUNOLOGICAL REVIEWS. 2020;293(1):57-69

B-cell memory in malaria: Myths and realities

Perez-Mazliah D; Ndungu FM; Aye R; Langhorne J
Review: NATURE IMMUNOLOGY. 2008;9(7):725-732

Immunity to malaria: more questions than answers

Langhorne J; Ndungu FM; Sponaas A-M; Marsh K
Review: PARASITE IMMUNOLOGY. 2005;27(10-11):373-384

Regulation of immune response by Plasmodium-infected red blood cells

Ndungu FM; Urban BC; Marsh K; Langhorne J
Corrigendum: JOURNAL OF INFECTIOUS DISEASES. 2005;192(9):1678

Plasmodium falciparum antigenic variation:: relationships between in vivo selection, acquired antibody response, and disease severity (vol 192, pg 1119, 2005)

Bull PC; Pain A; Ndungu FM
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2002;185(11):1688-1691

Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children

Bull PC; Lowe BS; Kaleli N; Njuga F; Kortok M; Ross A; Ndungu F; Snow RW; Marsh K
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2000;182(1):252-259

Plasmodium falciparum-infected erythrocytes:: Agglutination by diverse Kenyan plasma is associated with severe disease and young host age

Bull PC; Kortok M; Kai O; Ndungu F; Ross A; Lowe BS; Newbold CI; Marsh K

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