Flavio Ballante

About me
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About me

Flavio graduated in Pharmaceutical Chemistry and Technology, and holds a PhD in Pharmaceutical Sciences.

Research

Flavio's research focuses on ligand discovery through studies based on computational chemistry, organic chemistry, biochemistry and structural biology. Flavio contributed to several drug discovery and software development projects in academic institutes in the EU/USA and collaborated as a consultant or academic partner with companies in the USA and Sweden. Currently, he is a senior research infrastructure specialist in computational chemistry at the Chemical Biology Consortium Sweden (CBCS, SciLifeLab), Karolinska Institute-Sweden.

Articles

Journal article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2023;10:1264773
Modified N-acyl-L-homoserine lactone compounds abrogate Las-dependent quorum-sensing response in human pathogen Pseudomonas aeruginosa
Ballante F; Turkina MV; Ntzouni M; Magnusson K-E; Vikstrom E
Journal article: PHARMACOLOGICAL REVIEWS. 2021;73(4):527-565
Structure-Based Virtual Screening for Ligands of G Protein-Coupled Receptors: What Can Molecular Docking Do for You?
Ballante F; Kooistra AJ; Kampen S; de Graaf C; Carlsson J
Journal article: PLOS COMPUTATIONAL BIOLOGY. 2021;17(5):e1008936
Can molecular dynamics simulations improve the structural accuracy and virtual screening performance of GPCR models?
Kapla J; Rodriguez Espigares I; Ballante F; Selent J; Carlsson J
Journal article: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY. 2021;36(1):34-47
Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines
Nencetti S; Cuffaro D; Nuti E; Ciccone L; Rossello A; Fabbi M; Ballante F; Ortore G; Carbotti G; Campelli F; Banti I; Gangemi R; Marshall GR; Orlandini E
Journal article: JOURNAL OF MEDICINAL CHEMISTRY. 2020;63(2):613-620
Docking Finds GPCR Ligands in Dark Chemical Matter
Ballante F; Rudling A; Zeifman A; Luttens A; Duy DV; Irwin JJ; Kihlberg J; Brea J; Isabel Loza M; Carlsson J
Journal article: ACS PHARMACOLOGY AND TRANSLATIONAL SCIENCE. 2018;1(2):119-133
Structural Characterization of Agonist Binding to Protease-Activated Receptor 2 through Mutagenesis and Computational Modeling.
Kennedy AJ; Ballante F; Johansson JR; Milligan G; Sundström L; Nordqvist A; Carlsson J
Journal article: DRUG DEVELOPMENT RESEARCH. 2017;78(6):245-267
Limiting Assumptions in the Design of Peptidomimetics
Marshall GR; Ballante F
Journal article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2017;25(7):2105-2132
Structural insights of SmKDAC8 inhibitors: Targeting Schistosoma epigenetics through a combined structure-based 3D QSAR, in vitro and synthesis strategy
Ballante F; Reddy DR; Zhou NJ; Marshall GR
Journal article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2017;127:531-553
Design and synthesis of benzodiazepine analogs as isoform-selective human lysine deacetylase inhibitors
Reddy DR; Ballante F; Zhou NJ; Marshall GR
Journal article: JOURNAL OF MEDICINAL CHEMISTRY. 2016;59(4):1613-1633
Design and Synthesis of Simplified Largazole Analogues as Isoform-Selective Human Lysine Deacetylase Inhibitors
Reddy DN; Ballante F; Chuang T; Pirolli A; Marrocco B; Marshall GR
Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2016;56(1):54-72
An Automated Strategy for Binding-Pose Selection and Docking Assessment in Structure-Based Drug Design
Ballante F; Marshall GR
Journal article: JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. 2015;29(8):757-776
Vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitors: development and validation of predictive 3-D QSAR models through extensive ligand- and structure-based approaches
Ragno R; Ballante F; Pirolli A; Wickersham RBIII; Patsilinakos A; Hesse S; Perspicace E; Kirsch G
Journal article: JOURNAL OF MEDICINAL CHEMISTRY. 2014;57(12):5212-5225
Exploring the Role of 2-Chloro-6-fluoro Substitution in 2-Alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: Effects in HIV-1-Infected Cells and in HIV-1 Reverse Transcriptase Enzymes
Rotili D; Tarantino D; Nawrozkij MB; Babushkin AS; Botta G; Marrocco B; Cirilli R; Menta S; Badia R; Crespan E; Ballante F; Ragno R; Este JA; Maga G; Mai A
Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2014;54(3):970-977
Hsp90 Inhibitors, Part 2: Combining Ligand-Based and Structure-Based Approaches for Virtual Screening Application
Caroli A; Ballante F; Wickersham RBIII; Corelli F; Ragno R
Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2014;54(3):956-969
Hsp90 Inhibitors, Part 1: Definition of 3-D QSAutogrid/R Models as a Tool for Virtual Screening
Ballante F; Caroli A; Wickersham RBIII; Ragno R
Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2013;53(6):1463-1474
Pharmacophore Assessment Through 3-D QSAR: Evaluation of the Predictive Ability on New Derivatives by the Application on a Series of Antitubercular Agents
Friggeri L; Ballante F; Ragno R; Musmuca I; De Vita D; Manetti F; Biava M; Scipione L; Di Santo R; Costi R; Feroci M; Tortorella S
Journal article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2013;63:765-781
Design, synthesis and biological evaluation of new classes of thieno [3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2)
Perspicace E; Jouan-Hureaux V; Ragno R; Ballante F; Sartini S; La Motta C; Da Settimo F; Chen B; Kirsch G; Schneider S; Faivre B; Hesse S
Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2012;52(8):2215-2235
Histone Deacetylase Inhibitors: Structure-Based Modeling and Isoform-Selectivity Prediction
Silvestri L; Ballante F; Mai A; Marshall GR; Ragno R
Journal article: JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. 2012;26(8):907-919
Comprehensive model of wild-type and mutant HIV-1 reverse transciptases
Ballante F; Musmuca I; Marshall GR; Ragno R
Journal article: JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2012;52(6):1674-1685
3-D QSAutogrid/R: An Alternative Procedure To Build 3-D QSAR Models. Methodologies and Applications
Ballante F; Ragno R
Journal article: JOURNAL OF MEDICINAL CHEMISTRY. 2012;55(7):3558-3562
2-(Alkyl/Aryl)Amino-6-Benzylpyrimidin-4(3H)-ones as Inhibitors of Wild-Type and Mutant HIV-1: Enantioselectivity Studies
Rotili D; Samuele A; Tarantino D; Ragno R; Musmuca I; Ballante F; Botta G; Morera L; Pierini M; Cirilli R; Nawrozkij MB; Gonzalez E; Clotet B; Artico M; Este JA; Maga G; Mai A
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All other publications

Conference publication: 2023
Exploring the morphology of the host cell to open new possibilities for drug repurposing in viral infections
Tampere M; Kalman A; Rietdijk J; Axelsson H; Njenda D; Kaimal JM; Lapins M; Ballante F; Le TH; Bäckström A; Seashore-Ludlow B; Lundberg E; Spjuth O; Carreras-Puigvert J; Stadler C; Östling P
Book: METHODS IN MOLECULAR BIOLOGY. 2021
Protein-Ligand Interactions and Drug Design
Book chapter: METHODS IN MOLECULAR BIOLOGY. 2018;p. 67-88
Protein-Ligand Docking in Drug Design: Performance Assessment and Binding-Pose Selection.
Ballante F
Conference publication: AMINO ACIDS. 2013;45(3):567
Computational strategies to design new highly potential BSAO polyamine substrates
Ballante F; Tempera G; Agostinelli E; Ragno R

Employments

Senior Research Infrastructure Specialist, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2024-
Researcher, Medicinal chemistry, Department of Cell and Molecular Biology, Uppsala University, 2017-2022

Visiting research fellowships

Postdoctoral Research Associate, Washington University in St. Louis School of Medicine, 2014-2017

About me

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