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Publications

Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood
Johansson H, Mörk Lm, Li M, Sandblom Al, Björkhem I, Höijer J, et al
Journal of clinical and experimental hepatology 2018;8(2):162-168

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature
Bacalini Mg, Franceschi C, Gentilini D, Ravaioli F, Zhou X, Remondini D, et al
The journals of gerontology. Series A, Biological sciences and medical sciences 2018;():-

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Andersson Er, Chivukula Iv, Hankeova S, Sjöqvist M, Tsoi Yl, Ramsköld D, et al
Gastroenterology 2018;154(4):1080-1095

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, et al
European journal of immunology 2017;47(8):1280-1294

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression
Karadagi A, Johansson H, Zemack H, Salipalli S, Mörk Lm, Kannisto K, et al
PloS one 2017;12(5):e0177279-

Addition of Dexamethasone Alters the Bile Acid Composition by Inducing CYP8B1 in Primary Cultures of Human Hepatocytes
Mörk Lm, Strom Sc, Mode A, Ellis Ec
Journal of clinical and experimental hepatology 2016;6(2):87-93

Changes in gluconeogenesis and intracellular lipid accumulation characterize uremic human hepatocytes ex vivo
Li M, Ellis E, Johansson H, Nowak G, Isaksson B, Gnocchi D, et al
American journal of physiology. Gastrointestinal and liver physiology 2016;310(11):G952-61

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Bell Cc, Hendriks Df, Moro Sm, Ellis E, Walsh J, Renblom A, et al
Scientific reports 2016;6():25187-

De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning
Jorns C, Nowak G, Nemeth A, Zemack H, Mörk Lm, Johansson H, et al
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016;16(3):1021-30

Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins
Watanabe M, Zemack H, Johansson H, Hagbard L, Jorns C, Li M, et al
PloS one 2016;11(9):e0161383-

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
Lauschke Vm, Vorrink Su, Moro Sm, Rezayee F, Nordling Å, Hendriks Df, et al
Hepatology (Baltimore, Md.) 2016;64(5):1743-1756

Assay of Bile Acid Conjugation and Excretion in Human Hepatocytes
Johansson H, Ellis Ec
Methods in molecular biology (Clifton, N.J.) 2015;1250():323-31

Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
Olayanju A, Copple Im, Bryan Hk, Edge Gt, Sison Rl, Wong Mw, et al
Free radical biology & medicine 2015;78():202-12

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson Ma, Kekäläinen E, et al
Journal of immunology (Baltimore, Md. : 1950) 2015;194(6):2467-71

Hepatocyte transplantation normalizes hypercholesterolemia and aortic accumulation of cholesterol in apolipoprotein E knockout mice
Jorns C, Watanabe M, Mork Lm, Larsson L, Zemack H, Kuiper R, et al
XENOTRANSPLANTATION 2015;:S131-S131

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
Huch M, Gehart H, Van Boxtel R, Hamer K, Blokzijl F, Verstegen Mma, et al
CELL 2015;160(1-2):299-312

Hepatocyte transplantation ameliorates the metabolic abnormality in a mouse model of acute intermittent porphyria
Yin Z, Wahlin S, Ellis Ec, Harper P, Ericzon Bg, Nowak G
Cell transplantation 2014;23(9):1153-62

Hypothermic storage of human hepatocytes for transplantation
Gramignoli R, Dorko K, Tahan V, Skvorak Kj, Ellis E, Jorns C, et al
Cell transplantation 2014;23(9):1143-51

In situ characterization of intrahepatic non-parenchymal cells in PSC reveals phenotypic patterns associated with disease severity
Berglin L, Bergquist A, Johansson H, Glaumann H, Jorns C, Lunemann S, et al
PloS one 2014;9(8):e105375-

Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism (vol 8, e78550, 2013)
Ellis Ecs, Naugler We, Parini P, Mork Lm, Jorns C
PLOS ONE 2014;9(7):-

Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures
Liu J, Lu H, Lu Yf, Lei X, Cui Jy, Ellis E, et al
Toxicological sciences : an official journal of the Society of Toxicology 2014;141(2):538-46

Rapid and Sensitive Assessment of Human Hepatocyte Functions
Gramignoli R, Tahan V, Dorko K, Venkataramanan R, Fox Ij, Ellis Ecs, et al
CELL TRANSPLANTATION 2014;23(12):1545-56

Strategies for short-term storage of hepatocytes for repeated clinical infusions
Jorns C, Gramignoli R, Saliem M, Zemack H, Mörk Lm, Isaksson B, et al
Cell transplantation 2014;23(8):1009-18

Hepatobiliary Disposition of 17-OHPC and Taurocholate in Fetal Human Hepatocytes: A Comparison with Adult Human Hepatocytes
Sharma S, Ellis Ecs, Gramignoli R, Dorko K, Tahan V, Hansel M, et al
DRUG METABOLISM AND DISPOSITION 2013;41(2):296-304

IMPROVED SHORT TERM COLD STORAGE OF HUMAN HEPATOCYTES FOR TRANSPLANTATION
Jorns C, Gramignoli R, Saliem M, Zemack H, Mork Lm, Isaksson B, et al
TRANSPLANT INTERNATIONAL 2013;:118-118

Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism
Ellis Ecs, Nauglers S, Parini P, Mork Lm, Jorns C, Zemack H, et al
PLOS ONE 2013;8(11):e78550-

New potential cell source for hepatocyte transplantation: Discarded livers from metabolic disease liver transplants
Gramignoli R, Tahan V, Dorko K, Skvorak Kj, Hansel Mc, Zhao Wc, et al
STEM CELL RESEARCH 2013;11(1):563-73

Serum apolipoprotein E as a marker to monitor graft function after hepatocyte transplantation in a clinically relevant mouse model
Jorns C, Takahashi T, Callaghan E, Zemack H, Larsson L, Nowak G, et al
Transplantation proceedings 2013;45(5):1780-6

Comparison of culture media for bile Acid transport studies in primary human hepatocytes
Mörk Lm, Isaksson B, Boran N, Ericzon Bg, Strom S, Fischler B, et al
Journal of clinical and experimental hepatology 2012;2(4):315-22

Development and Application of Purified Tissue Dissociation Enzyme Mixtures for Human Hepatocyte Isolation
Gramignoli R, Green Ml, Tahan V, Dorko K, Skvorak Kj, Marongiu F, et al
CELL TRANSPLANTATION 2012;21(6):1245-60

Evaluation of organic anion-transporting polypeptide 1B1 and CYP3A4 activities in primary human hepatocytes and HepaRG cells cultured in a dynamic three-dimensional bioreactor system
Ulvestad M, Darnell M, Molden E, Ellis E, Åsberg A, Andersson Tb
The Journal of pharmacology and experimental therapeutics 2012;343(1):145-56

Hepatocyte transplantation for inherited metabolic diseases of the liver
Jorns C, Ellis Ec, Nowak G, Fischler B, Nemeth A, Strom Sc, et al
Journal of internal medicine 2012;272(3):201-23

Improved cryopreservation of human hepatocytes using a new xeno free cryoprotectant solution
Saliem M, Holm F, Tengzelius Rb, Jorns C, Nilsson Lm, Ericzon Bg, et al
World journal of hepatology 2012;4(5):176-83

Improving the Techniques for Human Hepatocyte Transplantation: Report From a Consensus Meeting in London
Puppi J, Strom Sc, Hughes Rd, Bansal S, Castell Jv, Dagher I, et al
CELL TRANSPLANTATION 2012;21(1):1-10

In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system
Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson Tb
The Journal of pharmacology and experimental therapeutics 2012;343(1):134-44

Hepatic Differentiation of Amniotic Epithelial Cells
Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade Ar, Serra Mp, et al
HEPATOLOGY 2011;53(5):1719-29

Liver X receptor agonist downregulates growth hormone signaling in the liver
Zadjali F, Santana-farre R, Mirecki-garrido M, Ellis E, Norstedt G, Fernandez-perez L, et al
Hormone molecular biology and clinical investigation 2011;8(2):471-8

Overexpression of Cholesterol 7 alpha-Hydroxylase Promotes Hepatic Bile Acid Synthesis and Secretion and Maintains Cholesterol Homeostasis
Li Tg, Matozel M, Boehme S, Kong B, Nilsson Lm, Guo G, et al
HEPATOLOGY 2011;53(3):996-1006

A Novel Bile Acid-Activated Vitamin D Receptor Signaling in Human Hepatocytes
Han Sx, Li Tg, Ellis E, Strom S, Chiang Jyl
MOLECULAR ENDOCRINOLOGY 2010;24(6):1151-64

ATPase Class I Type 8B Member 1 and Protein Kinase C zeta Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes
Chen F, Ellis E, Strom Sc, Shneider Bl
PEDIATRIC RESEARCH 2010;67(2):183-7

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXR beta in the hepatic acute phase response
Venteclef N, Jakobsson T, Ehrlund A, Damdimopoulos A, Mikkonen L, Ellis E, et al
GENES & DEVELOPMENT 2010;24(4):381-95

Isolation of amniotic epithelial stem cells
Miki T, Marongiu F, Dorko K, Ellis Ec, Strom Sc
Current protocols in stem cell biology 2010;Chapter 1():1E.3-

Isolation of amniotic mesenchymal stem cells
Marongiu F, Gramignoli R, Sun Q, Tahan V, Miki T, Dorko K, et al
Current protocols in stem cell biology 2010;Chapter 1():1E.5-

Metabolism of 17 alpha-Hydroxyprogesterone Caproate, an Agent for Preventing Preterm Birth, by Fetal Hepatocytes
Sharma S, Ellis Ecs, Dorko K, Zhang Sm, Mattison Dr, Caritis Sn, et al
DRUG METABOLISM AND DISPOSITION 2010;38(5):723-7

The Human ADFP Gene Is a Direct Liver-X-Receptor (LXR) Target Gene and Differentially Regulated by Synthetic LXR Ligands
Kotokorpi P, Venteclef N, Ellis E, Gustafsson Ja, Mode A
MOLECULAR PHARMACOLOGY 2010;77(1):79-86

The use of human hepatocytes to investigate bile acid synthesis
Ellis Ec, Nilsson Lm
Methods in molecular biology (Clifton, N.J.) 2010;640():417-30

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation
Miao J, Xiao Z, Kanamaluru D, Min G, Yau Pm, Veenstra Td, et al
GENES & DEVELOPMENT 2009;23(8):986-96

Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes
Basma H, Soto-gutierrez A, Yannam Gr, Liu Lp, Ito R, Yamamoto T, et al
GASTROENTEROLOGY 2009;136(3):990-9

Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease
Skvorak Kj, Paul Hs, Dorko K, Marongiu F, Ellis E, Chace D, et al
MOLECULAR THERAPY 2009;17(7):1266-73

Human Pregnane X Receptor Activation and CYP3A4/CYP2B6 Induction by 2,3-Oxidosqualene: Lanosterol Cyclase Inhibition
Duniec-dmuchowski Z, Fang Hl, Strom Sc, Ellis E, Runge-morris M, Kocarek Ta
DRUG METABOLISM AND DISPOSITION 2009;37(4):900-8

Long Term Cultures of Primary Human Hepatocytes as an Alternative to Drug Testing in Animals
Ullrich A, Soltz Db, Ellis Ec, Strom Sc, Michalopoulos Gk, Hengstler Jg, et al
ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN 2009;26(4):295-302

Production of hepatocyte-like cells from human amnion
Miki T, Marongiu F, Ellis Ec, Dorko K, Mitamura K, Ranade A, et al
Methods in molecular biology (Clifton, N.J.) 2009;481():155-68

Identification of oxysterol 7 alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha ( ROR alpha) (NR1F1) target gene and a functional cross-talk between ROR alpha and liver X receptor (NR1H3)
Wada T, Kang Hs, Angers M, Gong H, Bhatia S, Khadem S, et al
MOLECULAR PHARMACOLOGY 2008;73(3):891-9

Ethanol stimulates bile acid formation in primary human hepatocytes
Nilsson Lm, Sjovall J, Strom S, Bodin K, Nowak G, Einarsson C, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2007;364(4):743-7

Hepatocyte growth factor signaling pathway inhibits cholesterol 7 alpha-hydroxylase and bile acid synthesis in human hepatocytes
Song Kh, Ellis E, Strom S, Chiang Jyl
HEPATOLOGY 2007;46(6):1993-2002

Isolation of amniotic epithelial stem cells
Miki T, Marongiu F, Ellis E, C Strom S
Current protocols in stem cell biology 2007;Chapter 1():1E.3-

Isolation of mouse hepatocytes for transplantation: A comparison between antegrade and retrograde liver perfusion
Yin Zh, Ellis Ecs, Nowak G
CELL TRANSPLANTATION 2007;16(8):859-65

Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2diphenylethyl)amino]propyloxy] phenylacetic acid hydrochloride (GW3965)
Kotokorpi P, Ellis E, Parini P, Nilsson Lm, Strom S, Steffensen Kr, et al
MOLECULAR PHARMACOLOGY 2007;72(4):947-55

Positive and negative regulation of human hepatic hydroxysteroid sulfotransferase (SULT2A1) gene transcription by rifampicin: Roles of hepatocyte nuclear factor 4 alpha and pregnane X receptor
Fang Hl, Strom Sc, Ellis E, Duanmu Z, Fu J, Duniec-dmuchowski Z, et al
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2007;323(2):586-98

Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists
Duniec-dmuchowski Z, Ellis E, Strom Sc, Kocarek Ta
BIOCHEMICAL PHARMACOLOGY 2007;74(10):1535-40

Robust expansion of human hepatocytes in Fah(-/-)/Rag2(-/-)/Il2rg(-/-) mice
Azuma H, Paulk N, Ranade A, Dorrell C, Al-dhalimy M, Ellis E, et al
NATURE BIOTECHNOLOGY 2007;25(8):903-10

Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites
Kostrubsky Se, Strom Sc, Ellis E, Nelson Sd, Mutlib Ae
CHEMICAL RESEARCH IN TOXICOLOGY 2007;20(10):1503-12

Bigger may not be better when it comes to hepatocytes
Strom Sc, Call Hb, Ellis E, Mitamura K, Miki T
LIVER TRANSPLANTATION 2006;12(1):16-8

Hepatocyte transplantation: Clinical experience and potential for future use
Strom Sc, Bruzzone P, Cai Hb, Ellis E, Lehmann T, Mitamura K, et al
CELL TRANSPLANTATION 2006;:S105-10

Insulin regulation of cholesterol 7 alpha-hydroxylase expression in human hepatocytes - Roles of forkhead box O1 and sterol regulatory element-binding protein 1c
Li Tg, Kong Xy, Owsley E, Ellis E, Strom S, Chiang Jyl
JOURNAL OF BIOLOGICAL CHEMISTRY 2006;281(39):28745-54

Present status and perspectives of cell-based therapies for liver diseases
Nussler A, Konig S, Ott M, Sokal E, Christ B, Thasler W, et al
JOURNAL OF HEPATOLOGY 2006;45(1):144-59

Successful treatment of severe unconjugated hyperbilirubinemia via induction of UGT1A1 by rifampicin
Ellis E, Wagner M, Lammert F, Nemeth A, Gumhold J, Strassburg Cp, et al
JOURNAL OF HEPATOLOGY 2006;44(1):243-5

Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes
Ellis Ecs
WORLD JOURNAL OF GASTROENTEROLOGY 2006;12(29):4640-5

Feedback regulation of bile acid synthesis in human liver: Importance of HNF-4 alpha for regulation of CYP7A1
Abrahamsson A, Gustafsson U, Ellis E, Nilsson Lm, Sahlin S, Bjorkhem I, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2005;330(2):395-9

Feedback regulation of bile acid synthesis in primary human hepatocytes: Evidence that CDCA is the strongest inhibitor
Ellis E, Axelson M, Abrahamsson A, Eggertsen G, Thorne A, Nowak G, et al
HEPATOLOGY 2003;38(4):930-8

Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages
Hansson M, Ellis E, Hunt Mc, Schmitz G, Babiker A
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2003;1593(2-3):283-9

GH is a regulator of IGF2 promoter-specific transcription in human liver
Von Horn H, Ekstrom C, Ellis E, Olivecrona H, Einarsson C, Tally M, et al
JOURNAL OF ENDOCRINOLOGY 2002;172(3):457-65

Metabolism of 4 beta-hydroxycholesterol in Humans
Bodin K, Andersson U, Rystedt E, Ellis E, Norlin M, Pikuleva I, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(35):31534-40

From brain to bile - Evidence that conjugation and omega-hydroxylation are important for elimination of 24S-hydroxycholesterol (cerebrosterol) in humans
Bjorkhem I, Andersson U, Ellis E, Alvelius G, Ellegard L, Diczfalusy U, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2001;276(40):37004-10

Primary cultures of human hepatocytes but not HepG2 hepatoblastoma cells are suitable for the study of glycosidic conjugation of bile acids
Ellis E, Roeb E, Marschall Hu
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2001;1530(2-3):155-61

Bile acid formation in primary human hepatocytes
Einarsson C, Ellis E, Abrahamsson A, Ericzon Bg, Bjorkhem I, Axelson M
WORLD JOURNAL OF GASTROENTEROLOGY 2000;6(4):522-525

Bile acid synthesis in cultured human hepatocytes: Support for an alternative biosynthetic pathway to cholic acid
Axelson M, Ellis E, Mork B, Garmark K, Abrahamsson A, Bjorkhem I, et al
HEPATOLOGY 2000;31(6):1305-12

Cultured human hepatocytes but not HepG2 are suitable for the study of bile acid conjugation
Ellis E, Marschall Hu
JOURNAL OF HEPATOLOGY 2000;:124-124

Cultured human hepatocytes but not HepG2 are suitable for the study of bile acid conjugation.
Marschall Hu, Ellis E
GASTROENTEROLOGY 2000;118(4):A999-A999

Bile acid synthesis in primary cultures of rat and human hepatocytes
Ellis E, Goodwin B, Abrahamsson A, Liddle C, Mode A, Rudling M, et al
HEPATOLOGY 1998;27(2):615-20

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