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About me

I am Professor of Molecular Cardiovascular Medicine at the Department of Medicine, Karolinska University Hospital, Solna (MedS). I perform translational cardiovascular research and I am engaged in different questions regarding education at various levels.

My research is focusing on the interplay between lipid handling, inflammation and autophagy in relation to cardiovascular disease.

 

As regards education, previous and present appointments include assignments at different levels ranging from course to strategic levels in several working groups, committees and boards. I am a former member of the biomedicine programme committee and director of the Center for Clinical Education (CKU-KI). I have received the KI Pedagogical Prize and an educational prize from students at the biomedicine programme.

 

Other commissions include the Research Council of the Heart-Lung Foundation, a review panel of the Swedish Research Council, the Swedish Foundation for International Cooperation in Research and Higher Education (STINT), a review panel of the Finnish Academy, the organizing committee of the European Lipoprotein Club, the KI/SLL Board of Education and the research, development & educational committees at Karolinska University Hospital and Stockholm Health Care Services (SLSO).

 

In January 2018, I was appointed as the Deputy Dean for collaboration with the Stockholm County Council (SLL). This will provide great opportunities for contributing to beneficial collaboration between KI and SCC in order to develop and improve healthcare.

Education

  • MD, Karolinska Institutet, 1988
  • PhD, Karolinska Institutet, 1994
  • Postdoctoral fellow, University of British Columbia, Vancouver, Canada, 1995-1997
  • Junior researcher position (Swedish Medical Research Council), Karolinska Institutet, 1997-1999
  • “Teachers of the future”, Karolinska Institutet, 2000-2002
  • Associate Professor, Karolinska Institutet, 2001
  • Professor of Molecular Cardiovascular Medicine, Karolinska Institutet, 2011

Research description

My research is about cardiovascular disease, which is a leading cause of morbidity and mortality worldwide. The main culprit is atherosclerosis, which is characterized by accumulation of lipids and connective tissues as well as proliferation of vascular smooth muscle cells in the arteries accompanied by local inflammation. An important control mechanism for the quality of cells and survival in the vessel wall is autophagy, which is a highly conserved self-protecting process as cellular response to stress, in which cellular components are self-consumed and recycled for downstream metabolism.  Autophagy has also been shown to be involved in lipid handling inside the cells and how the inflammatory response is regulated. However, the role of autophagy in the pathogenesis of atherosclerosis in humans is largely unknown.

The overall objective is to identify which factors are of importance for the interplay between lipid metabolism, inflammation and autophagy in cardiovascular disease. We are focusing on how lipid handling in macrophages affects inflammation and autophagy during the atherosclerosis process. We are also aiming at identifying factors/proteins in the autophagy process that are of relevance for the development of vulnerable plaques and/or progression of atherosclerosis in the vessel wall. The objective is to provide new therapeutic approaches to reduce cardiovascular disease.

 

The research project is mainly supported by the Swedish Research Council and the Swedish Heart-Lung Foundation. I am/have been the principal supervisor of six PhD students, of which five have defended their theses and the co-supervisor of two PhD students, of which one has defended her thesis. I have been the principal supervisor of six postdoctoral fellows. In addition, I have been an examiner or member of examination boards at more than 40 thesis defences.

Teaching portfolio

I have been engaged in the biomedicine programme since 1999 as a teacher, course coordinator and/or member of the programme committee. I am involved in developing student-activating teaching that integrates the latest research and peer learning. Another important aim has been to develop interprofessional learning between clinically-oriented and experimentally-oriented student groups at undergraduate and postgraduate levels.

 

Other commissions at KI and/or SLL include chairperson for the pedagogical committee at Karolinska University Hospital (Solna), shared presidency of the Educational Congress, director of the Centre for Clinical Education (CKU-KI, coordinator for teaching capacity issues for the Board of Higher Education and director of education at department of Medicine (Solna).

Academic honours, awards and prizes

  • Pedagogical prize 2005, Student Organisation of the Biomedical Programme
  • Karolinska Institutet's Pedagogical Prize 2017

Publications

Lack of genetic susceptibility in takotsubo cardiomyopathy: a case-control study
Mattsson E, Saliba-gustafsson P, Ehrenborg E, Tornvall P
BMC medical genetics 2018;19(1):39-

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions
Jin H, Li Dy, Chernogubova E, Sun C, Busch A, Eken Sm, et al
Molecular therapy : the journal of the American Society of Gene Therapy 2018;26(4):1040-1055

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts
Andersson L, Drevinge C, Mardani I, Dalen Kt, Ståhlman M, Klevstig M, et al
The international journal of biochemistry & cell biology 2017;91(Pt A):9-13

Genetic variants of increased waist circumference in psychosis
Hukic Ds, Ösby U, Olsson E, Hilding A, Östenson Cg, Gu Hf, et al
Psychiatric genetics 2017;27(6):210-218

A Case-Control Study of Risk Markers and Mortality in Takotsubo Stress Cardiomyopathy
Tornvall P, Collste O, Ehrenborg E, Järnbert-petterson H
Journal of the American College of Cardiology 2016;67(16):1931-6

Melatonin receptor 1B gene associated with hyperglycemia in bipolar disorder
Hukic Ds, Lavebratt C, Frisén L, Backlund L, Hilding A, Gu Hf, et al
Psychiatric genetics 2016;26(3):136-9

MicroRNA 486-3P as a stability marker in acute coronary syndrome
Wei T, Folkersen L, Ehrenborg E, Gabrielsen A
Bioscience reports 2016;36(3):-

Perilipin 5 is protective in the ischemic heart
Drevinge C, Dalen Kt, Mannila Mn, Täng Ms, Ståhlman M, Klevstig M, et al
International journal of cardiology 2016;219():446-54

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-lleal M, Lengquist M, Miller Cl, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(9):1947-61

An ex vivo RT-qPCR-based assay for human peripheral leukocyte responsiveness to glucocorticoids in surgically induced inflammation
Gråberg T, Strömmer L, Hedman E, Uzunel M, Ehrenborg E, Wikström Ac
Journal of inflammation research 2015;8():149-60

ATG16L1 Expression in Carotid Atherosclerotic Plaques Is Associated With Plaque Vulnerability
Magné J, Gustafsson P, Jin H, Maegdefessel L, Hultenby K, Wernerson A, et al
Arteriosclerosis, thrombosis, and vascular biology 2015;35(5):1226-35

Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects
Matikainen N, Burza Ma, Romeo S, Hakkarainen A, Adiels M, Folkersen L, et al
PloS one 2013;8(11):e79473-

MicroRNA-9 regulates the expression of peroxisome proliferator-activated receptor δ in human monocytes during the inflammatory response
Thulin P, Wei T, Werngren O, Cheung L, Fisher Rm, Grandér D, et al
International journal of molecular medicine 2013;31(5):1003-10

Peroxisome proliferator-activated receptor delta and cardiovascular disease
Ehrenborg E, Skogsberg J
Atherosclerosis 2013;231(1):95-106

The minor allele of the missense polymorphism Ser251Pro in perilipin 2 (PLIN2) disrupts an α-helix, affects lipolysis, and is associated with reduced plasma triglyceride concentration in humans
Magné J, Aminoff A, Perman Sundelin J, Mannila Mn, Gustafsson P, Hultenby K, et al
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(8):3090-9

Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed
Makoveichuk E, Sukonina V, Kroupa O, Thulin P, Ehrenborg E, Olivecrona T, et al
Biochemical and biophysical research communications 2012;425(2):138-43

Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans
Rafter I, Gråberg T, Kotronen A, Strömmer L, Mattson Cm, Kim Rw, et al
International journal of molecular medicine 2012;30(5):1241-9

Childhood-onset chylomicronaemia with reduced plasma lipoprotein lipase activity and mass: identification of a novel GPIHBP1 mutation
Coca-prieto I, Kroupa O, Gonzalez-santos P, Magne J, Olivecrona G, Ehrenborg E, et al
JOURNAL OF INTERNAL MEDICINE 2011;270(3):224-8

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease
Aminoff A, Ledmyr H, Thulin P, Lundell K, Nunez L, Strandhagen E, et al
JOURNAL OF LIPID RESEARCH 2010;51(1):103-11

Mechanical Synchrony in Long-Distance Runners: Importance of Previous Exposure to Endurance Races
Sahlen A, Shahgaldi K, Aminoff A, Aagaard P, Manouras A, Winter R, et al
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 2010;23(9):977-84

Mutation of conserved cysteines in the Ly6 domain of GPIHBP1 in familial chylomicronemia
Olivecrona G, Ehrenborg E, Semb H, Makoveichuk E, Lindberg A, Hayden Mr, et al
JOURNAL OF LIPID RESEARCH 2010;51(6):1535-45

Stereotyping at the undergraduate level revealed during interprofessional learning between future doctors and biomedical scientists
Lewitt Ms, Ehrenborg E, Scheja M, Brauner A
JOURNAL OF INTERPROFESSIONAL CARE 2010;24(1):53-62

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
Kotronen A, Johansson Le, Johansson Lm, Roos C, Westerbacka J, Hamsten A, et al
DIABETOLOGIA 2009;52(6):1056-60

Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts
Kotronen A, Yki-jarvinen H, Aminoff A, Bergholm R, Pietilainen Kh, Westerbacka J, et al
EUROPEAN JOURNAL OF ENDOCRINOLOGY 2009;160(4):593-602

IGFBP-1 protease activity and IGFBP-1 fragments in a patient with multiple myeloma
Brandt K, Wang J, Lundell K, Stahlberg M, Von Horn H, Ehrenborg E, et al
GROWTH HORMONE & IGF RESEARCH 2009;19(6):507-12

PPAR delta in humans: genetic and pharmacological evidence for a significant metabolic function
Karpe F, Ehrenborg Ee
CURRENT OPINION IN LIPIDOLOGY 2009;20(4):333-6

Regulation of Skeletal Muscle Physiology and Metabolism by Peroxisome Proliferator-Activated Receptor delta
Ehrenborg E, Krook A
PHARMACOLOGICAL REVIEWS 2009;61(3):373-93

PPAR alpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes
Thulin P, Rafter I, Stockling K, Tomkiewicz C, Norjavaara E, Aggerbeck M, et al
TOXICOLOGY AND APPLIED PHARMACOLOGY 2008;231(1):1-9

PPAR delta increases expression of the human apolipoprotein A-II gene in human liver cells
Thulin P, Glinghammar B, Skogsberg J, Lundell K, Ehrenborg E
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2008;21(6):819-24

Alternative splicing of human peroxisome proliferator-activated receptor delta (PPARdelta): effects on translation efficiency and trans-activation ability
Lundell K, Thulin P, Hamsten A, Ehrenborg E
BMC MOLECULAR BIOLOGY 2007;:70-

Open-ended assignments and student responsibility
Brauner A, Carey J, Henriksson M, Sunnerhagen M, Ehrenborg E
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION 2007;35(3):187-92

Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: A study in monozygotic twins
Pietilainen Kh, Kannisto K, Korsheninnikova E, Rissanen A, Kaprio J, Ehrenborg E, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2006;91(7):2776-81

Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise
Kannisto K, Chibalin A, Glinghammar B, Zierath Jr, Hamsten A, Ehrenborg E
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2006;17(1):45-52

Promoter analysis of the murine squalene epoxidase gene. Identification of a 205 bp homing region regulated by both SREBP'S and NF-Y
Murphy C, Ledmyr H, Ehrenborg E, Gafvels M
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2006;1761(10):1213-27

The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein
Ledmyr H, Ottosson L, Sunnerhagen M, Ehrenborg E
JOURNAL OF LIPID RESEARCH 2006;47(7):1378-85

A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein
Targett-adams P, Mcelwee Mj, Ehrenborg E, Gustafsson Mc, Palmer Cn, Mclauchlan J
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 2005;1728(1-2):95-104

Direct activation of glucose transport in primary human myotubes after activation of peroxisome proliferator-activated receptor delta
Kramer Dk, Al-khalili L, Perrini S, Skogsberg J, Wretenberg P, Kannisto K, et al
DIABETES 2005;54(4):1157-63

Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines
Stephen Rl, Gustafsson Mcu, Jarvis M, Tatoud R, Marshall Br, Knight D, et al
CANCER RESEARCH 2004;64(9):3162-70

Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy
Sutinen J, Kannisto K, Korsheninnikova E, Fisher Rm, Ehrenborg E, Nyman T, et al
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2004;286(6):E941-9

In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11 beta-hydroxysteroid dehydrogenase type 1 in adipose tissue
Sutinen J, Kannisto K, Korsheninnikova E, Nyman T, Ehrenborg E, Andrew R, et al
DIABETOLOGIA 2004;47(10):1668-71

Overexpression of 11 beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: Studies in young adult monozygotic twins
Kannisto K, Pietilainen Kh, Ehrenborg E, Rissanen A, Kaprio J, Hamsten A, et al
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 2004;89(9):4414-21

The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease
Woscops, Ledmyr H, Mcmahon Ad, Ehrenborg E, Nielsen Lb, Neville M, et al
CIRCULATION 2004;109(19):2279-84

Allelic variation in the promoter region of the LDL receptor gene: analysis of an African-specific variant in the FP2 cis-acting regulatory element
Hoogendijk Cf, Scholtz Cl, Pimstone Sm, Ehrenborg E, Kastelein Jjp, Defesche Jc, et al
MOLECULAR AND CELLULAR PROBES 2003;17(4):175-81

Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men
Skogsberg J, Kannisto K, Cassel Tn, Hamsten A, Eriksson P, Ehrenborg E
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2003;23(4):637-43

Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy
Kannisto K, Sutinen J, Korsheninnikova E, Fisher Rm, Ehrenborg E, Gertow K, et al
AIDS 2003;17(12):1753-62

Influence of common variants in the CETP, LPL, HL and APO E genes on LDL heterogeneity in healthy, middle-aged men
Skoglund-andersson C, Ehrenborg E, Fisher Rm, Olivercrona G, Hamsten A, Karpe F
ATHEROSCLEROSIS 2003;167(2):311-7

Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content
Al-khalili L, Chibalin Av, Kannisto K, Zhang Bb, Permert J, Holman Gd, et al
CELLULAR AND MOLECULAR LIFE SCIENCES 2003;60(5):991-8

Peroxisome proliferator activated receptor delta genotype in relation to cardiovascular risk factors and risk of coronary heart disease in hypercholesterolaemic men
W Scotland Coronary Prevention Stu, Skogsberg J, Mcmahon Ad, Karpe F, Hamsten A, Packard Cj, et al
JOURNAL OF INTERNAL MEDICINE 2003;254(6):597-604

PPAR delta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells
Glinghammar B, Skogsberg J, Hamsten A, Ehrenborg E
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2003;308(2):361-8

Regulation of plasma PAI-1 concentrations in HAART-associated lipodystrophy during rosiglitazone therapy
Yki-jarvinen H, Sutinen J, Silveira A, Korsheninnikova E, Fisher Rm, Kannisto K, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2003;23(4):688-94

Troglitazone stimulates IGF-binding protein-1 by a PPAR gamma-independent mechanism
Hilding A, Hall K, Skogsberg J, Ehrenborg E, Lewitt Ms
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2003;303(2):693-9

Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index
Ledmyr H, Karpe F, Lundahl B, Mckinnon M, Skoglund-andersson C, Ehrenborg E
JOURNAL OF LIPID RESEARCH 2002;43(1):51-8

Characterization of the human peroxisome proliferator activated receptor delta gene and its expression
Skogsberg J, Kannisto K, Roshani L, Gagne E, Hamsten A, Larsson C, et al
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2000;6(1):73-81

Multi-hormonal regulation of IGFBP-6 expression in human neuroblastoma cells
Chambery D, De Galle B, Ehrenborg E, Babajko S
GROWTH HORMONE & IGF RESEARCH 2000;10(6):349-59

The Q/E27 polymorphism in the beta(2)-adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins
Ehrenborg E, Skogsberg J, Ruotolo G, Large V, Eriksson P, Arner P, et al
JOURNAL OF INTERNAL MEDICINE 2000;247(6):651-6

Characterization and chromosomal localization of the human insulin-like growth factor binding protein 6 gene
Ehrenborg E, Zazzi H, Lagercrantz S, Granqvist M, Hillerbrand U, Allander Sv, et al
MAMMALIAN GENOME 1999;10(4):376-80

Two common functional polymorphisms in the promoter region of the coagulation factor VII gene determining plasma factor VII activity and mass concentration
Van't Hooft Fm, Silveira A, Tornvall P, Iliadou A, Ehrenborg E, Eriksson P, et al
BLOOD 1999;93(10):3432-41

A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels
Karpe F, Lundahl B, Ehrenborg E, Eriksson P, Hamsten A
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1998;18(5):756-61

A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry
Foubert L, Bruin T, Degennes Jl, Ehrenborg E, Furioli J, Kastelein J, et al
HUMAN MUTATION 1997;10(3):179-85

Assessment of French patients with LPL deficiency for French Canadian mutations
Foubert L, Degennes Jl, Lagarde Jp, Ehrenborg E, Raisonnier A, Girardet Jp, et al
JOURNAL OF MEDICAL GENETICS 1997;34(8):672-5

Efficient adenovirus-mediated ectopic gene expression of human lipoprotein lipase in human hepatic (HepG2) cells
Liu Gq, Excoffon Kjda, Benoit P, Ginzinger Dg, Miao L, Ehrenborg E, et al
HUMAN GENE THERAPY 1997;8(2):205-14

Ethnic variation and in vivo effects of the -93t->g promoter variant in the lipoprotein lipase gene
Ehrenborg E, Clee Sm, Pimstone Sn, Reymer Pwa, Benlian P, Hoogendijk Cf, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1997;17(11):2672-8

Relationship between lipoprotein lipase and high density lipoprotein cholesterol in mice: modulation by cholesteryl ester transfer protein and dietary status
Clee Sm, Zhang Hf, Bissada N, Miao L, Ehrenborg E, Benlian P, et al
JOURNAL OF LIPID RESEARCH 1997;38(10):2079-89

Conservation of IGFBP structure during evolution: cloning of chicken insulin-like growth factor binding protein-5
Allander Sv, Ehrenborg E, Luthman H, Powell Dr
Progress in growth factor research 1995;6(2-4):159-65

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