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About me

My goal is to unravel how genetics and environment control embryonic development, to harness developmental pathways and design therapies for congenital disorders. I therefore performed PhD and post doc studies on developmental signaling pathways and embryonic development, and performed research at Rockefeller University to develop a high-throughput in vivo technology for genetic manipulation in utero. As the recipient of an EASL Mentorship Award, I also spent a min-sabbatical at Yale School of Medicine, establishing new collaborations and networks to address liver diseases. 

 

Research description

 

The Andersson lab focuses on gene discovery projects and technology development, to unravel the mechanisms driving Notch-related congenital disorders. For more info, see also http://www.anderssonlab.com

Academic honours, awards and prizes

2017     The Daniel Alagille Award

This prize for one internationally competitive young scientist (under 40) in Europe is awarded by the European Association for the Study of the Liver (EASL), for research in the field of genetic cholestatic liver disorders..

 

2017     EASL Mentoring Progamme recipient

This European mentorship program awards two mentees per year with a mentor, in international competition and provides funds for visits and networking. ER Andersson was matched with Mario Strazzabosco, Yale, USA, and spent a month at Yale, as Visiting Assistant Professor, in fall of 2017.

 

2014     Sven och Ebba-Christina Hagbergs prize & grant

 This prize for excellent young scientists, awarded every second year at Karolinska Institutet, is a personal prize and research grant.

 

Publications

Calcium Signaling in Liver Injury and Regeneration
Oliva-vilarnau N, Hankeova S, Vorrink Su, Mkrtchian S, Andersson Er, Lauschke Vm
Frontiers in medicine 2018;5():192-

Cholangiopathies - Towards a molecular understanding
Tam Pkh, Yiu Rs, Lendahl U, Andersson Er
EBioMedicine 2018;35():381-393

Corrigendum to "Cholangiopathies - Towards a molecular understanding" [EBioMedicine 35 (2018) 381-393]
Tam Pkh, Yiu Rs, Lendahl U, Andersson Er
EBioMedicine 2018;36():564-

Editorial: Signaling pathways instruct the blueprint of life
Bush Jo, Andersson Er
Developmental biology 2018;():-

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Andersson Er, Chivukula Iv, Hankeova S, Sjöqvist M, Tsoi Yl, Ramsköld D, et al
Gastroenterology 2018;154(4):1080-1095

Do as I say, Not(ch) as I do: Lateral control of cell fate
Sjöqvist M, Andersson Er
Developmental biology 2017;():-

The developmental biology of genetic Notch disorders
Mašek J, Andersson Er
Development (Cambridge, England) 2017;144(10):1743-1763

Therapeutic modulation of Notch signalling--are we there yet?
Andersson Er, Lendahl U
Nature reviews. Drug discovery 2014;13(5):357-78

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
Jin S, Mutvei Ap, Chivukula Iv, Andersson Er, Ramsköld D, Sandberg R, et al
Oncogene 2013;32(41):4892-902

Notch signaling maintains neural rosette polarity
Main H, Radenkovic J, Jin Sb, Lendahl U, Andersson Er
PloS one 2013;8(5):e62959-

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
Andersson Er, Saltó C, Villaescusa Jc, Cajanek L, Yang S, Bryjova L, et al
Proceedings of the National Academy of Sciences of the United States of America 2013;110(7):E602-10

SFRP1 and SFRP2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells
Kele J, Andersson Er, Villaescusa Jc, Cajanek L, Parish Cl, Bonilla S, et al
STEM CELLS 2012;30(5):865-75

The molecular basis of Alagille syndrome: Jagged/Notch signaling in liver development and disease
Andersson Er, Chivukula Iv, Ortega Mh, Ellis E, Strom S, Clevers H, et al
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2012;:S51-S51

The role of endocytosis in activating and regulating signal transduction
Andersson Er
CELLULAR AND MOLECULAR LIFE SCIENCES 2012;69(11):1755-71

Notch signaling: simplicity in design, versatility in function
Andersson Er, Sandberg R, Lendahl U
DEVELOPMENT 2011;138(17):3593-612

Control of Notch-ligand endocytosis by ligand-receptor interaction
Hansson Em, Lanner F, Das D, Mutvei A, Marklund U, Ericson J, et al
JOURNAL OF CELL SCIENCE 2010;123(17):2931-42

Delayed Dopaminergic Neuron Differentiation in Lrp6 Mutant Mice
Castelo-branco G, Andersson Er, Minina E, Sousa Km, Ribeiro D, Kokubu C, et al
DEVELOPMENTAL DYNAMICS 2010;239(1):211-21

Differential involvement of caveolin-1 in brown adipocyte signaling: Impaired beta(3)-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling
Mattsson Cl, Andersson Er, Nedergaard J
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2010;1803(8):983-9

Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development
Andersson E, Bryjova L, Biris K, Yamaguchi Tp, Arenas E, Bryja V
DEVELOPMENTAL DYNAMICS 2010;239(1):237-45

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells
Das D, Lanner F, Main H, Andersson Er, Bergmann O, Sahlgren C, et al
DEVELOPMENTAL BIOLOGY 2010;348(2):153-66

Enhanced dopaminergic differentiation of neural and embryonic stem cells by Wnt5a
Arenas E, Parish C, Liste I, Ribeiro D, Andersson E, Salto C, et al
HUMAN GENE THERAPY 2009;20(11):1368-1369

p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells
Joseph B, Andersson Er, Vlachos P, Sodersten E, Liu L, Teixeira Ai, et al
CELL DEATH AND DIFFERENTIATION 2009;16(9):1256-65

Regenerative medicine: a 2009 overview
Andersson Er, Lendahl U
JOURNAL OF INTERNAL MEDICINE 2009;266(4):303-10

The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo
Bryja V, Andersson Er, Schambony A, Esner M, Bryjova L, Biris Kk, et al
MOLECULAR BIOLOGY OF THE CELL 2009;20(3):924-36

The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo
Bryja V, Andersson Er, Schambony A, Esner M, Bryjova L, Biris Kk, et al
MOLECULAR BIOLOGY OF THE CELL 2009;20(3):924-36

Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/beta-Catenin and Protein Kinase C alpha
Yang Dh, Yoon Jy, Lee Sh, Bryja V, Andersson Er, Arenas E, et al
CIRCULATION RESEARCH 2009;104(3):372-9

alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres
Edman Lc, Mira H, Erices A, Malmersjo S, Andersson E, Uhlen P, et al
STEM CELLS 2008;26(7):1891-900

Genetic pathways controlling midbrain dopaminergic neuron development in vivo
Prakash N, Andersson E, Minina E, Klafke R, Simeone A, Arenas E, et al
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 2008;26(8):833-833

Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9-A10 Dopaminergic Cells In Vivo
Andersson Er, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, et al
PLOS ONE 2008;3(10):e3517-

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