I defended my PhD in 2009, from the group of Ernest Arenas at the Department of Medical Biochemistry and Biophysics, at Karolinska Institutet, where I investigated the role of Wnt signaling in brain development and basic developmental processes. I then did a post doc with Urban Lendahl at the department of Cell and Molecular Biology, also at KI. During my post doc I investigated the role of Notch signaling in development of the nervous system, in cancer and its basic signaling papthways.
In addition, I carried out a “post doc within the post doc” and performed guest research at the Rockefeller University in the laboratories of Elaine Fuchs and Mary Beth Hatten, where I learned the technique of ultrasound-guided nano-injection and adpated it from targeting the skin to targeting many other organ systems.
We study the genetic underpinnings of specific diseases; for example how genetic mutations translate into tubular structures forming incorrectly, compromise vascular integrity, or predispose to neural dysfunction. Within this, our lab has two main focuses:
1. Notch signaling deregulation in Alagille syndrome, and Notch control of biliary and vascular development therein.
2. Development of ultrasound-guided in utero nanoinjection as a powerful tool to manipulate gene expression in specific organs during development.
Notch signaling: simplicity in design, versatility in function
Control of Notch-ligand endocytosis by ligand-receptor interaction
JOURNAL OF CELL SCIENCE 2010;123(17):2931-42
Delayed Dopaminergic Neuron Differentiation in Lrp6 Mutant Mice
DEVELOPMENTAL DYNAMICS 2010;239(1):211-21
Differential involvement of caveolin-1 in brown adipocyte signaling: Impaired beta(3)-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2010;1803(8):983-9
Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development
DEVELOPMENTAL DYNAMICS 2010;239(1):237-45
Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells
DEVELOPMENTAL BIOLOGY 2010;348(2):153-66
Enhanced dopaminergic differentiation of neural and embryonic stem cells by Wnt5a
HUMAN GENE THERAPY 2009;20(11):1368-1369
p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells
CELL DEATH AND DIFFERENTIATION 2009;16(9):1256-65
Regenerative medicine: a 2009 overview
JOURNAL OF INTERNAL MEDICINE 2009;266(4):303-10
The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo
MOLECULAR BIOLOGY OF THE CELL 2009;20(3):924-36
Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/beta-Catenin and Protein Kinase C alpha
CIRCULATION RESEARCH 2009;104(3):372-9
Genetic pathways controlling midbrain dopaminergic neuron development in vivo
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 2008;26(8):833-833
Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9-A10 Dopaminergic Cells In Vivo
PLOS ONE 2008;3(10):e3517-