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About me

I defended my PhD in 2009, from the group of Ernest Arenas at the Department of Medical Biochemistry and Biophysics, at Karolinska Institutet, where I investigated the role of Wnt signaling in brain development and basic developmental processes. I then did a post doc with Urban Lendahl at the department of Cell and Molecular Biology, also at KI. During my post doc I investigated the role of Notch signaling in development of the nervous system, in cancer and its basic signaling papthways. 

In addition, I carried out a “post doc within the post doc” and performed guest research at the Rockefeller University in the laboratories of Elaine Fuchs and Mary Beth Hatten, where I learned the technique of ultrasound-guided nano-injection and adpated it from targeting the skin to targeting many other organ systems. 

Research description

We study the genetic underpinnings of specific diseases; for example how genetic mutations translate into tubular structures forming incorrectly, compromise vascular integrity, or predispose to neural dysfunction. Within this, our lab has two main focuses: 
1. Notch signaling deregulation in Alagille syndrome, and Notch control of biliary and vascular development therein. 
2. Development of ultrasound-guided in utero nanoinjection as a powerful tool to manipulate gene expression in specific organs during development.

Publications

Do as I say, Not(ch) as I do: Lateral control of cell fate
Sjöqvist M, Andersson Er
Developmental biology 2017;():-

Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations
Andersson Er, Chivukula Iv, Hankeova S, Sjöqvist M, Tsoi Yl, Ramsköld D, et al
Gastroenterology 2017;():-

The developmental biology of genetic Notch disorders
Mašek J, Andersson Er
Development (Cambridge, England) 2017;144(10):1743-1763

Therapeutic modulation of Notch signalling--are we there yet?
Andersson Er, Lendahl U
Nature reviews. Drug discovery 2014;13(5):357-78

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ
Jin S, Mutvei Ap, Chivukula Iv, Andersson Er, Ramsköld D, Sandberg R, et al
Oncogene 2013;32(41):4892-902

Notch signaling maintains neural rosette polarity
Main H, Radenkovic J, Jin Sb, Lendahl U, Andersson Er
PloS one 2013;8(5):e62959-

Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells
Andersson Er, Saltó C, Villaescusa Jc, Cajanek L, Yang S, Bryjova L, et al
Proceedings of the National Academy of Sciences of the United States of America 2013;110(7):E602-10

SFRP1 and SFRP2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells
Kele J, Andersson Er, Villaescusa Jc, Cajanek L, Parish Cl, Bonilla S, et al
STEM CELLS 2012;30(5):865-75

The molecular basis of Alagille syndrome: Jagged/Notch signaling in liver development and disease
Andersson Er, Chivukula Iv, Ortega Mh, Ellis E, Strom S, Clevers H, et al
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2012;:S51-S51

The role of endocytosis in activating and regulating signal transduction
Andersson Er
CELLULAR AND MOLECULAR LIFE SCIENCES 2012;69(11):1755-71

Notch signaling: simplicity in design, versatility in function
Andersson Er, Sandberg R, Lendahl U
DEVELOPMENT 2011;138(17):3593-612

Control of Notch-ligand endocytosis by ligand-receptor interaction
Hansson Em, Lanner F, Das D, Mutvei A, Marklund U, Ericson J, et al
JOURNAL OF CELL SCIENCE 2010;123(17):2931-42

Delayed Dopaminergic Neuron Differentiation in Lrp6 Mutant Mice
Castelo-branco G, Andersson Er, Minina E, Sousa Km, Ribeiro D, Kokubu C, et al
DEVELOPMENTAL DYNAMICS 2010;239(1):211-21

Differential involvement of caveolin-1 in brown adipocyte signaling: Impaired beta(3)-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling
Mattsson Cl, Andersson Er, Nedergaard J
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2010;1803(8):983-9

Genetic Interaction Between Lrp6 and Wnt5a During Mouse Development
Andersson E, Bryjova L, Biris K, Yamaguchi Tp, Arenas E, Bryja V
DEVELOPMENTAL DYNAMICS 2010;239(1):237-45

Notch induces cyclin-D1-dependent proliferation during a specific temporal window of neural differentiation in ES cells
Das D, Lanner F, Main H, Andersson Er, Bergmann O, Sahlgren C, et al
DEVELOPMENTAL BIOLOGY 2010;348(2):153-66

Enhanced dopaminergic differentiation of neural and embryonic stem cells by Wnt5a
Arenas E, Parish C, Liste I, Ribeiro D, Andersson E, Salto C, et al
HUMAN GENE THERAPY 2009;20(11):1368-1369

p57Kip2 is a repressor of Mash1 activity and neuronal differentiation in neural stem cells
Joseph B, Andersson Er, Vlachos P, Sodersten E, Liu L, Teixeira Ai, et al
CELL DEATH AND DIFFERENTIATION 2009;16(9):1256-65

Regenerative medicine: a 2009 overview
Andersson Er, Lendahl U
JOURNAL OF INTERNAL MEDICINE 2009;266(4):303-10

The Extracellular Domain of Lrp5/6 Inhibits Noncanonical Wnt Signaling In Vivo
Bryja V, Andersson Er, Schambony A, Esner M, Bryjova L, Biris Kk, et al
MOLECULAR BIOLOGY OF THE CELL 2009;20(3):924-36

Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/beta-Catenin and Protein Kinase C alpha
Yang Dh, Yoon Jy, Lee Sh, Bryja V, Andersson Er, Arenas E, et al
CIRCULATION RESEARCH 2009;104(3):372-9

alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres
Edman Lc, Mira H, Erices A, Malmersjo S, Andersson E, Uhlen P, et al
STEM CELLS 2008;26(7):1891-900

Genetic pathways controlling midbrain dopaminergic neuron development in vivo
Prakash N, Andersson E, Minina E, Klafke R, Simeone A, Arenas E, et al
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE 2008;26(8):833-833

Wnt5a Regulates Ventral Midbrain Morphogenesis and the Development of A9-A10 Dopaminergic Cells In Vivo
Andersson Er, Prakash N, Cajanek L, Minina E, Bryja V, Bryjova L, et al
PLOS ONE 2008;3(10):e3517-

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Events

StratNeuro Retreat 2018

31 May 2018 - 13:30
Sånga-Säby Hotell & Konferens, 179 96 Svartsjö