Emanuela Santini

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CV
Public outreach and news

Articles

Article: MOLECULAR PSYCHIATRY. 2021;26(11):6427-6450

Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function.

Longo F; Mancini M; Ibraheem PL; Aryal S; Mesini C; Patel JC; Penhos E; Rahman N; Mamcarz M; Santini E; Rice ME; Klann E
Article: MOVEMENT DISORDERS. 2021;36(5):1137-1146

Involvement of Autophagy in Levodopa-Induced Dyskinesia.

Feyder M; Plewnia C; Lieberman OJ; Spigolon G; Piccin A; Urbina L; Dehay B; Li Q; Nilsson P; Altun M; Santini E; Sulzer D; Bezard E; Borgkvist A; Fisone G
Article: ELIFE. 2020;9:e50843

Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy.

Lieberman OJ; Frier MD; McGuirt AF; Griffey CJ; Rafikian E; Yang M; Yamamoto A; Borgkvist A; Santini E; Sulzer D
Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2020;14:70

mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders.

Lieberman OJ; Cartocci V; Pigulevskiy I; Molinari M; Carbonell J; Broseta MB; Post MR; Sulzer D; Borgkvist A; Santini E
Article: ELIFE. 2019;8:e51607

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala.

Ostroff LE; Santini E; Sears R; Deane Z; Kanadia RN; LeDoux JE; Lhakhang T; Tsirigos A; Heguy A; Klann E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(7):2707-2712

Inositol polyphosphate multikinase mediates extinction of fear memory.

Park J; Longo F; Park SJ; Lee S; Bae M; Tyagi R; Han J-H; Kim S; Santini E; Klann E; Snyder SH
Article: NEURON. 2018;99(3):540-554.e4

Dopamine Triggers the Maturation of Striatal Spiny Projection Neuron Excitability during a Critical Period.

Lieberman OJ; McGuirt AF; Mosharov EV; Pigulevskiy I; Hobson BD; Choi S; Frier MD; Santini E; Borgkvist A; Sulzer D
Article: MOLECULAR PSYCHIATRY. 2018;23(6):1394-1401

Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory.

Huynh TN; Santini E; Mojica E; Fink AE; Hall BS; Fetcho RN; Grosenick L; Deisseroth K; LeDoux JE; Liston C; Klann E
Article: SCIENCE SIGNALING. 2017;10(504):eaan0665

Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice.

Santini E; Huynh TN; Longo F; Koo SY; Mojica E; D'Andrea L; Bagni C; Klann E
Article: CEREBRAL CORTEX. 2017;27(2):1670-1685

Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits.

Oaks AW; Zamarbide M; Tambunan DE; Santini E; Di Costanzo S; Pond HL; Johnson MW; Lin J; Gonzalez DM; Boehler JF; Wu GK; Klann E; Walsh CA; Manzini MC
Article: JOURNAL OF NEUROSCIENCE. 2016;36(45):11402-11410

Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy.

Chahrour M; O'Roak BJ; Santini E; Samaco RC; Kleiman RJ; Manzini MC
Article: BIOLOGICAL PSYCHIATRY. 2016;79(5):362-371

A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression.

Feyder M; Södersten E; Santini E; Vialou V; LaPlant Q; Watts EL; Spigolon G; Hansen K; Caboche J; Nestler EJ; Fisone G
Article: JOURNAL OF NEUROSCIENCE. 2015;35(49):16213-16220

Mitochondrial Superoxide Contributes to Hippocampal Synaptic Dysfunction and Memory Deficits in Angelman Syndrome Model Mice.

Santini E; Turner KL; Ramaraj AB; Murphy MP; Klann E; Kaphzan H
Article: NEUROBIOLOGY OF DISEASE. 2015;83:67-74

eIF4E/Fmr1 double mutant mice display cognitive impairment in addition to ASD-like behaviors.

Huynh TN; Shah M; Koo SY; Faraud KS; Santini E; Klann E
Article: JOURNAL OF NEUROSCIENCE. 2014;34(27):9034-9039

Requirement of Mammalian target of rapamycin complex 1 downstream effectors in cued fear memory reconsolidation and its persistence.

Huynh TN; Santini E; Klann E
Article: CELL REPORTS. 2013;4(3):405-412

Genetic reduction of the α1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome.

Kaphzan H; Buffington SA; Ramaraj AB; Lingrel JB; Rasband MN; Santini E; Klann E
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(3):240-252

Operant behavior to obtain palatable food modifies ERK activity in the brain reward circuit.

Guegan T; Cutando L; Gangarossa G; Santini E; Fisone G; Martinez A; Valjent E; Maldonado R; Martin M
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(2):146-159

Operant behavior to obtain palatable food modifies neuronal plasticity in the brain reward circuit.

Guegan T; Cutando L; Ayuso E; Santini E; Fisone G; Bosch F; Martinez A; Valjent E; Maldonado R; Martin M
Article: NATURE. 2013;493(7432):411-415

Exaggerated translation causes synaptic and behavioural aberrations associated with autism.

Santini E; Huynh TN; MacAskill AF; Carter AG; Pierre P; Ruggero D; Kaphzan H; Klann E
Article: JOURNAL OF NEUROPHYSIOLOGY. 2013;109(1):68-76

Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation.

Hoeffer CA; Santini E; Ma T; Arnold EC; Whelan AM; Wong H; Pierre P; Pelletier J; Klann E
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(33):27806-27812

Dopamine- and cAMP-regulated phosphoprotein of 32-kDa (DARPP-32)-dependent activation of extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin complex 1 (mTORC1) signaling in experimental parkinsonism.

Santini E; Feyder M; Gangarossa G; Bateup HS; Greengard P; Fisone G
Article: NEUROBIOLOGY OF DISEASE. 2012;45(3):1101-1110

Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex.

Chévere-Torres I; Kaphzan H; Bhattacharya A; Kang A; Maki JM; Gambello MJ; Arbiser JL; Santini E; Klann E
Article: NEUROBIOLOGY OF DISEASE. 2012;45(1):156-164

Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin.

Chévere-Torres I; Maki JM; Santini E; Klann E
Article: NEUROPSYCHOPHARMACOLOGY. 2011;36(12):2561-2570

Haloperidol regulates the state of phosphorylation of ribosomal protein S6 via activation of PKA and phosphorylation of DARPP-32.

Valjent E; Bertran-Gonzalez J; Bowling H; Lopez S; Santini E; Matamales M; Bonito-Oliva A; Hervé D; Hoeffer C; Klann E; Girault J-A; Fisone G
Article: PLOS ONE. 2010;5(8):e12322

Distinct changes in cAMP and extracellular signal-regulated protein kinase signalling in L-DOPA-induced dyskinesia.

Santini E; Sgambato-Faure V; Li Q; Savasta M; Dovero S; Fisone G; Bezard E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14845-14850

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors.

Bateup HS; Santini E; Shen W; Birnbaum S; Valjent E; Surmeier DJ; Fisone G; Nestler EJ; Greengard P
Article: CELL CYCLE. 2010;9(14):2713-2718

mTORC1 signaling in Parkinson's disease and L-DOPA-induced dyskinesia: A sensitized matter.

Santini E; Valjent E; Fisone G
Article: NEUROBIOLOGY OF DISEASE. 2010;38(3):434-445

Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia.

Napolitano F; Pasqualetti M; Usiello A; Santini E; Pacini G; Sciamanna G; Errico F; Tassone A; Di Dato V; Martella G; Cuomo D; Fisone G; Bernardi G; Mandolesi G; Mercuri NB; Standaert DG; Pisani A
Article: SCIENCE SIGNALING. 2009;2(80):ra36

Inhibition of mTOR signaling in Parkinson's disease prevents L-DOPA-induced dyskinesia.

Santini E; Heiman M; Greengard P; Valjent E; Fisone G
Article: JOURNAL OF NEUROCHEMISTRY. 2009;108(3):621-633

L-DOPA activates ERK signaling and phosphorylates histone H3 in the striatonigral medium spiny neurons of hemiparkinsonian mice.

Santini E; Alcacer C; Cacciatore S; Heiman M; Hervé D; Greengard P; Girault J-A; Valjent E; Fisone G
Article: NEUROPHARMACOLOGY. 2008;55(2):230-237

Delayed, context- and dopamine D1 receptor-dependent activation of ERK in morphine-sensitized mice.

Borgkvist A; Valjent E; Santini E; Hervé D; Girault J-A; Fisone G
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2008;37(2):335-345

The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons.

Errico F; Santini E; Migliarini S; Borgkvist A; Centonze D; Nasti V; Carta M; De Chiara V; Prosperetti C; Spano D; Herve D; Pasqualetti M; Di Lauro R; Fisone G; Usiello A
Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):8-14

Signaling in the basal ganglia: postsynaptic and presynaptic mechanisms.

Fisone G; Håkansson K; Borgkvist A; Santini E
Article: JOURNAL OF NEUROSCIENCE. 2007;27(26):6995-7005

Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia.

Santini E; Valjent E; Usiello A; Carta M; Borgkvist A; Girault J-A; Hervé D; Greengard P; Fisone G
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All other publications

Editorial comment: NEURON. 2016;90(1):1-3

Genetically Dissecting Cortical Neurons Involved in Epilepsy in Angelman Syndrome.

Santini E; Klann E
Review: SWISS MEDICAL WEEKLY. 2016;146:w14314

Unlocking the molecular mechanisms of antipsychotics - a new frontier for discovery.

Bowling H; Santini E
Review: SCIENCE SIGNALING. 2014;7(349):re10

Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders.

Santini E; Klann E
Review: PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY. 2014;122:131-167

Mechanisms of translation control underlying long-lasting synaptic plasticity and the consolidation of long-term memory.

Santini E; Huynh TN; Klann E
Review: FRONTIERS IN BEHAVIORAL NEUROSCIENCE. 2011;5:76

Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs.

Santini E; Klann E
Review: FEBS JOURNAL. 2008;275(7):1392-1399

Parkinson's disease: levodopa-induced dyskinesia and signal transduction.

Santini E; Valjent E; Fisone G

Employments

Principal Researcher, Department of Neuroscience, Karolinska Institutet, 2022-

Degrees and Education

Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2009

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