Elena Kochetkova

About me
Publications
Public outreach and news

About me

I am a PostDoctoral researcher at Helin Vakifahmetoglu-Norberg's Protein Degradation group.

I have completed my Bachelor, Master and PhD degrees in the field of cellular senescence and macroautophagy. After I switched my field of interest to metabolism in cancer and joined Erik Norberg's Metabolism group. My current research passion is to fill the gaps in our knowledge ión how dysregulation of metabolic pathways contributes to cancer progression and how can we target them.

Research

Metabolism, autophagy, lung cancer

Teaching

I take part in teaching at FyFa (Basic Science Module, Applied Physiology and Pharmacology, and Cancer module courses.

Articles

Article: EMBO MOLECULAR MEDICINE. 2025;:1-28
Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors
Zhou X; Berenger E; Shi Y; Shirokova V; Kochetkova E; Becirovic T; Zhang B; Kaminskyy VO; Esmaeilian Y; Hosaka K; Lindskog C; Hydbring P; Ekman S; Cao Y; Genander M; Iwanicki M; Norberg E; Vakifahmetoglu-Norberg H
Article: CELL DEATH DISCOVERY. 2024;10(1):502
USP39 regulates pyruvate handling in non-small cell lung cancer
Becirovic T; Zhang B; Vakifahmetoglu-Norberg H; Kaminskyy VO; Kochetkova E; Norberg E
Article: CELL DEATH DISCOVERY. 2024;10(1):342
Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer
Becirovic T; Zhang B; Lindskog C; Norberg E; Vakifahmetoglu-Norberg H; Kaminskyy VO; Kochetkova E
Article: NUTRIENTS. 2024;16(12):1816
Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection
Centeno D; Farsinejad S; Kochetkova E; Volpari T; Gladych-Macioszek A; Klupczynska-Gabryszak A; Polotaye T; Greenberg M; Kung D; Hyde E; Alshehri S; Pavlovic T; Sullivan W; Plewa S; Vakifahmetoglu-Norberg H; Monsma Jr FJ; Muller PAJ; Matysiak J; Zaborowski MP; DiFeo A; Norberg E; Martin LA; Iwanicki M
Article: AUTOPHAGY. 2023;19(9):2575-2577
Knockout validation of LAMP2A antibodies for immunostaining in human cancer cells
Zhou X; Shirokova V; Kaminskyy VO; Berenger E; Kochetkova E; Norberg E; Genander M; Vakifahmetoglu-Norberg H
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:329-335
Extraction of Metabolites from Cancer Cells.
Kochetkova E; Becirovic T; Norberg E
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:275-288
A Method to Identify Potential Prognostic Markers Across Distinct Tumor Types.
Zhang B; Kochetkova E; Norberg E
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:139-169
Approaches and Protocols to Analyze Autophagy and Its Role in Death of Apoptosis-Resistant Senescent Tumor Cells.
Kochetkova EY; Pospelov VA; Pospelova TV
Journal article: CELL AND TISSUE BIOLOGY. 2021;15(4):370-380
Establishment of HindIIIG-1 Cell Line, Obtained after Irradiation of HindIIIG Cells Resistant to Apoptosis, Characterizes by Genomic Instability, Altered DNA Repair Mechanisms and Activation of Autophagy
Chitikova ZV; Yartseva NM; Bykova TV; Zubova SG; Kochetkova EY; Pospelov VA; Pospelova TV
Journal article: CELL AND TISSUE BIOLOGY. 2021;15(3):248-259
Karyotypic Changes of Apoptosis-Resistant Rat Cells HindIIIG during Prolonged Cultivation after Exposure to Ionizing Irradiation
Yartseva NM; Shitikova ZV; Bykova TV; Zubova SG; Kochetkova EY; Pospelov VA; Pospelova TV
Journal article: CELL AND TISSUE BIOLOGY. 2020;14(6):437-447
Dependence of the Viability of Ras-Expressing Cells on Damage to Mitochondria Caused by Antitumor Agents
Kochetkova EY; Blinova GI; Boytsov AS; Pospelov VA; Pospelova TV
Journal article: CELL AND TISSUE BIOLOGY. 2019;13(5):344-352
Sensitivity of Cells with Various Levels of Ppm1d Expression to Classical Chemotherapeutic Drugs for Colorectal Cancer Treatment
Kochetkova EY; Grigorash BB; Demidov ON
Journal article: BIOPOLYMERS AND CELL. 2019;35(3):212-213
Nuclear protein phosphatase Wip1 regulate sensitivity of human colorectal cancer cells to DNA damaging anti-cancer agents
Grigorash BB; Uyanik B; Kochetkova EY; Demidov ON
Article: AGING-US. 2018;10(11):3574-3589
Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases.
Kochetkova EY; Blinova GI; Bystrova OA; Martynova MG; Pospelov VA; Pospelova TV
Article: AGING-US. 2017;9(11):2352-2375
Targeted elimination of senescent Ras-transformed cells by suppression of MEK/ERK pathway.
Kochetkova EY; Blinova GI; Bystrova OA; Martynova MG; Pospelov VA; Pospelova TV
Journal article: CELL AND TISSUE BIOLOGY. 2017;11(4):268-274
The MEK/ERK pathway is essential for maintenance of cytoprotective autophagy in E1A+cHA-RAS transformants after exposure to radiation
Kochetkova EY; Blinova GI; Zubova SG; Bykova TV; Pospelov VA; Pospelova TV
Journal article: JOURNAL OF DERMATOLOGICAL SCIENCE. 2017;87(1):85-88
Wip1 inhibition leads to severe pro-inflammatory phenotype in skin in response to chemical irritation.
Grigorash BB; Uyanik B; Kochetkova EY; Goloudina AR; Demidov ON
Journal article: CELL AND TISSUE BIOLOGY. 2016;10(4):290-296
Depletion of Wip1 phosphatase sensitizes murine skin cells to UV-B irradiation
Kochetkova EY; Pospelova TV; Demidov ON
Article: CELL DEATH & DISEASE. 2016;7(4):e2195
Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy.
Clausse V; Goloudina AR; Uyanik B; Kochetkova EY; Richaud S; Fedorova OA; Hammann A; Bardou M; Barlev NA; Garrido C; Demidov ON
Journal article: TSITOLOGIYA. 2016;38(12):955-963
CHLOROQUINE DOES NOT CANCEL E1A+cHa-Ras TRANSFORMANTS’ DEATH INDUCED BY mTOR KINASE INHIBITOR pp242.
Bykova TV; Zubova SG; Kochetkova EY; Pospelova TV
Article: TSITOLOGIYA. 2016;58(12):947-954
MEK/ERK-PATHWAY IS REQUIRED TO MAINTAIN CYTOPROTECTIVE AUTOPHAGY PROCESS IN IRRADIATED E1A+cHa-Ras TRANSFORMANTS.
Kochetkova EY; Blinova GI; Zubova SG; Bykova TV; Pospelov VA; Pospelova TV
Article: TSITOLOGIYA. 2016;58(12):955-963
CHLOROQUINE DOES NOT CANCEL E1A+cHa-Ras TRANSFORMANTS’ DEATH INDUCED BY mTOR KINASE INHIBITOR pp242.
Bykova TV; Zubova, SG; Kochetkova EY; Pospelova TV
Journal article: CELL AND TISSUE BIOLOGY. 2014;8(5):374-383
The role of the MEK/ERK pathway in regulation of HDACI-induced senescence of transformed rat embryo fibroblasts
Kochetkova EY; Bykova TV; Zubova SG; Pospelova TV
Journal article: CELL AND TISSUE BIOLOGY. 2013;7(2):126-135
Involvement of MAP-kinase cascades in regulation of sodium-butyrate-induced premature senescence
Kochetkova EY; Bykova TV; Zubova SG; Pospelova TV
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All other publications

Preprint: BIORXIV. 2024;BIORXIV
Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-damage-sensing-dependent Cell Protection.
Centeno D; Farsinejad S; Kochetkova E; Volpari T; Gladych-Macioszek A; Klupczynska-Gabryszak A; Polotaye T; Greenberg M; Kung D; Hyde E; Alshehri S; Pavlovic T; Sullivan W; Plewa S; Vakifahmetoglu-Norberg H; Monsma FJ; Muller PAJ; Matysiak J; Zaborowski M; DiFeo A; Norberg E; Martin LA; Iwanicki M
Preprint: BIORXIV. 2022
Chaperone-mediated Autophagy Deficiency Reprograms Cancer Metabolism Via TGFβ Signaling to drive Mesenchymal Tumor Growth
Zhou X; Shi Y; Shirokova V; Kochetkova E; Becirovic T; Zhang B; Kaminskyy VO; Lindskog C; Hydbring P; Ekman S; Genander M; Norberg E; Vakifahmetoglu-Norberg H
Conference publication: CELL DEATH DISCOVERY. 2021;7(SUPPL 1):6-7
Bafilomycin A1 induces different cell death types in nonsenescent and senescent Ras-transformed cells
Kochetkova E; Bystrova O; Martynova M; Zubova S; Bykova T; Pospelov V; Pospelova T
Review: ONCOTARGET. 2016;7(21):31563-31571
Wip1 phosphatase: between p53 and MAPK kinases pathways.
Goloudina AR; Kochetkova EY; Pospelova TV; Demidov ON

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