Elena Kashuba

Publications
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Articles

Article: SCIENTIFIC REPORTS. 2022;12(1):22154

STK4 protein expression pattern follows different trends in endometrioid and serous endometrial adenocarcinoma upon tumor progression.

Govorov I; Attarha S; Kovalevska L; Andersson E; Kashuba E; Mints M
Article: EXPERIMENTAL ONCOLOGY. 2022;44(1):39-46

EXPRESSION OF MARKERS OF BONE TISSUE REMODELING IN BREAST CANCER AND PROSTATE CANCER CELLS IN VITRO.

Lukianova N; Zadvornyi T; Kashuba E; Borikun T; Mushii О; Chekhun V
Article: EXPERIMENTAL ONCOLOGY. 2022;44(1):47-51

DIFFERENTIAL EXPRESSION PATTERN OF AIP, UCKL1, AND PKN1 GENES IN PROSTATE CANCER PATIENTS.

Kovalevska L; Zadvornyj T; Lukianova N; Kashuba E
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(7):3434

Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2.

Zvejniece L; Kozireva S; Rudevica Z; Leonciks A; Ehlin-Henriksson B; Kashuba E; Kholodnyuk I
Article: LIFE-BASEL. 2022;12(3):376

A Comparative Study on the Viability of Normal and Cancerous Cells upon Irradiation with a Steady Beam of THz Rays.

Kovalevska L; Golenkov O; Kulahina Y; Callender T; Sizov F; Kashuba E
Article: CANCER CONTROL. 2022;29:10732748221094797-107327482210947

Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer.

Govorov I; Attarha S; Kovalevska L; Andersson E; Kashuba E; Mints M
Article: ONCOLOGY LETTERS. 2022;23(1):30

Evaluation of dyskerin expression and the Cajal body protein WRAP53β as potential prognostic markers for patients with primary vaginal carcinoma.

Ranhem C; Larsson GL; Lindqvist D; Sorbe B; Karlsson MG; Farnebo M; Hellman K; Kovaleska L; Kashuba E; Andersson S
Article: EXPERIMENTAL ONCOLOGY. 2021;43(4):298-305

Differential expression patterns of AIP, UCKL1, and PKN1 genes in breast cancer of different molecular subtypes.

Kovalevska L; Kashuba E; Zadvornyj T; Astrid K; Lukianova N; Chekhun V
Article: EXPERIMENTAL ONCOLOGY. 2021;43(3):204-208

Expression pattern of MRPS18 family genes in gliomas.

Kovalevska LM; Malysheva TA; Kalman SS; Rozumenko AV; Verbova LV; Rozumenko VD; Kashuba EV
Article: EXPERIMENTAL ONCOLOGY. 2020;42(4):295-299

Expression pattern of MRPS18 family genes in malignantly transformed b-cells.

Kovalevska L; Kashuba E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(27):15673-15683

Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2.

Mushtaq M; Kovalevska L; Darekar S; Abramsson A; Zetterberg H; Kashuba V; Klein G; Arsenian-Henriksson M; Kashuba E
Article: BRAIN SCIENCES. 2020;10(5):E287-287

Persistent Roseoloviruses Infection in Adult Patients with Epilepsy.

Rasa-Dzelzkaleja S; Gravelsina S; Chapenko S; Krukle Z-N; Svirskis S; Suna N; Kashuba E; Karelis G; Murovska M
Article: CELLS. 2019;8(3):E208-208

The Immunogenicity in Mice of HCV Core Delivered as DNA Is Modulated by Its Capacity to Induce Oxidative Stress and Oxidative Stress Response.

Jansons J; Sominskaya I; Petrakova N; Starodubova ES; Smirnova OA; Alekseeva E; Bruvere R; Eliseeva O; Skrastina D; Kashuba E; Mihailova M; Kochetkov SN; Ivanov AV; Isaguliants MG
Article: EXPERIMENTAL ONCOLOGY. 2018;40(4):303-308

Overexpression of the mitochondrial ribosomal protein S18-2 in the invasive breast carcinomas.

Buchynska LG; Iurchenko NP; Kashuba EV; Brieieva OV; Glushchenko NM; Mints M; Lukianova NY; Chekhun VF
Article: MEDICINA-LITHUANIA. 2018;54(5):E67-67

Impact of the Uridine⁻Cytidine Kinase Like-1 Protein and IL28B rs12979860 and rs8099917 SNPs on the Development of Hepatocellular Carcinoma in Cirrhotic Chronic Hepatitis C Patients-A Pilot Study.

Buivydiene A; Liakina V; Kashuba E; Norkuniene J; Jokubauskiene S; Gineikiene E; Valantinas J
Article: VIRUSES-BASEL. 2018;10(5):E239-239

Upregulation of the Chemokine Receptor CCR2B in Epstein‒Barr Virus-Positive Burkitt Lymphoma Cell Lines with the Latency III Program.

Kozireva S; Rudevica Z; Baryshev M; Leonciks A; Kashuba E; Kholodnyuk I
Article: SCIENTIFIC REPORTS. 2018;8(1):2268

The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells.

Mushtaq M; Jensen L; Davidsson S; Grygoruk OV; Andrén O; Kashuba V; Kashuba E
Article: VIROLOGY. 2017;512:1-7

Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines.

Kholodnyuk I; Rudevica Z; Leonciks A; Ehlin-Henriksson B; Kashuba E
Article: EXPERIMENTAL ONCOLOGY. 2017;39(4):286-290

The TGF-beta - SMAD pathway is inactivated in cronic lymphocytic leukemia cells.

Matveeva A; Kovalevska L; Kholodnyuk I; Ivanivskaya T; Kashuba E
Article: ONCOTARGET. 2017;8(39):64907-64917

Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells.

Mushtaq M; Pangigadde PN; Darekar S; Dissen E; Kashuba E
Article: ACTA NATURAE. 2017;9(3):108-114

Expression Levels of the Uridine-Cytidine Kinase Like-1 Protein As a Novel Prognostic Factor for Hepatitis C Virus-Associated Hepatocellular Carcinomas.

Buivydiene A; Liakina V; Valantinas J; Norkuniene J; Mockiene E; Jokubauskiene S; Smaliukiene R; Jancoriene L; Kovalevska L; Kashuba E
Article: EXPERIMENTAL ONCOLOGY. 2017;39(1):12-16

Do MRPS18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development?

Kashuba E; Mushtaq M
Article: MICROBIAL ECOLOGY IN HEALTH AND DISEASE. 2017;28(1):1345574

Ancient permafrost staphylococci carry antibiotic resistance genes.

Kashuba E; Dmitriev AA; Kamal SM; Melefors O; Griva G; Römling U; Ernberg I; Kashuba V; Brouchkov A
Article: ONCOTARGET. 2016;7(34):55649-55662

S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma.

Mushtaq M; Ali RH; Kashuba V; Klein G; Kashuba E
Article: ONCOTARGET. 2016;7(16):22150-22158

Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1.

Mints M; Mushtaq M; Iurchenko N; Kovalevska L; Stip MC; Budnikova D; Andersson S; Polischuk L; Buchynska L; Kashuba E
Article: ONCOTARGET. 2015;6(25):21016-21028

Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts.

Darekar SD; Mushtaq M; Gurrapu S; Kovalevska L; Drummond C; Petruchek M; Tirinato L; Di Fabrizio E; Carbone E; Kashuba E
Article: PLOS ONE. 2015;10(8):e0136142

Different Mechanisms of Regulation of the Warburg Effect in Lymphoblastoid and Burkitt Lymphoma Cells.

Mushtaq M; Darekar S; Klein G; Kashuba E
Article: EXPERIMENTAL ONCOLOGY. 2014;36(1):34-37

Number of Langerhans cells is decreased in premalignant keratosis and skin cancers.

Shevchuk Z; Filip A; Shevchuk V; Kashuba E
Article: GENOME ANNOUNCEMENTS. 2013;1(4):e00561-e00513

Draft Genome Sequence of Bacillus cereus Strain F, Isolated from Ancient Permafrost.

Brenner EV; Brouchkov AV; Kurilshikov AM; Griva GI; Kashuba E; Kashuba VI; Melefors O; Repin VE; Melnikov VP; Vlassov VV
Article: ACTA NATURAE. 2013;5(1):85-89

Overexpression of MRPS18-2 in Cancer Cell Lines Results in Appearance of Multinucleated Cells.

Shevchuk Z; Yurchenko MY; Darekar SD; Holodnuka-Kholodnyuk I; Kashuba VI; Kashuba EV
Article: ANALYST. 2012;137(16):3767-3772

Analysis of protein-protein interactions in a complex environment: capture of an analyte-receptor complex with standard additions of the receptor (CARSAR) approach.

Snopok BA; Darekar S; Kashuba EV
Article: CELL DEATH & DISEASE. 2012;3(1):e357

Stem cell gene expression in MRPS18-2-immortalized rat embryonic fibroblasts.

Yenamandra SP; Darekar SD; Kashuba V; Matskova L; Klein G; Kashuba E
Article: PLOS ONE. 2012;7(10):e47012

Alterations of the WNT7A gene in clear cell renal cell carcinomas.

Kondratov AG; Kvasha SM; Stoliar LA; Romanenko AM; Zgonnyk YM; Gordiyuk VV; Kashuba EV; Rynditch AV; Zabarovsky ER; Kashuba VI
Article: PLOS ONE. 2012;7(7):e42072

Epstein-Barr virus immortalization of human B-cells leads to stabilization of hypoxia-induced factor 1 alpha, congruent with the Warburg effect.

Darekar S; Georgiou K; Yurchenko M; Yenamandra SP; Chachami G; Simos G; Klein G; Kashuba E
Article: EXPERIMENTAL ONCOLOGY. 2011;33(1):9-18

CD150-mediated Akt signalling pathway in normal and malignant B cells.

Yurchenko M; Shlapatska LM; Romanets OL; Ganshevskiy D; Kashuba E; Zamoshnikova A; Ushenin YV; Snopok BA; Sidorenko SP
Article: INTERNATIONAL JOURNAL OF CANCER. 2011;128(4):817-825

Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53.

Kashuba E; Yurchenko M; Yenamandra SP; Snopok B; Szekely L; Bercovich B; Ciechanover A; Klein G
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(24):4249-4256

Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes.

Yenamandra SP; Hellman U; Kempkes B; Darekar SD; Petermann S; Sculley T; Klein G; Kashuba E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):67-73

Interaction of Epstein-Barr virus (EBV) with human B-lymphocytes.

Klein G; Klein E; Kashuba E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(47):19866-19871

MRPS18-2 protein immortalizes primary rat embryonic fibroblasts and endows them with stem cell-like properties.

Kashuba E; Pavan Yenamandra S; Darekar SD; Yurchenko M; Kashuba V; Klein G; Szekely L
Article: COMPUTERS IN BIOLOGY AND MEDICINE. 2009;39(11):1036-1042

Comparative analysis of the Epstein-Barr virus encoded nuclear proteins of EBNA-3 family.

Yenamandra SP; Sompallae R; Klein G; Kashuba E
Article: EXPERIMENTAL ONCOLOGY. 2009;31(2):92-96

Expression profile of nuclear receptors upon Epstein -- Barr virus induced B cell transformation.

Yenamandra SP; Lundin A; Arulampalam V; Yurchenko M; Pettersson S; Klein G; Kashuba E
Article: MOLECULAR CANCER. 2009;8:23

PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.

Stuber G; Flaberg E; Petranyi G; Otvös R; Rökaeus N; Kashuba E; Wiman KG; Klein G; Szekely L
Article: MOLECULAR BIOTECHNOLOGY. 2009;41(3):270-277

Study on the spatial architecture of p53, MDM2, and p14ARF containing complexes.

Savchenko A; Yurchenko M; Snopok B; Kashuba E
Article: EXPERIMENTAL ONCOLOGY. 2008;30(4):327-329

Immunofluorescence staining of paraffin sections: creating DAB staining like virtual digital images using CMYK color conversion.

Buchynska L; Kashuba E; Szekely L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(14):5489-5494

EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus, resulting in the disruption of pRb-E2F1 complexes.

Kashuba E; Yurchenko M; Yenamandra SP; Snopok B; Isaguliants M; Szekely L; Klein G
Article: EXPERIMENTAL ONCOLOGY. 2007;29(4):287-294

Different trends of p53, MDM2 and p14 ARF expression patterns in endometrial adenocarcinomas versus hyperplasia.

Buchynska LG; Nesina IP; Kashuba EV
Article: ANALYTICAL CHEMISTRY. 2007;79(4):1349-1355

Imaging technique for the screening of protein-protein interactions using scattered light under surface plasmon resonance conditions.

Savchenko A; Kashuba E; Kashuba V; Snopok B
Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2006;386(7-8):2063-2073

SPR-based immunocapture approach to creating an interfacial sensing architecture: Mapping of the MRS18-2 binding site on retinoblastoma protein.

Snopok B; Yurchenko M; Szekely L; Klein G; Kashuba E
Article: VACCINE. 2006;24(21):4541-4547

HIV-1 reverse transcriptase targeted for proteasomal degradation as a prototype vaccine against drug-resistant HIV-1.

Starodubova E; Boberg A; Kashuba EV; Wahren B; Karpov V; Isaguliants M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(2):1215-1223

Regulation of transactivation function of the aryl hydrocarbon receptor by the Epstein-Barr virus-encoded EBNA-3 protein.

Kashuba EV; Gradin K; Isaguliants M; Szekely L; Poellinger L; Klein G; Kazlauskas A
Article: CELLULAR ONCOLOGY. 2006;28(4):177-190

Hepatitis C virus core protein transforms murine fibroblasts by promoting genomic instability.

Smirnova IS; Aksenov ND; Kashuba EV; Payakurel P; Grabovetsky VV; Zaberezhny AD; Vonsky MS; Buchinska L; Biberfeld P; Hinkula J; Isaguliants MG
Article: EXPERIMENTAL CELL RESEARCH. 2005;303(1):47-55

Epstein-Barr virus-encoded EBNA-5 binds to Epstein-Barr virus-induced Fte1/S3a protein.

Kashuba E; Yurchenko M; Szirak K; Stahl J; Klein G; Szekely L
Article: VACCINE. 2004;22(13-14):1656-1665

Immunization with hepatitis C virus core gene triggers potent T-cell response, but affects CD4+ T-cells.

Isaguliants MG; Petrakova NV; Kashuba EV; Suzdaltzeva YG; Belikov SV; Mokhonov VV; Prilipov AG; Matskova L; Smirnova IS; Jolivet-Reynaud C; Nordenfelt E
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;105(5):644-653

EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells.

Kashuba E; Mattsson K; Pokrovskaja K; Kiss C; Protopopova M; Ehlin-Henriksson B; Klein G; Szekely L
Article: MOLECULAR CANCER. 2003;2:18

p14ARF induces the relocation of HDM2 and p53 to extranucleolar sites that are targeted by PML bodies and proteasomes.

Kashuba E; Mattsson K; Klein G; Szekely L
Article: BMC CELL BIOLOGY. 2002;3:23

Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase.

Kashuba E; Kashuba V; Sandalova T; Klein G; Szekely L
Article: JOURNAL OF GENERAL VIROLOGY. 2002;83(Pt 1):179-188

Latent nuclear antigen of Kaposi's sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions.

Mattsson K; Kiss C; Platt GM; Simpson GR; Kashuba E; Klein G; Schulz TF; Szekely L
Article: JOURNAL OF GENERAL VIROLOGY. 2001;82(Pt 2):345-358

Proteasome inhibitor induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5.

Pokrovskaja K; Mattsson K; Kashuba E; Klein G; Szekely L
Article: ONCOGENE. 2000;19(14):1801-1806

Epstein-Barr virus encoded nuclear protein EBNA-3 binds XAP-2, a protein associated with Hepatitis B virus X antigen.

Kashuba E; Kashuba V; Pokrovskaja K; Klein G; Szekely L
Article: JOURNAL OF GENERAL VIROLOGY. 1999;80 ( Pt 11):2889-2900

Human herpesvirus-8-encoded LNA-1 accumulates in heterochromatin- associated nuclear bodies.

Szekely L; Kiss C; Mattsson K; Kashuba E; Pokrovskaja K; Juhasz A; Holmvall P; Klein G
Article: JOURNAL OF GENERAL VIROLOGY. 1999;80 ( Pt 4):987-995

Epstein-Barr virus infection and mitogen stimulation of normal B cells induces wild-type p53 without subsequent growth arrest or apoptosis.

Pokrovskaja K; Okan I; Kashuba E; L Wbeer M; Klein G; Szekely L
Article: JOURNAL OF HUMAN VIROLOGY. 1999;2(1):33-37

Epstein-Barr virus-encoded nuclear protein EBNA-3 interacts with the epsilon-subunit of the T-complex protein 1 chaperonin complex.

Kashuba E; Pokrovskaja K; Klein G; Szekely L
Article: JOURNAL OF GENERAL VIROLOGY. 1997;78 ( Pt 4):893-903

Role of p53 mutation in polyomavirus-induced tumorigenesis.

Qian W; Kashuba E; Magnusson KP; Pokrovskaja K; Okan I; Klein G; Wiman KG
Article: EUROPEAN JOURNAL OF CANCER PART B: ORAL ONCOLOGY. 1995;31B(5):328-332

Infrequent MDM2 gene amplification and absence of gross WAF1 gene alterations in nasopharyngeal carcinoma.

Qian W; Hu LF; Chen F; Wang Y; Magnusson KP; Kashuba E; Klein G; Wiman KG
Article: NUCLEIC ACIDS RESEARCH. 1995;23(3):362-369

p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain.

Bakalkin G; Selivanova G; Yakovleva T; Kiseleva E; Kashuba E; Magnusson KP; Szekely L; Klein G; Terenius L; Wiman KG
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All other publications

Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2016;131:133-157

Role of the RB-Interacting Proteins in Stem Cell Biology.

Mushtaq M; Gaza HV; Kashuba EV
Review: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2016;2016:6468342-9

DNA Tumor Viruses and Cell Metabolism.

Mushtaq M; Darekar S; Kashuba E
Review: EXPERIMENTAL ONCOLOGY. 2009;31(2):67-73

Nuclear receptors and their role in Epstein -- Barr virus induced B cell transformation.

Yenamandra SP; Klein G; Kashuba E
Review: EXPERIMENTAL ONCOLOGY. 2005;27(1):24-30

The role of CD150-SH2D1A association in CD150 signaling in Hodgkin's lymphoma cell lines.

Yurchenko MY; Kashuba EV; Shlapatska LM; Sivkovich SA; Sidorenko SP
Published paper: STUDIES IN SURFACE SCIENCE AND CATALYSIS. 1997;110:1175-1182

Photoimmobilized catalysts for low-temperature oxidation of olefins

Lyashenko LV; Belousov VM; Kashuba EV

Employments

Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2013-

Degrees and Education

Docent, Karolinska Institutet, 2009
Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 2003

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