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About me

DDS, PhD. Research group leader at the Dept. of Dental Medicine.


DDS, Göteborg University.

PhD, Rheumatology & Inflammation Research, Göteborg University.

Postdoc, Lab. of Molecular Autoimmunity, Harvard Medical School.

Research description

My research group focuses on immune processes and molecular mechanisms underlying chronic inflammatory conditions with the emphasis on monocytes and macrophages (myeloid cells). The lab studies the pathogenesis of periodontitis, inflammatory bowel disease, and rheumatoid arthritis. We employ advanced methodology to characterize the function or dys-function of involved immune cells and molecules, and have a translational approach where human clinical samples and primary cells are used for mechanistic studies.

The lab also studies oral manifestations of Crohn’s disease with the overall hypothesis that oral mucosa mirrors intestinal mucosa. Immune alterations, presented in oral mucosa and saliva, may reflect not only local involvement but also intestinal disease, and may be of value in the diagnosis and monitoring of Crohn’s patients.



Clinical, immunological and microbial gingival profile of juvenile systemic lupus erythematosus patients
Sete Mrc, Carlos Jc, Lira-junior R, Boström Ea, Sztajnbok Fr, Figueredo Cm
Lupus 2019;28(2):189-198

MMP-12 and S100s in saliva reflect different aspects of periodontal inflammation
Holmström Sb, Lira-junior R, Zwicker S, Majster M, Gustafsson A, Åkerman S, et al
Cytokine 2019;113():155-161

Immune response profiling of primary monocytes and oral keratinocytes to different Tannerella forsythia strains and their cell surface mutants
Bloch S, Zwicker S, Bostanci N, Sjöling Å, Boström Ea, Belibasakis Gn, et al
Molecular oral microbiology 2018;33(2):155-167

Oral-gut connection: one step closer to an integrated view of the gastrointestinal tract?
Lira-junior R, Boström Ea
Mucosal immunology 2018;11(2):316-318

Presence of anti-Porphyromonas gingivalis-peptidylarginine deiminase antibodies in serum from juvenile systemic lupus erythematosus patients
Figueredo Cm, Sete Mr, Carlos Jc, Lira R, Boström E, Sztajnbok F
Acta reumatologica portuguesa 2018;43(3):239-240

Salivary microbial profiles in relation to age, periodontal, and systemic diseases
Lira-junior R, Åkerman S, Klinge B, Boström Ea, Gustafsson A
PloS one 2018;13(3):e0189374-

Colony stimulating factor-1 in saliva in relation to age, smoking, and oral and systemic diseases
Lira-junior R, Åkerman S, Gustafsson A, Klinge B, Boström Ea
Scientific reports 2017;7(1):7280-

Effects of polyhexamethylene guanidine phosphate on human gingival fibroblasts
Vitt A, Slizen V, Boström Ea, Yucel-lindberg T, Kats A, Sugars Rv, et al
Acta odontologica Scandinavica 2017;75(7):524-529

Gingival Tissue Inflammation Promotes Increased Matrix Metalloproteinase-12 Production by CD200Rlow Monocyte-Derived Cells in Periodontitis
Björnfot Holmström S, Clark R, Zwicker S, Bureik D, Kvedaraite E, Bernasconi E, et al
Journal of immunology (Baltimore, Md. : 1950) 2017;199(12):4023-4035

Salivary and Serum Markers Related to Innate Immunity in Generalized Aggressive Periodontitis
Lira-junior R, Öztürk VÖ, Emingil G, Bostanci N, Boström Ea
Journal of periodontology 2017;88(12):1339-1347

Salivary Colony Stimulating Factor-1 and Interleukin-34 in Periodontal Disease
Martinez Gl, Majster M, Bjurshammar N, Johannsen A, Figueredo Cm, Boström Ea
Journal of periodontology 2017;88(8):e140-e149

Systemic Chemokine Levels with "Gut-Specific" Vedolizumab in Patients with Inflammatory Bowel Disease-A Pilot Study
Zwicker S, Lira-junior R, Höög C, Almer S, Boström Ea
International journal of molecular sciences 2017;18(8):-

FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
Bosma M, Gerling M, Pasto J, Georgiadi A, Graham E, Shilkova O, et al
Nature communications 2016;7():11314-

Receptor-Type Protein-Tyrosine Phosphatase ζ and Colony Stimulating Factor-1 Receptor in the Intestine: Cellular Expression and Cytokine- and Chemokine Responses by Interleukin-34 and Colony Stimulating Factor-1
Zwicker S, Bureik D, Bosma M, Martinez Gl, Almer S, Boström Ea
PloS one 2016;11(11):e0167324-

Increased Eotaxin and MCP-1 Levels in Serum from Individuals with Periodontitis and in Human Gingival Fibroblasts Exposed to Pro-Inflammatory Cytokines
Boström Ea, Kindstedt E, Sulniute R, Palmqvist P, Majster M, Holm Ck, et al
PloS one 2015;10(8):e0134608-

Interleukin 34: a new modulator of human and experimental inflammatory bowel disease
Zwicker S, Martinez Gl, Bosma M, Gerling M, Clark R, Majster M, et al
Clinical science (London, England : 1979) 2015;129(3):281-90

Faecal analysis and plasma complement factor 3c levels at admission for an acute attack of ulcerative colitis are predictive of the need for colectomy
Pagoldh M, Lange S, Jennische E, Almer S, Boström Ea, Eriksson A
European journal of gastroenterology & hepatology 2014;26(3):295-300

The newly discovered cytokine IL-34 is expressed in gingival fibroblasts, shows enhanced expression by pro-inflammatory cytokines, and stimulates osteoclast differentiation
Boström Ea, Lundberg P
PloS one 2013;8(12):e81665-

Aberrant Macrophages Mediate Defective Kidney Repair That Triggers Nephritis in Lupus-Susceptible Mice
Iwata Y, Bostrom Ea, Menke J, Rabacal Wa, Morel L, Wada T, et al
JOURNAL OF IMMUNOLOGY 2012;188(9):4568-80

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Boström P, Wu J, Jedrychowski Mp, Korde A, Ye L, Lo Jc, et al
Nature 2012;481(7382):463-8

High prevalence of autoantibodies to C-reactive protein in patients with chronic hepatitis C infection: association with liver fibrosis and portal inflammation
Sjowall C, Cardell K, Bostrom Ea, Bokarewa Mi, Enocsson H, Ekstedt M, et al
HUMAN IMMUNOLOGY 2012;73(4):382-8

Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis
Boström Ea, Svensson M, Andersson S, Jonsson Im, Ekwall Ak, Eisler T, et al
Arthritis and rheumatism 2011;63(10):2894-904

Resistin is Associated with Breach of Tolerance and Anti-nuclear Antibodies in Patients with Hepatobiliary Inflammation
Bostrom Ea, Ekstedt M, Kechagias S, Sjowall C, Bokarewa Mi, Almer S

Bostrom Ea, Bokarewa M, Almer Sh

Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli
Bostrom Ea, Tarkowski A, Bokarewa M

Salivary resistin reflects local inflammation in Sjogren's syndrome
Bostrom Ea, D'elia Hf, Dahlgren U, Simark-mattsson C, Hasseus B, Carlsten H, et al
JOURNAL OF RHEUMATOLOGY 2008;35(10):2005-11

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