DDS, PhD. Research group leader at the Dept. of Dental Medicine.
DDS, Göteborg University.
PhD, Rheumatology & Inflammation Research, Göteborg University.
Postdoc, Lab. of Molecular Autoimmunity, Harvard Medical School.
My research group focuses on immune processes and molecular mechanisms underlying chronic inflammatory conditions with the emphasis on monocytes and macrophages (myeloid cells). The lab studies the pathogenesis of periodontitis, inflammatory bowel disease, and rheumatoid arthritis. We employ advanced methodology to characterize the function or dys-function of involved immune cells and molecules, and have a translational approach where human clinical samples and primary cells are used for mechanistic studies.
The lab also studies oral manifestations of Crohn’s disease with the overall hypothesis that oral mucosa mirrors intestinal mucosa. Immune alterations, presented in oral mucosa and saliva, may reflect not only local involvement but also intestinal disease, and may be of value in the diagnosis and monitoring of Crohn’s patients.
Salivary Colony Stimulating Factor-1 and Interleukin-34 in Periodontal Disease
Journal of periodontology 2017;88(8):e140-e149
Systemic Chemokine Levels with "Gut-Specific" Vedolizumab in Patients with Inflammatory Bowel Disease-A Pilot Study
International journal of molecular sciences 2017;18(8):-
FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice
Nature communications 2016;7():11314-
Receptor-Type Protein-Tyrosine Phosphatase ζ and Colony Stimulating Factor-1 Receptor in the Intestine: Cellular Expression and Cytokine- and Chemokine Responses by Interleukin-34 and Colony Stimulating Factor-1
PloS one 2016;11(11):e0167324-
Interleukin 34: a new modulator of human and experimental inflammatory bowel disease
Clinical science (London, England : 1979) 2015;129(3):281-90
Faecal analysis and plasma complement factor 3c levels at admission for an acute attack of ulcerative colitis are predictive of the need for colectomy
European journal of gastroenterology & hepatology 2014;26(3):295-300
Aberrant Macrophages Mediate Defective Kidney Repair That Triggers Nephritis in Lupus-Susceptible Mice
JOURNAL OF IMMUNOLOGY 2012;188(9):4568-80
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Resistin and insulin/insulin-like growth factor signaling in rheumatoid arthritis
Arthritis and rheumatism 2011;63(10):2894-904
Resistin is Associated with Breach of Tolerance and Anti-nuclear Antibodies in Patients with Hepatobiliary Inflammation
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2011;74(5):463-70
HIGH PLASMA RESISTIN LEVELS IN AUTOIMMUNE HEPATITIS
JOURNAL OF HEPATOLOGY 2009;:S242-S242
Resistin is stored in neutrophil granules being released upon challenge with inflammatory stimuli
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2009;1793(12):1894-900
Salivary resistin reflects local inflammation in Sjogren's syndrome
JOURNAL OF RHEUMATOLOGY 2008;35(10):2005-11
Alfred Nobels Allé 8