Ekaterina Morgunova

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Articles

Article: CELL. 2024;187(3):692-711.e26
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme
Kim S; Morgunova E; Naqvi S; Goovaerts S; Bader M; Koska M; Popov A; Luong C; Pogson A; Swigut T; Claes P; Taipale J; Wysocka J
Article: GASTROENTEROLOGY. 2023;165(4):861-873
Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5
Giri AK; Aavikko M; Wartiovaara L; Lemmetyinen T; Karjalainen J; Mehtonen J; Palin K; Valimaki N; Tamlander M; Saikkonen R; Karhu A; Morgunova E; Sun B; Runz H; Palta P; Luo S; Joensuu H; Makela TP; Kostiainen I; Schalin-Jantti C; FinnGen; Palotie A; Aaltonen LA; Ollila S; Daly MJ
Journal article: BIORXIV. 2023;:2023.05.29.541540
DNA-guided transcription factor cooperativity shapes face and limb mesenchyme.
Kim S; Morgunova E; Naqvi S; Bader M; Koska M; Popov A; Luong C; Pogson A; Claes P; Taipale J; Wysocka J
Article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2021;71:171-179
Structural insights into the interaction between transcription factors and the nucleosome
Morgunova E; Taipale J
Article: GENOME RESEARCH. 2020;30(7):962-973
Binding specificities of human RNA-binding proteins toward structured and linear RNA sequences
Jolma A; Zhang J; Mondragon E; Morgunova E; Kivioja T; Laverty KU; Yin Y; Zhu F; Bourenkov G; Morris Q; Hughes TR; Maher III LJ; Taipale J
Article: NATURE COMMUNICATIONS. 2019;10(1):1252
Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans
Kaasinen E; Kuismin O; Rajamaki K; Ristolainen H; Aavikko M; Kondelin J; Saarinen S; Berta DG; Katainen R; Hirvonen EAM; Karhu A; Taira A; Tanskanen T; Alkodsi A; Taipale M; Morgunova E; Franssila K; Lehtonen R; Makinen M; Aittomaki K; Palotie A; Kurki MI; Pietilainen O; Hilpert M; Saarentaus E; Niinimaki J; Junttila J; Kaikkonen K; Vahteristo P; Skoda RC; Seppanen MRJ; Eklund KK; Taipale J; Kilpivaara O; Aaltonen LA
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2770
Novel TMEM173 Mutation and the Role of Disease Modifying Alleles
Keskitalo S; Haapaniemi E; Einarsdottir E; Rajamaki K; Heikkila H; Ilander M; Poyhonen M; Morgunova E; Hokynar K; Lagstrom S; Kivirikko S; Mustjoki S; Eklund K; Saarela J; Kere J; Seppanen MRJ; Ranki A; Hannula-Jouppi K; Varjosalo M
Article: NATURE. 2018;562(7725):76-81
The interaction landscape between transcription factors and the nucleosome
Zhu F; Farnung L; Kaasinen E; Sahu B; Yin Y; Wei B; Dodonova SO; Nitta KR; Morgunova E; Taipale M; Cramer P; Taipale J
Article: ELIFE. 2018;7:e32963
Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima
Morgunova E; Yin Y; Das PK; Jolma A; Zhu F; Popov A; Xu Y; Nilsson L; Taipale J
Article: CURRENT OPINION IN STRUCTURAL BIOLOGY. 2017;47:1-8
Structural perspective of cooperative transcription factor binding
Morgunova E; Taipale J
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(3):782-796
Damaging heterozygous mutations in NFKB1 lead to diverse immunologic phenotypes
Kaustio M; Haapaniemi E; Goos H; Hautala T; Park G; Syrjanen J; Einarsdottir E; Sahu B; Kilpinen S; Rounioja S; Fogarty CL; Glumoff V; Kulmala P; Katayama S; Tamene F; Trotta L; Morgunova E; Krjutskov K; Nurmi K; Eklund K; Lagerstedt A; Helminen M; Martelius T; Mustjoki S; Taipale J; Saarela J; Kere J; Varjosalo M; Seppanen M
Article: SCIENCE. 2017;356(6337):eaaj2239
Impact of cytosine methylation on DNA binding specificities of human transcription factors
Yin Y; Morgunova E; Jolma A; Kaasinen E; Sahu B; Khund-Sayeed S; Das PK; Kivioja T; Dave K; Zhong F; Nitta KR; Taipale M; Popov A; Ginno PA; Domcke S; Yan J; Schubeler D; Vinson C; Taipale J
Journal article: NATURE. 2016;534(7607):s15-s16
DNA-dependent formation of transcription factor pairs alters their binding specificity
Jolma A; Yin Y; Nitta KR; Dave K; Popov A; Taipale M; Enge M; Kivioja T; Morgunova E; Taipale J
Article: NATURE COMMUNICATIONS. 2015;6:10050
Structural insights into the DNA-binding specificity of E2F family transcription factors
Morgunova E; Yin Y; Jolma A; Dave K; Schmierer B; Popov A; Eremina N; Nilsson L; Taipale J
Article: NATURE. 2015;527(7578):384-388
DNA-dependent formation of transcription factor pairs alters their binding specificity
Jolma A; Yin Y; Nitta KR; Dave K; Popov A; Taipale M; Enge M; Kivioja T; Morgunova E; Taipale J
Article: JOURNAL OF INFECTIOUS DISEASES. 2015;211(11):1842-1851
Whole-Genome Sequencing Identifies STAT4 as a Putative Susceptibility Gene in Classic Kaposi Sarcoma
Aavikko M; Kaasinen E; Nieminen JK; Byun M; Donner I; Mancuso R; Ferrante P; Clerici M; Brambilla L; Tourlaki A; Sarid R; Guttman-Yassky E; Taipale M; Morgunova E; Pekkonen P; Ojala PM; Pukkala E; Casanova J-L; Vaarala O; Vahteristo P; Aaltonen LA
Article: ELIFE. 2015;4:e04837
Conservation of transcription factor binding specificities across 600 million years of bilateria evolution
Nitta KR; Jolma A; Yin Y; Morgunova E; Kivioja T; Akhtar J; Hens K; Toivonen J; Deplancke B; Furlong EEM; Taipale J
Article: CELL. 2013;152(1-2):327-339
DNA-Binding Specificities of Human Transcription Factors
Jolma A; Yan J; Whitington T; Toivonen J; Nitta KR; Rastas P; Morgunova E; Enge M; Taipale M; Wei G; Palin K; Vaquerizas JM; Vincentelli R; Luscombe NM; Hughes TR; Lemaire P; Ukkonen E; Kivioja T; Taipale J
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;91(3):520-526
Loss of SUFU Function in Familial Multiple Meningioma
Aavikko M; Li S-P; Saarinen S; Alhopuro P; Kaasinen E; Morgunova E; Li Y; Vesanen K; Smith MJ; Evans DGR; Poyhonen M; Kiuru A; Auvinen A; Aaltonen LA; Taipale J; Vahteristo P
Article: THE FEBS JOURNAL. 2012;279(16):2940-2956
An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity
Wuxiuer Y; Morgunova E; Cols N; Popov A; Karshikoff A; Sylte I; Gonzalez-Duarte R; Ladenstein R; Winberg J-O
Article: NDT PLUS. 2011;4(1):17-19
Novel mutation in Wilms' tumour 1 gene associated with steroid-resistant nephrotic syndrome.
Beltcheva O; Boueva A; Morgunova E; Boiadjieva E; Marinova S; Kaneva R; Mitev V
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2010;66(Pt 9):1001-1011
Structural study and thermodynamic characterization of inhibitor binding to lumazine synthase from Bacillus anthracis
Morgunova E; Illarionov B; Saller S; Popov A; Sambaiah T; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2010;18(10):3518-3534
Virtual screening, selection and development of a benzindolone structural scaffold for inhibition of lumazine synthase
Talukdar A; Morgunova E; Duan J; Meining W; Foloppe N; Nilsson L; Bacher A; Illarionov B; Fischer M; Ladenstein R; Cushman M
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2009;65(Pt 10):1081-1088
Structural insights into the adaptation of proliferating cell nuclear antigen (PCNA) from Haloferax volcanii to a high-salt environment
Morgunova E; Gray FC; MacNeill SA; Ladenstein R
Article: JOURNAL OF ORGANIC CHEMISTRY. 2008;73(7):2715-2724
N-[2,4-dioxo-6-d-ribitylamino-1,2,3,4-tetrahydropyrimidin-5-yl]oxalamic acid derivatives as inhibitors of lumazine synthase and riboflavin synthase:: Design, synthesis, biochemical evaluation, crystallography, and mechanistic implications
Zhang Y; Illarionov B; Morgunova E; Jin G; Bacher A; Fischer M; Ladenstein R; Cushman M
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2007;63(Pt 10):852-854
Isolation, crystallization and preliminary crystallographic analysis of Salmonella typhimurium uridine phosphorylase crystallized with 2,2′-anhydrouridine
Timofeev VI; Lashkov AA; Gabdoulkhakov AG; Pavlyuk BP; Kachalova GS; Betzel C; Morgunova EY; Zhukhlistova NE; Mikhailov AM
Article: CRYSTALLOGRAPHY REPORTS. 2007;52(5):826-837
Comparative analysis of spatial organization of laccases from Cerrena maxima and Coriolus zonatus
Zhukova YN; Zhukhlistova NE; Lyashenko AV; Morgunova EY; Zaitsev VN; Mikhailov AM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(23):17231-17241
Lumazine synthase from Candida albicans as an anti-fungal target enzyme -: Structural and biochemical basis for drug design
Morgunova E; Saller S; Haase I; Cushman M; Bacher A; Fischer M; Ladenstein R
Article: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2006;11(8):963-973
X-ray structural studies of the fungal laccase from Cerrena maxima
Lyashenko AV; Bento I; Zaitsev VN; Zhukhlistova NE; Zhukova YN; Gabdoulkhakov AG; Morgunova FY; Voelter W; Kachalova GS; Stepanova EV; Koroleva GV; Lamzin VS; Tishkov VI; Betzel C; Lindley PF; Mikhailov AM
Article: CRYSTALLOGRAPHY REPORTS. 2006;51(5):817-823
Three-dimensional structure of laccase from Coriolus zonatus at 2.6 Å resolution
Lyashenko AV; Zhukova YN; Zhukhlistova NE; Zaitsev VN; Stepanova EV; Kachalova GS; Koroleva OV; Voelter W; Betzel C; Tishkov VI; Bento I; Gabdulkhakov AG; Morgunova EY; Lindley PF; Mikhailov AM
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 10):954-957
Purification, crystallization and preliminary X-ray study of the fungal laccase from Cerrena maxima
Lyashenko AV; Zhukhlistova NE; Gabdoulkhakov AG; Zhukova YN; Voelter W; Zaitsev VN; Bento I; Stepanova EV; Kachalova GS; Koroleva OV; Cherkashyn EA; Tishkov VI; Lamzin VS; Schirwitz K; Morgunova EY; Betzel C; Lindley PF; Mikhailov AM
Article: THE FEBS JOURNAL. 2006;273(20):4790-4804
Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis
Morgunova E; Illarionov B; Sambaiah T; Haase I; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2005;61(Pt 4):337-340
Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state
Dontsova MV; Gabdoulkhakov AG; Molchan OK; Lashkov AA; Garber MB; Mironov AS; Zhukhlistova NE; Morgunova EY; Voelter W; Betzel C; Zhang Y; Ealick SE; Mikhailov AM
Article: BIOCHEMISTRY. 2005;44(8):2746-2758
Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design:: Binding mode of a new class of purinetrione inhibitors
Morgunova E; Meining W; Illarionov B; Haase I; Jin GY; Bacher A; Cushman M; Fischer M; Ladenstein R
Article: THE FEBS JOURNAL. 2005;272(1):228-243
Characterization of the interactions of the nephrin intracellular domain -: Evidence that the scaffolding protein IQGAP1 associates with nephrin
Liu XL; Kilpeläinen P; Hellman U; Sun Y; Wartiovaara J; Morgunova E; Pikkarainen T; Yan K; Jonsson AP; Tryggvason K
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2004;60(Pt 4):709-711
Purification, crystallization and preliminary X-ray analysis of uridine phosphorylase from Salmonella typhimurium
Dontsova MV; Savochkina YA; Gabdoulkhakov AG; Baidakov SN; Lyashenko AV; Zolotukhina M; Lopes LE; Garber MB; Morgunova EY; Nikonov SV; Mironov AS; Ealick SE; Mikhailov AM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(36):33378-33385
Characterization of recombinant soluble macrophage scavenger receptor MARCO
Sankala M; Brännström A; Schulthess T; Bergmann U; Morgunova E; Engel J; Tryggvason K; Pikkarainen T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(11):7414-7419
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
Morgunova E; Tuuttila A; Bergmann U; Tryggvason K
Article: SCIENCE. 1999;284(5420):1667-1670
Structure of human pro-matrix metalloproteinase-2: Activation mechanism revealed
Morgunova E; Tuuttila A; Bergmann U; Isupov M; Lindqvist Y; Schneider G; Tryggvason K
Article: JOURNAL OF MOLECULAR BIOLOGY. 1998;284(4):1133-1140
Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 Å resolution
Tuuttila A; Morgunova E; Bergmann U; Lindqvist Y; Maskos K; Fernandez-Catalan C; Bode W; Tryggvason K; Schneider G
Article: FEBS LETTERS. 1995;367(2):183-187
ATOMIC-STRUCTURE AT 2.5 ANGSTROM RESOLUTION OF URIDINE PHOSPHORYLASE FROM ESCHERICHIA-COLI AS REFINED IN THE MONOCLINIC CRYSTAL-LATTICE
MORGUNOVA EY; MIKHAILOV AM; POPOV AN; BLAGOVA EV; SMIRNOVA EA; VAINSHTEIN BK; MAO C; ARMSTRONG SR; EALICK SE; KOMISSAROV AA; LINKOVA EV; BURLAKOVA AA; MIRONOV AS; DEBABOV VG
Journal article: CRYSTALLOGRAPHY REPORTS. 1995;40(4):672-680
STRUCTURE-FUNCTIONAL ASPECT OF THE INVESTIGATION OF THE MOLECULAR-STRUCTURE OF URIDINE PHOSPHORYLASE FROM ESCHERICHIA-COLI
MORGUNOVA EY; MIKHAILOV AM; KOMISSAROV AA; MAO C; LINKOVA EV; MIRONOV AS; POPOV AN; ARMSTRONG S; BURLAKOVA AA; ROMANOVA DV; BLAGOVA EV; SMIRNOVA EA; DEBABOV VG; EALICK SE
Journal article: LANGMUIR. 1994;10(11):4232-4236
SUCCESSIVE DEPOSITION OF ALTERNATE LAYERS OF POLYELECTROLYTES AND A CHARGED VIRUS
LVOV Y; HAAS H; DECHER G; MOHWALD H; MIKHAILOV A; MTCHEDLISHVILY B; MORGUNOVA E; VAINSHTEIN B
Journal article: FEBS LETTERS. 1994;338(3):267-271
THE ATOMIC-STRUCTURE OF CARNATION MOTTLE VIRUS CAPSID PROTEIN
MORGUNOVA EY; DAUTER Z; FRY E; STUART DI; STELMASHCHUK VY; MIKHAILOV AM; WILSON KS; VAINSHTEIN BK
Journal article: MOLEKULYARNAYA BIOLOGIYA. 1993;27(2):225-232
X-RAY-ANALYSIS OF SPHERICAL VIRUSES
MORGUNOVA EY; MIKHAILOV AM; VAINSHTEIN BK
Journal article: CRYSTALLOGRAPHY REPORTS. 1992;37(2):396-404
CRYSTAL-STRUCTURE OF CMTV CAPSID AT 6-ANGSTROM RESOLUTION
MORGUNOVA EY; MIKHAILOV AM; URZHUMTSEV AG; VAINSHTEIN BK
Journal article: BIOCHEMISTRY INTERNATIONAL. 1991;24(5):813-822
2 ISOFORMS OF SERRATIA-MARCESCENS NUCLEASE - CRYSTALLIZATION AND PRELIMINARY-X-RAY INVESTIGATION OF THE ENZYME
BANNIKOVA GE; BLAGOVA EV; DEMENTIEV AA; MORGUNOVA EY; MIKCHAILOV AM; SHLYAPNIKOV SV; VARLAMOV VP; VAINSHTEIN BK
Journal article: BIOORGANICHESKAYA KHIMIYA. 1990;16(12):1678-1682
SEPARATION OF ISOFORMS OF A SERRATIA-MARCESCENS ENDONUCLEASE AND CRYSTALLIZATION OF THE ENZYME
BANNIKOVA GE; BLAGOVA EV; VARLAMOV VP; MORGUNOVA EY; DEMENTIEV AA; SHLYAPNIKOV SV
Journal article: DOKLADY - AKADEMIYA NAUK SSSR, EARTH SCIENCE SECTIONS. 1989;305(2):469-474
CMTV VIRION STRUCTURE AT 18-A RESOLUTION
MORGUNOVA EI; MIKHAILOV AM; NIKITENKO AN; VAINSTEIN BK
Journal article: DOKLADY - AKADEMIYA NAUK SSSR, EARTH SCIENCE SECTIONS. 1988;299(5):1129-1134
LOCALIZATION OF CANATION MOTTLE VIRUSES IN A CRYSTAL
MORGUNOVA EI; MIKHAILOV AM; NEKRASOV IV; KAFTANOVA AS; VAINSTEIN BK
Journal article: CRYSTALLOGRAPHY REPORTS. 1987;32(6):1414-1418
STRUCTURE OF THE CARNATION MOTTLE VIRUS IN A SOLUTION
DEMBO AT; MORGUNOVA EY; MCHEDLISHVILI BV; MIKHAILOV AM
Journal article: STUDIA BIOPHYSICA. 1987;122(1-3):71-76
CMTV PROTEIN SUBUNIT - TERTIARY STRUCTURE AND ITS PACKING IN THE CAPSID
MORGUNOVA EY; MICHAILOV AM; DEMBO AT; KAFTANOVA AS; KORNEV AN; POPOV AN
Journal article: DOKLADY - AKADEMIYA NAUK SSSR, EARTH SCIENCE SECTIONS. 1984;276(1):119-&
STRUCTURAL DATA ON THE CARNATION MOTTLE VIRUS STRUCTURE
MORGUNOVA EI; KAFTANOVA AS; KULINICH AV; MIKHAILOV AM; VAINSTEIN BK
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Preprint: BIORXIV. 2023
Interfacial water confers transcription factors with dinucleotide specificity
Morgunova E; Yin Y; Zhu F; Xiao T; Sokolov I; Popov A; Laughton C; Taipale J
Review: BIOTECHNOLOGY REPORTS. 2020;27:e00494
Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development.
Ladenstein R; Morgunova E
Preprint: BIORXIV. 2018
Characterization of novel TMEM173 mutation with additive IFIH1 risk allele
Keskitalo S; Haapaniemi E; Einarsdottir E; Rajamäki K; Heikkilä H; Ilander M; Pöyhönen M; Morgunova E; Hokynar K; Lagström S; Kivirikko S; Mustjoki S; Eklund K; Saarela J; Kere J; Seppänen M; Ranki A; Hannula-Jouppi K; Varjosalo M
Preprint: BIORXIV. 2018
Binding specificities of human RNA binding proteins towards structured and linear RNA sequences
Jolma A; Zhang J; Mondragón E; Morgunova E; Kivioja T; Laverty KU; Yin Y; Zhu F; Bourenkov G; Morris Q; Hughes TR; Maher LJ; Taipale J
Preprint: BIORXIV. 2017
Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima
Morgunova E; Yin Y; Das PK; Jolma A; Popov A; Xu Y; Nilsson L; Taipale J
Letter: JOURNAL OF APPLIED CRYSTALLOGRAPHY. 2008;41:659
Of crystals, structure factors and diffraction images
Jovine L; Morgunova E; Ladenstein R
Book chapter: CENTRIFUGAL MATERIALS PROCESSING. 1997;p. 203-211
Crystallization of Uridine Phosphorylase from E. Coli on Earth, Macrogravity and Microgravity
Blagova E; Morgunova E; Smirnova E; Mikhailov A; Armstrong S; Mao C; Ealick S
Meeting abstract: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 1996;52:C108
THE X-RAY STRUCTURE OF URIDINE PHOSPHORYLASE FROM E-Coli AT 2.5 Å RESOLUTION
Mikhailov AM; Morgunova EY; Ealick SE; Mao C; Armstrong SR; Mironov AS; Komissarov AA
Conference publication: ACTA CRYSTALLOGRAPHICA SECTION A: FOUNDATIONS AND ADVANCES. 1996;52:C182
X-RAY STRUCTURE OF CARNATION MOTTLEVIRUS AT 3.2 Å RESOLUTION
Mikhailov AM; Morgunova EY; Vainshtein BK; Stuart DI; Fry EE; Dauter Z; Wilson KS
Published conference paper: JOURNAL OF CHROMATOGRAPHY A. 1995;711(1):113-118
NEW APPROACHES TO CHROMATOGRAPHIC PURIFICATION OF BOVINE DOPAMINE-BETA-HYDROXYLASE
VARLAMOV VP; LOPATIN SA; ILYINA AV; BANNIKOVA GE; CHLENOV MA; VASIYAROV GG; MITROCHKIN AA; MORGUNOVA EY; PIERROT M; REGLIER M
Book chapter: GROWTH OF CRYSTALS: GROWTH OF CRYSTALS. 1991;p. 181-196
Chromatographic Methods of Purification and Crystallization of Spherical Viruses
Mchedlishvili BV; Morgunova EY; Mikhailov AM

Grants

Interactions that define the gene regulatory code - structural basis of cooperative binding of transcription factors to free and nucleosomal DNA
Swedish Research Council
1 January 2024 - 31 December 2027

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