I'm an Assistant Professor in the laboratory of Prof. Johan K. Sandberg at Center for Infectious Medicine. I obtained my doctoral degree in HIV immunopathogenesis in 2008 at Monash University in Australia. I have since continued working in HIV immunopathogenesis research, and broadened my research interests in innate and mucosal immunity.
Doctor of Philosophy (PhD) in Immunology. The Burnet Institute, and Department of Medicine, Monash University, Melbourne, Australia (2008).
Bachelor of Biomedical Sciences (Honours). First Class Honours. The Burnet Institute, and Monash University, Melbourne, Australia (2003).
Bachelor of Biomedical Sciences. Monash University, Melbourne, Australia (2002).
I'm currently studying the newly-described mucosal-associated invariant T (MAIT) cells in health and disease. MAIT cells are a large subset of innate-like invariant T cells that are abundant in mucosal tissues, the liver, and circulation of healthy humans. MAIT cells recognise the very recently discovered microbial vitamin B2 metabolites derived from a wide range of microbes presented by the highly evolutionarily conserved MHC class I-like MR1 molecules. Recent studies indicate that they respond rapidly through cell-mediated cellular cytotoxicity, suppression of intracellular microbial growth, and secretion of pro-inflammatory cytokines. Therefore, MAIT cells represent an arm of cell-mediated immunity that can recognise and respond to a principally novel and conserved type of antigenic structure.
The study of human MAIT cells is still in its infancy, and many aspects of MAIT cells immunobiology in health and disease are still unexplored. My primary research interest is to understand their biology in health and their role in chronic infections associated with persistent inflammation. We have very recently shown that, unlike in mice, the development and maturation of MAIT cells in humans occurs prior to the establishment of the commensal microflora. We have also recently shown the involvement and potential role of MAIT cells in HIV immunopathogenesis.
No difference in the rate of change in telomere length or telomerase activity in HIV-infected patients after three years of darunavir/ritonavir with and without nucleoside analogues in the MONET trial
PloS one 2014;9(11):e109718-
Will loss of your mucosa-associated invariant T cells weaken your HAART? (vol 27, pg 2501, 2013)
Ex-vivo analysis of human natural killer T cells demonstrates heterogeneity between tissues and within established CD4(+) and CD4(-) subsets
Clinical and experimental immunology 2013;172(1):129-37
Inhibition of Telomerase Activity by Human Immunodeficiency Virus (HIV) Nucleos(t)ide Reverse Transcriptase Inhibitors: A Potential Factor Contributing to HIV-Associated Accelerated Aging
JOURNAL OF INFECTIOUS DISEASES 2013;207(7):1157-65
Soluble biomarkers of HIV transmission, disease progression and comorbidities
Current opinion in HIV and AIDS 2013;8(2):117-24
Will loss of your MAITs weaken your HAART [corrected]?
AIDS (London, England) 2013;27(16):2501-4
Contact-dependent interference with invariant NKT cell activation by herpes simplex virus-infected cells
Journal of immunology (Baltimore, Md. : 1950) 2012;188(12):6216-24
Testing the NKT cell hypothesis in lenalidomide-treated myelodysplastic syndrome patients
The mechanism underlying defective Fc gamma receptor-mediated phagocytosis by HIV-1-infected human monocyte-derived macrophages
JOURNAL OF IMMUNOLOGY 2007;178(2):1096-104
Impaired complement-mediated phagocytosis by HIV type-1-infected human monocyte-derived macrophages involves a cAMP-dependent mechanism
AIDS RESEARCH AND HUMAN RETROVIRUSES 2006;22(7):619-29