Eduardo Villablanca
About me
During my Master degree, I was trained as a developmental biologist, with expertise in cell migration using zebrafish as in vivo model. As a doctoral student in the molecular medicine program at San Raffaele University, Milan, I started my training as immunologist with specific focus on dendritic cells (DC) and tumor cell interaction. I identified a novel immune escape mechanism in which tumors produce and secrete oxysterols, which in turn target LXR receptors inhibiting CCR7 expression in DC (*J. **immunol**, J. Leuko. Biol.* and *Nat. Medicine*). Interested in intestinal leukocyte trafficking, I joined J. Rodrigo Mora’s lab (Massachusetts General Hospital, Boston) to perform my postdoctoral training. During the first two years I contributed to determine the mechanisms by which intestinal DC gain their gut-associated tolerogenic properties (*Gastroenterology*, *J. Immunology, Cell*, etc.).
In 2010, I won the prestigious postdoctoral fellow award from the Crohn’s and Colitis Foundation of America (CCFA) and took the lead of a project aimed to further characterize the mechanisms of oral immunological tolerance induction. I found that expressions of gut homing receptors (e.g. CCR9) are crucial on leukocytes to establish oral immunological tolerance (*Gastroenteroglogy* and *Gut*). Given my accomplishments during my fourth and last year as a postdoctoral training I was supported by Dr. Mora and Dr. Ramnik Xavier (chief of the GI unit) to be promoted Instructor in Medicine at Harvard Medical School. As Instructor in Medicine and in order to start defining my own research path I joined Dr. Xavier lab to study the function of IBD risk genes in the context of intestinal immune homeostasis (*Nat. Comm., Immunity, Cell rep*., etc).
Motivated by cutting-edge research performed as well as the prestige of the institution I decide to look for a position at the Karolinska Institutet. In 2013, I was awarded the Center for Immune Modulatory Therapies for Autoimmnity and Cancer (IMTAC) senior research fellow Based on a scientific plan proposing to study the connection between DC trafficking from the bone marrow and gut immunological tolerance. Hence I started my own research group in November 2014, as an assistant professor at the department of Medicine, Solna (MedS). With background in developmental biology, tumor and mucosal immunology using either zebrafish and mouse models as well as human samples, I believe I am poised to uniquely contribute to elucidate the molecular and cellular mechanisms underlying IBD.
In 2010, I won the prestigious postdoctoral fellow award from the Crohn’s and Colitis Foundation of America (CCFA) and took the lead of a project aimed to further characterize the mechanisms of oral immunological tolerance induction. Hence I started my own research group as an assistant professor at the department of Medicine, Solna (MedS). I have received the Swedish Research Council Young Scientist Award (6 MSEK/4 years), FORMAS (3 MSEK/3 years) and I have been appointed as Wallenberg Academy Fellow (7.5 MSEK/5 years) towards developing a cutting-edge biomedical research program focused on intestinal mucosal immunology. I have achieved national and international recognition for my work as can be inferred from the numerous talks I have been giving in U.S., Europe, Asia and South-America, and from awards and funding I have obtained thus far. I have also been named one of the 40 under 40 most promising Latin-American Scientist by the South American magazine “Que Pasa”.
Selected awards
- Wallenberg Academy Fellow, Knut and Alice Wallenberg foundation (2014)
- IMTAC FoAss position award, chosen as primary candidate (2014)
- CCFA research award, Crohn’s and Colitis Foundation of America (CCFA), NY,
- USA (2010)
Others awards- 40 under 40 in Latin American Science, Que Pasa magazine (2014)
- Best paper award, San Raffaele Institute, Milan, Italy (2010)
- Best presentation award, RCAI International summer Program 2010, Yokohama,
Japan (2010)
Scholarships and travel awards
- DC2012 Travel Award
- Keystone symposia scholarship, To attend the Mucosal Immunology Symposia, Vancouver, Canada (2011)
- RCAI Fellowship, To attend the RCAI International Summer Program, Yokohama, Japan (2010)
- LACI Scholarship, To attend “The 9th Latin American congress of Immunology”, Chile (2009)
- EMBO Travelling fellowship, To participate in the EMBO practical course: "Enhancer Detection, Gene Trapping and TILLING in Zebrafish”, Bergen, Norway (2005)
- Travelling fellowship Leloir Institute. To attend the course “Gene Therapy in Latin America: from the bench to the clinic”, Buenos Aires, Argentina. (2002)
- ECOS-Conicyt ICM P99-137 Fellowship, To perform research at the laboratory of Dr. Alain Ghysen, Montpellier, France (2002)
Courses and degrees
1998, B.S. Bachelor of Science, University of Chile, Santiago
12/2004, M.Sc.Molecular Biotechnology Engineer University of Chile, Santiago
10/2007, Ph.D. Biomedical Sciences, Immunology, Under the supervision of Vincenzo Russo, M.D., Universita Vita-Salute, Milan
Current position
11/2014 – Present, Assistant Professor, Department of Medicine, Karolinska Institutet
11/2015 – Present Faculty member, SciLifeLab
02/2016 – Present Group Leader, Department of Medicine, Karolinska Institutet
Previous positions including post doc-appointments
03/2008 – 02/2012 Postdoctoral Fellow in Mucosal Immunology, MGH, Harvard Medical School, Boston. Under the supervision of J. Rodrigo Mora, M.D.. Ph.D.
02/2012 – 11/2014 Instructor in Medicine, Harvard Medical School, Boston, MA. Under the supervision of Ramnik J. Xavier, M.D.. Ph.D.
02/2012 – 11/2014 Assistant Immunologist, Massachusetts General Hospital, Boston, MA
03/2012 – 11/2014 Research Scientist, Broad Institute, Cambridge, MA
Research
Our lab is seeking to understand the genetic, cellular and environmental contribution towards inflammatory bowel disease (IBD) susceptibility. We have developed a research program that integrates cellular immunology, bioinformatics, and the creation of novel in vivo models to ultimately interrogate the function of IBD-associated polymorphisms as well as to study host-microbiota interactions. In particular, we are trying to understand how deregulation of intestinal immune homeostasis might lead to IBD and trying to discover the function of IBD-risk genes identified by Genome Wide Association Studies (GWAS).
To discover the function of IBD-risk genes, we focus on biological processes that are involved at the initiation (priming of adaptive immune responses), progression (chronic inflammation) or resolution (tissue repair) of IBD. To translate genetic mutations to function, we have developed an innovative pipeline that integrate bioinformatics and animal models, including zebrafish and mouse, to ultimately validate candidate mutations in human tissues by using organoids. We aim to transform the way in which the gene-environment interactions are currently being investigated.
Articles
- Article: NATURE. 2024;:1-9
- Journal article: NATURE PROTOCOLS. 2024;19(10):3085-3137
- Article: NATURE COMMUNICATIONS. 2024;15(1):1752
- Article: MUCOSAL IMMUNOLOGY. 2024;17(1):81-93
- Journal article: JOURNAL OF CROHN'S AND COLITIS. 2024;18(Supplement_1):i2266
- Journal article: JOURNAL OF CROHN'S AND COLITIS. 2024;18(Supplement_1):i450-i451
- Journal article: JOURNAL OF CROHN'S AND COLITIS. 2024;18(Supplement_1):i332
- Article: NATURE COMMUNICATIONS. 2023;14(1):8402
- Article: NATURE IMMUNOLOGY. 2023;24(9):1473-1486
- Article: EBIOMEDICINE. 2023;94:104691
- Journal article: JOURNAL OF HEPATOLOGY. 2023;78:s65
- Article: CELL REPORTS MEDICINE. 2023;4(5):101038
- Article: JCI INSIGHT. 2023;8(4):e161042
- Article: NATURE BIOTECHNOLOGY. 2023;41(2):222-231
- Article: FRONTIERS IN MEDICINE. 2023;10:1258395
- Article: IMMUNITY. 2022;55(12):2336-2351.e12
- Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088
- Article: MUCOSAL IMMUNOLOGY. 2022;15(5):940-951
- Article: MUCOSAL IMMUNOLOGY. 2022;15(3):443-458
- Article: NATURE COMMUNICATIONS. 2022;13(1):828
- Article: MUCOSAL IMMUNOLOGY. 2022;15(2):257-267
- Article: IMMUNITY. 2022;55(1):129-144.e8
- Article: DISEASE MODELS & MECHANISMS. 2021;14(12):dmm049104
- Article: MUCOSAL IMMUNOLOGY. 2021;14(2):411-419
- Article: IMMUNITY. 2021;54(2):259-275.e7
- Article: SCIENTIFIC REPORTS. 2020;10(1):22190
- Article: JOURNAL OF CROHN'S AND COLITIS. 2020;14(12):1748-1758
- Article: CELL REPORTS. 2020;32(5):107979
- Article: NATURE COMMUNICATIONS. 2020;11(1):2049
- Article: REPRODUCTIVE TOXICOLOGY. 2020;93:163-168
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2020;217(2):e20191155
- Journal article: JOURNAL OF CROHN'S AND COLITIS. 2020;14(Supplement_1):s641-s642
- Article: FRONTIERS IN IMMUNOLOGY. 2020;11:591240
- Article: NATURE COMMUNICATIONS. 2019;10(1):2892
- Article: JOURNAL OF AUTOIMMUNITY. 2019;98:86-94
- Article: NATURE COMMUNICATIONS. 2018;9(1):5457
- Article: JOURNAL OF THE ENDOCRINE SOCIETY. 2018;2(12):1363-1380
- Article: DISEASE MODELS & MECHANISMS. 2018;11(11):dmm034876
- Article: MUCOSAL IMMUNOLOGY. 2018;11(3):703-715
- Article: IMMUNITY. 2018;48(1):120-132.e8
- Article: SCIENTIFIC REPORTS. 2018;8(1):154
- Article: PLOS ONE. 2018;13(9):e0204181
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(1):279-292
- Journal article: MOLECULAR & CELLULAR PROTEOMICS. 2017;16(8):1547
- Article: MUCOSAL IMMUNOLOGY. 2017;10(4):884-886
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2017;16(3):502-511
- Article: IMMUNITY. 2016;44(6):1392-1405
- Article: NATURE COMMUNICATIONS. 2015;6:7838
- Article: CELL REPORTS. 2015;11(12):1905-1918
- Article: GUT. 2014;63(9):1431-1440
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(21):7741-7746
- Article: GASTROENTEROLOGY. 2013;145(6):1347-1357
- Article: GASTROENTEROLOGY. 2013;145(3):591-601.e3
- Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2013;210(9):1711-1728
- Article: GASTROENTEROLOGY. 2012;143(3):719-729.e2
- Article: CELL. 2012;149(7):1578-1593
- Article: METHODS IN MOLECULAR BIOLOGY. 2012;757:411-434
- Article: GASTROENTEROLOGY. 2011;141(6):2109-2118
- Article: JOURNAL OF IMMUNOLOGY. 2011;187(4):1877-1883
- Article: JOURNAL OF IMMUNOLOGY. 2011;187(1):141-150
- Article: GASTROENTEROLOGY. 2011;141(1):176-185
- Article: GASTROENTEROLOGY. 2011;140(6):1776-1784
- Journal article: JOURNAL OF IMMUNOLOGY. 2011;186(1_Supplement):161.2
- Journal article: JOURNAL OF VISUALIZED EXPERIMENTS. 2011;(49)
- Article: BMC DEVELOPMENTAL BIOLOGY. 2010;10:120
- Article: NATURE MEDICINE. 2010;16(1):98-105
- Article: BMC DEVELOPMENTAL BIOLOGY. 2009;9:58
- Article: GASTROENTEROLOGY. 2009;137(1):320-329
- Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2008;84(3):871-879
- Article: JOURNAL OF IMMUNOLOGY. 2007;179(1):357-364
- Article: DEVELOPMENTAL BIOLOGY. 2006;295(2):534-545
- Article: DEVELOPMENTAL DYNAMICS. 2006;235(6):1578-1588
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All other publications
- Review: NATURE IMMUNOLOGY. 2024;25(3):405-417
- Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2024;18:I445-I446
- Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2024;18:I328
- Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2024;18:I2254
- Preprint: BIORXIV. 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
- Preprint: BIORXIV. 2023;BIORXIV
- Conference publication: GLIA. 2023;71:E810
- Review: NATURE REVIEWS GASTROENTEROLOGY AND HEPATOLOGY. 2022;19(8):493-507
- Book chapter: CELL MOVEMENT IN HEALTH AND DISEASE. 2022;p.
- Book chapter: CELL MOVEMENT IN HEALTH AND DISEASE. 2022;p. 203-235
- Review: JOURNAL OF CROHN'S AND COLITIS. 2021;15(11):1959-1973
- Review: BIOCHEMICAL SOCIETY TRANSACTIONS. 2021;49(5):2371-2380
- Preprint: BIORXIV. 2021
- Editorial comment: IMMUNITY. 2021;54(6):1097-1099
- Preprint: BIORXIV. 2021
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:35
- Conference publication: SWISS MEDICAL WEEKLY. 2021;151:2
- Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:89
- Preprint: SSRN ELECTRONIC JOURNAL. 2021
- Other: GASTROENTEROLOGY. 2020;158(5):1506-1508
- Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2020;14:S641-S642
- Preprint: BIORXIV. 2019
- Corrigendum: MUCOSAL IMMUNOLOGY. 2019;12(2):580
- Conference publication: JOURNAL OF CROHN'S AND COLITIS. 2019;13:S123
- Conference publication: SWISS MEDICAL WEEKLY. 2019;:3S
- Conference publication: SHOCK. 2019;51(6):41-42
- Book chapter: MOLECULAR GENETICS OF INFLAMMATORY BOWEL DISEASE. 2019;p. 47-76
- Preprint: SSRN ELECTRONIC JOURNAL. 2019
- Review: JOURNAL OF AUTOIMMUNITY. 2018;87:50-60
- Review: FRONTIERS IN IMMUNOLOGY. 2018;9:3177
- Review: FRONTIERS IN IMMUNOLOGY. 2018;9:2667
- Review: NUTRIENTS. 2017;9(1):E68-68
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):268
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):288
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):271
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):291-292
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):269
- Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):293
- Review: ANNUAL REVIEW OF IMMUNOLOGY. 2016;34:31-64
- Review: FRONTIERS IN IMMUNOLOGY. 2015;6:415
- Conference publication: CANCER RESEARCH. 2013;73(8):lb-346-lb-346
- Editorial comment: ONCOIMMUNOLOGY. 2013;2(2):e22987
- Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(12):3136-3140
- Review: MOLECULAR ASPECTS OF MEDICINE. 2012;33(1):63-76
- Editorial comment: JOURNAL OF VISUALIZED EXPERIMENTS. 2011;(49):2619
- Editorial comment: EUROPEAN JOURNAL OF IMMUNOLOGY. 2008;38(11):2975-2980
- Review: HISTOLOGY AND HISTOPATHOLOGY. 2008;23(7):897-910
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Grants
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2023 - 31 December 2025
- Characterization of UC1 and UC2 patients; towards precision medicine in UCCrohn's and Colitis Foundation1 July 2022 - 30 June 2023
- Swedish Research Council1 December 2021 - 30 November 2025
- Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council for Environment Agricultural Sciences and Spatial Planning1 January 2017 - 31 December 2019
- Deutsche Forschungsgemeinschaft1 January 2017 - 31 December 2019
- Swedish Research Council1 January 2015 - 31 December 2018
- Role of retinoic acid in dendritic cell 'education' in the gut: Implications for tolerogenic mucosaCrohn's and Colitis Foundation1 July 2010 - 30 June 2013
Employments
- Principal Researcher, Department of Medicine, Karolinska Institutet, 2022-
Degrees and Education
- Docent, Karolinska Institutet, 2018