Donald Cameron
Affiliated to Research
E-mail: donald.cameron@ki.se
Visiting address: Solnavägen 9, 17165 Stockholm
Postal address: C5 Cell- och molekylärbiologi, C5 CMB Nikkola, 171 77 Stockholm
About me
- My background is in ribosomal DNA (rDNA) transcription, topoisomerase biology
and cancer therapy. I graduated with a Bachelor of Science (Hons) from the
University of Melbourne in 2010. After working at the Peter MacCallum Cancer
Centre as a research assistant for three years, I undertook my PhD studies
supervised by Professor Hannan and Dr. Gretchen Poortinga spilt between the
PMCC and the John Curtin School of Medical Research in Canberra. My PhD
investigated how tumour cells develop resistance to CX-5461, a first-in-class
inhibitor of rDNA transcription initiation currently in multi-site Phase I/II
clinical trials. Through this research, I discovered that CX-5461 acts as a
hyper-targeted Topoisomerase II inhibitor able to cause DNA damage
specifically at the site of rDNA transcription initiation, suggesting that
CX-5461 could provide a less genotoxic alternative to commonly used
chemotherapy agents.
Research
- I joined Laura Baranello’s group in June 2018 to investigate the
interaction between two of the most essential proteins for a tumour cell:
Top2α and c-Myc. I am also researching potential combination therapies using
topoisomerase inhibitors and chromatin modulators in patient-derived
xenograft models of cancer. My goal is to better understand the fundamental
drivers of tumourigenesis thereby enabling us to design drugs to disrupt
these processes and inhibit tumour growth in a non-invasive way.
Articles
- Article: SCIENCE ADVANCES. 2023;9(41):eadg5109Cameron DP; Grosser J; Ladigan S; Kuzin V; Iliopoulou E; Wiegard A; Benredjem H; Jackson K; Liffers ST; Lueong S; Cheung PF; Vangala D; Pohl M; Viebahn R; Teschendorf C; Wolters H; Usta S; Geng K; Kutter C; Arsenian-Henriksson M; Siveke JT; Tannapfel A; Schmiegel W; Hahn SA; Baranello L
- Article: STAR PROTOCOLS. 2022;3(3):101581Kuzin V; Wiegard A; Cameron DP; Baranello L
- Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(3):182-201Castell A; Yan Q; Fawkner K; Bazzar W; Zhang F; Wickstrom M; Alzrigat M; Franco M; Krona C; Cameron DP; Dyberg C; Olsen TK; Verschut V; Schmidt L; Lim SY; Mahmoud L; Hydbring P; Lehmann S; Baranello L; Nelander S; Johnsen JI; Larsson L-G
- Article: MOLECULAR CELL. 2022;82(1):140-158.e12Das SK; Kuzin V; Cameron DP; Sanford S; Jha RK; Nie Z; Rosello MT; Holewinski R; Andresson T; Wisniewski J; Natsume T; Price DH; Lewis BA; Kouzine F; Levens D; Baranello L
- Article: MOLECULAR CELL. 2021;81(24):5007-5024.e9Wiegard A; Kuzin V; Cameron DP; Grosser J; Ceribelli M; Mehmood R; Ballarino R; Valant F; Grochowski R; Karabogdan I; Crosetto N; Lindqvist A; Bizard AH; Kouzine F; Natsume T; Baranello L
- Article: PLOS PATHOGENS. 2021;17(9):e1009954Li J; Nagy N; Liu J; Gupta S; Frisan T; Hennig T; Cameron DP; Baranello L; Masucci MG
- Article: PLOS GENETICS. 2021;17(9):e1009763Wu P-S; Grosser J; Cameron DP; Baranello L; Strom L
- Article: METHODS IN MOLECULAR BIOLOGY. 2021;2318:161-185Cameron DP; Kuzin V; Baranello L
- Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:568Son J; Hannan KM; Poortinga G; Hein N; Cameron DP; Ganley ARD; Sheppard KE; Pearson RB; Hannan RD; Sanij E
- Article: CANCER DISCOVERY. 2019;9(8):1036-1049Khot A; Brajanovski N; Cameron DP; Hein N; Maclachlan KH; Sanij E; Lim J; Soong J; Link E; Blombery P; Thompson ER; Fellowes A; Sheppard KE; McArthur GA; Pearson RB; Hannan RD; Poortinga G; Harrison SJ
- Article: COMMUNICATIONS BIOLOGY. 2019;2:39Diesch J; Bywater MJ; Sanij E; Cameron DP; Schierding W; Brajanovski N; Son J; Sornkom J; Hein N; Evers M; Pearson RB; McArthur GA; Ganley ARD; O'Sullivan JM; Hannan RD; Poortinga G
- Article: INTERNATIONAL JOURNAL OF CANCER. 2018;142(10):2139-2152Martin CA; Cullinane C; Kirby L; Abuhammad S; Lelliott EJ; Waldeck K; Young RJ; Brajanovski N; Cameron DP; Walker R; Sanij E; Poortinga G; Hannan RD; Pearson RB; Hicks RJ; McArthur GA; Sheppard KE
- Article: BLOOD. 2017;129(21):2882-2895Hein N; Cameron DP; Hannan KM; Nguyen N-YN; Fong CY; Sornkom J; Wall M; Pavy M; Cullinane C; Diesch J; Devlin JR; George AJ; Sanij E; Quin J; Poortinga G; Verbrugge I; Baker A; Drygin D; Harrison SJ; Rozario JD; Powell JA; Pitson SM; Zuber J; Johnstone RW; Dawson MA; Guthridge MA; Wei A; McArthur GA; Pearson RB; Hannan RD
- Article: NATURE COMMUNICATIONS. 2017;8:14581-10Lefebure M; Tothill RW; Kruse E; Hawkins ED; Shortt J; Matthews GM; Gregory GP; Martin BP; Kelly MJ; Todorovski I; Doyle MA; Lupat R; Li J; Schroeder J; Wall M; Craig S; Poortinga G; Cameron D; Bywater M; Kats L; Gearhart MD; Bardwell VJ; Dickins RA; Hannan RD; Papenfuss AT; Johnstone RW
- Article: PLOS NEGLECTED TROPICAL DISEASES. 2017;11(3):e0005432Kerry LE; Pegg EE; Cameron DP; Budzak J; Poortinga G; Hannan KM; Hannan RD; Rudenko G
- Article: CLINICAL CANCER RESEARCH. 2016;22(22):5539-5552Rebello RJ; Kusnadi E; Cameron DP; Pearson HB; Lesmana A; Devlin JR; Drygin D; Clark AK; Porter L; Pedersen J; Sandhu S; Risbridger GP; Pearson RB; Hannan RD; Furic L
- Article: ONCOTARGET. 2016;7(31):49800-49818Quin J; Chan KT; Devlin JR; Cameron DP; Diesch J; Cullinane C; Ahern J; Khot A; Hein N; George AJ; Hannan KM; Poortinga G; Sheppard KE; Khanna KK; Johnstone RW; Drygin D; McArthur GA; Pearson RB; Sanij E; Hannan RD
- Article: GENOME RESEARCH. 2015;25(2):201-212Sanij E; Diesch J; Lesmana A; Poortinga G; Hein N; Lidgerwood G; Cameron DP; Ellul J; Goodall GJ; Wong LH; Dhillon AS; Hamdane N; Rothblum LI; Pearson RB; Haviv I; Moss T; Hannan RD
- Journal article: PIGMENT CELL & MELANOMA RESEARCH. 2014;27(4):590-600Young RJ; Waldeck K; Martin C; Foo JH; Cameron DP; Kirby L; Do H; Mitchell C; Cullinane C; Liu W; Fox SB; Dutton-Regester K; Hayward NK; Jene N; Dobrovic A; Pearson RB; Christensen JG; Randolph S; McArthur GA; Sheppard KE
- Article: EUROPEAN JOURNAL OF CANCER. 2013;49(18):3936-3944Sheppard KE; Cullinane C; Hannan KM; Wall M; Chan J; Barber F; Foo J; Cameron D; Neilsen A; Ng P; Ellul J; Kleinschmidt M; Kinross KM; Bowtell DD; Christensen JG; Hicks RJ; Johnstone RW; McArthur GA; Hannan RD; Phillips WA; Pearson RB
All other publications
- Meeting abstract: CANCER RESEARCH. 2017;77:B23Rebello RJ; Kusnadi E; Cameron DP; Pearson HB; Lesmana A; Devlin JR; Drygin D; Clark AK; Porter L; Pedersen J; Sandhu S; Risbridger GP; Pearson RB; Hannan RD; Furic L
- Meeting abstract: CANCER RESEARCH. 2016;76:5181Rebello RJ; Kusnadi E; Cameron D; Lesmana A; Drygin D; Clark AK; Porter L; Sandhu S; Risbridger GP; Pearson RB; Hannan RD; Furic L
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2016;61:s167Rebello R; Kusnadi E; Cameron D; Pearson H; Lesmana A; Devlin J; Drygin D; Clark A; Porter L; Pedersen J; Sandhu S; Risbridger G; Pearson R; Hannan R; Furic L
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2016;61:s134-s135Cameron D; Sanij E; Bywater M; Hein N; Lim J; McArthur G; Poortinga G; Hannan R
- Meeting abstract: MOLECULAR CANCER RESEARCH. 2015;13:a31Poortinga G; Diesch J; Sanij E; Hein N; Sornkum J; Cameron D; Bywater MJ; Johnstone R; Drygin D; O'Brien S; Pearson RB; McArthur GA; Hannan RD
- Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2015;33(15):e280-e281Harrison SJ; Khot A; Brajanovski N; Cameron D; Hein N; McArthur GA; Lim JKC; O'Brien S; Ryckman DM; Yu GI; Link E; Donohoe C; Snowden A; Kuru N; Hannan R
- Meeting abstract: CANCER RESEARCH. 2014;74(19):2735Pearson RB; Devlin JR; Hannan KM; Hein N; Bywater MJ; Poortinga G; Cameron D; Drygin D; O'Brien S; Cullinane C; McArthur GA; Hannan RD
- Meeting abstract: EUROPEAN JOURNAL OF CANCER. 2014;50:s185Rebello R; Drygin D; Cameron D; Risbridger GP; Pearson RB; Hannan RD; Furic L
- Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1842(6):802-816Quin JE; Devlin JR; Cameron D; Hannan KM; Pearson RB; Hannan RD
- Meeting abstract: CANCER RESEARCH. 2013;73:PR16Hannan R; Devlin J; Hannan K; Hein N; Bywater M; Poortinga G; Cameron D; Drygin D; Cullinane C; O'Brien S; McArthur G; Pearson R
Employments
- Affiliated to Research, Department of Cell and Molecular Biology, Karolinska Institutet, 2026-2027
- Research Specialist, Department of Cell and Molecular Biology, Karolinska Institutet, 2024-2024