Désirée Gavhed

About me
Publications
CV
Public outreach and news

About me

I currently share my worktime (50% from 1 April 2024) between research administration tasks at the Division of Pediatric Oncology
and Surgery (10%) and research studies of CNS-LCH (pathology, treatment and late
effects) in the Histiocytosis Research Group (40%).

Activity areas
CNS in Langerhans cell histiocytosis (research), Treatment study protocol of Langerhans cell histiocytosis in children LCH-IV, European LCH-CNS registry, Administrator at the Division of Pediatric Oncology and Surgery (Childhood Cancer Research Unit
and Pediatric Surgery unit)
Rare Diseases (policy and research)
Member of The Histiocyte Society, ICORD (International Conferences of Rare Diseases and Orphan drugs)
and NOPHO (Nordic Society of Pediatric Hematology and Oncology).

Education: MSc Biology with specialization in Biomedicine and Physiology, Stockholm University
PhD in Medical Science (Physiology) at KI

Research

Neurology, Inflammation and late effects in CNS-LCH (Langerhans cell histiocytosis), diagnosis, monitoring, treatment of pediatric LCH

Teaching

Administrator of Specialist Medical courses in Pediatric Hematology and
Oncology and PhD Research Course in Pediatric Hematology and Oncology since 2008.
Co-supervisor of PhD students at KI and Umeå University.
Supervised students at the Medical Programme at KI, Master students in
Biomedicine and Occupational Hygiene, and teached Applied Physiology at
University Programmes of Sports Exercise and Occupational Hygiene.

Selected publications

Article: BRITISH JOURNAL OF HAEMATOLOGY. 2022;198(4):721-728
Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma
Sveijer M; Greenwood TVB; Jadersten M; Kvedaraite E; Zetterberg H; Blennow K; Lourda M; Gavhed D; Henter J-I
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2022;196(1):248-254
Response to mitogen-activated protein kinase inhibition of neurodegeneration in Langerhans cell histiocytosis monitored by cerebrospinal fluid neurofilament light as a biomarker: a pilot study
Henter J-I; Kvedaraite E; Martin Munoz D; Cheng Munthe-Kaas M; Zeller B; Nystad TA; Bjorklund C; Donner I; Lourda M; Zetterberg H; Blennow K; Herold N; Gavhed D; von Bahr Greenwood T

Articles

Article: FRONTIERS IN ONCOLOGY. 2021;11:780191
Neutralizing Anti-IL-17A Antibody Demonstrates Preclinical Activity Enhanced by Vinblastine in Langerhans Cell Histiocytosis
Akefeldt SO; Ismail MB; Belot A; Salvatore G; Bissay N; Gavhed D; Arico M; Henter J-I; Valentin H; Delprat C
Article: CYTOKINE. 2020;126:154877
High levels of plasma interleukin-17A are associated with severe neurological sequelae in Langerhans cell histiocytosis
Ismail MB; Akefeldt SO; Lourda M; Gavhed D; Arico M; Henter J-I; Delprat C; Valentin H
Article: METHODSX. 2020;7:100997
Comparison of three different ELISAs for the detection of recombinant, native and plasma IL-17A
Ismail MB; Akefeldt SO; Lourda M; Gavhed D; Gayet R; Arico M; Henter J-I; Delprat C; Valentin H
Article: GUT. 2016;65(10):1632-1641
Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD
Kvedaraite E; Lourda M; Idestrom M; Chen P; Olsson-Akefeldt S; Forkel M; Gavhed D; Lindforss U; Mjosberg J; Henter J-I; Svensson M
Article: CLINICAL IMMUNOLOGY. 2014;153(1):112-122
Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients
Lourda M; Olsson-Akefeldt S; Gavhed D; Bjornfot S; Clausen N; Hjalmars U; Sabel M; Tazi A; Arico M; Delprat C; Henter J-I; Svensson M
Journal article: ORPHANET JOURNAL OF RARE DISEASES. 2014;9(Suppl 1):o14
RARE-Bestpractices: a platform for sharing best practices for the management of rare diseases
Taruscio D; Morciano C; Laricchiuta P; Mincarone P; Palazzo F; Leo C; Sabina S; Guarino R; Auld J; Sejersen T; Gavhed D; Ritchie K; Hilton-Boon M; Manson J; Kanavos P; Tordrup D; Tzouma V; Le Cam Y; Senecat J; Filippini G; Minozzi S; Del Giovane C; Schünemann H; Meerpohl J; Prediger B; Schell L; Stefanov R; Iskrov G; Miteva-Katrandzhieva T; Serrano-Aguilar P; Perestelo-Perez L; Trujillo-Martín M; Pérez-Ramos J; Rivero-Santana A; Brand A; van Kranen H; Bushby K; Atalaia A; Ramet J; Siderius L; Posada M; Abaitua-Borda I; Ferreira VA; Hens-Pérez M; Manzanares F
Article: INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS. 2014;20(2):309-321
Self-Rated Physical Loads of Work Tasks Among Firefighters
Lindberg A-S; Malm C; Oksa J; Gavhed D
Article: PUBLIC HEALTH GENOMICS. 2013;16(6):278-287
EUROPLAN: A Project to Support the Development of National Plans on Rare Diseases in Europe
Taruscio D; Gentile AE; De Santis M; Ferrelli RM; de la Paz MP; Hens M; Huizer J; Fregonese L; Stefanov R; Bottarelli V; Weinman A; Le Cam Y; Gavhed D; Mincarone P; Bushby K; Frazzica RG; Donati C; Vittozzi L; Jessop E
Article: PLOS ONE. 2013;8(7):e68047
Field Tests for Evaluating the Aerobic Work Capacity of Firefighters
Lindberg A-S; Oksa J; Gavhed D; Malm C
Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2012;101(11):1151-1155
Langerhans cell histiocytosis in children born 1982-2005 after in vitro fertilization
Akefeldt SO; Finnstrom O; Gavhed D; Henter J-I
Article: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2012;101(8):805-807
The need for worldwide policy and action plans for rare diseases
Forman J; Taruscio D; Llera VA; Barrera LA; Cote TR; Edfjaell C; Gavhed D; Haffner ME; Nishimura Y; Posada M; Tambuyzer E; Groft SC; Henter J-I
Article: PEDIATRIC BLOOD AND CANCER. 2011;56(2):250-257
Incidence and Pattern of Radiological Central Nervous System Langerhans Cell Histiocytosis in Children: A Population Based Study
Laurencikas E; Gavhed D; Stalemark H; van't Hooft I; Prayer D; Grois N; Henter J-I
Article: PEDIATRIC BLOOD AND CANCER. 2009;53(7):1264-1270
Biomarkers in the Cerebrospinal Fluid and Neurodegeneration in Langerhans Cell Histiocytosis
Gavhed D; Akefeldt SO; Osterlundh G; Laurencikas E; Hjorth L; Blennow K; Rosengren L; Henter J-I
Article: PEDIATRIC BLOOD AND CANCER. 2008;51(5):669-674
Neuropsychological sequelae in patients with neurodegenerative Langerhans cell histiocytosis
van't Hooft I; Gavhed D; Laurencilkas E; Henter J-I
Article: INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS. 2008;38(11-12):1051-1061
Workstation layout and work postures at call centres in Sweden in relation to national law, EU-directives and ISO-standards, and to operators' comfort and symptoms
Toomingas A; Gavhed D
Article: PEDIATRIC BLOOD AND CANCER. 2008;51(1):76-81
Incidence of Langerhans cell histiocytosis in children:: A population-based study
Stalemark H; Laurencikas E; Karis J; Gavhed D; Fadeel B; Henter J-I
Article: INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS. 2007;37(9-10):790-800
Observed physical working conditions in a sample of call centres in Sweden and their relations to directives, recommendations and operators' comfort and symptoms
Gavhed D; Toomingas A
Article: APPLIED ERGONOMICS. 2007;38(1):45-52
Classification of metabolic and respiratory demands in fire fighting activity with extreme workloads
Holmer I; Gavhed D
Article: LAKARTIDNINGEN. 2005;102(18-19):1444-1446
[Enigmatic diseases in children. Still a lot of questions left in spite of great research progress on LCH and HLH].
Fadeel B; Trottestam H; Löfstedt M; Gavhed D; Henter J-I
Article: INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS. 2004;10(2):111-117
Effectiveness of a light-weight ice-vest for body cooling while wearing fire fighter's protective clothing in the heat.
Smolander J; Kuklane K; Gavhed D; Nilsson H; Holmér I
Article: INTERNATIONAL JOURNAL OF BIOMETEOROLOGY. 2003;47(3):148-155
Face cooling by cold wind in walking subjects
Gavhed D; Mäkinen T; Holmér I; Rintamäki H
Article: INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS. 2001;7(2):135-148
Validation of methods for determination of metabolic rate in the Edholm scale and ISO 8996.
Giedraityte L; Holmér I; Gavhed D
Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2000;83(4-5):449-456
Face temperature and cardiorespiratory responses to wind in thermoneutral and cool subjects exposed to-10 °C
Gavhed D; Mäkinen T; Holmér I; Rintamäki H
Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2000;81(5):397-402
Thermal responses to cold wind of thermoneutral and cooled subjects
Mäkinen T; Gavhed D; Holmér I; Rintamäki H
Article: EUROPEAN RESPIRATORY JOURNAL. 1998;12(4):825-830
Inhalation of cold air increases the number of inflammatory cells in the lungs in healthy subjects
Larsson K; Tornling G; Gavhed D; Muller-Suur C; Palmberg L
Article: INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS. 1998;21(6):465-474
Thermal responses at three low ambient temperatures: Validation of the duration limited exposure index
Gavhed DCE; Holmer I
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 1997;29(12):1631-1636
Influence of a β₂-agonist on physical performance at low temperature in elite athletes
Larsson K; Gavhed D; Larsson L; Holmér I; Jorfelt L; Ohlsén P
Article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY. 1996;73(6):573-581
Physiological and subjective responses to thermal transients of exercising subjects dressed in cold-protective clothing.
Gavhed DC; Holmér I
Journal article: ARCTIC MEDICAL RESEARCH. 1991;50 Suppl 6:94-98
Resultant clothing insulation during exercise in the cold.
Holmér I; Gavhed DC
Journal article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY. 1991;63(1):29-35
Thermoregulatory and subjective responses of clothed men in the cold during continuous and intermittent exercise.
Gavhed DC; Nielsen R; Holmér I
Journal article: ERGONOMICS. 1989;32(12):1581-1594
Thermal function of a clothing ensemble during work: dependency on inner clothing layer fit.
Nielsen R; Gavhed DC; Nilsson H
Journal article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY. 1989;59(1-2):115-122
Thermoregulatory responses of firemen to exercise in the heat.
Gavhed DC; Holmér I
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All other publications

Conference publication: PEDIATRIC BLOOD AND CANCER. 2023;70:S26
CLINICALLY SILENT LATE RELAPSE OF LANGERHANS CELL HISTIOCYTOSIS (LCH) IN CNS: VALUE OF REGULAR MONITORING OF RADIOLOGICAL NEURODEGENERATIVE DISEASE RELATED TO LCH AND THE ROLE OF DETECTION OF ELEVATED NFL PROTEIN IN CEREBROSPINAL FLUID
Krenova Z; Gavhed D; Henter J-I; Senkyrik J; Sterba J
Conference publication: PEDIATRIC BLOOD AND CANCER. 2023;70:S20-S21
SCREENING FOR NEURODEGENERATION IN LCH WITH NEUROFILAMENT LIGHT IN PLASMA
Henter J-I; Sveijer M; Jadersten M; Kvedaraite E; Zetterberg H; Blennow K; Lourda M; Gavhed D; Greenwood TVB
Conference publication: PEDIATRIC BLOOD AND CANCER. 2022;69:S10
Response to Mapk Inhibition of Neurodegeneration in Lch Monitored by Csf Neurofilament Light as a Biomarker
Henter J-I; Kvedaraite E; Munoz DM; Munthe-Kaas MC; Zeller B; Nystad T; Bjorklund C; Donner I; Lourda M; Zetterberg H; Blennow K; Herold N; Gavhed D; Greenwood TVB
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2020;191(1):115-119
High prevalence of peripheral lymphopenia in Langerhans cell histiocytosis
Lourda M; Wideskold S; Kvedaraite E; Gavhed D; Akber M; von Bahr Greenwood T; Svensson M; Olsson-Akefeldt S; Henter J-I
Editorial comment: NATURE GENETICS. 2020;52(1):21-26
A call for global action for rare diseases in Africa
Baynam GS; Groft S; van der Westhuizen FH; Gassman SD; du Plessis K; Coles EP; Selebatso E; Selebatso M; Gaobinelwe B; Selebatso T; Joel D; Llera VA; Vorster BC; Wuebbels B; Djoudalbaye B; Austin CP; Kumuthini J; Forman J; Kaufmann P; Chipeta J; Gavhed D; Larsson A; Stojiljkovic M; Nordgren A; Roldan EJA; Taruscio D; Wong-Rieger D; Nowak K; Bilkey GA; Easteal S; Bowdin S; Reichardt JKV; Beltran S; Kosaki K; van Karnebeek CDM; Gong M; Zhang S; Mehrian-Shai R; Adams DR; Puri RD; Zhang F; Pachter N; Muenke M; Nellaker C; Gahl WA; Cederroth H; Broley S; Schoonen M; Boycott KM; Posada M
Conference publication: PEDIATRIC BLOOD AND CANCER. 2020;67:S17-S18
PERSISTENT LYMPHOPENIA IN LCH PATIENTS LIKELY RELATED TO CONSTANTLY HIGH LEVELS OF IL-7 AND IL-21
Lourda M; Wideskold S; Kvedaraite E; Gavhed D; Greenwood TVB; Svensson M; Olsson-Akefeldt S; Henter J-I
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):316
Increased prevalence of lymphopenia in patients with Langerhans cell histiocytosis
Lourda M; Olsson-Akefeldt S; Gavhed S; Kvedaraite E; Gavhed D; Svensson M; Henter J-I
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):253
Stromal cell - innate immune cell interactions in inflammatory bowel disease patients
Kvedaraite E; Lourda M; Van Acker A; Jess DU; Gavhed D; Mjosberg J; Idestrom M; Henter J-I; Svensson M
Conference publication: PEDIATRIC BLOOD AND CANCER. 2017;64:S21-S22
High Prevalence of Lymphopenia in Langerhans Cell Histiocytosis: Correlation with Early Onset and More Severe Disease
Lourda M; Olsson-Akefeldt S; Gavhed S; Kvedaraite E; Gavhed D; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2017;64:S20
When Langerhans Met Crohn: A Clinical Case Report and a First Three-Dimentional Reconstruction of Human Gut
Kvedaraite E; Jess DU; Gavhed D; Idestrom M; Svensson M; Lourda M; Henter J-I
Letter: BLOOD. 2016;128(9):1302-1305
Adsorptive depletion of blood monocytes reduces the levels of circulating interleukin-17A in Langerhans cell histiocytosis
Lourda M; Olsson-Akefeldt S; Gavhed D; Nygell UA; Berlin G; Laurencikas E; Greenwood TVB; Svensson M; Henter J-I
Book chapter: OCCUPATIONAL PHYSIOLOGY. 2016;p. 154-195
Prolonged, Low-Intensity, Sedentary Work
Conference publication: PEDIATRIC BLOOD AND CANCER. 2016;63:S24-S25
Adsorptive Depletion of Blood Monocytes Reduces the Levels of Circulating Interleukin-17A in Langerhans Cell Histiocytosis
Lourda M; Olsson-Akefeldt S; Gavhed D; Nygell UA; Berlin G; Laurencikas E; Greenwood TVB; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2015;62:S131-S132
INTERLEUKIN-17A AS A BIOMARKER IN NEURODEGENERATIVE LANGERHANS CELL HISTIOCYTOSIS
Lourda M; Olsson-Akefeldt S; Gavhed D; Greenwood TVB; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2015;62:S10
EXPLORATION OF THE IL-23/IL-17A AXIS IN LANGERHANS CELL HISTIOCYTOSIS
Kvedaraite E; Lourda M; Chen P; Gavhed D; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2014;61(11):2135
PRODUCTION BY BLOOD MONOCYTES IS TIGHTLY RELATED TO THE DEGREE OF ACTIVITY OF LANGERHANS CELL HISTIOCYTOSIS
Lourda M; Akefeldt SO; Gavhed D; Clausen N; Hjalmars U; Sabel M; Tazi A; Arico M; Delprat C; Svensson M; Henter J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2013;60(9):E79-E80
CIRCULATING CYTOKINE-PRODUCING CELLS IN LANGERHANS CELL HISTIOCYTOSIS
Lourda M; Akefeldt SO; Gavhed D; Svensson M; Henter J-I
Editorial comment: ACTA PAEDIATRICA, INTERNATIONAL JOURNAL OF PAEDIATRICS. 2011;100(7):e36-e39
Fifteen years of treatment with intravenous immunoglobulin in central nervous system Langerhans cell histiocytosis
Gavhed D; Laurencikas E; Akefeldt SO; Henter J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2009;53(4):695
IMAGING OF LANGERHANS CELL HISTIOCYTOSIS WITH IN-111-PENTETREOTIDE SCINTIGRAPHY IN CHILDREN
Stalemark H; Skytt N; Borgwardt L; Gormsen M; Gavhed D; Jacobsson H; Nysom K; Henter J-I; Laurencikas E
Conference publication: PEDIATRIC BLOOD AND CANCER. 2009;53(4):690
TWELVE YEARS OF TREATMENT WITH IVIG IN A PATIENT WITH CNS-LCH
Gavhed D; Laurencikas E; Olsson S; Henter J-I
Conference publication: PEDIATRIC BLOOD AND CANCER. 2007;48(7):749
Neuropsychological profiles in children with CNS-LCH
Gavhed D; van't Hooft I; Laurencikas E; Henter J-I
Book chapter: ENVIRONMENTAL ERGONOMICS - THE ERGONOMICS OF HUMAN COMFORT, HEALTH AND PERFORMANCE IN THE THERMAL ENVIRONMENT: ELSEVIER ERGONOMICS BOOK SERIES. 2005;p. 225-230
Perceived problems and discomfort at low air humidity among office workers
Gavhed D; Klasson L
Thesis / dissertation: 2003
Human responses to cold and wind
Gavhed, Désirée
Published conference paper: INTERNATIONAL JOURNAL OF INDUSTRIAL ERGONOMICS. 2001;27(6):367-373
A field study in dairy farms: thermal condition of feet
Kuklane K; Gavhed D; Fredriksson K
Published conference paper: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY -PART A : MOLECULAR AND INTEGRATIVE PHYSIOLOGY. 2001;128(4):759-768
Effects of metabolic rate on thermal responses at different air velocities in-10°C
Mäkinen TT; Gavhed D; Holmér I; Rintamäki H
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Employments

Senior Research Specialist, Department of Women's and Children's Health, Karolinska Institutet, 2022-

Degrees and Education

Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2003

Supervisor

Malin Sveijer, Reducing CNS complications in Langerhans cell histiocytosis, 2022

About me

Research

Teaching

Selected publications

Articles

All other publications

Employments

Degrees and Education

Supervisor

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